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| 1 | Chaperones in hepatitis C virus infection显示文摘The hepatitis C virus(HCV) infects approximately 3% of the world population or more than 185 million people worldwide. Each year, an estimated 350000-500000 deaths occur worldwide due to HCV-associated diseases including cirrhosis and hepatocellular carcinoma. HCV is the most common indication for liver transplantation in patients with cirrhosis worldwide. HCV is an enveloped RNA virus classified in the genus Hepacivirus in the Flaviviridae family. The HCV viral life cycle in a cell can be divided into six phases:(1) binding and internalization;(2) cytoplasmic release and uncoating;(3) viral polyprotein translation and processing;(4) RNA genome replication;(5) encapsidation(packaging) and assembly; and(6) virus morphogenesis(maturation) and secretion. Many host factors are involved in the HCV life cycle. Chaperones are an important group of host cytoprotective molecules that coordinate numerous cellular processes including protein folding, multimeric protein assembly, protein trafficking, and protein degradation. All phases of the viral life cycle require chaperone activity and the interaction of viral proteins with chaperones. This review will present our current knowledge and understanding of the role of chaperones in the HCV life cycle. Analysis of chaperones in HCV infection will provide further insights into viral/host interactions and potential therapeutic targets for both HCV and other viruses. | Ronik Khachatoorian Samuel W French | 2016 | World Journal of Hepatology2016，8，1： | 5 |
| 2 | Epterenone, a selective aldosterone blocker, in mild-to-moderate hyper pension显示文摘 | WE1NBERGER M RONIKER B KRAUSE S L | 2002 | Am Hypertens2002，15，： | 1 |
| 3 | Eplerenone,aselective aldoster one blocker,in mild-to-moderate hypertension显示文摘 | RONIKER B KRAUSE SL | 2002 | Am J Hypertens2002，15，8： | 1 |
| 4 | Eplerenone prevents adverse cardiac remodelling induced by pressure overload in atrial natriuretic peptide-null mice显示文摘 | Weinberger MH Roniker B Krause SL | 2006 | Clin Exp Pharmacol Physiol2006，33，9： | 1 |
| 5 | Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension显示文摘 | Gordon H Williams Ellen Burgess Rainer E Kolloch Luis Miguel Ruilope Joanna Niegowska Mark S Kipnes Barbara Roniker Jeffrey L Patrick Scott L Krause | 2004 | The American Journal of Cardiology2004，，： | 1 |
| 6 | Eplerenone,a selective aldosterone blocker,in mild-to-moderate hypertension显示文摘 | Weinberger MH Roniker B | 2002 | Am J Hypertens2002，15，： | 1 |
| 7 | Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension显示文摘 | Weinberger MH Roniker B Krause SL | 2002 | Am J Hypertens2002，15，8： | 1 |
| 8 | Eplerenone,a novel selective aldosterone receptor antagonist(SARA):dose finding study in patients with heart failure显示文摘 | Pitt B Roniker B | 1999 | J Am Coll Cardiol1999，33，2： | 1 |
| 9 | Eplerenone, a selec- tive aldosterone blocker, in mild- to- moderate hypertension 显示文摘 | Weinberger MH Roniker B Krause SL | 2002 | Am J Hypertens2002，15，8： | 1 |
| 10 | Eplerenone,a selective aldosterone blocker,in mild-to-moderate hypertension显示文摘 | Weinberger M H Roniker B Krause S L | 2002 | Am J Hypertens2002，15，8： | 1 |
| 11 | Eplerenoone,a selective aldosterone blocker,in mild-to-moderate hypertension显示文摘 | WEINBERGER MH RONIKER B KRAUSE SL | 2002 | Am J Hypertens2002，15，8： | 1 |
| 12 | Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension 显示文摘 | WEINBERGER M H RONIKER B KRAUSE S L | 2002 | Am J Hypertens2002，15，2： | 1 |
| 13 | Efficacy and tolerability of eplerenone and losartan in hypertensive black and white patients显示文摘 | John M Flack Suzanne Oparil J.Howard Pratt Barbara Roniker Susan Garthwaite Jay H Kleiman Yonghong Yang Scott L Krause Diane Workman Elijah Saunders | 2003 | Journal of the American College of Cardiology2003，，7： | 1 |
| 14 | Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension 显示文摘 | WEINBERGER M H RONIKER B KRAUSE S L | 2002 | Am J Hypertens2002，15，8： | 1 |
| 15 | Eplerenone,as elective aldosterone blocker,in mild to moderate hypertension显示文摘 | Weinberger MH Roniker B Krause SL | 2002 | Am J Hypertension2002，15，8： | 1 |
| 16 | Eplerenone,a selective aldosterone blocker,in mild-to-moderate hypertension显示文摘 | Weinberger MH Roniker B Krause SL | 2002 | Am J Hypertens2002，15，8： | 1 |
| 17 | Eplerenone, a slective aldosterone blocker, in mild-to-moderate hypertension显示文摘 | Weinberger MI-I Roniker B Krause SL | 2002 | Am J Hyertens2002，15，： | 1 |
| 18 | Eplerenone, a selective aldosterone blocker, in mild to moderate hypertension显示文摘 | Weinberger M Roniker B Krause SL | 2002 | Am J Hy- pertens2002，15，： | 1 |
| 19 | Eplerenone, a selective aldosterone blocker, in mild - tomoderate hypertension显示文摘 | Roniker B Krause SL | 2002 | Am J Hypertens2002，15，8： | 1 |
| 20 | Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension 显示文摘 | Weinberger MH Roniker B Krause SL | 2002 | Am Hyper''tens2002，15，8： | 1 |
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