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| 1 | 16 × 16 silicon Mach–Zehnder interferometer switch actuated with waveguide microheaters显示文摘We experimentally demonstrate a 16 × 16 reconfigurably nonblocking optical switch fabric using a Benes architecture. The switch fabric consists of 56 2 × 2 Mach–Zehnder interferometer based elementary switches, with each integrated with a pair of waveguide microheaters. The average on-chip insertion loss is ~5.2 dB for both of the 'all-cross' and the 'all-bar' states, with a loss variation of 1 dB over all routing paths. The cross talk for all switching states is better than -30 d B. The switching time of the switch element is about 22 μs. The switching functionality is verified by transmission of a 40 Gb∕s quadrature phase-shift keying optical signal. | Shuoyi Zhao Liangjun Lu Linjie Zhou Dong Li Zhanzhi Guo Jianping Chen | 2016 | Photonics Research2016，4，5： | 7 |
| 2 | Modeling and optimization of a single-drive push–pull silicon Mach–Zehnder modulator显示文摘We present an equivalent circuit model for a silicon carrier-depletion single-drive push–pull Mach–Zehnder modulator(MZM)with its traveling wave electrode made of coplanar strip lines.In particular,the partialcapacitance technique and conformal mapping are used to derive the capacitance associated with each layer.The PN junction is accurately modeled with the fringe capacitances taken into consideration.The circuit model is validated by comparing the calculations with the simulation results.Using this model,we analyze the effect of several key parameters on the modulator performance to optimize the design.Experimental results of MZMs confirm the theoretical analysis.A 56 Gb/s on–off keying modulation and a 40 Gb/s binary phase-shift keying modulation are achieved using the optimized modulator. | Yanyang Zhou Linjie Zhou Haike Zhu Chiyan Wong Yida Wen Lei Liu Xinwan Li Jianping Chen | 2016 | Photonics Research2016，4，4： | 5 |
| 3 | Silicon high-speed binary phase-shift keying modulator with a single-drive push–pull high-speed traveling wave electrode显示文摘We demonstrate binary phase shift keying(BPSK) modulation using a silicon Mach–Zehnder modulator with aπ-phase-shift voltage(Vπ) of-4.5 V.The single-drive push–pull traveling wave electrode has been optimized using numerical simulations with a 3 dB electro-optic bandwidth of 35 GHz.The 32 Gb/s BPSK constellation diagram is measured with an error vector magnitude of 18.9%. | Jinting Wang Linjie Zhou Haike Zhu Rui Yang Yanyang Zhou Lei Liu Tao Wang Jianping Chen | 2015 | Photonics Research2015，3，3： | 4 |
| 4 | A design method for high fabrication tolerance integrated optical mode multiplexer显示文摘The tapered asymmetric directional coupler has the potential to realize high fabrication tolerance and high transmission efficiency on-chip mode multiplexer.However,the geometry parameter selection of tapered structure remains empirical.In this paper,we propose a design method for the tapered structure based on genetic algorithm.Combined with the adjusted coupling equations and interpolation method,lowtime-cost optimization can be realized.Three mode multiplexers(TE0&TE1,TE0&TE2 and TE0&TE5)are designed by our method.According to simulation results,the insertion loss of the designed devices is lower than 1.8 dB and the crosstalk is lower than-15 dB when the fabrication error is within required range(±10 nm for TE0&TE2 and TE0&TE5,and±20 nm for TE0&TE1)in the bandwidth of 1.5–1.6μm.In addition,the entire optimization process takes only 2 h for each device,which is around the time cost of a single 3 D simulation. | Bitao SHEN Haowen SHU Linjie ZHOU Xingjun WANG | 2020 | Science China(Information Sciences)2020，63，6： | 3 |
