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| 1 | 中国e抗原阳性慢性乙型肝炎抗病毒治疗方案的经济学评价显示文摘目的 对HBeAg阳性慢性乙型肝炎短期和长期的抗病毒治疗方案进行经济学评价。方法 建立包含10个健康状态的Markov模型,估计不同方案治疗HBeAg阳性CHB患者的长期效果和费用,并进行增量分析。结果 与非抗病毒治疗相比,拉米夫定治疗1年是具有高度成本效果的短期治疗方案;拉米夫定治疗必要时换用阿德福韦,或者阿德福韦治疗必要时换用拉米夫定作挽救用药治疗5年,可以更持续地延缓疾病进展。与拉米夫定治疗1年相比,更具成本效果的长期治疗方案则是拉米夫定+阿德福韦,或者阿德福韦+拉米夫定作为挽救用药治疗5年,每单位质量调整生命年的增量费用分别为25 115元和35 577元,分别比国际阈值的中国估计值低55.2%和36.5%。结论 在HBeAg阳性CHB短期治疗方案中,拉米夫定比IFNα、恩替卡韦、聚乙二醇干扰素α-2a和非抗病毒治疗更具成本效果。在长期治疗方案中,拉米夫定+阿德福韦或阿德福韦+拉米夫定挽救治疗均具有成本效果。 | Larry Lacey 卢宪中 Alison Tan | 2007 | 中华肝脏病杂志2007，15，6： | 8 |
| 2 | 中国HBeAg阴性慢性乙型肝炎抗病毒治疗方案的经济学评价显示文摘目的从中国医疗系统的角度,对HBeAg阴性慢性乙型肝炎(乙肝)短期和长期抗病毒治疗方案进行经济学评价。方法建立包含10个健康状态的Markov模型,估计不同方案治疗HBeAg阴性慢性乙肝患者的长期效果和费用,并进行增量分析。结果与非抗病毒治疗比较,最具成本效果的短期治疗方案是拉米夫定治疗1年;拉米夫定治疗必要时换用阿德福韦,或阿德福韦治疗必要时换用拉米夫定作为挽救治疗5年,可更持续地延缓疾病进展。与拉米夫定治疗1年比较,最具成本效果的长期治疗方案是拉米夫定+阿德福韦,或阿德福韦+拉米夫定作为挽救治疗5年,每单位质量调整生命年(QALY)的增量费用分别为16 465元和17 884元,分别比国际阈值的中国估值低70.6%和68.1%。结论HBeAg阴性慢性乙肝短期治疗方案中,拉米夫定比恩替卡韦、聚乙二醇干扰素α-2a和非抗病毒治疗更具成本效果;长期治疗方案中,拉米夫定加阿德福韦或阿德福韦加拉米夫定挽救治疗均具有成本效果。 | Larry Lacey 卢宪中 Alison Tan | 2007 | 中华传染病杂志2007，25，8： | 3 |
| 3 | 贺普丁治疗慢性乙型肝炎的成本-效果分析显示文摘该研究运用中国上海慢性乙型肝炎与肝硬化病人的年总成本和直接医疗成本以及葛兰素史克公司NUCB 30 0 9,NUCB 30 10 ,NUCA 30 10临床研究中的血清转换率与肝硬化转归率 ,分析了贺普丁治疗 1年后的四种成本节约模型。结果显示 :模型Ⅰ采用贺普丁治疗所有慢性乙型肝炎病人一年后 ,每一病人节省的卫生保健成本可抵消 4 6 .3%贺普丁年治疗成本 ;模型Ⅱ采用贺普丁治疗ALT水平高于 2倍正常值的慢性乙型肝炎病人 ,每一病人节省的卫生保健成本可抵消 90 .8%贺普丁年治疗成本 ;模型Ⅲ采用贺普丁治疗ALT水平高于 2倍正常值的慢性乙型肝炎 ,每一病人节省的卫生保健成本可抵消 6 2 .2 %贺普丁年直接医疗成本 ;模型Ⅳ采用贺普丁治疗亚州ALT水平高于 2倍正常值的慢性乙型肝炎病人 ,除可抵消贺普丁年治疗成本外 ,每一病人还可净节省 4 2 6 .9元卫生保健成本。由此可见 ,贺普丁治疗慢性乙型肝炎 | 陈兴宝 Alison Tan Lanrry Lacey Saal GB | 2003 | 中国卫生资源2003，6，5： | 2 |
| 4 | The Role of Short-Chain Fatty Acids in Health and Disease显示文摘 | Jian Tan Craig McKenzie Maria Potamitis Alison N. Thorburn Charles R. Mackay Laurence Macia | 2014 | Advances in Immunology2014，，： | 1 |
| 5 | Are children on jejunal feeds at risk of iron deficiency?显示文摘Children on exclusive jejunal feeding may be at risk of iron deficiency due to the feeds bypassing the duodenum,which is the primary site for iron absorption.We describe the biochemical and hematological features of six children on exclusive jejunal feeding who did not receive iron supplementation.At a mean(standard deviation)period of 11(6.5)mo after commencing jejunal feeds,there was a significant reduction in both serum iron(18.5 g/L vs 9.8 g/L,P=0.01)and transferrin saturation levels(23.1%vs 13.7%,P=0.02),suggesting iron deficiency.However,there was no significant change in ferritin,hemoglobin and mean corpuscular volume levels post-commencement of jejunal feeds.This may be the result of small bowel adaptation in response to early iron deficiency.Larger and longer term prospective studies are required to investigate if children on jejunal feeds are at risk of developing iron deficiency. | Li-Zsa Tan Susan E Adams Alison Kennedy Helen Kepreotes Chee Y Ooi | 2015 | World Journal of Gastroenterology2015，21，18： | 0 |
| 6 | Long term survival of patients with raised pulmonary arterial systolic pressure utilizing echocardiography—a five-year prospective study显示文摘Ba ckground Pulmonary arterial systolic pressure (PASP) can be estimated with transthoracic echocardiography. However, the significance of raised PASP on routine echocardiography is uncertain. In this study, we evaluated the mortality and hospitalization rates of subjects with raised PASP in a cohort of patients referred directly by their general practitioners for routine outpatient (open access) echocardiography for further analysis of suspected heart failure. Results A total of 485 subjects were referred for open access echocardiography at our hospital in 2002. A cohort of 209/485 (43%) consecutive subjects with measurable tricuspid regurgitation were followed for a minimum of five years investigating hospitalization rates and survival. Some 62 of 209 (30%) subjects had pulmonary hypertension (PH). Subjects with PH were significantly more likely to have four or more hospital admissions (22% vs. 8%; P < 0.01) and > 30 days of cumulative hospital stay over five years (29% vs. 13%; P < 0.01). PH was significantly associated with mortality (P = 0.003), while moderate to severe PHwas an independent predictor of mortality (hazard ratio: 4.31; 95% confidence interval (95% CI): 1.51–12.30). Records from the Office of National Statistics revealed that subjects with PH were more likely to have chronic lung diseases recorded as immediate or contributory causes of death (50% vs. 14%; P < 0.05). Conclusions PASP ≥36 mmHg on routine echocardiography is associated with recurrent hospital admissions, prolonged hospitalizations and increased cause of mortality. Therefore, the diagnosis of PHon echocardiography deserves further clinical evaluation, with future studies designed at defining a suitable diagnostic strategy. | Maw Pin Tan Sushil K Bansal Nu Nu Wynn Murad Umerov Angela Gillham Alison Henderson Anthony Hildreth Shahid Junejo | 2012 | Journal of Geriatric Cardiology2012，9，4： | 0 |
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