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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Mineralogical characteristics of airborne particles collected in Beijing during a severe Asian dust storm period in spring 2002显示文摘Asian dust storm (ADS) samples were collected on March 20,2002 in Beijing,China. High-resolution field emission scanning electron microscopy with energy dispersive X-ray detector (FESEM-EDX) and X-ray diffraction (XRD) were used to study the morphology,chemical compositions,number-size dis-tributions and mineralogical compositions of ADS particles. The mineral particles were major compo-nents in the ADS samples,accounting for 94% by number. The XRD analysis indicated that the dust particles were dominated by clay (40.3%),and quartz (19.5%),followed by plagioclase (8.4%),calcite (7.5%),K-feldspar (1.5%),hematite (0.9%),pyrite (0.9%),hornblende (0.4%) and gypsum (0.3%),with a certain amount of noncrystalline materials (20.3%). Clay minerals were mainly illite/smectite mixed lay-ers (78%),followed by illite (9%),kaolinite (6%),and chlorite (7%). In addition to these main minerals,FESEM-EDX also detected some trace minerals,such as dolomite,pyrite,thenardite,as well as heavy minerals represented by rutile,ilmenite and apatite. The mineralogical compositions of the 2002-03-20 Asian dust storm and the Saharan dust plumes were similar but the clay mineralogy showed a great distinction,with the illite/smectite mixed layers being common in the Asian dust storm but illite being common in the Saharan dust plumes. | SHAO LongYi LI WeiJun YANG ShuShen SHI ZongBo LÜ SenLin | 2007 | Science China Earth Sciences2007，50，6： | 11 |
| 3 | Reversibly enhanced aqueous solubilization of volatile organic compounds using a redox-reversible surfactant显示文摘Surfactant-enhanced remediation (SER) is an effective method for the removal of volatile organic compounds (VOCs) from contaminated soils and groundwater.To reuse the surfactant the VOCs must be separated from the surfactant solutions.The water solubility of VOCs can be enhanced using reversible surfactants with a redox-acive group,(ferrocenylmethyl)dodecyldimethylammonium bromide (Fc12) and (ferrocenylmethyl)tetradecanedimethylammonium bromide (Fc14),above and below their critical micelle concentrations (CMC) under reducing (I + ) and oxidative (I 2+ ) conditions.The CMC values of Fc12 and Fc14 in I + are 0.94 and 0.56 mmol/L and the solubilization of toluene by Fc12 and Fc14 in I + for toluene is higher than the solubilization achieved with sodium dodecyl sulfate,cetyltrimethylammonium bromide and Trition X-114.The solubilization capacity of the ferrocenyl surfactants for each tested VOCs ranked as follows: ethylbenzene > toluene > benzene.The solubilities of VOCs by reversible surfactant in I + were 30% higher than those in I 2+ at comparable surfactant concentrations.The effects of Fc14 concentrations on VOCs removal efficiency were as follows: benzene > toluene > ethylbenzene.However,an improved removal efficiency was achieved at low ferrocenyl surfactant concentrations.Furthermore,the reversible surfactant could be recycled through chemical approaches to remove organic pollutants,which could significantly reduce the operating costs of SER technology. | Yingjie Li Senlin Tian Hong Mo Ping Ning | 2011 | Journal of Environmental Sciences2011，23，9： | 5 |
| 4 | Effect of dexamethasone on intelligence and hearing in preterm infants: a meta-analysis显示文摘OBJECTIVE: A meta-analysis of published randomized controlled trials investigating the longterm effect of dexamethasone on the nervous system of preterm infants.DATA SOURCES: Online literature retrieval was conducted using The Cochrane Library(from January 1993 to June 2013), EMBASE(from January 1980 to June 2013), MEDLINE(from January 1963 to June 2013), OVID(from January 1993 to June 2013), Springer(from January 1994 to June 2013) and Chinese Academic Journal Full-text Database(from January 1994 to June 2013). Key words were preterm infants and dexamethasone in English and Chinese.STUDY SELECTION: Selected studies were randomized controlled trials assessing the effect of intravenous dexamethasone in preterm infants. The quality of the included papers was evaluated and those without the development of the nervous system and animal experiments were excluded. Quality assessment was performed through bias risk evaluation in accordance with Cochrane Handbook 5.1.0 software in the Cochrane Collaboration. The homogeneous studies were analyzed and compared using Revman 5.2.6 