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| 1 | Tumor-infiltrating lymphocytes in the immunotherapy era显示文摘The clinical success of cancer immune checkpoint blockade(ICB)has refocused attention on tumor-infiltrating lymphocytes(TILs)across cancer types.The outcome of immune checkpoint inhibitor therapy in cancer patients has been linked to the quality and magnitude of T cell,NK cell,and more recently,B cell responses within the tumor microenvironment.State-of-the-art single-cell analysis of TIL gene expression profiles and clonality has revealed a remarkable degree of cellular heterogeneity and distinct patterns of immune activation and exhaustion.Many of these states are conserved across tumor types,in line with the broad responses observed clinically.Despite this homology,not all cancer types with similar TIL landscapes respond similarly to immunotherapy,highlighting the complexity of the underlying tumor-immune interactions.This observation is further confounded by the strong prognostic benefit of TILs observed for tumor types that have so far respond poorly to immunotherapy.Thus,while a holistic view of lymphocyte infiltration and dysfunction on a single-cell level is emerging,the search for response and prognostic biomarkers is just beginning.Within this review,we discuss recent advances in the understanding of TIL biology,their prognostic benefit,and their predictive value for therapy. | Sterre T.Paijens Annege Vledder Marco de Bruyn Hans W.Nijman | 2021 | Cellular & Molecular Immunology2021，18，4： | 37 |
| 2 | Disappearing Colorectal Liver Metastases after Chemotherapy: Should we be Concerned?显示文摘 | Mark G. Vledder Mechteld C. Jong Timothy M. Pawlik Richard D. Schulick Luis A. Diaz Michael A. Choti | 2010 | Journal of Gastrointestinal Surgery2010，，11： | 2 |
| 3 | Safety and efficacy of radiofrequency ablation for hepatocellular adenoma显示文摘 | van Vledder MG van Aalten SM Terkivatan T | 2011 | J Vasc Interv Radiol2011，22，6： | 1 |
| 4 | Body composition and outcome in patients undergoing resection of colorectal liver metastases显示文摘 | van Vledder MG Levolger S Ayez N | 2012 | Br J Surg2012，99，4： | 1 |
| 5 | Disappearing coloreetal liver metastases after chemotherapy: Should we be concerned? 显示文摘 | van Vledder MG de Jong MC Pawlik TM | 2010 | J Gastrointest Surg2010，14，11： | 1 |
| 6 | Disappearing colorectal liver metastases after chemotherapy: should we be con- cerned? 显示文摘 | VAN VLEDDER M G DE JONG M C PAWLIK T M | 2010 | J Gastrointest Surg2010，14，11： | 1 |
| 7 | Disappear- ing colorectal liver metastases after chemotherapy:should we be concerned?显示文摘 | van Vledder MG de Jong MC Pawlik TM | 2010 | J Gastrointest Surg2010，14，： | 1 |
| 8 | Disappearing colorectal liver metastases after chemotherapy: should we be concerned?显示文摘 | van Vledder MG dejong MC Pawlik TM | 2010 | J Gastrointest Surg2010，14，11： | 1 |
| 9 | Intra‐operative ultrasound elasticity imaging for monitoring of hepatic tumour thermal ablation显示文摘 | Mark G.Van Vledder Emad M.Boctor Lia R.Assumpcao HassanRivaz PezhmanForoughi Gregory D.Hager Ulrike M.Hamper Timothy M.Pawlik Michael A.Choti | 2010 | HPB2010，，10： | 1 |
| 10 | A ten-year data set for fetch-and depth-limited wave growth显示文摘 | Bottema M Vledder G | | Coastal Engineering0，56，6： | 1 |
| 11 | A ten-year data set for fetch- and depth-limited wave growth显示文摘 | Marcel Bottema Gerbrant Ph. van Vledder | 2009 | Coastal Engineering2009，，7： | 1 |
| 12 | Sarcopenia negatively impacts short-term outcomes in patients undergoing hepatic re- section for co|orectal liver metastasis 显示文摘 | Peter DP Mark G van Vledder ST | 2011 | HPB2011，13，7： | 1 |
| 13 | Behavior of tipsteerable needles in ex vivo and in vivo tissue显示文摘 | MAJEWICZ A MARRA S VLEDDER M | 2012 | IEEE Transactions on Bio-Medical Engineering2012，59，： | 1 |
| 14 | A ten-year data set for fetch-and depth-limited wave growth显示文摘 | Bottema M Vledder G | 2009 | Coastal Engineering2009，56，6： | 1 |
| 15 | Intra - operative ultrasound elasticity imaging for monitoring of hepatic tumour thermal ablation显示文摘 | van Vledder MG Boctor EM Assumpcao LR | 2010 | HPB2010，12，10： | 1 |
| 16 | Disappearing colorectal liver metastases afler chemotherapy: should we be concerned?显示文摘 | van Vledder MG de Jong MC Pawlik TM | 2010 | J Gastraintest Surg2010，14，11： | 1 |
| 17 | Disappearing Colorectal Liver Metastases after Chemotherapy: Should we be Concerned?显示文摘 | Mark G. Vledder Mechteld C. Jong Timothy M. Pawlik Richard D. Schulick Luis A. Diaz Michael A. Choti | 2010 | Journal of Gastrointestinal Surgery2010，，11： | 1 |
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