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| 1 | Role of the intestinal barrier in inflammatory bowel disease显示文摘A critical function of the intestinal mucosa is to form a barrier that separates luminal contents from the interstitium. The single layer of intestinal epithelial cells (IECs) serves as a dynamic interface between the host and its environment. Cell polarity and structural properties of the epithelium is complex and is important in the development of epithelial barrier function. Epithelial cells associate with each other via a series of intercellular junctions. The apical most intercellular junctional complex referred to as the Apical Junction Complex (AJC) is important in not only cell-cell recognition, but also in the regulation of paracellular movement of fluid and solutes. Defects in the intestinal epithelial barrier function have been observed in a number of intestinal disorders such as inflammatory bowel disease (IBD). It is now becoming evident that an aberrant epithelial barrier function plays a central role in the pathophysiology of IBD. Thus, a better understanding of the intestinal epithelial barrier structure and function in healthy and disease states such as IBD will foster new ideas for the development of therapies for such chronic disorders. | Mike G Laukoetter Porfirio Nava Asma Nusrat | 2008 | World Journal of Gastroenterology2008，14，3： | 18 |
| 2 | Cirrhosis and its complications:Evidence based treatment显示文摘Cirrhosis results from progressive fibrosis and is the final outcome of all chronic liver disease.It is among the ten leading causes of death in United States.Cirrhosis can result in portal hypertension and/or hepatic dysfunction.Both of these either alone or in combination can lead to many complications,including ascites,varices,hepatic encephalopathy,hepatocellular carcinoma,hepatopulmonary syndrome,and coagulation disorders.Cirrhosis and its complications not only impair quality of life but also decrease survival.Managing patients with cirrhosis can be a challenge and requires an organized and systematic approach.Increasing physicians’knowledge about prevention and treatment of these potential complications is important to improve patient outcomes.A literature search of the published data was performed to provide a comprehensive review regarding the management of cirrhosis and its complications. | Salman Nusrat Muhammad S Khan Javid Fazili Mohammad F Madhoun | 2014 | World Journal of Gastroenterology2014，20，18： | 14 |
| 3 | 青藏高原东北缘冬给错纳湖全新世湖面波动显示文摘青藏高原处于东亚季风、印度季风和西风环流交互作用区.末次冰消期以来,太阳辐射对该地区的古气候环境产生了重要影响,湖泊随着季风系统的变化发生了明显的水位升降,对湖岸阶地的形成起到了直接作用.本项研究重建了青藏高原东北缘冬给错纳湖湖岸阶地记录的湖面波动历史,试图了解青藏高原季风系统演变过程.通过湖泊北岸265 cm厚湖岸阶地沉积物粒度、碳酸盐、矿物、元素和介形虫古环境指标,结合OSL年代模式,分析表明在约10. 2 ka B. P.之前水体较浅;约10. 2~9. 0 ka B. P.湖面开始上升,气候凉湿;9. 0~8. 5 ka B. P.为印度季风强盛期,湖面明显上升,降雨量增高、温度上升;8. 5~7. 9 ka B. P.湖面降低与气候变冷有关;7. 9~7. 0 ka B. P.印度季风开始减弱,气温、降雨下降,但有效湿度较大,湖面降低;7. 0~6. 1 ka B. P.湖面上升可能与低蒸发作用有关,印度季风仍然影响该地区;6. 1~5. 2 ka B. P.,印度季风衰退,气候逐渐变冷、降雨量减小、水体变浅;5. 2~4. 6 ka B. P.气候冷干,有效湿度减小,湖面进一步下降;4. 6 ka B. P.至今气候干冷,东亚季风衰退,湖面下降,期间也可能受西风环流影响而有短暂的降雨增加时期. | 张菀漪 张静雅 Nusrat Nazir Safarov Khomid 郑淇 Mischke Steffen 张成君 | 2019 | 第四纪研究2019，39，4： | 9 |
| 4 | Kadsura coccinea:A rich source of structurally diverse and biologically important compounds显示文摘Kadsura coccinea belongs to medicinally important genus Kadsura from the Schisandraceae family.It has been used in traditional Chinese medicine(TCM)for the treatment of rheumatoid arthritis and gastroenteric disorders.The initial phytochemical work focused on the identification of some structurally novel and diverse natural products,which turned the attention of many researchers towards this plant.Thus far,202 compounds have been reported in this plant.Lignans and terpenoids were found as the main chemical constituents of this plant.Some of the triterpenoids and sesquiterpenoids with novel structures are of particular interest for natural product researchers.The isolated compounds of this plant have shown different bioactivities including anti-tumor,anti-HIV,anti-inflammatory,nitric oxide(NO)production inhibitory and other pharmacological effects.This review systematically summarizes all the phytochemical and pharmacological work done so far on K.coccinea,and can be used as a reference for future research on this plant. | Yu-pei Yang Nusrat Hussain Liu Zhang Yan-zhe Jia Yu-qing Jian Bin Li Muhammad Iqbal Choudhary Atta-ur Rahman Wei Wang | 2020 | Chinese Herbal Medicines2020，12，3： | 8 |