software, and then effect model was selected and analyzed. Those papers failed to be included in the meta-analysis were subjected to descriptive analysis.MAIN OUTCOME MEASURES: Nervous system injury in preterm infants.RESULTS: Ten randomized controlled trials were screened, involving 1,038 subjects. Among them 512 cases received dexamethasone treatment while 526 cases served as placebo control group and blank control group. Meta-analysis results showed that the incidence of cerebral palsy, visual impairment and hearing loss in preterm infants after dexamethasone treatment within 7 days after birth was similar to that in the control group(RR = 1.47, 95%CI: 0.97–2.21; RR = 1.46, 95%CI: 0.97–2.20; RR = 0.80, 95%CI: 0.54–1.18; P > 0.05), but intelligence quotient was significantly decreased compared with the control group(MD =-3.55, 95%CI:-6.59 to-0.51; P = 0.02). Prete rm infants treated with dexamethasone 7 days after birth demonstrated an incidence of cerebral palsy and visual impairment, and changes in intelligence quotient similar to those in the control group(RR = 1.26, 95%CI: 0.89–1.79; RR = 1.37, 95%CI: 0.73–2.59; RR = 0.53, 95%CI: 0.32–0.89; RR = 1.66, 95%CI:-4.7 to 8.01; P > 0.05). However, the incidence of hearing loss was significantly increased compared with that in the control group(RR = 0.53, 95%CI: 0.32–0.89; P = 0.02).CONCLUSION: Dexamethasone may affect the intelligence of preterm infants in the early stages after birth, but may lead to hearing impairment at later stages after birth. More reliable conclusions should be made through large-size, multi-center, well-designed randomized controlled trials. | Ruolin Zhang Tao Bo Li Shen Senlin Luo Jian Li | 2014 | Neural Regeneration Research2014，9，6： | 3 |
| 5 | Dietary L-arginine supplementation reduces lipid accretion by regulating fatty acid metabolism in Nile tilapia(Oreochromis niloticus)显示文摘Background: Excessive white fat accumulation in humans and other animals is associated with the development of multiple metabolic diseases. It is unknown whether dietary L-arginine supplementation reduces lipid deposition in high fat diet-fed Nile tilapia(Oreochromis niloticus).Results: In the present study, we found that dietary supplementation with 1% or 2% arginine decreased the deposition and concentration of fats in the liver;the concentrations of triglycerides, low-density lipoprotein, total cholesterol, and high-density lipoprotein in the serum;and the diameter of adipocytes in intraperitoneal adipose tissue. Compared with the un-supplementation control group, the hepatic activities of alanine aminotransferase,aspartate aminotransferase, and lactate dehydrogenase, and hepatic concentration of malondialdehyde were reduced but these for catalase and superoxide dismutase were enhanced by dietary supplementation with 2% arginine. Arginine supplementation reduced the total amounts of monounsaturated fatty acids, while increasing the total amounts of n-3 and n-6 polyunsaturated fatty acids in the liver. These effects of arginine were associated with reductions in mRNA levels for genes related to lipogenesis(sterol regulatory element-binding protein-1, acetyl-CoA carboxylase α, stearoyl-CoA desaturase, and fatty acid synthase) but increases in mRNA levels for genes involved in fatty acid β-oxidation(carnitine palmitoyltransferase 1α and peroxisome proliferator-activated receptor α). In addition, hepatic mRNA levels for Δ4 fatty acyl desaturase 2 and elongase 5 of very long-chain fatty acids were enhanced by arginine supplementation.Conclusion: These results revealed that dietary L-arginine supplementation to tilapia reduced high fat diet-induced fat deposition and fatty acid composition in the liver by regulating the expression of genes for lipid metabolism. | Senlin Li Yunchang Zhang Ning Liu Jingqing Chen Lina Guo Zhaolai Dai Chao Wang Zhenlong Wu Guoyao Wu | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 3 |
| 6 | ILK and PRDX1 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder显示文摘 | Jinghe Li Zhu-lin Yang Xuebao Ren Qiong Zou Yuan Yuan Lufeng Liang Meigui Chen Senlin Chen | 2013 | Tumor Biology2013，，1： | 3 |
