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| 1 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 2 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 3 | Insights into seasonal variation of litter decomposition and related soil degradative enzyme activities in subtropical forest in China显示文摘We used a litterbag method to investigate litter decomposition and related soil degradative enzyme activities across four seasons in a broad-leaved forest and a coniferous forest on Zijin Mountain in sub-tropical China.Across four seasons, we quantified litter mass losses,soil pH values, and related soil degradative enzyme activities.Litter decomposition rates differed significantly by season.Litter decomposition rates of broadleaf forest leaves were higher than for coniferous forests needles across four seasons, and maximal differences in litter decomposition rates between the two litter types were found in spring.Obvious differences in litter decomposition rates of the two litter types were found in winter, which were similar to rates in spring.Litter decomposition rates of the two litter types in autumn were significantly higher than in spring.Soil degradative enzyme activities were lowest in winter and highest in summer in most cases across four seasons. | WANG Cong-yan Lü Yan-na WANG Lei LIU Xue-yan TIAN Xingjun | 2013 | Journal of Forestry Research2013，24，4： | 6 |
| 4 | Balancing the anionic framework polarity for enhanced thermoelectric performance in YbMg_(2)Sb_(2) Zintl compounds显示文摘1-2-2-type Zintl phase compound has aroused great interest for potential thermoelectric applications.However,YbMg_(2)Sb_(2) is seldom studied due to the very low electrical conductivity resulting from the large difference in the electronegativity between Mg and Sb.In this paper,we adjust the covalently bonded network of MgeSb by replacing part of the Mg with Zn which has the electronegativity closer to that of Sb.The decreased polarity in the anionic framework offers more free distance for electrons for the enhanced Hall mobility and electrical conductivity.Together with the increased point defect and the decreased lattice thermal conductivity by introduction of Zn,the maximum ZT value of ~0.8 at 773 K is achieved in YbMg_(0.9)Zn_(1.1)Sb_(2) which is~100% enhancement compared with that of YbMg_(2)Sb_(2). | Zongwei Zhang Xinyu Wang Yijie Liu Chen Chen Honghao Yao Li Yin Xiaofang Li Shan Li Fan Zhang Fengxian Bai Jiehe Sui Bo Yu Feng Cao Xingjun Liu Jun Mao Guoqiang Xie Qian Zhang | 2019 | Journal of Materiomics2019，5，4： | 3 |
| 5 | Role ofβ(FeA1)nanoparticles in abnormal grain growth in the annealing of cast Cu-Al-Mn-Fe shape memory alloys显示文摘In this study,the low-cost production of Cu-AI-Mn-Fe shape memory alloy single crystals exceeding 46 mm by abnormal grain growth was realized only through annealing their cast alloys.The results show that the mis-orientation formed during annealing may be responsible for such abnormal grain growth process.It was con-firmed that this misorientation resulted from the dissolution of bec B(FeAI)nanoparticles during heat treatment at a sufficiently temperature of approximately 1173 K.The rate of migration of the abnormal grain boundary was experimentally measured to be approximately9.3 x 10^-m s^-1within 2 min of the commencement of abnormal grain growth.Additionally,the range of composition of the alloys that can lead to abnormal grain growth was determined.When the Cu-13.0AI-6.5Mn-3.2Fe single crystal close to the[100]direction was deformed to a pre-strain of 12%,full shape recovery happened without any residual strain.At that time,the superelastic strain was approximately 9%.Such a superelastic characteristic remained nearly constant over 50 cycles,showing excellent fatigue resistance.The superelastic properties of the present Cu-13.0AI-6.5Mn-3.2Fe single crystal are compared to those of commercial Ni-Ti-based shape memory alloys.Therefore,it can be considered as a new kind of superelastic material having practical applications.The obtained results should be of great significance in the development of Cu based shape memory alloys.Furthermore,it is expected that a similar microstructure can be designed for the production of more metallic single crystals. | Shuiyuan Yang Xinyu Qing Jixun Zhang Lipeng Guo Shen Hong Mingpei Li Jinbin Zhang Cuiping Wang Xingjun Liu | 2020 | Progress in Natural Science:Materials International2020，30，4： | 2 |
