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| 1 | The antitumor effect of tanshinone IIA on antiproliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line显示文摘The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were investigated.The exploration of the interaction between tanshinone IIA and its target proteins provides a feasible platform for studying the anticancer mechanism of active components of herbs.The CCK-8 assay was used to evaluate the proliferative activity of A549 cells treated with tanshinone IIA(2.5 80 μmol/L) for 24,48 and 72 h,respectively.Flow cytometry was used for the detection of cell apoptosis and cell cycle perturbation.VEGF and VEGFR2 expression were studied by Western blotting.The binding mode of tanshinone IIA within thecrystal structure of the VEGFR2 protein was evaluated with molecular docking analysis by use of the CDOCKER algorithm in Discovery Studio 2.1.The CCK-8 results showed that tanshinone IIA can significantly inhibit A549 cell proliferation in a dose-and time-dependent manner.Flow cytometry results showed that the apoptosis rate of tested group was higher than the vehicle control,and tanshinone IIAtreated cells accumulated at the S phase,which was higher than the vehicle control.Furthermore,the expression of VEGF and VEGFR2 was decreased in Western blot.Finally,molecular docking analysis revealed that tanshinone IIA could be stably docked into the kinase domain of VEGFR2 protein with its unique modes to form H-bonds with Cys917 and π–π stacking interactions with Val848.In conclusion,tanshinone IIA may suppress A549 proliferation,induce apoptosis and cell cycle arrest at the S phase.This drug may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. | Jun Xie Jiahui Liu Heng Liu Shihui Liang Meigui Lin Yueyu Gu Taoli Liu Dongmei Wang Hui Gee Sui-lin Mo | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 26 |
| 2 | Electroacupuncture inhibits annulus fibrosis cell apoptosis in vivo via TNF-α-TNFR1-caspase-8 and integrin β1/Akt signaling pathways显示文摘OBJECTIVE: To examine whether electroacupuncture(EA) treatment inhibited cell apoptosis of intervertebral annulus fibrosis(AF) via tumor necrosis factor-α(TNF-α)-tumor necrosis factor receptor 1(TNFR1)-caspase-8 and integrin β1/Akt signaling pathways in a rat model of cervical intervertebral disc degeneration caused by unbalanced dynamic and static forces.METHODS: Thirty-two Sprague-Dawley rats were included in this study, of which 24 rats underwent surgery to induce cervical intervertebral disc degeneration, while eight rats received EA treatment at Dazhui(GV 14). Immunohistochemical staining was used to detect TNF-α, TNFR1, and caspase-8Apoptosis of AF cells was examined with terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end labeling(TUNEL) staining. The m RNA and protein expression levels of integrin β1 andAkt were evaluated with real-time polymerase chain reaction and western blot analysis, respectively.RESULTS: Treatment with EA decreased TUNEL-positive AF cells and lowered TNF-α, TNFR1 and caspase-8 positive cells compared with control groups. EA treatment also increased integrin β1and Akt m RNA and protein levels compared with controls.CONCLUSION: Treatment with EA inhibits AF cell apoptosis through suppression of the TNF-α-TNFR1-caspase-8 signal pathway and increases the expression of integrin β1 and Akt. EA may be a good alternative therapy for treating cervical spondylosis. | Jun Liao Le Zhang Jiaxuan Zheng Debiao Yu Meigui Ke Teng Xu | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 12 |