| 7 | Analysis of the relationship between bile duct and duodenal microbiota reveals that potential dysbacteriosis is the main cause of primary common bile duct stones显示文摘Bacteria play an important role in the formation of primary Common Bile Duct(CBD)stones.However,the composition and function of the microbiota of bile duct in patients with primary CBD stones remained to be explored.We utilized the 16S rRNA gene high-throughput sequencing technology to analyze the microbial diversity and community composition of biliary and duodenal microbiota in 15 patients with primary CBD stones and 4 patients without biliary tract diseases.Alpha diversity analysis showed that the microbiota richness was similar in bile and intestinal fluid;Beta diversity analysis showed that there were differences in the composition between biliary microbiota and the duodenal microbiota,but the abundance of the main groups showed similarities.The composition of the biliary microbiota from gallstone patients was more complex,as was the duodenal microbiota.Proteobacteria and Firmicutes were the dominant bacteria at phylum level,accounting for at least 75%of the total reads in each subgroup.Pseudomonas and EscherichiaShigella were the major genus among subgroups,but Escherichia-Shigella had increased abundance in duodenal microbiota with primary choledocholithiasis,which may play an important role in stone formation.It is noteworthy that Clostridiumsensu_stricto,Lachnospiraceae_UCG-008,Butyrivibrio and Roseburia which could produce short chain fatty acids(SCFAs),were significantly decreased in biliary microbiota with primary CBD stones(p<0.05).Our study provided new insights into the compositional of normal biliary microbiota.The micro-ecology of biliary and duodenal in patients with stones is complex and closely related,and there is a potential for dysbacteriosis.The decrease in abundance of certain major acid-producing bacteria affects the health of the biliary tract and thus leads to the formation of stones. | Zhitang Lyu Tingting Yu Lichao Zhang Xiaona Xu Yijun Zhang Jihong Li Zhirong Li Wei Zhang Senlin Hou | 2021 | Synthetic and Systems Biotechnology2021，6，4： | 2 |
| 8 | A low dose cell therapy system for treating osteoarthritis:In vivo study and in vitro mechanistic investigations显示文摘Mesenchymal stem cells(MSCs)can be effective in alleviating the progression of osteoarthritis(OA).However,low MSC retention and survival at the injection site frequently require high doses of cells and/or repeated injections,which are not economically viable and create additional risks of complications.In this study,we produced MSC-laden microcarriers in spinner flask culture as cell delivery vehicles.These microcarriers containing a low initial dose of MSCs administered through a single injection in a rat anterior cruciate ligament(ACL)transection model of OA achieved similar reparative effects as repeated high doses of MSCs,as evaluated through imaging and histological analyses.Mechanistic investigations were conducted using a co-culture model involving human primary chondrocytes grown in monolayer,together with MSCs grown either within 3D constructs or as a monolayer.Co-culture supernatants subjected to secretome analysis showed significant decrease of inflammatory factors in the 3D group.RNA-seq of co-cultured MSCs and chondrocytes using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed processes relating to early chondrogenesis and increased extracellular matrix interactions in MSCs of the 3D group,as well as phenotypic maintenance in the co-cultured chondrocytes.The cell delivery platform we investigated may be effective in reducing the cell dose and injection frequency required for therapeutic applications. | Bin Wang Wei Liu Jiao Jiao Li Senlin Chai Dan Xing Hongsheng Yu Yuanyuan Zhang Wenjin Yan Zhihong Xu Bin Zhao Yanan Du Qing Jiang | 2022 | Bioactive Materials2022，7，1： | 2 |
| 9 | Chaos Criteria Design Based on Modified Sign Functions with One or Three-Threshold显示文摘The complexity measures of chaotic or periodic signals are perpetual topics of interest to data scientists. This work adheres to the framework of the traditional 0-1 test for chaos and replaces sine and cosine functions by modified sign functions. The compressive mapping rules chosen are one-threshold of three-value or three-threshold of five-value. In new criteria for chaos in forms of the 3s plot and Ks metric compared with 0-1 test results, the periodic state of data features a short beeline instead of a big ring in the pq plot and signs the nearest zero mark, while the chaotic state signs a simple curve instead of a random-walking shape in the pq plot, and shows the nearest one mark. By computing the Lorenz equation evolution under the contrast tests of the Poincare section and Lyapunov index, we visualize a new chaoscriteria design in symbolic dynamics and data compression principles, and our work may lay the foundation for further expressing the chaotic appearance of novel signals deep into future brainets. | WU Senlin LI Yaotian LI Wenshi LI Lei | 2019 | Chinese Journal of Electronics2019，28，2： | 2 |