| 5 | Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer显示文摘Colorectal cancer is one of the leading causes of cancer death worldwide.According to global genomic status,colorectal cancer can be classified into two main types:microsatellite-stable and microsatellite-instable tumors.Moreover,the two subtypes also exhibit different responses to chemotherapeutic agents through distinctive molecular mechanisms.Recently,mitochondrial DNA depletion has been shown to induce apoptotic resistance in microsatellite-instable colorectal cancer.However,the effects of altered mitochondrial DNA copy number on the progression of microsatellite-stable colorectal cancer,which accounts for the majority of colorectal cancer,remain unclear.In this study,we systematically investigated the functional role of altered mitochondrial DNA copy number in the survival and metastasis of microsatellite-stable colorectal cancer cells.Moreover,the underlying molecular mechanisms were also explored.Our results demonstrated that increased mitochondrial DNA copy number by forced mitochondrial transcription factor A expression significantly facilitated cell proliferation and inhibited apoptosis of microsatellitestable colorectal cancer cells both in vitro and in vivo.Moreover,we demonstrated that increased mitochondrial DNA copy number enhanced the metastasis of microsatellite-stable colorectal cancer cells.Mechanistically,the survival advantage conferred by increased mitochondrial DNA copy number was caused in large part by elevated mitochondrial oxidative phosphorylation.Furthermore,treatment with oligomycin significantly suppressed the survival and metastasis of microsatellite-stable colorectal cancer cells with increased mitochondrial DNA copy number.Our study provides evidence supporting a possible tumor-promoting role for mitochondrial DNA and uncovers the underlying mechanism,which suggests a potential novel therapeutic target for microsatellite-stable colorectal cancer. | Xiacheng Sun Lei Zhan Yibing Chen Gang Wang Linjie He Qian Wang Feng Zhou Fang Yang Jin Wu Yousheng Wu Jinliang Xing Xianli He Qichao Huang | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 3 |
| 6 | Formation and cytotoxicity of a new disinfection by-product (DBP) phenazine by chloramination of water containing diphenylamine显示文摘Disinfection by-products (DBPs) in drinking water have caused worldwide concern due to their potential carcinogenic effects. The formation of phenazine from diphenylamine (DPhA) chloramination was studied and its cytotoxicities for two human cancer cells were also investigated. Phenazine was detected synchronously with the consumption of DPhA by chloramination, which further confirmed that the new DBP phenazine can be produced along with N-nitrosodiphenylamine (NDPhA) from DPhA chloramination. The formation of phenazine had a maximum molar yield with solution pH increasing from 5.0 to 9.0, with phenazine as the main product for DPhA chloramination at lower pH, but higher pH favored the formation of NDPhA. Thus, solution pH is the key factor in controlling the formation of phenazine and NDPhA. Both the initial DPhA and chloramine concentrations did not show a significant effect on the molar yields of phenazine, although increasing the chloramine concentration could speed up the reaction rate of DPhA with chloramines. The cytotoxicity assays showed that phenazine had significant cell-specific toxicity towards T24 (bladder cancer cell lines) and HepG2 (hepatic tumor cell lines) cells with IC50 values of 0.50 and 2.04 mmol/L, respectively, and T24 cells being more sensitive to phenazine than HepG2 cells. The IC50 values of phenazine, DPhA, and NDPhA for T24 cells were of the same order of magnitude and the cytotoxicity of phenazine for T24 cells was slightly lower than that of NDPhA (IC50, 0.16 mmol/L), suggesting that phenazine in drinking water may have an adverse effect on human health. | Wenjun Zhou Linjie Lou Lifang Zhu Zhimin Li Lizhong Zhu | 2012 | Journal of Environmental Sciences2012，24，7： | 3 |
| 7 | 4×4 nonblocking optical switch fabric based on cascaded multimode interferometers显示文摘We experimentally demonstrate a 4 × 4 nonblocking silicon thermo-optic(TO) switch fabric consisting of three stages of tunable generalized Mach–Zehnder interferometers. All 24 routing states for nonblocking switching are characterized. The device's footprint is 4.6 mm × 1.0 mm. Measurements show that the worst cross talk of all switching states is-7.2 dB. The on-chip insertion loss is in the range of 3.7–13.1 dB. The average TO switching power consumption is 104.8 mW. | Zuxiang Li Linjie Zhou Liangjun Lu Shuoyi Zhao Dong Li Jianping Chen | 2016 | Photonics Research2016，4，1： | 2 |