| 5 | RNAi-Mediated Silencing of ITPK Gene Reduces Phytic Acid Content,Alters Transcripts of Phytic Acid Biosynthetic Genes,and Modulates Mineral Distribution in Rice Seeds显示文摘Phytic acid is the principal storage form of phosphorus in plant seeds and an essential signalling molecule in several regulatory processes of plant development.However,it is known as an anti-nutrient compound owing to its potent chelating property.Thus,reducing the phytic acid content in crops is desirable.Studies involving regulation of MIPS and IPK1 genes to generate low phytate rice have been reported earlier.However,the functional significance of OsITPK and the effect of its down-regulation on phytic acid content and the associated pleiotropic effects on rice have not yet been investigated.In this study,tissue specific RNA interference(RNAi)-mediated down-regulation of a major ITPK homolog(OsITP5/6K-1)resulted in 46.2%decrease in phytic acid content of T2 transgenic seeds with a subsequent 3-fold enhancement in the inorganic phosphorus content.Silencing of OsITP5/6K-1 altered the transcript levels of essential phytic acid pathway genes,without significantly affecting the transcript levels of other OsITPK homologs.Furthermore,the mapping of elements through X-ray microfluorescence analysis revealed significant changes in the spatial distribution pattern and translocation of elements in low phytate seeds.Additionally,low phytate polished seeds exhibited 1.3-fold and 1.6-fold enhancement in iron and zinc content in the grain endosperm,respectively.Silencing of OsITP5/6K-1 also altered the amino acid and myo-inositol content of the transgenic seeds.Our results successfully established that RNAi-mediated silencing of OsITP5/6K-1 gene significantly reduced the phytate levels in seeds without hampering the germination potential of seeds and plant growth.The present study provided an insight into the mechanism of phytic acid biosynthesis pathway. | Aritra KARMAKAR Sananda BHATTACHARYA Shinjini SENGUPTA Nusrat ALI Sailendra Nath SARKAR Karabi DATTA Swapan K.DATTA | 2020 | Rice science2020，27，4： | 7 |
| 6 | 利用图像和机器学习检测大豆作物幼苗期玉米杂苗显示文摘在大豆-玉米轮作生产过程中,玉米杂苗会与大豆苗竞争水和肥料,而且很容易遮住大豆苗,影响害虫(如玉米根虫)的防控,降低大豆品质。因此,在大豆幼苗期及时检测出玉米杂苗并对其进行处理非常重要。传统的人工检测方法主观性强、效率低,传感器和算法的发展为自动检测玉米杂苗提供了更好的解决方案。本研究在温室环境下模仿田间条件,待玉米和大豆发芽后,连续5天用因特尔RealSense D435相机采集彩色图像,并人工裁剪幼苗图像区域,在此基础上对图像进行分割和去噪。在采集图像形状、色彩和纹理特征值后,对所采集的特征值进行权重分析,保留前10种重要的特征值导入基于特征的机器学习算法中进行模型训练和预测。预测结果表明,支持向量机模型(SVM)、神经网络(NN)和随机森林(RF)的预测精度分别为85.3%,81.5%和82.6%。将数据集导入GoogLeNet和VGG-16两种深度学习模型进行训练,预测精度分别为96.0%和96.2%。VGG-16模型在区分大豆幼苗和玉米杂苗中有较好的表现,彩色图像和VGG-16模型组成的系统可以自动检测大豆生长过程中玉米杂苗的情况,为农民提供准确的信息,帮助其进行生产决策和田间管理。 | Paulo FLORES 张昭 Jithin MATHEW Nusrat JAHAN John STENGER | 2020 | 智慧农业(中英文)2020，2，3： | 6 |
| 7 | Enhanced thermoelectric performance of CoSbS_(0.85)Se_(0.15) by point defect显示文摘In this study, we report the effect of Zn doping on the thermoelectric properties of Co_(1-x)Zn_xSbS_(0.85)Se_(0.15)solid solutions(x = 0, 0.02, 0.05, 0.08). The results show the dimensionless figure of merit(zT) increases from 0.17 to 0.34 at 875 K for Co_(0.95)Zn_(0.05)SbS_(0.85)Se_(0.15) sample, due to the noticeable decrease in the lattice thermal conductivity by introducing point defect, which is further confirmed by an analysis based on the Debye-CallawayKlemens model. Meanwhile, the thermoelectric power factor is maintained at high temperatures. This work highlights the important role of point defect in improving the thermoelectric performance of CoSbS-based compounds. | Shan-Shan Zhang Ding-Feng Yang Nusrat Shaheen Xing-Chen Shen Dan-Dan Xie Yan-Ci Yan Xu Lu Xiao-Yuan Zhou | 2018 | Rare Metals2018，37，4： | 4 |
| 8 | Fisheries resources of Bangladesh:Present status and future direction显示文摘Bangladesh is considered one of the most suitable regions for fisheries in the world,with the world's largest flooded wetland and the third largest aquatic biodiversity in Asia after China and India.This paper reviews the performance of fisheries in Bangladesh using data collected from the Bangladesh Department of Fisheries,and related un-published grey literatures.The findings within describe recent growth within Bangladeshi inland fisheries,primarily in the inland aquaculture sector(2014e2015).This increase in the aquaculture production has been made possible with the implementation of scientific and technological modernization.From 2000 and 2016,aquaculture production increased from 712,640 and 2,060,408 metric t,a much larger quantity than wild capture production(1.023 million t)in 2016.There has also been a recent increase in the value of fishery exports,with more than US$34.08 billion in 2010 rising to more than US$46.60 billion in 2015.However,fisheries production is well below production targets despite the large gains seen in the aquaculture sector. | Md.Mostafa Shamsuzzaman Mohammad Mahmudul Islam Nusrat Jahan Tania Md.Abdullah Al-Mamun Partho Protim Barman Xiangmin Xu | 2017 | Aquaculture and Fisheries2017，2，4： | 4 |
