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| 1 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 2 | Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis显示文摘 | John A Green John M Kirwan Jayne F Tierney Paul Symonds Lydia Fresco Mandy Collingwood Christopher J Williams | 2001 | The Lancet . 2001 (9284)2001，，： | 2 |
| 3 | Does Nonalcoholic Fatty Liver Disease Predispose Patients to Hepatocellular Carcinoma in the Absence of Cirrhosis?显示文摘 | Guzman Grace Brunt Elizabeth M Petrovic Lydia M Chejfec Gregorio Layden Thomas J Cotler Scott J | 2008 | Archives of Pathology & Laboratory Medicine2008，，11： | 2 |
| 4 | Influence of sugars on the characteristics of glucono- δ -lactone-induced soy protein isolate gels 显示文摘 | XIN Gu LYDIA J CAMPBEL L | 2009 | Food Hydrocolloids2009，23，： | 1 |
| 5 | Defective tight junctions in refractory celiac disease显示文摘 | Michael Schumann Sarah Kamel Marie‐Luise Pahlitzsch Lydia Lebenheim Claudia May Michael Krauss Michael Hummel Severin Daum Michael Fromm J?rg‐Dieter Schulzke | 2012 | Annals of the New York Academy of Sciences2012，，1： | 1 |
| 6 | Antilipoxygen ase activity of compounds from Hypericum perfora- tum显示文摘 | MAREK O B LYDIA J HOLKOV A etal | 2006 | Section Celhiar Molecular Biology2006，61，3： | 1 |
| 7 | Young age is an independent prognostic factor for survival of sporadic renal cell carcinoma显示文摘 | Ricardo F S Charles J R Lydia T M | 2004 | J Urol2004，171，61： | 1 |
| 8 | The differential expression of oestrogen receptors,progesterone receptors,bcl-2 and ki-67 in endometrial polyps显示文摘 | Lydia J Taylor Tracy L et a1 | 2003 | Br J Obstet Gynaecol2003，110，9： | 1 |
| 9 | Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis显示文摘 | John A Green John M Kirwan Jayne F Tierney Paul Symonds Lydia Fresco Mandy Collingwood Christopher J Williams | 2001 | The Lancet2001，，9284： | 1 |
| 10 | Identification of kinetic and temporal factors related to vertical jump performance显示文摘 | James J Dowling Lydia Vamos | | 0，，： | 1 |
| 11 | Coupling protein stability and protein function in Escherichia coli CspA显示文摘 | Brian J Hillier Hector M Rodriguez Lydia M Gregoret | 1998 | Folding and Design1998，，2： | 1 |
| 12 | Corporate reputation in the People's Republic of China:A B2B Perspective显示文摘 | MICHAEL T E LYDIA W FIONA J N | 2010 | Industrial Marketing Management2010，，39： | 1 |
| 13 | Infectivity of blood products from donors with occult hepatitis B virus infection显示文摘 | Jean‐Pierre Allain Ivanka Mihaljevic Maria Isabel Gonzalez‐Fraile Knut Gubbe Lene Holm‐Harritsh?j Jose Maria Garcia Ewa Brojer Christian Erikstrup Mona Saniewski Lorenz Wernish Lydia Bianco Henrik Ullum Daniel Candotti Nico Lelie Wolfram H. Gerlich Michae | 2013 | Transfusion2013，，7： | 1 |
| 14 | 3D printing of patient-specific implants for osteochondral defects: workflow for an MRI-guided zonal design显示文摘Magnetic resonance imaging(MRI)is a common clinical practice to visualize defects and to distinguish different tissue types and pathologies in the human body.So far,MRI data have not been used to model and generate a patient-specific design of multilayered tissue substitutes in the case of interfacial defects.For orthopedic cases that require highly individual surgical treatment,implant fabrication by additive manufacturing holds great potential.Extrusion-based techniques like 3D plot-ting allow the spatially defined application of several materials,as well as implementation of bioprinting strategies.With the example of a typical multi-zonal osteochondral defect in an osteochondritis dissecans(OCD)patient,this study aimed to close the technological gap between MRI analysis and the additive manufacturing process of an implant based on dif-ferent biomaterial inks.A workflow was developed which covers the processing steps of MRI-based defect identification,segmentation,modeling,implant design adjustment,and implant generation.A model implant was fabricated based on two biomaterial inks with clinically relevant properties that would allow for bioprinting,the direct embedding of a patient’s own cells in the printing process.As demonstrated by the geometric compatibility of the designed and fabricated model implant in a stereolithography(SLA)model of lesioned femoral condyles,a novel versatile CAD/CAM workflow was successfully established that opens up new perspectives for the treatment of multi-zonal(osteochondral)defects. | David Kilian Philipp Sembdner Henriette Bretschneider Tilman Ahlfeld Lydia Mika Jörg Lützner Stefan Holtzhausen Anja Lode Ralph Stelzer Michael Gelinsky | 2021 | Bio-Design and Manufacturing2021，4，4： | 1 |
| 15 | Influence of sugars on the characteristics of glucono--lactone-induced soy protein isolate gels显示文摘 | Lydia J Campbell | | 0，，： | 1 |
| 16 | Bifla- vonoids from Brazilian pine Araucaria angustifolia as poten- tials protective agents against DNA damage and lipoperoxi- dation显示文摘 | Lydia F Yamaguchi Daniel G Vassio Massuo J Kato | 2005 | Phytochemistry2005，66，： | 1 |
| 17 | Health practitioners' and healthplanners' information needs and seeking behavior for decision making in Uganda显示文摘 | Lydia Kapiriri Susan J Bondy | 2006 | International Journal of Medical Informatics2006，75，1011： | 1 |
| 18 | Fatal inhala- tional anthrax in a 94-year-old Connecticut woman 显示文摘 | Lydia A Barakat H L Quentze J A | 2002 | JA- MA2002，287，7： | 1 |
| 19 | C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors显示文摘 | Derek G Cook Mike A Mendall Peter H Whincup Iain M Carey Lydia Ballam Julia E Morris George J Miller David P Strachan | 2000 | Atherosclerosis2000，，1： | 1 |
| 20 | The management of variety reference collections in distinctness,uniformity and stability testing of wheat显示文摘 | Robert J Jarman Lydia Austin | 2003 | Euphytica2003，132，： | 1 |
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