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| 1 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 2 | Widespread use of gastric acid inhibitors in infants:Are they needed? Are they safe?显示文摘Gastroesophageal reflux is a common phenomenon in infants,but the differentiation between gastro-esophageal reflux and gastroesophageal reflux disease can be difficult.Symptoms are non-specific and there is increasing evidence that the majority of symptoms may not be acid-related.Despite this,gastric acid inhibitors such as proton pump inhibitors are widely and increasingly used,often without objective evidence or investigations to guide treatment.Several studies have shown that these medications are ineffective at treating symptoms associated with reflux in the absence of endoscopically proven oesophagitis.With a lack of evidence for efficacy,attention is now being turned to the potential risks of gastric acid suppression.Previously assumed safety of these medications is being challenged with evidence of potential side effects including GI and respiratory infections,bacterial overgrowth,adverse bone health,food allergy and drug interactions. | Mark Safe Wei H Chan Steven T Leach Lee Sutton Kei Lui Usha Krishnan | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 3 | Disappearing Colorectal Liver Metastases after Chemotherapy: Should we be Concerned?显示文摘 | Mark G. Vledder Mechteld C. Jong Timothy M. Pawlik Richard D. Schulick Luis A. Diaz Michael A. Choti | 2010 | Journal of Gastrointestinal Surgery2010，，11： | 2 |
| 4 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 5 | Structurefunction analysis of hepatocyte growth factor:identification of variants that lack mitogenic activity yet retain high affinity receptor binding显示文摘 | Lokker NA Mark MR Luis EA | 1992 | EMBO J1992，11，7： | 1 |
| 6 | Wireless SAW Sensor Temperature Extraction Precision 显示文摘 | Luis M Rodrigucz Daniel R Gallagher Mark W Gallagher | 2014 | IEEE Sensors Journal2014，14，11： | 1 |
| 7 | Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension显示文摘 | Gordon H Williams Ellen Burgess Rainer E Kolloch Luis Miguel Ruilope Joanna Niegowska Mark S Kipnes Barbara Roniker Jeffrey L Patrick Scott L Krause | 2004 | The American Journal of Cardiology2004，，： | 1 |
| 8 | Discrimination between six species of canine microfilariae by a single polymerase chain reaction显示文摘 | Mark Rishniw Stephen C. Barr Kenny W. Simpson Marguerite F. Frongillo Marc Franz Jose Luis Dominguez Alpizar | 2005 | Veterinary Parasitology2005，，3： | 1 |
| 9 | Improved nitrogen removal by application of new nitrogen-cycle bacteria显示文摘 | Mike S.M. Jetten Markus Schmid Ingo Schmidt Mariska Wubben Udo van Dongen Wiebe Abma Olav Sliekers Niels Peter Revsbech Hubertus J.E. Beaumont Lars Ottosen Eveline Volcke H.J. Laanbroek Jose Luis Campos-Gomez Jeff Cole Mark van Loosdrecht Jan Willem Mulde | 2002 | Reviews in Environmental Science and Biotechnology2002，，1： | 1 |
| 10 | Radical addition of a conjugated polymer to multilayer fullerenes (carbon nano onions)显示文摘 | Rettenbacher Arno S Perpall Mark W Echegoyen Luis | 2007 | Chemistry of Materials2007，19，6： | 1 |
| 11 | Antioxidant activity of the cruciferous vegetable Maca ( Lepidium meyenii )显示文摘 | Manuel Sandoval Nataly N. Okuhama Fausto M. Angeles Vanessa V. Melchor Luis A. Condezo Juan Lao Mark J.S. Miller | 2002 | Food Chemistry2002，，2： | 1 |
| 12 | Validity of four pain intensity rating scales显示文摘 | Maria Alexandra Ferreira-Valente Jose Luis Pais-Ribeiro Mark P J | 2011 | Pain2011，152，10： | 1 |
| 13 | Rare earth doped fluoride waveguides fabricated using molecular beam epitaxy显示文摘 | McFarlane Ross A Lui Mark Yap Daniel | 1995 | IEEE Journal of Selected Topics in Quantum Electronics1995，1，1： | 1 |
| 14 | Diagnostic Criteria and Yield of Real-Time Transcranial Doppler Monitoring of Intra-Arterial Reperfusion Procedures显示文摘 | Marta Rubiera Luis Cava Georgios Tsivgoulis Damon E. Patterson Limin Zhao Yi Zhang Aaron M. Anderson Alice Robinson Mark R. Harrigan Edward Underwood Joseph Horton Andrei V. Alexandrov | 2010 | Stroke2010，，4： | 1 |
| 15 | Riboflavin/Ultraviolet A Corneal Collagen Cross-linking for the Treatment of Keratoconus: Visual Outcomes and Scheimpflug Analysis显示文摘 | Maria A Henriquez Luis Izquierdo Cesar Bernilla Peter A Zakrzewski Mark Mannis | 2011 | Cornea2011，，3： | 1 |
| 16 | Riboflavin/Ultraviolet A Corneal Collagen Cross-linking for the Treatment of Keratoconus: Visual Outcomes and Scheimpflug Analysis显示文摘 | Maria A Henriquez Luis Izquierdo Cesar Bernilla Peter A Zakrzewski Mark Mannis | 2011 | Cornea2011，，3： | 1 |
| 17 | Phase I dose escalation clinical trial of phenylbutyrate sodium administered twice daily to patients with advanced solid tumors显示文摘 | Luis H. Camacho Jon Olson William P. Tong Charles W. Young David R. Spriggs Mark G. Malkin | 2007 | Investigational New Drugs2007，，2： | 1 |
| 18 | Radical addition of a conjugated polymer to multilayer fullerenes (carbon nano-onions) 显示文摘 | Amo S R Mark W P Luis E | 2007 | Chem Mater2007，19，7： | 1 |
| 19 | The Lunar Reconnaissance Orbiter Laser Ranging Investigation显示文摘 | Maria T. Zuber David E. Smith Ronald S. Zellar Gregory A. Neumann Xiaoli Sun Richard B. Katz Igor Kleyner Adam Matuszeski Jan F. McGarry Melanie N. Ott Luis A. Ramos-Izquierdo David D. Rowlands Mark H. Torrence Thomas W. Zagwodzki | 2010 | Space Science Reviews (-)2010，，1： | 1 |
| 20 | Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin显示文摘 | Miguel López Ricardo Lage Asish K. Saha Diego Pérez-Tilve María J. Vázquez Luis Varela Susana Sangiao-Alvarellos Sulay Tovar Kawtar Raghay Sergio Rodríguez-Cuenca Rosangela M. Deoliveira Tamara Casta?eda Rakesh Datta Jesse Z. Dong Michael Culler Mark W. S | 2008 | Cell Metabolism2008，，5： | 1 |
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