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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | SIRT3 Is a mitochondrial tumor suppressor:a scientific tale that connects aberrant cellular ROS,the warburg effect, and carcinogenesis 显示文摘 | Marcia C H Deng C X Lydia W S | 2012 | Cancer Research2012，72，10： | 1 |
| 3 | Methods for the enhancement of fingermarks in blood 显示文摘 | Lydia C A M Bossers Claude Roux Michael Bell | 2011 | Forensic Science International2011，，210： | 1 |
| 4 | Heat stability and emulsifying ability of whole egg and egg yolk as related to heat treatment 显示文摘 | Lydia c Vassilios R Stephen R E | 2005 | Food Hydrocolloids2005，19，3： | 1 |
| 5 | Design and development of food safety knowledge and attitude scales for consumer food safety education 显示文摘 | Lydia C Medeiros PhD RD Virginia N HiRers PhD | 2004 | J Am Diet Assoc2004，104，： | 1 |
| 6 | Growth of very low birth weight infant to age 20 year显示文摘 | Maureen H Mark S Lydia C | 2003 | J Pediatr2003，112，： | 1 |
| 7 | Effects of cryotherapy or chemotherapy on apoptosis in a non-small-cell lung cancer xenografted into SCID mice显示文摘 | Vale'fie F Michel P Lydia C | 2005 | Cryobiology2005，50，： | 1 |
| 8 | Collaborative Design: A Learner- Centered Library Planning Approach显示文摘 | Mary M Somerville Lydia C | 2009 | The Electronic Library2009，，6： | 1 |
| 9 | Clinical significance of multidrug resistance P - glycoprotein expression on acute nolymphoblastic leukemia cells at diagnosis显示文摘 | Lydia C Dmia G Eric A | 1992 | Blood1992，79，： | 1 |
| 10 | Synthesis of Structured Triacylglycerols by Lipase-Catalyzed Acidolysis in a Packed Bed Bioreactor显示文摘 | Xue B X Lydia B F Casimir C A | 2000 | J Agric Food Chem2000，48，1： | 1 |
| 11 | The revised generalized expectancy for success scale: a validity and reliability study显示文摘 | HALE W DANIEL FIEDLER LYDIA R COCHRAN C D | 1992 | American: Journal of Clin- ical Psychology1992，48，4： | 1 |
| 12 | Design and development of food safety knowledge and attitude scales for consumer food safety education显示文摘 | Lydia C Medeiros PhD RD Virginia N Hillers PhD | 2004 | J Am Diet Assoc2004，104，： | 1 |
| 13 | Modification of menhaden oil by enzymatic aeidolysis to produce structured lipids 显示文摘 | Xu Xuebing Fomuso Lydia B Akoh Ca- simir C | 2000 | Journal of American Oil Chemists Society2000，77，2： | 1 |
| 14 | Blocking retinoic acidreceptor-a enhances the efficacy of a dendritic cell vaccineagainst tumours by suppressing the induction of regulatory Tcells显示文摘 | Karen C Galvin Lydia Dyck | 2013 | Cancer Immunol Immunother2013，62，： | 1 |
| 15 | Separation and identification of hen egg protein isoforms using SDS-PAGE and 2D gel electrophoresis with MALDI-TOF mass spectrometry显示文摘 | Vassilios R Rasmus H Lydia C | | 0，，： | 1 |
| 16 | Growth of very low birth weight infant to age 20 year 显示文摘 | Maureen H Mark S Lydia C | 2003 | J Pediatr2003，112，： | 1 |
| 17 | Benefit of a combined treatment of eryotherapy and chemotherapy on tumour growth and late cryo- induced angiogenesis in a non-small-cell lung cancer model 显示文摘 | Valerie F Michel P Lydia C | 2006 | Lung Cancer2006，54，1： | 1 |
| 18 | Incidence and characterization of intcgrons, genetic elements mediating multiple-drud resistance, in Avian Escherichia coli显示文摘 | LYDIA BASS LIEBERT C A LEE M D | 1999 | Antimicrob Agents Chemother1999，43，12： | 1 |
| 19 | Growth of very low birth weight infant to age 20 year显示文摘 | Maureen H Mark S Lydia C | 2003 | J Pediatr2003，112，： | 1 |
| 20 | Clinicl significance of multidrig resstence P-glycoprotein expression on acute nolymphoblastic leukemia cells at diagnosis显示文摘 | Lydia C Demia G Eric A | 1992 | Blood1992，79，： | 1 |
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