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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Spatial Conflicts and Urban Renewal in a Southwest City 显示文摘 | Lydia R Otero La Calle | 2011 | Reviews/Journal of Historical Geogra- phy2011，37，4： | 1 |
| 3 | Young age is an independent prognostic factor for survival of sporadic renal cell carcinoma显示文摘 | Ricardo F S Charles J R Lydia T M | 2004 | J Urol2004，171，61： | 1 |
| 4 | Selenium determination in urine with atomic fluorescence detection显示文摘 | ROSA S ROSER R LYDIA G-B | 2001 | Analytica Chimica Acta2001，436，2： | 1 |
| 5 | Heat stability and emulsifying ability of whole egg and egg yolk as related to heat treatment 显示文摘 | Lydia c Vassilios R Stephen R E | 2005 | Food Hydrocolloids2005，19，3： | 1 |
| 6 | Microstructure of milk gel and cheese curd observed using cryo scanning electron microscopy and confocal microscopy显示文摘 | LYDIA ONG RAYMOND R DAGASTINE SANDRA E KENT- ISH | 2011 | LWT - Food Science and Technology2011，44，： | 1 |
| 7 | The revised generalized expectancy for success scale: a validity and reliability study显示文摘 | HALE W DANIEL FIEDLER LYDIA R COCHRAN C D | 1992 | American: Journal of Clin- ical Psychology1992，48，4： | 1 |
| 8 | Pregnancy-associated deaths:a 15-year retrospective study and overall review of maternal pathophysiology显示文摘 | CHRISTIANSEN LYDIA R COLLINS | 2006 | Am J Foresic Med and Patho2006，27，1： | 1 |
| 9 | The adaptive consumer: Shifting at-titudes, behavior change and CSA membership renewal显示文摘 | Willows R Lydia Z | 2008 | Re- newable Agriculture and Food Systems2008，23，2： | 1 |
| 10 | Coping as a Multisystem Construct Associated With Pathways Mediating HIV- Relevant Immune Function and Disease Progressiion 显示文摘 | Lydia R Temoshok PHD Rebecca L | 2008 | Psychosomatic Medicine2008，70，： | 1 |
| 11 | Separation and identification of hen egg protein isoforms using SDS-PAGE and 2D gel electrophoresis with MALDI-TOF mass spectrometry显示文摘 | Vassilios R Rasmus H Lydia C | | 0，，： | 1 |
| 12 | The role of the basal ganglia and cerebellum in language processing显示文摘 | James R Booth Lydia Wood | 2007 | Brain Res2007，1133，1： | 1 |
| 13 | Did Convergent Protein Evolution Enable Phytoplasmas to Generate ‘Zombie Plants’?显示文摘 | Florian Rümpler Lydia Gramzow Günter Thei?en Rainer Melzer | 2015 | Trends in Plant Science2015，，： | 1 |
| 14 | Heat stability and emulsifying ability of whole egg and egg yolk as related to heat treatment显示文摘 | Vassilios Raikos Stephen R Euston | 2005 | Food Hydrocolloids2005，19，3： | 1 |
| 15 | Structural and optical proper ties of Cu2 ZnSnS4 nanopartieles for solar cell applications 显示文摘 | Lydia R Reddy P Sreedhara | 2013 | J Nano Electronic Phys2013，5，3： | 1 |
| 16 | The cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells 显示文摘 | Robert G Catharina G Lydia R | 2004 | J Immunol2004，172，9： | 1 |
| 17 | Notch‐3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury显示文摘 | Sonja Djudjaj Christos Chatziantoniou Ute Raffetseder Dominique Guerrot Jean‐Claude Dussaule Peter Boor Monique Kerroch Lydia Hanssen Sabine Brandt Annemarie Dittrich Tammo Ostendorf Jürgen Floege Cheng Zhu Maja Lindenmeyer Clemens D Cohen Peter R Mertens | 2012 | J Pathol2012，，3： | 1 |
| 18 | Rheology and texture of hen's egg protein heat-set gels as affected by pH and the addition of sugar and/or salt显示文摘 | Vassilios R Lydia C Stephen R E | | 0，，21： | 1 |
| 19 | The cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells 显示文摘 | Robert G Catharina G Lydia R | 2004 | J Immunol2004，172，1： | 1 |
| 20 | Heat stability and emul- sifying ability of whole egg and egg yolk as related to heat treatment显示文摘 | Lydia C Vassilios R Stephen R E | 2005 | Food Hydrocolloids2005，19，3： | 1 |
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