| 8 | Nonvolatile waveguide transmission tuning with electrically-driven ultra-small GST phase-change material显示文摘Low-power reconfigurable optical circuits are highly demanded to satisfy a variety of different applications. Conventional electro-optic and thermo-optic refractive index tuning methods in silicon photonics are not suitable for reconfiguration of optical circuits due to their high static power consumption and volatility. We propose and demonstrate a nonvolatile tuning method by utilizing the reversible phase change property of GST integrated on top of the silicon waveguide. The phase change is enabled by applying electrical pulses to the lm-sized GST active region in a sandwich structure. The experimental results show that the optical transmission of the silicon waveguide can be tuned by controlling the phase state of GST. | Hanyu Zhang Linjie Zhou Jian Xu Ningning Wang Hao Hu Liangjun Lu B. M. A. Rahman Jianping Chen | 2019 | Science Bulletin2019，64，11： | 2 |
| 9 | All-optical wavelength converter using a microdisk resonator integrated with p-n junctions显示文摘We explore all-optical wavelength conversion in a microdisk resonator integrated with interleaved p-n junctions.Numerical simulation based on temporal coupled mode theory is performed to study the free-carrier dynamics inside the cavity.It reveals that the detuning of pump and probe frequencies and the carrier lifetime have a significant effect on the device performance.Experimental result confirms that the conversion speed can be considerably improved by applying a reverse bias on the p-n junctions.Wavelength conversion at 10 Gb/s data rate is achieved with a pump power of 5.41 dBm and a bias voltage of-6 V. | Linjie Zhou Jingya Xie Jianping Chen | 2014 | Chinese Science Bulletin2014，59，22： | 2 |
| 10 | Seasonal dynamics of soil water content in the typical vegetation and its response to precipitation in a semi-arid area of Chinese Loess Plateau显示文摘Soil water content is a key limiting factor for vegetation growth in the semi-arid area of Chinese Loess Plateau and precipitation is the main source of soil water content in this area.To further understand the impact of vegetation types and environmental factors such as precipitation on soil water content,we continuously monitored the seasonal dynamics in soil water content in four plots(natural grassland,Caragana korshinskii,Armeniaca sibirica and Pinus tabulaeformis)in Chinese Loess Plateau.The results show that the amplitude of soil water content fluctuation decreases with an increase in soil depth,showing obvious seasonal variations.Soil water content of artificial vegetation was found to be significantly lower than that of natural grassland,and most precipitation events have difficulty replenishing soil water content below a depth of 40 cm.Spring and autumn are the key seasons for replenishment of soil water by precipitation.Changes in soil water content are affected by precipitation,vegetation types,soil evaporation and other factors.The interception effect of vegetation on precipitation and the demand for water consumption by transpiration are the key factors affecting the efficiency of soil water replenishment by precipitation in this area.Due to artificial vegetation plantation in this area,soil will face a water deficit crisis in the future. | ZHOU Tairan HAN Chun QIAO Linjie REN Chaojie WEN Tao ZHAO Changming | 2021 | Journal of Arid Land2021，13，10： | 2 |