| 6 | Phase Boundary Mapping in ZrNiSn Half-Heusler for Enhanced Thermoelectric Performance显示文摘The solubility range of interstitial Ni in the ZrNi1+xSn half-Heusler phase is a controversial issue,but it has an impact on the thermoelectric properties.In this study,two isothermal section phase diagrams of the Zr-Ni-Sn ternary system at 973K and 1173 K were experimentally constructed based on the binary phase diagrams of Zr-Ni,Zr-Sn,and Ni-Sn.The thermodynamic equilibrium phases were obtained after a long time of heating treatment on the raw alloys prepared by levitation melting.Solubilities of x<0:07 at 973 K and x<0:13 at 1173 K were clearly indicated.An intermediate-Heusler phase with a partly filled Ni void was observed,which is believed to be beneficial to the lowered lattice thermal conductivity.The highest ZT value~0:71 at 973 K was obtained for ZrNi_(1.11)Sn_(1.04).The phase boundary mapping provides an important instruction for the further optimization of ZrNiSn-based materials and other systems. | Xiaofang Li Pengbo Yang Yumei Wang Zongwei Zhang Dandan Qin Wenhua Xue Chen Chen Yifang Huang Xiaodong Xie Xinyu Wang Mujin Yang Cuiping Wang Feng Cao Jiehe Sui Xingjun Liu Qian Zhang | 2020 | Research2020，，1： | 2 |
| 7 | Thermodynamic database of the phase diagrams in the Mg-Al-Zn-Y-Ce system显示文摘The Mg-Al-Zn-Y-Ce system is one of the key systems for designing high-strength Mg alloys. The purpose of the present article is to develop a thermodynamic database for the Mg-Al-Zn-Y-Ce multicomponent system to design Mg alloys using the calculation of phase diagrams (CALPHAD) method, where the Gibbs energies of solution phases such as liquid, fcc, bcc, and hcp phases were described by the subregular solution model, whereas those of all the compounds were de- scribed by the sublattice model. The thermodynamic parameters describing Gibbs energies of the different phases in this database were evaluated by fitting the experimental data for phase equilibria and thermodynamic properties. On the basis of this database, a lot of information concerning stable and metastable phase equilibria of isothermal and vertical sections, mo- lar fractions of constituent phases, the liquidus projection, etc., can be predicted. This database is expected to play an im- portant role in the design of Mg alloys. | LIU Xingjun WANG Cuiping WEN Mingzhong CHEN Xing PAN Fusheng | 2006 | Rare Metals2006，25，5： | 2 |
| 8 | Optical coherent dot-product chip for sophisticated deep learning regression显示文摘Optical implementations of neural networks(ONNs)herald the next-generation high-speed and energy-efficient deep learning computing by harnessing the technical advantages of large bandwidth and high parallelism of optics.However,due to the problems of the incomplete numerical domain,limited hardware scale,or inadequate numerical accuracy,the majority of existing ONNs were studied for basic classification tasks.Given that regression is a fundamental form of deep learning and accounts for a large part of current artificial intelligence applications,it is necessary to master deep learning regression for further development and deployment of ONNs.Here,we demonstrate a silicon-based optical coherent dot-product chip(OCDC)capable of completing deep learning regression tasks.The OCDC adopts optical fields to carry out operations in the complete real-value domain instead of in only the positive domain.Via reusing,a single chip conducts matrix multiplications and convolutions in neural networks of any complexity.Also,hardware deviations are compensated via in-situ backpropagation control provided the simplicity of chip architecture.Therefore,the OCDC meets the requirements for sophisticated regression tasks and we successfully demonstrate a representative neural network,the AUTOMAP(a cutting-edge neural network model for image reconstruction).The quality of reconstructed images by the OCDC and a 32-bit digital computer is comparable.To the best of our knowledge,there is no precedent of performing such state-of-the-art regression tasks on ONN chips.It is anticipated that the OCDC can promote the novel accomplishment of ONNs in modern AI applications including autonomous driving,natural language processing,and scientific study. | Shaofu Xu Jing Wang Haowen Shu Zhike Zhang Sicheng Yi Bowen Bai Xingjun Wang Jianguo Liu Weiwen Zou | 2021 | Light(Science & Applications)2021，10，12： | 2 |
