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| 1 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 2 | Regulation of hematopoietic stem cells in the niche显示文摘Hematopoiesis provides a suitable model for understanding adult stem cells and their niche. Hematopoietic stem cells(HSCs) continuously produce blood cells through orchestrated proliferation, self-renewal, and differentiation in the bone marrow(BM). Within the BM exists a highly organized microenvironment termed 'niche' where stem cells reside and are maintained. HSC niche is the first evidence that a microenvironment contributes to protecting stem cell integrity and functionality in mammals. Although multiple models exist, recent progress has principally elucidated the cellular complexity of the HSC niche that maintains and regulates HSCs in BM. Here we introduce the development and summarize the achievements of HSC niche studies. | ZHAO Meng LI LinHeng | 2015 | Science China(Life Sciences)2015，58，12： | 6 |
| 3 | The Wnt Antagonist Dkk1 Regulates Intestinal Epithelial Homeostasis and Wound Repair显示文摘 | Stefan Koch Porfirio Nava Caroline Addis Wooki Kim Timothy L. Denning Linheng Li Charles A. Parkos Asma Nusrat | 2011 | Gastroenterology2011，，1： | 1 |
| 4 | Current View: Intestinal Stem Cells and Signaling显示文摘 | David H. Scoville Toshiro Sato Xi C. He Linheng Li | 2008 | Gastroenterology2008，，3： | 1 |
| 5 | STEM CELL NICHE: Structure and Function显示文摘 | Linheng Li Ting Xie | 2005 | Annual Review of Cell and Developmental Biology2005，，： | 1 |
| 6 | Normal stem cells and cancer stem cells: the niche matters 显示文摘 | Linheng Li Neaves WB | 2006 | Cancer2006，66，9： | 1 |
| 7 | Normal Stem Cells and Cancer Stern Cells:The Niche Matters显示文摘 | Linheng Li William B Neaves | 2006 | Cancer Research2006，66，9： | 1 |
| 8 | Myo-inositol reduces β-catenin activation in colitis显示文摘AIM To assess dietary myo-inositol in reducing stem cell activation in colitis,and validate pβ-cateninS^(552) as a biomarker of recurrent dysplasia.METHODS We examined the effects of dietary myo-inositol treatment on inflammation,pβ-cateninS^(552) and p Akt levels by histology and western blot in IL-10-/-and dextran sodium sulfate-treated colitic mice. Additionally,we assessed nuclear pβ-cateninS^(552) in patients treated with myo-inositol in a clinical trial,and in patients with and without a history of colitis-induced dysplasia.RESULTS In mice,pβ-cateninS^(552) staining faithfully reported the effects of myo-inositol in reducing inflammation and intestinal stem cell activation. In a pilot clinical trial of myo-inositol administration in patients with a history of low grade dysplasia(LGD),two patients had reduced numbers of intestinal stem cell activation compared to the placebo control patient. In humans,pβ-cateninS^(552) staining discriminated ulcerative colitis patients with a history of LGD from those with benign disease.CONCLUSION Enumerating crypts with increased numbers of pβ-cateninS^(552)-positive cells can be utilized as a biomarker in colitis-associated cancer chemoprevention trials. | Emily M Bradford Corey A Thompson Tatiana Goretsky Guang-Yu Yang Luz M Rodriguez Linheng Li Terrence A Barrett | 2017 | World Journal of Gastroenterology2017，23，28： | 1 |
| 9 | Normal stem cells and cancer stem cells The niche matters 显示文摘 | Linheng Li Neaves WB | 2006 | Cancer Res2006，66，9： | 1 |
| 10 | Interferon-γ Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling Pathways显示文摘 | Porfirio Nava Stefan Koch Mike G. Laukoetter Winston Y. Lee Keli Kolegraff Christopher T. Capaldo Neal Beeman Caroline Addis Kirsten Gerner-Smidt Irmgard Neumaier Arne Skerra Linheng Li Charles A. Parkos Asma Nusrat | 2010 | Immunity2010，，3： | 1 |
| 11 | Brief Report: CD24 and CD44 mark human intestinal epithelial cell populations with characteristics of active and facultative stem cells显示文摘 | Adam D. Gracz Megan K. Fuller Fengchao Wang Linheng Li Matthias Stelzner James C.Y. Dunn Martin G. Martin Scott T. Magness | 2013 | Stem Cells2013，，9： | 1 |
| 12 | Mesalamine Inhibits Epithelial β-Catenin Activation in Chronic Ulcerative Colitis显示文摘 | Jeffrey B. Brown Goo Lee Elizabeth Managlia Gery R. Grimm Ramanarao Dirisina Tatiana Goretsky Paul Cheresh Nichole R. Blatner Khashayarsha Khazaie Guang–Yu Yang Linheng Li Terrence A. Barrett | 2010 | Gastroenterology2010，，2： | 1 |
| 13 | The Wnt Antagonist Dkk1 Regulates Intestinal Epithelial Homeostasis and Wound Repair显示文摘 | Stefan Koch Porfirio Nava Caroline Addis Wooki Kim Timothy L. Denning Linheng Li Charles A. Parkos Asma Nusrat | 2011 | Gastroenterology2011，，1： | 1 |
| 14 | Does ‘Immortal DNA strand' exist in ‘immortal' stem cells?显示文摘 | Linheng Li | 2007 | Cell Research2007，17，10： | 0 |
| 15 | Fountain of Youth: aged blood-forming stem cells could be rejuvenated by young microenvironment显示文摘 | Tong Yin Linheng Li | 2010 | Cell Research2010，20，5： | 0 |
| 16 | Single-cell RNA-seq technology lends a hand into HSC ontogeny显示文摘Hematopoietic stem cells(HSCs)are rare populations in the bone marrow of adult mammals which produce millions of blood cells for daily circulation by balancing self-renewal and multi-lineage differentiation.In vertebrates,a subset | Pengxu Qian Linheng Li | 2016 | Science China(Life Sciences)2016，59，9： | 0 |
| 17 | Dissecting the bone marrow HSC niches显示文摘 | Meng Zhao Linheng Li | 2016 | Cell Research2016，26，9： | 0 |
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