| 11 | Geologic,Fluid Inclusion and Stable Isotope Constraints on Mechanisms of Ore Deposition at the Datuanshan Copper Deposit,Middle-Lower Yangtze Valley,Eastern China显示文摘The Datuanshan deposit is one of the largest and most representative stratabound copper deposits in the Tongling area,the largest ore district in the Middle-Lower Yangtze River metallogenic belt.The location of the orebodies is controlled by the interlayer-slipping faults between the Triassic and Permian strata,and all the orebodies are distributed in stratiform shape around the Mesozoic quartz monzodiorite dikes.Based on field evidence and petrographic observations,four mineralization stages in the Datuanshan deposit have been identified:the skarn,early quartz-sulfide,late quartzsulfide and carbonate stages.Chalcopytite is the main copper mineral and mainly formed at the late quartz-sulfide stage.Fluid inclusions at different stages were studied for petrography,microthermometry,laser Raman spectrometry and stable isotopes.Four types of fluid inclusions,including three-phase fluid inclusions(type 1),liquid-rich fluid inclusions(type 2),vapour-rich fluid inclusions(type 3) and pure vapour fluid inclusions(type 4),were observed.The minerals from the skarn,early and late quartz-sulfide stages contain all fluid inclusion types,but only type 2 fluid inclusions were observed at the carbonate stage.Petrographic observations suggest that most of the inclusions studied in this paper are likely primary.The coexistence of different types of fluid inclusions with contrasting homogenization characteristics(to the liquid and vapour phase,respectively) and similar homogenization temperatures(the modes are 440-480℃,380-400℃ and 280-320℃ for the skarn,early and late quartz-sulfide stages,respectively) in the first three stages,strongly suggests that three episodes of fluid boiling occurred during these stages,which is supported by the hydrogen isotope data.Laser Raman spectra identified CH_4 at the skarn and early quartz-sulfide stages.Combined with other geological features,the early ore-forming fluids were inferred to be under a relatively reduced environment.The CO_2 component has been identified at the late quartz-sulfide and carbonate stages,indicating that the late ore-forming fluids were under a relatively oxidized environment,probably as a result of inflow of and mixing with meteoric water.In addition,microthermometric results of fluid inclusions and H-O isotope data mdicate that the ore forming fluids were dominated by magmatic water in the early stages(skarn and early quartz-sulfide stages) and mixed with meteoric water in the late stages(late quartz-sulfide and carbonate stages).The evidence listed above suggests that the chalcopyrite deposition in the Datuanshan deposit probably resulted from the combination of multiepisode fluid boiling and mixing of magmatic and meteoric water. | CAO Yi DU Yangsong PANG Zhenshan DU Yilun KOU Shaolei CHEN Linjie GAO Fuping ZHOU Guibi | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 2 |
| 12 | RNA Methylome Reveals the m^(6)A-mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-withering显示文摘The epitranscriptomic mark N6-methyladenosine(m^(6)A),which is the predominant internal modification in RNA,is important for plant responses to diverse stresses.Multiple environmental stresses caused by the tea-withering process can greatly influence the accumulation of specialized metabolites and the formation of tea flavor.However,the effects of the m^(6)A-mediated regulatory mechanism on flavor-related metabolic pathways in tea leaves remain relatively uncharacterized.We performed an integrated RNA methylome and transcriptome analysis to explore the m^(6)Amediated regulatory mechanism and its effects on flavonoid and terpenoid metabolism in tea(Camellia sinensis)leaves under solar-withering conditions.Dynamic changes in global m^(6)A level in tea leaves were mainly controlled by two m^(6)A erasers(CsALKBH4A and CsALKBH4B)during solar-withering treatments.Differentially methylated peak-associated genes following solarwithering treatments with different shading rates were assigned to terpenoid biosynthesis and spliceosome pathways.Further analyses indicated that CsALKBH4-driven RNA demethylation can directly affect the accumulation of volatile terpenoids by mediating the stability and abundance of terpenoid biosynthesis-related transcripts and also indirectly influence the flavonoid,catechin,and theaflavin contents by triggering alternative splicing-mediated regulation.Our findings revealed a novel layer of epitranscriptomic gene regulation in tea flavor-related metabolic pathways and established a link between the m^(6)A-mediated regulatory mechanism and the formation of tea flavor under solar-withering conditions. | Chen Zhu Shuting Zhang Chengzhe Zhou Caiyun Tian Biying Shi Kai Xu Linjie Huang Yun Sun Yuling Lin Zhongxiong Lai Yuqiong Guo | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 2 |