| 9 | Novel and durable composite phase change thermal energy storage materials with controllable melting temperature显示文摘The development of high temperature phase change materials(PCMs)with great comprehensive performance is significant in the future thermal energy storage system.In this study,novel and durable Al-Si/Al_(2)O_(3)-Al N composite PCMs with controllable melting temperature were successfully synthesized by using pristine Al powder as raw material and tetraethyl orthosilicate as SiO_(2)source.The Al_(2)O_(3)shell and Al-Si alloy were in-situ produced via the substitution reaction between molten Al and SiO_(2).Importantly,the crack caused by the incomplete encapsulation of the Al_(2)O_(3)shell could repair itself by the nitridation reaction of internal molten Al and thereby forming a highly dense Al_(2)O_(3)-Al N composite shell.The produced dense Al_(2)O_(3)-Al N composite shell could significantly improve the thermal cycling stability of composite PCMs,and thus,the thermal storage density decrease of the Al-Si/Al_(2)O_(3)-Al N(59.8 J/g to77.7 J/g)was far less than that of the Al-Si/Al_(2)O_(3)(118.5 J/g)after 3000 thermal cycles.Moreover,the synthesized Al-Si/Al_(2)O_(3)-Al N still exhibited a controllable melting temperature(571.5-637.9℃),relatively high thermal storage density(105.6-150.7 J/g),great dimensional stability and structural stability after3000 thermal cycles.Hence,the synthesized Al-Si/Al_(2)O_(3)-Al N composite PCMs,as promising preferential thermal energy storage materials,can be stably used in the energy utilization efficiency improvement of various systems for more than 6 years. | Haiting Wei Shuiyuan Yang Cuiping Wang Changrui Qiu Kairui Lin Jiajia Han Yong Lu Xingjun Liu | 2021 | Journal of Materials Science & Technology2021，，27： | 1 |
| 10 | Is Prehypertension Really Different from Normotension and Hypertension? A Case-Control Pilot Proteomic Study in Chinese显示文摘 | Zuoguang Wang Xiaoyun Peng Yanduo Tao Ya Liu Jieling Liu Xingjun Chen Shaojun Wen Zhaosu Wu | 2009 | Clinical and Experimental Hypertension2009，，4： | 1 |
| 11 | Fast and stable K-ion storage enabled by synergistic interlayer and pore-structure engineering显示文摘Carbon-based material has been regarded as one of the most promising electrode materials for potassium-ion batteries(PIBs).However,the battery performance based on reported porous carbon electrodes is still unsatisfactory,while the in-depth K-ion storage mechanism remains relatively ambiguous.Herein,we propose a facile“in situ self-template bubbling”method for synthesizing interlayer-tuned hierarchically porous carbon with different metallic ions,which delivers superior K-ion storage performance,especially the high reversible capacity(360.6 mAh·g^(−1)@0.05 A·g^(−1)),excellent rate capability(158.6 mAh·g^(−1)@10.0 A·g^(−1))and ultralong high-rate cycling stability(82.8%capacity retention after 2,000 cycles at 5.0 A·g^(−1)).Theoretical simulation reveals the correlations between interlayer distance and K-ion diffusion kinetics.Experimentally,deliberately designed consecutive cyclic voltammetry(CV)measurements,ex situ Raman tests,galvanostatic intermittent titration technique(GITT)method decipher the origin of the excellent rate performance by disentangling the synergistic effect of interlayer and pore-structure engineering.Considering the facile preparation strategy,superior electrochemical performance and insightful mechanism investigations,this work may deepen the fundamental understandings of carbon-based PIBs and related energy storage devices like sodium-ion batteries,aluminum-ion batteries,electrochemical capacitors,and dual-ion batteries. | Deping Li Qing Sun Yamin Zhang Xinyue Dai Fengjun Ji Kaikai Li Qunhui Yuan Xingjun Liu Lijie Ci | 2021 | Nano Research2021，14，12： | 1 |
| 12 | An analysis on interaction parameters of binary solid solutions显示文摘 | Liu Xingjun Hao Shiming | 1993 | Calphad1993，17，： | 1 |
| 13 | Unsupervised machine learning for discovery of promising half-Heusler thermoelectric materials显示文摘hermoelectric materials can be potentially applied to waste heat recovery and solid-state cooling because they allow a direct energy conversion between heat and electricity and vice versa.The accelerated materials design based on machine learning has enabled the systematic discovery of promising materials.Herein we proposed a successful strategy to discover and design a series of promising half-Heusler thermoelectric materials through the iterative combination of unsupervised machine learning with the labeled known half-Heusler thermoelectric materials.Subsequently,optimized zT values of~0.5 at 925 K for p-type Sc_(0.7)Y_(0.3)NiSb_(0.97)Sn_(0.03)and~0.3 at 778 K for n-type Sc_(0.65)Y_(0.3)Ti_(0.05)NiSb were experimentally achieved on the same parent ScNiSb. | Xue Jia Yanshuai Deng Xin Bao Honghao Yao Shan Li Zhou Li Chen Chen Xinyu Wang Jun Mao Feng Cao Jiehe Sui Junwei Wu Cuiping Wang Qian Zhang Xingjun Liu | 2022 | npj Computational Materials2022，，1： | 1 |