| 3 | ILK and PRDX1 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder显示文摘 | Jinghe Li Zhu-lin Yang Xuebao Ren Qiong Zou Yuan Yuan Lufeng Liang Meigui Chen Senlin Chen | 2013 | Tumor Biology2013，，1： | 3 |
| 4 | Slightly ruthenium doping enables better alloy nanoparticle exsolution of perovskite anode for high-performance direct-ammonia solid oxide fuel cells显示文摘Fuel flexibility is one of the most distinguished advantages of solid oxide fuel cells(SOFCs)over other low-temperature fuel cells.Furthermore,the combination of ammonia fuel and SOFCs technology should be a promising clean energy system after considering the high energy density,easy transportation/storage,matured synthesis technology and carbon-free nature of NH_(3) as well as high efficiency of SOFCs.However,the large-scale applications of direct-ammonia SOFCs(DASOFCs)are strongly limited by the inferior anti-sintering capability and catalytic activity for ammonia decomposition reaction of conventional nickel-based cermet anode.Herein,a slightly ruthenium(Ru)doping in perovskite oxides is proposed to promote the alloy nanoparticle exsolution,enabling better DA-SOFCs with enhanced power outputs and operational stability.After treating Ru-doped Pr_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.75)Ru_(0.05)O_(3-δ) single-phase perovskite in a reducing atmosphere,in addition to the formation of two layered Ruddlesden-Popper perovskites and Pr_(2)O_(3) nanoparticles(the same as the Ru-free counterpart,Pr_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3-δ)),the exsolution of CoFeRu-based alloy nanoparticles is remarkably promoted.Such reduced Pr_(0.6)Sr0.4Co_(0.2)Fe_(0.75)Ru_(0.05)O_(3-δ) composite anode shows superior catalytic activity and stability for NH_(3) decomposition reaction as well as anti-sintering capability in DA-SOFCs to those of reduced Pr0.6Sr0.4Co0.2Fe0.8O_(3-δ)due to the facilitated nanoparticle exsolution and stronger nanoparticle/substrate interaction.This work provides a facile and effective strategy to design highly active and durable anodes for DA-SOFCs,promoting large-scale applications of this technology. | Xiandong Xiong Jian Yu Xiaojian Huang Dan Zou Yufei Song Meigui Xu Ran Ran Wei Wang Wei Zhou Zongping Shao | 2022 | Journal of Materials Science & Technology2022，，30： | 3 |
| 5 | Effects of temperature on conversion of Li2CO3 to LiOH in Ca(OH)2 suspension显示文摘 | Bo Yuan Jing Wang Wei Cai Yurong Yang Meigui Yi Lan Xiang | 2017 | Particuology2017，15，5： | 3 |
| 6 | Transglutaminase cross -linking effect on sensory characteristics and antioxidant activities of Maillard reaction products from soybean protein hydrolysates显示文摘 | SONG Na TAN Chen HUANG Meigui | 2013 | Food Chemistry2013，136，1： | 1 |
| 7 | The application of optimization technology on food project 显示文摘 | Wang Meigui | 1995 | Food Science1995，，4： | 1 |
| 8 | Transglutaminase cross-linking effect on sensory characteristics and antioxidant activities of Maillard reaction products from soybean protein hydrolysates显示文摘 | Na Song Chen Tan Meigui Huang Ping Liu Karangwa Eric Xiaoming Zhang Shuqin Xia Chengsheng Jia | 2013 | Food Chemistry2013，，1： | 1 |
| 9 | Contribution of beef base to aroma characteristics of beeflike process flavour assessed by descriptive sensory analysis and gas chromatography olfactometry and partial least squares regression显示文摘 | Shiqing Song Xiaoming Zhang Khizar Hayat Meigui Huang Ping Liu Eric Karangwa Fenglin Gu Chengsheng Jia Shuqin Xia Zuobing Xiao Yunwei Niu | 2010 | Journal of Chromatography A2010，，49： | 1 |
| 10 | Sensory attributes and antioxidant capacity of Maillard reaction products derived from xylose, cysteine and sunflower protein hydrolysate model system显示文摘 | Karangwa Eric Linda Virginie Raymond Meigui Huang Maureen Jepkorir Cheserek Khizar Hayat Nshimiyimana Dominique Savio Mukasa Amédée Xiaoming Zhang | 2013 | Food Research International2013，，2： | 1 |
