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| 1 | Direct-fed microbes: A tool for improving the utilization of low quality roughages in ruminants显示文摘For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restriction of antibiotics subtherapeutic uses from ruminant diets has amplified interest in improving nutrient utilization and animal performance and search for more safe alternatives. Some bacterial and fungal microorganisms as a direct-fed microbial(DFM) can be the most suitable solutions. Microorganisms that are commonly used in DFM for ruminants may be classified mainly as lactic acid producing bacteria(LAB), lactic acid utilizing bacteria(LUB), or other microorganism's species like Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Bacillus, Propionibacterium, Megasphaera elsdenii and Prevotellabryantii, in addition to some fungal species of yeast such as Saccharomyces and Aspergillus. A definitive mode of action for bacterial or fungal DFM has not been established; although a variety of mechanisms have been suggested. Bacterial DFM potentially moderate rumen conditions, and improve weight gain and feed efficiency. Fungal DFM may reduce harmful oxygen from the rumen, prevent excess lactate production, increase feed digestibility, and alter rumen fermentation patterns. DFM may also compete with and inhibit the growth of pathogens, immune system modulation, and modulate microbial balance in the gastrointestinal tract. Improved dry matter intake, milk yield, fat corrected milk yield and milk fat content were obtained with DFM administration. However, the response to DFM is not constant; depending on dosages, feeding times and frequencies, and strains of DFM. Nonetheless, recent studies have supported the positive effects of DFM on ruminant performance. | Mona M Y Elghandour Abdelfattah Z M Salem Jose S Martínez Castaeda Luis M Camacho Ahmed E Kholif Juan C Vázquez Chagoyán | 2015 | Journal of Integrative Agriculture2015，14，3： | 7 |
| 2 | Biological treatments as a mean to improve feed utilization in agriculture animals——An overview显示文摘As a result of agriculture practices, million tons of agriculture are produced as a secondary or by-products; however, with low nutritive values. Many methods are applied to improve the nutritive value and increase its utilization in ruminant's nutrition. The biological treatments are the most common with more safe-treated products. In most cases, the biological treatments are paralleled with decreased crude fiber and fiber fractions content with increased crude protein content. Direct-fed microbial and exogenous enzymes to animal are other ways of biological methods for improving nutritive value of feeds. Here in this review, we will try to cover the biological treatments of by-products from different sides view with different types of animals and different animal end-products. | Nahla A Abdel-Aziz Abdelfattah Z M Salem Mounir M El-Adawy Luis M Camacho Ahmed E Kholif Mona M Y Elghandour Borhami E Borhami | 2015 | Journal of Integrative Agriculture2015，14，3： | 4 |
| 3 | Rectal tone and compliance affected in patients with fecal incontinence after fistulotomy显示文摘AIM: To investigate the anal sphincter and rectal factors that may be involved in fecal incontinence that develops following fistulotomy(FIAF).METHODS: Eleven patients with FIAF were compared with 11 patients with idiopathic fecal incontinence and with 11 asymptomatic healthy subjects(HS). All of the study participants underwent anorectal manometry and a barostat study(rectal sensitivity, tone, compliance and capacity). The mean time since surgery was 28 ± 26 mo. The postoperative continence score was 14 ± 2.5(95%CI: 12.4-15.5, St Mark's fecal incontinence grading system).RESULTS: Compared with the HS, the FIAF patients showed increased rectal tone(42.63 ± 27.69 vs 103.5 ± 51.13, P = 0.002) and less rectal compliance(4.95 ± 3.43 vs 11.77 ± 6.9, P = 0.009). No significant differences were found between the FIAF patients and the HS with respect to the rectal capacity; thresholds for the non-noxious stimuli of first sensation, gas sensation and urge-to-defecate sensation or the noxious stimulus of pain; anal resting pressure or squeeze pressure; or the frequency or percentage of relaxation of the rectoanal inhibitory reflex. No significant differences were found between the FIAF patients and the patients with idiopathic fecal incontinence.CONCLUSION: In patients with FIAF, normal motor anal sphincter function and rectal sensitivity are preserved, but rectal tone and compliance are impaired. The results suggest that FIAF is not due to alterations in rectal sensitivity and that the rectum is more involved than the anal sphincters in the genesis of FIAF. | Richard Alexander Awad Santiago Camacho Francisco Flores Evelyn Altamirano Mario Antonio García | 2015 | World Journal of Gastroenterology2015，21，13： | 3 |
