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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Pattern response of dendritic cells in the tumor microenvironment and breast cancer显示文摘Breast cancer(BC) is the most common malignant neoplasm and the cause of death by cancer among women worldwide. Its development, including malignancy grade and patient prognosis, is influenced by various mutations that occur in the tumor cell and by the immune system's status, which has a direct influence on the tumor microenvironment and, consequently, on interactions with non-tumor cells involved in the immunological response. Among the immune response cells, dendritic cells(DCs) play a key role in the induction and maintenance of anti-tumor responses owing to their unique abilities for antigen cross-presentation and promotion of the activation of specific lymphocytes that target neoplasic cells. However, the tumor microenvironment can polarize DCs, transforming them into immunosuppressive regulatory DCs, a tolerogenicphenotype which limits the activity of effector T cells and supports tumor growth and progression. Various factors and signaling pathways have been implicated in the immunosuppressive functioning of DCs in cancer, and researchers are working on resolving processes that can circumvent tumor escape and developing viable therapeutic interventions to prevent or reverse the expression of immunosuppressive DCs in the tumor microenvironment. A better understanding of the pattern of DC response in patients with BC is fundamental to the development of specific therapeutic approaches to enable DCs to function properly. Various studies examining DCs immunotherapy have demonstrated its great potential for inducing immune responses to specific antigens and thereby reversing immunosuppression and related to clinical response in patients with BC. DCbased immunotherapy research has led to immense scientific advances, both in our understanding of the antitumor immune response and for the treatment of these patients. | Alessandra da Cunha Marcia A Michelin Eddie FC Murta | 2014 | World Journal of Clinical Oncology2014，5，3： | 5 |
| 3 | Plasticity of Human Adipose Lineage Cells Toward Endothelial Cells: Physiological and Therapeutic Perspectives显示文摘 | Valérie Planat-Benard Jean-Sébastien Silvestre Béatrice Cousin Mireille André Maryse Nibbelink Radia Tamarat Michel Clergue Carole Manneville Corinne Saillan-Barreau Micheline Duriez Alain Tedgui Bernard Levy Luc Pénicaud Louis Casteilla | 2004 | Circulation: Journal of the American Heart Association2004，，5： | 2 |
| 4 | The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood显示文摘 | Emmanuel Jacquemin J. Marleen L. De Vree Danièle Cresteil Etienne M. Sokal Ekkehard Sturm Micheline Dumont George L. Scheffer Marianne Paul Martin Burdelski Piter J. Bosma Olivier Bernard Michelle Hadchouel Ronald P.J. Oude Elferink | 2001 | Gastroenterology2001，，6： | 2 |
| 5 | 衰老对大鼠阴茎勃起机制的影响显示文摘为探讨衰老对阴茎勃起机制的影响程度 ,以不同月龄的雄性大鼠分别观察海绵体神经诱导的阴茎勃起 ,海绵体平滑肌的舒张功能以及阴茎含NOS神经和平滑肌量。结果表明电刺激老年鼠海绵体神经可取得与年轻和中年鼠相当的勃起压力 ,但勃起潜伏期较长。注射罂粟碱提示老年鼠海绵体平滑肌顺应性较年轻鼠差。检查还提示老年鼠阴茎内含NOS神经和平滑肌纤维量有一定减少。实验证实衰老对阴茎勃起机制中关键性的组织结构和功能有一定影响 ,但影响较为缓慢 ,老年大鼠仍保留完整的勃起机制且能获得较好的勃起水平 。 | 林宗明 张永康 王国民 SergeCarrier Micheline Cournoyer | 2000 | 中国男科学杂志2000，14，2： | 2 |
| 6 | Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens显示文摘 | Micheline Fromont-Racine Jean-Christophe Rain Pierre Legrain | 1997 | Nature Genetics1997，16，： | 1 |
| 7 | Data Mining--Concepts and Techniques显示文摘 | Jiawei Han Micheline Kambr | 2001 | Higher Education Press &Morgn Kaufmann publishers2001，，： | 1 |
| 8 | Highgrowth entrepreneurial firms in Africa: a quantile regression approach显示文摘 | MICHELINE GOEDHUYS LEO SLEUWAEGEN | 2010 | Small Business Economics2010，340，： | 1 |
| 9 | GRA12,a Toxoplasma dense granule protein associated with the intravacuolar membranous nanotubular network显示文摘 | MICHELIN A BITTAME A BORDAT Y | 2009 | Int J Parasitol2009，39，3： | 1 |
| 10 | Characterization of the granular packing and percolation threshold of reactive powder concrete显示文摘 | Olivier Bonneau Christian Vemet Micheline Moranville etal | 2000 | Cement andConcrete Research2000，30，： | 1 |
| 11 | Ibogaine attenuation of morphine withdrawal in mice: role of glutamate N - methyl - D - aspartate receptors 显示文摘 | Leal MB Michelin K Souza DO | 2003 | Prog Neruopsychopharmacol Biol Psychiatry2003，27，5： | 1 |
| 12 | Design and test of the VLT M1 mirror passive and active supporting system显示文摘 | HOVSEPIAN T MICHELIN J M STANGHELLINI S | | 0，，3352： | 1 |
| 13 | Distribution ofcanthaxanthin andlycopene in rats and monkeys显示文摘 | Micheline M M Sudha W Prabahat K S | 1990 | J Nutr1990，120，： | 1 |
| 14 | Effect of iron metal and siderite on the durability of simulated archeological glassy material显示文摘 | A. Michelin E. Burger E. Leroy E. Foy D. Neff K. Benzerara P. Dillmann S. Gin | 2013 | Corrosion Science2013，，： | 1 |
| 15 | Influence of storage period and effect of different brands of acrylic resin on the dimensional accuracy of the maxillary denture base显示文摘 | Miéssi Ana Carolina Goiato Marcelo Coelho dos Santos Daniela Micheline | 2008 | Brazilian dental journal2008，19，3： | 1 |
| 16 | 2-Amino-2-oxazoline and trialkylisourea Pt(ll) complexes derived from organocyanamides 显示文摘 | FERREIRA C M P SILVA DA M F C G MICHELIN R A | 2003 | Dalton Trans2003，，19： | 1 |
| 17 | Data Mining Concepts and Techniques显示文摘 | JIAWEI HAN MICHELINE KAMBER | 2000 | Italy:Morgan Kaufmarm Publishers2000，，： | 1 |
| 18 | Atypical squanmous cell of undetermined significance:analysis of microbiology,cytological criteria conduct显示文摘 | Barcelos AC Adad SJ Michelin MA | 2006 | Turmori2006，92，： | 1 |
| 19 | Industrial Application of an H-Infinity Design Method for Flexible Structures显示文摘 | COUSTAL P MICHELIN J M | 1994 | IEEE Control System1994，14，4： | 1 |
| 20 | Endobronchial and trans-bronchial biopsies in children显示文摘 | Tagliaferro T Michelin E Snijders D | 2008 | Expert Rev Respir Med2008，2，2： | 1 |
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