| 14 | Projected hydrologic regime changes in the Poyang Lake Basin due to climate change显示文摘 | Le Wang Shenglian Guo Xingjun Hong Dedi Liu Lihua Xiong | 2017 | Frontiers of Earth Science2017，11，1： | 1 |
| 15 | Study of Ni 50+ x Mn 25 Ga 25? x ( x显示文摘 | Yunqing Ma Chengbao Jiang Yan Li Huibin Xu Cuiping Wang Xingjun Liu | 2006 | Acta Materialia2006，，5： | 1 |
| 16 | Soil microbial responses to warming and increased precipitation and their implications for ecosystem C cycling显示文摘 | Naili Zhang Weixing Liu Haijun Yang Xingjun Yu Jessica L. M. Gutknecht Zhe Zhang Shiqiang Wan Keping Ma | 2013 | Oecologia2013，，3： | 1 |
| 17 | Overexpression of high-mobility group box 1 correlates with tumor progression and poor prognosis in human colorectal carcinoma显示文摘 | Xingjun Yao Gang Zhao Hongfa Yang Xinyu Hong Li Bie Guojin Liu | 2010 | Journal of Cancer Research and Clinical Oncology2010，，5： | 1 |
| 18 | ISOTHERMAL SECTION AT 1000 AND 1100℃ OF Fe-Mn-Al PHASE DIAGRAM显示文摘Phase equilibria at Fe-Mn side of isothermal section at 1000 and 1100℃ in Fe-Mn-Al system have been determined using the diffusion couple technique and metallography.A three-phase,α+γ+β,region was found at 1000℃.The method of solid/gas diffusioncouple used to determine equilibrium phase composition is believed to be feasible for thesystem containing volatile component. | LIU Xingjun HAO Shiming SUN Rongyao Northeast University of Technology,Shenyang,China Department of Materials Science and Engineering,Northeast University of Technology,Shenyang 110006,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，7： | 1 |
| 19 | Microwave frequency upconversion employing a coupling-modulated ring resonator显示文摘We present a method to generate a frequency-doubled microwave signal by employing a coupling-modulated ring resonator. Critical coupling is achieved when the resonator intrinsic loss is perfectly balanced by the external coupling enabled by a Mach–Zehnder interferometer coupler. The high suppression of the carrier leads to a clean two-tone optical signal with the frequency interval two times larger than that of the input microwave frequency.The beating of the two-tone signal at a photodiode generates the frequency upconverted microwave signal.A theoretical model is established to analyze the modulation process and the microwave signal generation.Experimental results show that the electrical harmonic suppression ratio is around ~20 dB(29 dB) for an input microwave signal with 5 dBm(10 dBm) power. | YIMING ZHONG LINJIE ZHOU YANYANG ZHOU YUJIE XIA SIQI LIU LIANGJUN LU JIANPING CHEN XINGJUN WANG | 2017 | Photonics Research2017，5，6： | 1 |
| 20 | Enhanced thermoelectric performance in Ti(Fe, Co, Ni)Sb pseudoternary Half-Heusler alloys显示文摘TiFe0.5Ni0.5Sb-based half-Heusler compounds have the intrinsic low lattice thermal conductivity and the adjustable band structure.Inspired by the previously reports to achieve both p-and n-type components by tuning the ratio of Fe and Ni based on the same parent TiFe0.5Ni0.5Sb,we selected Co as the amphoteric dopants to prepare both n-type and p-type pseudo-ternary Ti(Fe,Co,Ni)Sb-based halfHeusler alloys.The carrier concentration,as well as the density of states effective mass was significantly increased by Co doping,contributing to the enhanced power factor of 1.80 mW m^(-1) K^(-2) for n-type TiFe0.3Co_(0.2)Ni_(0.5)Sb and 2.21 mW m^(-1) K^(-2) for p-type TiFe_(0.5)Co_(0.15)Ni_(0.35)Sb at 973 K.Combined with the further decreased lattice thermal conductivity due to the strain field and mass fluctuation scattering induced by alloying Hf on the Ti site,peak ZTs of 0.65 in n-type Ti0.8Hf_(0.2)Fe_(0.3)Co_(0.2)Ni_(0.5)Sb and 0.85 in ptype Ti0.8Hf_(0.2)Fe_(0.5)Co_(0.15)Ni_(0.35)Sb were achieved at 973 K,which is of great significance for the thermoelectric power generation applications. | Qingmei Wang Xiaodong Xie Shan Li Zongwei Zhang Xiaofang Li Honghao Yao Chen Chen Feng Cao Jiehe Sui Xingjun Liu Qian Zhang | 2021 | Journal of Materiomics2021，7，4： | 0 |
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