| 13 | Autophagy in tumorigenesis and cancer therapy 显示文摘 | Shengtao Zhou Linjie Zhao Manchao Kuang | 2012 | Cancer Letters2012，323，1： | 1 |
| 14 | Real-time full-field arbitrary optical waveform measurement显示文摘 | Fontaine N K Scott R P Zhou Linjie | 2010 | Nature Photonics2010，4，： | 1 |
| 15 | De- sign and analysis of a phase modulator based on amet- al-polymer-silicon hybrid plasmonic waveguide 显示文摘 | Xiaomeng Sun Linjie Zhou Xinwan Li | 2011 | Applied Optics2011，50，20： | 1 |
| 16 | Engineered high-strength biohydrogel as a multifunctional platform to deliver nucleic acid for ameliorating intervertebral disc degeneration显示文摘Intervertebral disc degeneration(IVDD)is a leading cause of low back pain.The strategy of using functional materials to deliver nucleic acids provides a powerful tool for ameliorating IVDD.However,the immunogenicity of nucleic acid vectors and the poor mechanical properties of functional materials greatly limit their effects.Herein,antagomir-204-3p(AM)shows low immunogenicity and effectively inhibits the apoptosis of nucleus pulposus cells.Moreover,a high-strength biohydrogel based on zinc-oxidized sodium alginate-gelatin(ZOG)is designed as a multifunctional nucleic acid delivery platform.ZOG loaded with AM(ZOGA)exhibits great hygroscopicity,antibacterial activity,biocompatibility,and biodegradability.Moreover,ZOGA can be cross-linked with nucleus pulposus tissue to form a high-strength collagen network that improves the mechanical properties of the intervertebral disc(IVD).In addition,ZOGA provides an advantageous microenvironment for genetic expression in which AM can play an efficient role in maintaining the metabolic balance of the extracellular matrix.The results of the radiological and histological analyses demonstrate that ZOGA restores the height of the IVD,retains moisture in the IVD,and maintains the tissue structure.The ZOGA platform shows the sustained release of nucleic acids and has the potential for application to ameliorate IVDD,opening a path for future studies related to IVD. | Tao Chen Qiuping Qian Pooyan Makvandi Ehsan Nazarzadeh Zare Qizhu Chen Linjie Chen Zhiguang Zhang Hao Zhou Wenxian Zhou Hui Wang Xiangyang Wang Yu Chen Yunlong Zhou Aimin Wu | 2023 | Bioactive Materials2023，，7： | 1 |
| 17 | Tea Polyphenols Reducing Lipopolysaccharide-induced Inflammatory Responses in RAW264.7 Macrophages via NF-κB Pathway显示文摘The anti-inflammatory activity of tea polyphenols(TPs)in RAW264.7 macrophages stimulated by lipopolysaccharide(LPS)was investigated in this paper.RAW264.7 macrophages were treated with different concentrations of TP(0,12.5,25,50,100,and 200μg/mL)and then stimulated by LPS.Another blank control group was set up.The expression of pro-inflammatory cytokines associated with the nuclear factor-kappa B(NF-κB)signaling pathway was investigated before and after TP treatment.Pretreatment of RAW264.7 cells with TP decreased the expression of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin 1 beta(IL-1β)pro-inflammatory cytokines.In addition,TP inhibited the phosphorylation of p65 and IκB by blocking the phosphorylation and the degradation of NF-κB inhibitor protein.In conclusion,TP exerts anti-inflammatory effects by regulating the release of inflammatory mediators via the NF-κB signaling pathway. | SU Siyi LI Xiaoyu GUO Xu ZHOU Ruiming LI Manman MING Pengfei HUANG Yingying Sajid Ur RAHMAN DING Hongyan FENG Shibin LI Jinchun WANG Xichun LI Yu WU linjie | 2019 | Chemical Research in Chinese Universities2019，35，6： | 1 |
