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| 1 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | γ-Catenin is an independent prognostic marker in early stage colorectal cancer显示文摘 | Jutta Maria Nagel Lydia Kriegl David Horst Jutta Engel Shiva Gautam Christos S. Mantzoros Thomas Kirchner Burkhard G?ke Frank Thomas Kolligs | 2010 | International Journal of Colorectal Disease2010，，11： | 1 |
| 4 | Time to 'achieve remission determines time to be in remission 显示文摘 | Lydia G Alfons A | 2010 | Arthritis Research & Therapy2010，12，3： | 1 |
| 5 | Clinical significance of multidrug resistance P - glycoprotein expression on acute nolymphoblastic leukemia cells at diagnosis显示文摘 | Lydia C Dmia G Eric A | 1992 | Blood1992，79，： | 1 |
| 6 | Bifla- vonoids from Brazilian pine Araucaria angustifolia as poten- tials protective agents against DNA damage and lipoperoxi- dation显示文摘 | Lydia F Yamaguchi Daniel G Vassio Massuo J Kato | 2005 | Phytochemistry2005，66，： | 1 |
| 7 | Phylogenomics of MADS-box genes in plants two opposing life styles in one gene family显示文摘 | Lydia G Gunter T | 2013 | Biology2013，2，3： | 1 |
| 8 | C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors显示文摘 | Derek G Cook Mike A Mendall Peter H Whincup Iain M Carey Lydia Ballam Julia E Morris George J Miller David P Strachan | 2000 | Atherosclerosis2000，，1： | 1 |
| 9 | Adenomyosis: review of the lit- erature显示文摘 | Lydia G Keith L | 2011 | J Minim Invas Gynecol2011，18，4： | 1 |
| 10 | Did Convergent Protein Evolution Enable Phytoplasmas to Generate ‘Zombie Plants’?显示文摘 | Florian Rümpler Lydia Gramzow Günter Thei?en Rainer Melzer | 2015 | Trends in Plant Science2015，，： | 1 |
| 11 | Influence of sugars on the characteristics of glucono - δ - lactone - induced soy protein iso- late gels 显示文摘 | Xin G Lydia J Campbell | 2009 | Food Hydrocolloids2009，23，： | 1 |
| 12 | Parenting behaviours as- sociated with the development of adaptive and maladaptive offspring personality traits显示文摘 | Jeffrey G Johnson Lydia Liu Patricia Cohen | 2011 | Can J Psychiatry2011，56，8： | 1 |
| 13 | Nilotinib in imatinib -resistant CML and Philadelphia chromosome - positive ALL 显示文摘 | Hagop K Francis G Lydia W | 2006 | N Engl J Med2006，354，24： | 1 |
| 14 | Geographically and technologically mediated knowledge spillovers between European regions 显示文摘 | Lydia G | 2003 | The Annals of Regional Science2003，37，4： | 1 |
| 15 | “What If I Make a Mistake?”: Intolerance of Uncertainty Is Associated With Poor Behavioral Performance显示文摘 | Michel A. Thibodeau R. Nicholas Carleton Lydia Gómez-Pérez Gordon J.G. Asmundson | 2013 | The Journal of Nervous and Mental Disease2013，，9： | 1 |
| 16 | Clinicl significance of multidrig resstence P-glycoprotein expression on acute nolymphoblastic leukemia cells at diagnosis显示文摘 | Lydia C Demia G Eric A | 1992 | Blood1992，79，： | 1 |
| 17 | Industrial structure and innovation - evidence from European regions显示文摘 | LYDIA G | 2004 | Journal of Evolutionary Eco nomics2004，14，5： | 1 |
| 18 | Control of particle interfaces—the critical issue in nanoparticle technology显示文摘 | Wolfgang Peukert Hans-Christoph Schwarzer Martin G?tzinger Lydia Günther Frank Stenger | 2003 | Advanced Powder Technology2003，，4： | 1 |
| 19 | The cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells 显示文摘 | Robert G Catharina G Lydia R | 2004 | J Immunol2004，172，9： | 1 |
| 20 | Model for breast cancer survival: relative prognostic roles of axillary nodal status, TNM stage, Estrogen receptor concentration, and tumor necrosis 显示文摘 | Lydia LMS William G | 1988 | Cancer Research1988，48，19： | 1 |
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