| 11 | TiO 2 Wedgy Nanotubes Array Flims for Photovoltaic Enhancement显示文摘 | Hao Pan Jieshu Qian Ang Yu Meigui Xu Luo Tu Qingli Chai Xingfu Zhou | 2011 | Applied Surface Science2011，，11： | 1 |
| 12 | Role of plant stanol derivatives in the modulation of cholesterol metabolism and liver gene expression in mice 显示文摘 | HE Wensen WANG Meigui PAN Xiaoxia | 2013 | Food Chem2013，140，： | 1 |
| 13 | Contribution of sulfur-containing compounds to the color inhibition effect and improved antioxidative activity of Maillard reaction products of soybean protein hydrolysates 显示文摘 | Meigui Huang Ping Liu Shiqing Song | 2010 | Journal of the Science of Food and Agriculture2010，91，4： | 1 |
| 14 | CO2 reforming of CH4 by atmospheric pressure glow discharge plasma:A high conversion ability显示文摘 | LI Daihong LI Xiang BAI Meigui | 2009 | Int J Hydrogen Energy2009，34，1： | 1 |
| 15 | CFL1 and Arp3 are Biomarkers for Metastasis and Poor Prognosis of Squamous Cell/Adenosquamous Carcinomas and Adenocarcinomas of Gallbladder显示文摘 | Zhu-Lin Yang Xiongying Miao Li Xiong Qiong Zou Yuan Yuan Jinghe Li Lufeng Liang Meigui Chen Senlin Chen | 2013 | Cancer Investigation2013，，2： | 1 |
| 16 | Selective fluorometry of cytochrome C using glutathione-capped CdTe quantum dots in weakly basic medium显示文摘 | CAO Ming CAO Chun LIU Meigui | | 0，，： | 1 |
| 17 | Enhancing Verbal Creativity via Brief Interventions During an Incubation Interval显示文摘 | Ning Hao Yixuan Ku Meigui Liu Yi Hu RolandH. Grabner Andreas Fink | 2014 | Creativity Research Journal2014，，1： | 1 |
| 18 | Studies on the Preparation of Stable PSt Latex in the Presence of Cyclodextrins and a Small Amount of Surfactant显示文摘 | Nana Huang Yuhong Zhang Meigui Zhao Peixin He | 2012 | Journal of Dispersion Science and Technology2012，，11： | 1 |
| 19 | THE THREE HIGHLAND“MUSKETEERS”——A RECORD OF COACH MEIGUI DORJE AND HIS JAVELIN-THROWING ATHLETES显示文摘On China’s grand stage of track-and-field sports,a group of Tibetan athletes has recently been seen sprouting up again and again at various events.These athletes,such as Tseyang Shijie from the 2012London Olympics and Tobgyal from the 2016 Rio de Janeiro Olympics,have all performed quite well, | Zhong Yuan Meigui Dorje | 2017 | China's Tibet2017，28，4： | 0 |
| 20 | Using radium isotopes to evaluate the uncertainty of submarine groundwater discharge in the northeast and entirety of Daya Bay显示文摘Submarine groundwater discharge(SGD),which can be traced using naturally occurring radium isotopes,has been recognized as a significant nutrient source and land-ocean interaction passage for the coastal waters of the Daya Bay,China.However,uncertainties in assessing SGD fluxes must still be discussed in detail.In this study,we attempted to utilize the Monte Carlo method to evaluate the uncertainties of radium-derived SGD flux in the northeast and entirety of the Daya Bay.The results show that the uncertainties of the SGD estimate in the northeast bay are very sensitive to variations in excess radium inventories as well as radium inputs from bottom sediments,while the uncertainties of the SGD estimate for the entire bay are strongly affected by fluctuations in radium inputs from bottom sediments and radium end-members of SGD.This study will help to distinguish the key factors controlling the accuracy of SGD estimates in similar coastal waters. | Hequan Gu Feng Zhao Zhixin Ni Meigui Wu Li Zhao Aicui Dang Dongmei Li Minxia Zhang Qin Hu | 2023 | Acta Oceanologica Sinica2023，42，8： | 0 |
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