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| 1 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | Xuebijing injection alleviates liver injury by inhibiting secretory function of Kupffer cells in heat stroke rats显示文摘OBJECTIVE:To evaluate the effects of Xuebijing(XBJ) injection in heat stroke(HS) rats and to investigate the mechanisms underlying these effects.METHODS:Sixty anesthetized rats were randomized into three groups and intravenously injected twice daily for 3 days with 4 mL XBJ(XBJ group) or phosphate buffered saline(HS and Sham groups) per kg body weight.HS was initiated in the HS and XBJ groups by placing rats in a simulated climate chamber(ambient temperature 40 ℃,humidity 60%).Rectal temperature,aterial pressure,and heart rate were monitored and recorded.Time to HS onset and survival were determined,and serum concentrations of tumor necrosis factor(TNF)-α,inRESULTS:Time to HS onset and survival were significantly longer in the XBJ than in the HS group.Moreover,the concentrations of TNF-α,IL-1β,IL-6,ALT and AST were lower and liver injury was milder in the XBJ than in the HS group.Heat-stress induced structural changes in KCs and hepatic cells were more severe in the HS than in the XBJ group and the concentrations of TNF-α,IL-β and IL-6 secreted by KCs were lower in the XBJ than in the HS group.CONCLUSION:XBJ can alleviate HS-induced systemic inflammatory response syndrome and liver injury in rats,and improve outcomes.These protective effects may be due to the ability of XBJ to inhibit cytokine secretion by KCs. | Yi Chen Huasheng Tong Xingqin Zhang Liqun Tang Zhiguo Pan Zhifeng Liu Pengkai Duan Lei Su | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 14 |
| 4 | Arabidopsis F-box gene FOA1 involved in ABA signaling显示文摘The expression of FOA1(F-box overexpressed/oppressed ABA signaling) in different organs of Arabidopsis,and in response to ABA and NaCl,was analyzed.The expression level of FOA1 is higher in the root and is lower in the stem,and is induced rapidly by ABA and NaCl.The phenotypes of T-DNA insertion mutant foa1 and FOA1 overexpression lines FOA1ox1 and FOA1ox2 were analyzed.The foa1 mutant exhibited a lower germination rate,shorter root length,more stomatal opening,increased proline accumulation and hypersensitivity to ABA compared with the wild type.In contrast,the overexpression lines showed lower sensitivity to ABA than the wild type.The expression levels of several ABA and stress-responsive transcription factors and genes were altered in the foa1 mutant in response to ABA.Compared with the wild type,the expression levels of ABA-responsive transcription factors were higher,but ABA and stress-responsive genes were lower in foa1 mutant.This study demonstrates that FOA1 is an ABA signaling-related gene,and may play a negative role in ABA signaling. | PENG Juan YU DaShi WANG LiQun XIE MinMin YUAN CongYing WANG Yu TANG DongYing ZHAO XiaoYing LIU XuanMing | 2012 | Science China(Life Sciences)2012，55，6： | 12 |
| 5 | Heterogeneous parallel computing accelerated iterative subpixel digital image correlation显示文摘Parallel computing techniques have been introduced into digital image correlation(DIC) in recent years and leads to a surge in computation speed. The graphics processing unit(GPU)-based parallel computing demonstrated a surprising effect on accelerating the iterative subpixel DIC, compared with CPU-based parallel computing. In this paper, the performances of the two kinds of parallel computing techniques are compared for the previously proposed path-independent DIC method, in which the initial guess for the inverse compositional Gauss-Newton(IC-GN) algorithm at each point of interest(POI) is estimated through the fast Fourier transform-based cross-correlation(FFT-CC) algorithm. Based on the performance evaluation, a heterogeneous parallel computing(HPC) model is proposed with hybrid mode of parallelisms in order to combine the computing power of GPU and multicore CPU. A scheme of trial computation test is developed to optimize the configuration of the HPC model on a specific computer. The proposed HPC model shows excellent performance on a middle-end desktop computer for real-time subpixel DIC with high resolution of more than 10000 POIs per frame. | HUANG JianWen ZHANG LingQi JIANG ZhenYu DONG ShouBin CHEN Wei LIU YiPing LIU ZeJia ZHOU LiCheng TANG LiQun | 2018 | Science China(Technological Sciences)2018，61，1： | 9 |
