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| 1 | Small bowel adenocarcinoma in Crohn's disease:A case report and review of literature显示文摘小肠腺癌为他们的稀有,困难的诊断和差的预后是显著的。这里,我们报导小肠的渗透性的腺癌在 Crohn 的疾病的 10 年的历史以后在被诊断的一个 33 岁的病人的一个不平常的案例。在最以前报导的案例中, Crohn 的疾病的察觉对小肠的癌的随后或包含的病人有疾病的甚至更长的历史。我们的文学评论建议小肠腺癌的风险比在全面人口在有 Crohn 的疾病的病人是更高的。我们传染病学以及这个稀罕疾病实体的临床、诊断的方面上的现在的细节。 | Irmgard E Kronberger Ivo W Graziadei Wolfgang Vogel | 2006 | World Journal of Gastroenterology2006，12，8： | 8 |
| 2 | Acupotomy versus sodium hyaluronate for treatment of knee osteoarthritis in rabbits显示文摘OBJECTIVE: To investigate the possible advantages of acupotomy over sodium hyaluronate injection for the treatment of knee osteoarthritis(KOA).METHODS: Twenty rabbits were divided randomly into four groups(n = 5 in each): a control group,model group, acupotomy group, and sodium hyaluronate injection group. The model, acupotomy,and sodium hyaluronate groups underwent anterior cruciate ligament transection plus partial medial meniscectomy. Sodium hyaluronate injection and acupotomy were administered to the respective groups from weeks 5 to 8, and samples of the tibial plateau and medial condyle of the femur were collected in week 9. Vascular endothelial growth factor(VEGF) expression was assessed in cartilage and subchondral bone by immunohistochemical staining.RESULTS: Articular cartilage degeneration was less pronounced in the acupotomy compared with the model and sodium hyaluronate groups. VEGF expression levels in cartilage and subchondral bone were increased in the model group compared with the control group(P < 0.01), and acupotomy had a more pronounced therapeutic effect than sodium hyaluronate injection(P < 0.01).CONCLUSION: Acupotomy and sodium hyaluronate injection may both reduce degeneration in the cartilage and subchondral bone in KOA based on the results from a rabbit model, but acupotomy improved the histopathology and reduced the VEGF content more effectively than sodium hyaluronate injection, probably by reducing venous stasis and intraosseous pressure. Acupotomy may improve KOA by lowering VEGF. | Ding Yu Yuan Xueling Wang Yongcheng Wang Aiyuan Shi Xian Wang Lu Daniela Litscher Ingrid Gaischek Irmgard Th.Lippe Gerhard Litscher | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 8 |
| 3 | Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension显示文摘AIM To investigate the potential effect of inhibitors of phosphodiesterase-5(PDE-5) for therapy of portal hypertension in liver cirrhosis.METHODS In the rat model of thioacetamide-induced liver fibrosis/cirrhosis the nitric oxide-cyclic guanosine monophosphate(NO-cGMP) pathway was investigated. Expression and localization of PDE-5, the enzyme that converts vasodilating cGMP into inactive 5'-GMP, was in the focus of the study. Hepatic gene expression of key components of the NO-cGMP pathway was determined by qRT-PCR: Endothelial NO synthase(eNOS), inducible NO synthase(iNOS), soluble guanylate cyclase subunits α1 and β1(sGCa1, sGCb1), and PDE-5. Hepatic PDE-5 protein expression and localization were detected by immunohistochemistry. Serum cGMP concentrations were measured using ELISA. Acute effects of the PDE-5 inhibitor Sildenafil(0.1 mg/kg or 1.0 mg/kg) on portal and systemic hemodynamics were investigated using pressure transducers.RESULTS Hepatic gene expression of eNOS(2.2-fold; P = 0.003), sGCa1(1.7-fold; P = 0.003), sGCb1(3.0-fold; P = 0.003), and PDE-5(11-fold; P = 0.003) was increased in cirrhotic livers compared to healthy livers. Overexpression of PDE-5(7.7-fold; P = 0.006) was less pronounced in fibrotic livers. iNOS expression was only detected in fibrotic and cirrhotic livers. In healthy liver, PDE-5 protein was localized primarily in zone 3 hepatocytes and to a lesser extent in perisinusoidal cells. This zonation was disturbed in cirrhosis: PDE-5 protein expression in perisinusoidal cells was induced approximately 8-fold. In addition, PDE-5-expressing cells were also found in fibrous septa. Serum cGMP concentrations were reduced in rats with cirrhotic livers by approximately 40%. Inhibition of PDE-5 by Sildenafil caused a