| 10 | On the Uniqueness of Isosceles Orthogonality in Normed Linear Spaces显示文摘 | JI Donghai LI Jingying WU Senlin | 2011 | Results Math2011，59，： | 1 |
| 11 | Nu- merical simulation of the impact of different vegetation species on the outdoor thermal envi- ronment显示文摘 | ZHENG Senlin ZHAO Lihua LI Qiong | 2016 | Urban forestry & urban greening2016，18，： | 1 |
| 12 | Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants is still a pandemic raging across the world(Supplementary information,Fig.S1a,b).A new variant,Omicron,was first detected in South Africa and got dominant in many regions.1 Omicron has been classified as a variant of concern by the World Health Organization(WHO),whose spike carried more than 30 mutations(Supplementary information,Fig.S1c).1,2 To make a comprehensive evaluation of the susceptibility of Omicron,we summarized plasma samples from 19 convalescent individuals infected with the wild-type(WT)virus,and measured their neutralizing activities against the WT,Beta,Delta,Mu,C.1.2,and Omicron(Supplementary information,Figs.S1d and S2).The Omicron showed more serious resistance to neutralizing antibodies(nAbs)than other variants including Beta and Mu(45.6-fold,9.6-fold,and 15.4-fold,respectively,compared with that against the WT)。 | Bin Ju Qingbing Zheng Huimin Guo Qing Fan Tingting Li Shuo Song Hui Sun Senlin Shen Xinrong Zhou Wenhui Xue Lingyan Cui Bing Zhou Shaowei Li Ningshao Xia Zheng Zhang | 2022 | Cell Research2022，32，5： | 1 |
| 13 | Minicyclotron-based accelerator mass spectrometry and real 14C measurement 显示文摘 | Chen Maobai Li Deming Xu Senlin | 2000 | Nucl Instr Meth B2000，172，： | 1 |
| 14 | Nanofiltration for drinking water treatment: a review显示文摘In recent decades,nanofiltration(NF)is considered as a promising separation technique to produce drinking water from different types of water source.In this paper,we comprehensively reviewed the progress of NFbased drinking water treatment,through summarizing the development of materials/fabrication and applications of NF membranes in various scenarios including surface water treatment,groundwater treatment,water reuse,brackish water treatment,and point of use applications.We not only summarized the removal of target major pollutants(e.g.,hardness,pathogen,and natural organic matter),but also paid attention to the removal of micropollutants of major concern(e.g.,disinfection byproducts,per-and polyfluoroalkyl substances,and arsenic).We highlighted that,for different applications,fit-for-purpose design is needed to improve the separation capability for target compounds of NF membranes in addition to their removal of salts.Outlook and perspectives on membrane fouling control,chlorine resistance,integrity,and selectivity are also discussed to provide potential insights for future development of high-efficiency NF membranes for stable and reliable drinking water treatment. | Hao Guo Xianhui Li Wulin Yang Zhikan Yao Ying Mei Lu Elfa Peng Zhe Yang Senlin Shao Chuyang Y.Tang | 2022 | Frontiers of Chemical Science and Engineering2022，16，5： | 1 |
| 15 | Genotoxic and inflammatory effects of organic extracts from traffic-related particulate matter in human lung epithelial A549 cells: The role of quinones显示文摘 | Yu Shang Lanlan Fan Jialiang Feng Senlin Lv Minghong Wu Bing Li Yuan-Sheng Zang | 2013 | Toxicology in Vitro2013，，2： | 1 |
| 16 | Practical stability of nonlinear differential equation with initial time difference显示文摘 | Xinyu Song Senlin Li An Li | 2008 | Applied Mathematics and Computation2008，，1： | 1 |
| 17 | Strict practical stability of nonlinear impulsive systems by employing two Lyapunov-like functions显示文摘 | Senlin Li Xinyu Song An Li | 2007 | Nonlinear Analysis: Real World Applications2007，，5： | 1 |
| 18 | Strict practical stability of nonlinear impulsive systems by employing two Lyapunov-like functions 显示文摘 | SENLIN LI XINYU SONG AN LI | 2008 | Nonlinear Analysis2008，，9： | 1 |
| 19 | The PCDD/F and PBDD/F pollution in the ambient atmosphere of Shanghai, China显示文摘 | Huiru Li Jialiang Feng Guoying Sheng Senlin Lü Jiamo Fu Ping’an Peng Ren Man | 2007 | Chemosphere2007，，4： | 1 |
| 20 | Strict practical stability of nonlinear impulsive systems by employing two Lyapunowlike functions显示文摘 | Senlin Li Xinyu Song An Li | 2008 | Nonlinear Analysis: Real World Applications2008，9，： | 1 |
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