| 6 | Nonlinear free transverse vibrations of axially moving Timoshenko beams with two free ends显示文摘In this paper, nonlinear transverse vibrations of axially moving Timoshenko beams with two free ends are investigated. The governing equations and the associated boundary conditions are derived by the extended Hamilton principle. The method of multiple scales is applied to analyze the nonlinear partial differential equation. The natural frequencies and modes are investigated by performing the complex mode approach. The effect of natural frequencies with the stiffness and the axial speeds are numerically demonstrated. The solvability conditions are established for the cases of without and with 3:1 internal resonances. The relationships between the nonlinear frequencies and the initial amplitudes at different axial speeds and the nonlinear coefficients are showed for the case of without internal resonances. The effects of the related coefficients are demonstrated for the case of 3:1 internal resonances. | LI Biao TANG YouQi CHEN LiQun | 2011 | Science China(Technological Sciences)2011，54，8： | 6 |
| 7 | The OsNAC23-Tre6P-SnRK1 a feed-forward loop regulates sugar homeostasis and grain yield in rice显示文摘Tre6P(trehalose-6-phosphate)mediates sensing of carbon availability to maintain sugar homeostasis in plants,which underpins crop yield and resilience.However,how Tre6P responds to fluctuations in sugar levels and regulates the utilization of sugars for growth remains to be addressed.Here,we report that the sugar-inducible rice NAC transcription factor OsNAC23 directly represses the transcription of the Tre6P phosphatase gene TPP1 to simultaneously elevate Tre6P and repress trehalose levels,thus facilitating carbon partitioning from source to sink organs.Meanwhile,OsNAC23 and Tre6P suppress the transcription and enzyme activity of SnRK1a,a low-carbon sensor and antagonist of OsNAC23,to prevent the SnRK1a-mediated phosphorylation and degradation of OsNAC23.Thus,OsNAC23,Tre6P,and SnRK1a form a feed-forward loop to sense sugar and maintain sugar homeostasis by transporting sugars to sink organs.Importantly,plants over-expressing OsNAC23 exhibited an elevated photosynthetic rate,sugar transport,and sink organ size,which consistently increased rice yields by 13%–17%in three elite-variety backgrounds and two locations,suggesting that manipulation of OsNAC23 expression has great potential for rice improvement.Collectively,these findings enhance our understanding of Tre6P-mediated sugar signaling and homeostasis,and provide a new strategy for genetic improvement of rice and possibly also other crops. | Zhiyong Li Xiangjin Wei Xiaohong Tong Juan Zhao Xixi Liu Huimei Wang Liqun Tang Yazhou Shu Guanghao Li Yifeng Wang Jiezheng Ying Guiai Jiao Honghong Hu Peisong Hu Jian Zhang | 2022 | Molecular Plant2022，15，4： | 4 |
| 8 | Features of long-term health monitored strains of a bridge with wavelet analysis显示文摘This paper analyses the five years' monitored strains collected from a long-term health monitoring system installed on a bridge with wavelet transform.In the analysis,the monitored strains are pre-processed,features of the monitored data are summarized briefly.The influences of the base functions on the results of wavelet analysis are studied simultaneously.The results show that the db wavelet is a good mother wavelet function in the analysis,and the order N should be larger than 20,but less than 46 in decomposing the monitored strains of the bridge.According to the strain variation features of concrete bridge,the proper decomposition level is 4 in the wavelet multi-resolution analysis.With the present method,the strains caused by random loads and daily sunlight can be accurately extracted from the monitored strains.The decomposed components of the monitored strains show that the amplitudes of the strains caused by random loads,daily sunlight,and annual temperature effect,are about 5 με,25 με,and 50 με respectively.The structural response under random load is smaller than the other parts. | Zejia Liu,Bin Jiang,Liqun Tang,Yiping Liu,Chunyu Zhang,and Yinghua Li School of Civil Engineering and Transportation,State Key Laboratory of Subtropical Building Science,South China University of Technology,Guangzhou 510640,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，5： | 3 |
