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| 1 | Mi R-122 in hepatitis B virus and hepatitis C virus dual infection显示文摘Hepatitis B virus(HBV) and hepatitis C virus(HCV) infections are the most common causes of chronic liver diseases and hepatocelluar carcinomas. Over the past few years, the liver-enriched micro RNA-122(mi R-122) has been shown to differentially regulate viral replication of HBV and HCV. It is notable that thelevel of mi R-122 is positively and negatively regulated by HCV and HBV, respectively. Consistent with the welldocumented phenomenon that mi R-122 promotes HCV accumulation, inhibition of mi R-122 has been shown as an effective therapy for the treatment of HCV infection in both chimpanzees and humans. On the other hand, mi R-122 is also known to block HBV replication, and HBV has recently been shown to inhibit mi R-122 expression; such a reciprocal inhibition between mi R-122 and HBV suggests an intriguing possibility that mi R-122 replacement may represent a potential therapy for treatment of HBV infection. As HBV and HCV have shared transmission routes, dual infection is not an uncommon scenario, which is associated with more advanced liver disease than either HBV or HCV mono-infection. Thus, there is a clear need to further understand the interaction between HBV and HCV and to delineate the role of mi R-122 in HBV/HCV dual infection in order to devise effective therapy. This review summarizes the current understanding of HBV/HCV dual infection, focusing on the pathobiological role and therapeutic potential of mi R-122. | Kyoungsub Song Chang Han Srikanta Dash Luis A Balart Tong Wu | 2015 | World Journal of Hepatology2015，7，3： | 6 |
| 2 | Randomized Controlled Trial of Danoprevir Plus Peginterferon Alfa-2a and Ribavirin in Treatment-Naive Patients with HCV Genotype 1 Infection显示文摘 | P. Marcellin C. Cooper L. Balart D. Larrey T. Box E. Yoshida E. Lawitz P. Buggisch P. Ferenci M. Weltman E. Labriola-Tompkins S. Le Pogam I. Nájera D. Thomas G. Hooper N.S. Shulman Y. Zhang M.T. Navarro C.Y. Lim M. Brunda N.A. Terrault E.S. Yetzer | 2013 | Gastroenterology2013，，： | 2 |
| 3 | Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs. | Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 4 | Observations of Cleavage Initiation at (Ti,V)(C,N) Particles of Heterogeneous Composition in Microalloyed Steels显示文摘 | Balart M J Davis C L Strangwood M | 2004 | Scripta Materialia2004，50，3： | 1 |
| 5 | Kidney Transplantation Alone in ESRD Patients With Hepatitis C Cirrhosis显示文摘 | Anil S. Paramesh John Y. Davis Chaitanya Mallikarjun Rubin Zhang Robert Cannon Nathan Shores Mary T. Killackey Jennifer McGee Bob H. Saggi Douglas P. Slakey Luis Balart Joseph F. Buell | 2012 | Transplantation Journal2012，，3： | 1 |
| 6 | Hepatitis C–related hepatocellular carcinoma in the United States: influence of ethnic status显示文摘 | Adrian M Di Bisceglie Andre C Lyra Myron Schwartz Rajender K Reddy Paul Martin Gregory Gores Anna S.F Lok Khozema B Hussain Robert Gish David H Van Thiel Zobair Younossi Myron Tong Tarek Hassanein Luis Balart Jacquelyn Fleckenstein Stephen Flamm Andres Bl | 2003 | The American Journal of Gastroenterology2003，，9： | 1 |
| 7 | Surface modification of polypropylene substrates by UV photografting of methyl meth- acrylate (MMA) for improved surface wettability 显示文摘 | Balart J Fommbuena V Boronat T | 2012 | J Mater Sci2012，47，5： | 1 |
| 8 | Substitu- tion of di (2 -ethylhexy) phthalate by di (isononyl) cy- clohexane - 1, 2 - dicarboxylate as a plasticizer for indus- trial vinyl plastisol formulations 显示文摘 | CRESPO J E BALART R SANCHEZ L | 2007 | J Appl Polym Sci2007，104，2： | 1 |
| 9 | Characterization of blends of poly (vinyl chloride) waste for building applications显示文摘 | David Garcia Ra fael Balart Francisco Parres | 2007 | J Mater Sci2007，42，10： | 1 |
| 10 | Development of the Vertebral Column, Finsand Fin Supports in the Japanese Anchor, Engraulisjaponicus ( Clupeiformes : Engraulididae) 显示文摘 | BALART E F | 1995 | Bull Mar Sci1995，56，2： | 1 |
| 11 | Osteological development of the hyobranehial ap- paratus in Engraulis japonicas显示文摘 | BALART E F | 1985 | Bull Jap SoeSei Fish1985，51，4： | 1 |
| 12 | Recent Ad- vances in Cancer Therapy: An Overview显示文摘 | Urruticoechea A Alemany R Balart J et aI | 2010 | Curr Pharm Des2010，16，1： | 1 |
| 13 | A prospective randomized controlled trial of chronic esophageal variceal sclerotherapy显示文摘 | Korula J Yamada S Balart LA | 1985 | Hepatology1985，5，3： | 1 |
| 14 | Development of the vertebral column, fins and fin supports in the Japanese anchovy, Engraulis japonieus ( Clu- peifonnes : Engraulididae) 显示文摘 | BALART E F | 1995 | Bull Mar Sei1995，56，2： | 1 |
| 15 | Mechanical proper- ties of recycled PVC blends with styrenic polymer显示文摘 | Garcia D Balart R Crespo J E | 2006 | J Ap- pl Polym Sci2006，101，4： | 1 |
| 16 | Substitution of di(2- ethylhexyl ) phthalate by di ( isononyl ) eyclohexane-1, 2- dicarboxylate as a plasticizer for industrial vinyl plastisol formulations显示文摘 | Crespo J E Balart R Sanehez L | 2007 | Journal of Applied Polymer Science2007，104，： | 1 |
| 17 | Inertization of pyrite cinders and co-inertization with electric arc furnace flue dusts by pyroconsolidation at solid state显示文摘 | Vinals J Balart M J Roca A | 2002 | Waste Managenent2002，22，7： | 1 |
| 18 | Osteologlcal Development of the HyobranchialApparatus in Engraulis japonicas 显示文摘 | BALART E F | 1985 | Bull Jap Soc Sci Fish1985，51，4： | 1 |
| 19 | The influence of the gut microbiomeon obesity,metabolic syndrome and gastrointestinal disease 显示文摘 | Parekh PJ Balart LA Johnson DA | 2015 | ClinTransl Gastroenterol2015，18，6： | 1 |
| 20 | Characterization of blends of poly( vinyl chloride) waste for building applications 显示文摘 | David Garcia Rafacl Balart Francisco Parres | 2007 | J Mater Sci2007，42，10： | 1 |
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