| 4 | Risk of hyperamylasemia and acute pancreatitis after double-balloon enteroscopy: a prospective study显示文摘 | S. Zepeda-Gómez R. Barreto-Zu?iga S. Ponce-de-León A. Meixueiro-Daza J. Herrera-López J. Camacho F. Tellez-Avila F. Valdovinos-Andraca F. Vargas-Vorackova | 2011 | Endoscopy2011，，09： | 3 |
| 5 | 接受他汀治疗患者新发糖尿病风险:人群为基础的研究显示文摘目的 研究接受HMG-CoA还原酶抑制剂(他汀类药物)治疗的患者的新发糖尿病风险。设计 人群为基础的队列研究,以时间事件分析的方法评估各种他汀类药物应用和新发糖尿病风险的相关性分析。计算危害比(hazard ratios,HR)来确定他汀的种类及剂量与新发糖尿病的关系。 | Aleesa A Caner Tara Gomes Ximena Camacho David N Juurlink Baiju R Shah Muhammad M Mamdani 张秀珍(译) 骆斯慧(译) 翁建平(校) | 2013 | 英国医学杂志中文版2013，16，5： | 2 |
| 6 | Evaluation of the Finnish Diabetes Risk Score to predict type 2 diabetes mellitus in a Colombian population: A longitudinal observational study显示文摘AIM: To assess the performance of the Finnish Diabetes Risk Score(FINDRISC) questionnaire for detecting and predicting type 2 diabetes mellitus(DM2) in a Colombian population.METHODS: This is a longitudinal observational study conducted in Floridablanca, Colombia. Adult subjects(age ≥ 35 years) without known diabetes, were included. A modified version of FINDRISC was completed, and the glycemia values from all the subjects were collected from the hospital's database. Firstly, a cross-sectional analysis was performed and then, the subsample of prediabetic participants was followed for diabetes incidence. RESULTS: A total of 772 subjects were suitable for the study. The overall prevalence of undiagnosed DM2 was 2.59%, and the incidence of DM2 among the prediabetic participants was 7.5 per 100 person-years after a total of 265257 person-years follow-up. The FINDRISC at baseline was significantly associated with undiagnosed and incident DM2. The area under receiver operating characteristics curve of the FINDRISC score for detecting undiagnosed DM2 in both men and women was 0.7477 and 0.7175, respectively; and for predicting the incidence of DM2 among prediabetics was 71.99% in men and 67.74% in women. CONCLUSION: The FINDRISC questionnaire is a useful screening tool to identify cross-sectionally unknown DM2 and to predict the incidence of DM2 among prediabetics in the Colombian population. | Diego Gomez-Arbelaez Laura Alvarado-Jurado Miguel Ayala-Castillo Leonardo Forero-Naranjo Paul Anthony Camacho Patricio Lopez-Jaramillo | 2015 | World Journal of Diabetes2015，6，17： | 2 |
| 7 | Hepatic Resection for Metastatic Melanoma: Distinct Patterns of Recurrence and Prognosis for Ocular Versus Cutaneous Disease显示文摘 | Timothy M. Pawlik MD MPH Daria Zorzi MD Eddie K. Abdalla MD Bryan M. Clary MD Jeffrey E. Gershenwald MD Merrick I. Ross MD Thomas A. Aloia MD Steven A. Curley MD Luis H. Camacho MD MPH Lorenzo Capussotti MD Dominique Elias MD Jean-Nicolas Vauthey MD | 2006 | Annals of Surgical Oncology2006，，5： | 2 |
| 8 | Cirrhosis complicating Shwachman-Diamond syndrome: A case report显示文摘BACKGROUND The features of Shwachman-Diamond syndrome (SDS) include exocrine pancreatic insufficiency, skeletal abnormalities and bone marrow dysfunction;an often overlooked feature is hepatic involvement. CASE SUMMARY We report a child who initially presented with failure to thrive and mildly elevated transaminase levels and was determined to have pancreatic insufficiency due to SDS. During follow-up he had persistently elevated transaminase levels and developed hepatosplenomegaly. An investigation was performed to determine the etiology of ongoing liver injury, including a liver biopsy which revealed hepatic cirrhosis. CONCLUSION Cirrhosis has rarely been reported with SDS. While many of the hepatic disorders associated with SDS improve with age, there are rare exceptions with serious implications for long-term outcome. | Sandra M Camacho Lucille McLoughlin Michael J Nowicki | 2019 | World Journal of Clinical Cases2019，7，12： | 2 |