| 9 | Performance of global look-up table strategy in digital image correlation with cubic B-spline interpolation and bicubic interpolation显示文摘Global look-up table strategy proposed recently has been proven to be an efficient method to accelerate the interpolation, which is the most time-consuming part in the iterative sub-pixel digital image correlation(DIC) algorithms. In this paper, a global look-up table strategy with cubic B-spline interpolation is developed for the DIC method based on the inverse compositional Gauss–Newton(IC-GN) algorithm.The performance of this strategy, including accuracy, precision, and computation efficiency, is evaluated through a theoretical and experimental study, using the one with widely employed bicubic interpolation as a benchmark. The global look-up table strategy with cubic B-spline interpolation improves significantly the accuracy of the IC-GN algorithm-based DIC method compared with the one using the bicubic interpolation, at a trivial price of computation efficiency. | Zhiwei Pan Wei Chen Zhenyu Jiang Liqun Tang Yiping Liu Zejia Liu | 2016 | Theoretical & Applied Mechanics Letters2016，6，3： | 3 |
| 10 | WRKY72 Negatively Regulates Seed Germination Through Interfering Gibberellin Pathway in Rice显示文摘Seed germination is associated with grain yield and quality in crop production.Gibberellic acid(GA)serves as a major phytohormone in the promotion of seed germination.It is synthesized in the embryos and transmitted to the aleurone layers,where GA triggers the synthesis and secretion of a set of hydrolases,especiallyα-amylase.Subsequently,the storage nutrients such as starch in the endosperm are digested by these hydrolases and absorbed by the embryo to sustain seed germination and early seedling establishment(Kaneko et al,2002).The detailed GA biosynthesis process has been well studied and thoroughly reviewed in several literatures(Sakamoto et al,2004;Reinecke et al,2013).Briefly,geranylgeranyl diphosphate(GGDP)is turned into ent-kaurene by two terpene synthases,ent-copalyl diphosphate synthase(CPS)and ent-kaurene synthase(KS).Subsequently,the conversion of GA precursor ent-kaurene to ent-kaurenoic acid is catalyzed by ent-kaurene oxidase(KO),and that from ent-kaurenoic acid to GA12 is catalyzed by ent-kaurenoic acid oxidase(KAO).Ultimately,GA12 is converted to various GA intermediates and bioactive GAs by GA20-oxidase(GA20ox)and GA3-oxidase(GA3ox),respectively. | Wang Huimei Hou Yuxuan Wang Shuang Tong Xiaohong Tang Liqun Abolore Adijat Ajadi Zhang Jian Wang Yifeng | 2021 | Rice science2021，28，1： | 2 |
| 11 | Preparation and characterization of rubber-clay nanocomposites 显示文摘 | Wang Yizhong Zhang Liqun Tang Chunhong | 2000 | Journal of Applied Polymer Science2000，78，11： | 1 |
| 12 | A new two-way nesting technique for ocean modeling based on the smoothed semi-prognostic method显示文摘 | Jinyu Sheng Richard J. Greatbatch Xiaoming Zhai Liqun Tang | 2005 | Ocean Dynamics (-)2005，，3： | 1 |
| 13 | A two-way nested-grid ocean-circulation model for the Meso-American Barrier Reef System显示文摘 | Jinyu Sheng Liqun Tang | 2004 | Ocean Dynamics2004，，2： | 1 |
| 14 | Self-assembled 3D flower-like NaY(MoO 4 ) 2 :Eu 3+ microarchitectures: Hydrothermal synthesis, formation mechanism and luminescence properties显示文摘 | Ying Huang Liqun Zhou Lan Yang Ziwei Tang | 2010 | Optical Materials2010，，6： | 1 |
| 15 | Internal strain measurement by fiber Bragg grating sensors in textile composites 显示文摘 | TAO XIAOMING TANG LIQUN DU WEI CHONG | 2000 | Composites Science and Technology2000，，60： | 1 |
| 16 | Renal Cell Carcinoma with Infrahepatic Vena Caval Tumor Thrombus Treated with a Novel Combined Retroperitoneal and Transperitoneal Pure Laparoscopic Procedure显示文摘 | Qi Tang Tianyu Wang Xuesong Li Zheng Zhang Gang Song Zhisong He Liqun Zhou | 2014 | Urology2014，，： | 1 |
| 17 | Preparation and characterization of rubber-clay nanocomposites 显示文摘 | Yizhong Wang Liqun Zhang Chunhong Tang | 2000 | Journal of Applied Polymer Science2000，，78： | 1 |
| 18 | Dynamic response of a poroelastic half-space with semi-permeable surface subjected to time-harmonic vertical load显示文摘 | Luo Xi Zeng Xianwei Tang Liqun | 2012 | Advanced Materials Research2012，，： | 1 |
| 19 | A study on the structure transformation and luminescence of Eu(Ⅲ) titanate nanotubes synthesized at various hydrothermal temperatures 显示文摘 | Tang Ziwei Zhou Liqun Yang Lan Wang Fen | 2009 | Journal of Alloys and Compounds2009，481，： | 1 |
| 20 | Palmitoylation signaling: a novel mechanism of mitochondria dynamics and diverse pathologies显示文摘 | Mingzhu Tang Liqun Lut Zhen Huang Linxi Chen | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 1 |
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