significant increase in serum cGMP concentrations [+ 64% in healthy rats(P = 0.024), + 85% in cirrhotic rats(P = 0.018)]. Concomitantly, the portal venous pressure was reduced by 19% in rats with liver cirrhosis. CONCLUSION Overexpression and abrogated zonation of PDE-5 likely contribute to the pathogenesis of cirrhotic portal hypertension. PDE-5 inhibition may therefore be a reasonable therapeutic approach for portal hypertension. | Denise Schaffner Adhara Lazaro Peter Deibert Peter Hasselblatt Patrick Stoll Lisa Fauth Manfred W Baumstark Irmgard Merfort Annette Schmitt-Graeff Wolfgang Kreisel | 2018 | World Journal of Gastroenterology2018，24，38： | 2 |
| 4 | Immunolocalization of type X collagen in human lumbar intervertebral discs during ageing and degeneration显示文摘 | N. Boos Andreas G. Nerlich Irmgard Wiest Klaus von der Mark Max Aebi | 1997 | Histochemistry and Cell Biology1997，，6： | 1 |
| 5 | Electron microscopical characterization of Sn/SnSb composite electrodes for lithium-ion batteries 显示文摘 | Irmgard Rom Mario Wachtler | 2001 | Solid State Ionics2001，143，： | 1 |
| 6 | Synthetic Transformations of Abietic Acid Va: Structure Modification and Ozonization显示文摘 | Armin Presser Irmgard P?tschger Ernst Haslinger Antje Hüfner | 2002 | Monatshefte fuer Chemie / Chemical Monthly2002，，3： | 1 |
| 7 | Caffeylquinic acids from flowers of ArnicaMontana and Arnica Chamissonis 显示文摘 | Irmgard M | 1992 | Phytochemistry1992，31，6： | 1 |
| 8 | Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation显示文摘 | Greta Guarda Marion Braun Francesco Staehli Aubry Tardivel Chantal Mattmann Irmgard F?rster Matthias Farlik Thomas Decker Renaud A. Du Pasquier Pedro Romero Jürg Tschopp | 2011 | Immunity2011，，2： | 1 |
| 9 | Seasonal changes of mechanisms maintaining clear water in a shallow lake with abundant Chara vegetation显示文摘 | IRMGARD B ANDERS H GUNNAR A | 2002 | Aquatic botany2002，72，： | 1 |
| 10 | Microbiological investigations for sanitary assessment of wastewater treated in constructed wetlands 显示文摘 | Hagendorf Ulrich Diehl Klaus Feuerpfeil Irmgard | 2005 | Water Research2005，39，20： | 1 |
| 11 | Differences in goblet cell differentiation between Crohn’s disease and ulcerative colitis显示文摘 | Michael Gersemann Svetlana Becker Irmgard Kübler Maureen Koslowski Guoxing Wang Klaus Robert Herrlinger Joscha Griger Peter Fritz Klaus Fellermann Matthias Schwab Jan Wehkamp Eduard Friedrich Stange | 2008 | Differentiation2008，，1： | 1 |
| 12 | Determination of Some Pharmacologically Active Phenolic Acids in Juices by High Performance Liquid Chromatography显示文摘 | SIRANOUS S IRMGARD B | 1996 | Journal of Chromatography1996，741，： | 1 |
| 13 | Activation of the inflammasome by amorphous silica and TiO<sub>2</sub> nanoparticles in murine dendritic cells显示文摘 | Meike Winter Hans-Dietmar Beer Veit Hornung Ursula Kr?mer Roel P. F. Schins Irmgard F?rster | 2011 | Nanotoxicology2011，，3： | 1 |
| 14 | Effects of trophoblast invasion on the distribution of leukocytes in uterine and tubal impantation site显示文摘 | Ulrike R Irmgard C L | 2001 | Repro Endocrinol2001，76，： | 1 |
| 15 | Anti-Oxidant, Anti-Inflammatory and Anti-Allergic Activities of Luteolin显示文摘 | Günter Seelinger Irmgard Merfort Christoph Schempp | 2008 | Planta Med2008，，： | 1 |
| 16 | NMR Spectral Analysis of Polyphenols from Punica Granatum 显示文摘 | Nawwar MAM Hussein SAM Irmgard M | 1994 | Phytochemistry1994，36，3： | 1 |
| 17 | BARD1,a possible biomarker for breast and ovarian cancer显示文摘 | Irmgard I F | 2010 | Gynecologic Oncology2010，117，2： | 1 |
| 18 | Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95‐induced apoptosis in a Bim‐ and Bid‐dependent manner显示文摘 | Kathrin Schmich Rebekka Schlatter Nadia Corazza Karine Sá Ferreira Michael Ederer Thomas Brunner Christoph Borner Irmgard Merfort | 2011 | Hepatology2011，，： | 1 |
| 19 | NMR spectral analysis of polyphenols from Punica granatum显示文摘 | NAWWAR M A M HUSSEIN S A M IRMGARD M | 1994 | Phyto Chemistry1994，36，3： | 1 |
| 20 | Flavonoid glycosides from arnica montana and arnica ahamissonis显示文摘 | Irmgard M Detlf W | 1987 | Plant Med1987，53，5： | 1 |
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