| 18 | Dingxin recipe alleviates atherosclerosis injury in Apo E-knockout mice via downregulation of visfatin expression and inhibition of the visfatin-induced inflammatory response显示文摘OBJECTIVE:To further elucidate the mechanism underlying the anti-atherosclerotic effect of Dingxin recipe(DXR).METHODS:Fifty 6-week-old male Apo E^-/-mice were randomly divided into the following groups:model,simvastatin(5 mg·kg^-1·d^-1),DXR low-dose(9.30 g·kg^-1·d^-1),DXR middle-dose(18.59 g·kg^-1·d^-1)and DXR high-dose(37.18 g·kg^-1·d^-1)(n=10).Ten male C57BL/6J mice were used as the control group.All Apo E^-/-mice were fed a high-fat diet(HFD)and the control mice received a common diet.After HFD for 12 weeks,the mice were treated with DXR or simvastatin for another 12 weeks.The expression of inflammatory cytokines and visfatin was determined in serum and atherosclerotic lesions by enzyme-linked immunosorbent assay.Visfatin expression was also assessed in aortic atherosclerotic plaques.Cultured vessel endothelial cells(VECs)were pretreated with DXR sera prior to visfatin.The effects of DXR were analyzed to elucidate its protective mechanism against visfatin-induced inflammation in VECs.RESULTS:DXR regulated blood lipids and reduced tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),intercellular adhesion molecules-1(ICAM-1),vascular cell adhesion molecule-1(VCAM-1)and visfatin expression in Apo E^-/-mice,particularly at the higher doses.The areas of atherosclerotic lesions in the DXR groups were significantly smaller than those in the model group.DXR alleviated visfatin-induced VEC injury via downregulation of TNF-α,IL-6,ICAM-1 and VCAM-1 through mitogen-activated protein kinase pathways.CONCLUSION:DXR alleviated atherosclerosis injury via downregulation of visfatin expression and inhibition of the visfatin-induced inflammatory response in VECs. | Cui Xiaobing Huang Zhiyong Lou Linjie Cheng Saibo Zhang Yu Zhang Yaxin Jia Yuhua Zhou Fenghua | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 1 |
| 19 | CVD synthesis of nitrogen-doped graphene using urea显示文摘This work provides an effective low-cost synthesis and in-depth mechanistic study of high quality large-area nitrogen-doped graphene(NG) films. These films were synthesized using urea as nitrogen source and methane as carbon source, and were characterized by scanning electron microscopy(SEM), Raman spectroscopy and X-ray photoelectron spectroscopy(XPS). The N doping level was determined to be 3.72 at.%, and N atoms were suggested to mainly incorporated in a pyrrolic N configuration. All distinct Raman peaks display a shift due to the nitrogen-doping and compressive strain. The increase in urea concentration broadens the D and 2D peak's Full Width at Half Maximum(FWHM), due to the decrease of mean free path of phonons. The N-doped graphene exhibited an n-type doping behavior with a considerably high carrier mobility of about 74.1 cm2/(V s), confirmed by electrical transport measurements. | ZHANG CanKun LIN WeiYi ZHAO ZhiJuan ZHUANG PingPing ZHAN LinJie ZHOU YingHui CAI WeiWei | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，10： | 1 |
| 20 | Microwave frequency upconversion employing a coupling-modulated ring resonator显示文摘We present a method to generate a frequency-doubled microwave signal by employing a coupling-modulated ring resonator. Critical coupling is achieved when the resonator intrinsic loss is perfectly balanced by the external coupling enabled by a Mach–Zehnder interferometer coupler. The high suppression of the carrier leads to a clean two-tone optical signal with the frequency interval two times larger than that of the input microwave frequency.The beating of the two-tone signal at a photodiode generates the frequency upconverted microwave signal.A theoretical model is established to analyze the modulation process and the microwave signal generation.Experimental results show that the electrical harmonic suppression ratio is around ~20 dB(29 dB) for an input microwave signal with 5 dBm(10 dBm) power. | YIMING ZHONG LINJIE ZHOU YANYANG ZHOU YUJIE XIA SIQI LIU LIANGJUN LU JIANPING CHEN XINGJUN WANG | 2017 | Photonics Research2017，5，6： | 1 |
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