| 9 | Comparison of lipid extraction methods for the microalgae Acutodesmus obliquus显示文摘Microalgae are widely used in the pharmaceutical and energy industries,therefore the conditions for their cultivation and extraction methods play an important role in the profiling and acquisition of lipids.The efficiency of lipid extraction from microalgae has attracted great interest from industry because of the wide variety of lipids and amounts that can be obtained.Acutodesmus obliquus(Scenedesmus obliquus UTEX 393)was used in this study.It was cultivated in Bold 3N medium modified with 75%nitrogen at 25℃,pH 6.8,125 r/min and a photoperiod of 18/6 h and illuminated with white light provided by a Light-Emitting Diode Surface Mount Device extensions(LED SMD)with an intensity of 1200μE/(m^(2)·s).The cells were stained with the Red Nile(RN)technique to indicate lipid production.Four extraction methods were compared,classical,microwave(MW),Soxhlet,and ultrasound(US),using the same solvent proportions(hexane:chloroform:methanol=1:2:3).All samples were analyzed with Fourier Transform Infrared Spectroscopy(FTIR)and Gas Chromatography coupled to Mass Spectrometry(GC-MS).The results showed:1)lipid production detected by RN was consistent with microalgal growth;2)the MW technique was the best extraction method,according to the statistical analysis through Randomized Complete Block(RCB)design and performance of 4.6%;and 3)the presence of saturated and unsaturated acids was indicated by FTIR spectra.GC-MS was able to identify palmitic and linoleic acids as the likely major constituents of the sample. | Diana Ximena Hurtado Claudia Lorena Garzón-Castro Jhon Cortés-Romero Edisson Tello Camacho | 2018 | International Journal of Agricultural and Biological Engineering2018，11，5： | 2 |
| 10 | Current and novel approaches in the pharmacological treatment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most lethal malignant tumours worldwide.The mortality-to-incidence ratio is up to 91.6%in many countries,representing the third leading cause of cancer-related deaths.Systemic drugs,including the multikinase inhibitors sorafenib and lenvatinib,are first-line drugs used in HCC treatment.Unfortunately,these therapies are ineffective in most cases due to late diagnosis and the development of tumour resistance.Thus,novel pharmacological alternatives are urgently needed.For instance,immune checkpoint inhibitors have provided new approaches targeting cells of the immune system.Furthermore,monoclonal antibodies against programmed cell death-1 have shown benefits in HCC patients.In addition,drug combinations,including first-line treatment and immunotherapy,as well as drug repurposing,are promising novel therapeutic alternatives.Here,we review the current and novel pharmacological approaches to fight HCC.Preclinical studies,as well as approved and ongoing clinical trials for liver cancer treatment,are discussed.The pharmacological opportunities analysed here should lead to significant improvement in HCC therapy. | Fernanda Villarruel-Melquiades María Eugenia Mendoza-Garrido Claudia M García-Cuellar Yesennia Sánchez-Pérez Julio Isael Pérez-Carreón Javier Camacho | 2023 | World Journal of Gastroenterology2023，29，17： | 2 |
| 11 | Role of serum cytokine profile in ulcerative colitis assessment显示文摘 | Manuel Luis Rodríguez‐Perlvárez Valle García‐Sánchez Carlos Manuel Villar‐Pastor Raál González Eva Iglesias‐Flores Jordi Muntane Federico Gómez‐Camacho | 2012 | Inflamm Bowel Dis2012，，10： | 2 |
| 12 | Cerebral Metastasis显示文摘 | Massot Punyet R Almajano J Camacho J M | 2000 | RevNeurol2000，31，12： | 1 |
| 13 | Growth and biochemical characterization of microalgal biomassproduced in bubble column and airlift photobioreactors: studies in fed-batch culture显示文摘 | Asterio Sanchez Miron Marie-Carmen Ceron Garc'1a Francisco Garc'a Camacho | 2002 | Enzyme and Microbial Technology2002，31，： | 1 |
| 14 | Role of glutamate transporters in the clearance and release of glutamate during ischemia and its relation to neuronal death显示文摘 | Camacho A Massieu L | 2006 | Arch Med Res2006，37，1： | 1 |
| 15 | Simultaneous high-biomass protein production and nutrient removal using spirulina maxina in sea watersupplemented with anaerobic effluents 显示文摘 | Olguin E J Galacia S Camacho R | 1994 | World Journal of Microbiology & Biotechnology1994，，10： | 1 |
| 16 | Glucorticoid-induced spinal epidural lipomatosis 显示文摘 | Camacho M Mugnier B Foutrier-Morello C | 2001 | Joint Bone Spine2001，68，4： | 1 |
| 17 | Geometrical ray tracing for the characterization of a heterogeneous interface 显示文摘 | Tentori D Camacho J | 2000 | SPIE2000，4096，： | 1 |
| 18 | Increased lysophosphatidylcholine and non-esterified fatty acid content in LDL induces chemokine release in endothelial cell:Relationship with electronegative LDL显示文摘 | Benitez S Camacho M Arcelus R Vila L Bancell C Ordonez-Llanos J | 2004 | Atherosclerosis2004，177，2： | 1 |
| 19 | The role of social anxiousness in group brainstorming 显示文摘 | Camacho L M & Paulus P B | 1995 | Journal of Personality and Social Psychology1995，，68： | 1 |
| 20 | A Smith- predictor based generalised predictive controller for mobile robot path-tracking 显示文摘 | NORMEY-RICO E GOMEZ-OMEGA J CAMACHO E | 1999 | Control Engineering Practice1999，7，6： | 1 |
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