| 9 | CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice显示文摘 | Medina-Contreras Oscar Geem Duke Laur Oskar Williams Ifor R Lira Sergio A Nusrat Asma Parkos Charles A Denning Timothy L | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 10 | Group psychological intervention for maternal depression: A nested qualitative study from Karachi, Pakistan显示文摘AIM To understand the experience of maternal depression, the factors implicated in accessing health, and the acceptability of the psychosocial intervention. METHODS The participants were recruited from the paediatrics outpatient department of Civil Hospital Karachi, Pakistan. The study started in December 2009 and completed in December 2010. Women with maternal depression, aged 18-44 years with children aged 0-30 mo who had received nutritional supplements, and participated in the intervention programme [called Learning through Play(LTP) plus] were included in the study. Qualitative interviews were conducted with 8 participants before the intervention and 7 participants after the intervention. A semi structured topic guide was used to conduct the interviews.RESULTS Framework analysis procedures were used to analyse the qualitative data. Four themes emerged:(1) the women's contextual environment: Interpersonal conflicts, lack of social support and financial issues being the major barriers in assessing healthcare;(2) women's isolation and powerlessness within the environment: Sense of loneliness was identified as a restricting factor to access healthcare;(3) the impact of the intervention(LTP-Plus): Women felt 'listened to' and seemed empowered; and(4) empowered transformed women within the same contextual environment: The facilitator provided a 'gardening role' in nurturing the women resulting in a positive transformation within the same environment. The women's homes seemed to be more happy homes and there was a positive change in their behaviour towards their children.CONCLUSION Findings informed the further development and testing of culturally-appropriate psychosocial intervention(LTP^+) for addressing maternal depression. | Nusrat Husain Nasim Chaudhry Christine Furber Hina Fayyaz Tayyeba Kiran Farah Lunat Raza Ur Rahman Saira Farhan Batool Fatima | 2017 | World Journal of Psychiatry2017，7，2： | 2 |
| 11 | Phytochemical screening and evaluation of cytotoxic and hypoglycemic properties of Mangifera indica peels显示文摘Objective: To investigate the presence of different phytoconstituents in Mangifera indica(M. indica) peel and evaluate its cytotoxicity to Artemia salina and hypoglycemic potential in Swiss albino mice.Methods: The methanolic extract of M. indica peel was used to determine the presence of phytoconstituents. Brine shrimp lethality bioassay method was followed to determine the cytotoxic potential of plant extract. In the case of hypoglycemic activity, oral administration of extract at 200 and 400 mg/kg and standard glibenclamide at 10 mg/kg was done, followed by determining the percentage of reduction of plasma glucose from the initial level.Results: The methanolic extract of M. indica peel showed the presence of flavonoid,saponin, steroid, tannins, terpenoids, glycosides and alkaloids. In brine shrimp lethality bioassay, the LC_(50) of the extract and standard vincristine sulfate was found to be 2.04 and0.41 mg/mL, respectively. After 90 and 150 min, the methanolic extract at 200 and 400 mg/kg showed prominent plasma glucose reduction of 13.95%, 22.48% and 14.16%,26.18% respectively compared to standard glibenclamide showing 14.90% and 20.67% plasma glucose reduction.Conclusions: This current research affirms prominent cytotoxic and moderate hypoglycemic potential of M. indica peel. Further bioactivity guided isolation of phytoconstituents and investigation on higher animals can lead to development of new drug molecules. | Sabiha Chowdhury Saikat Kumar Poddar Sarah Zaheen Farah Ashrafi Noor Najneen Ahmed Sanjana Haque Abhijit Sukul Sauda Binte Sunjida MdMahabob Ullah Mazumder Nusrat Akbar | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，1： | 2 |
| 12 | Endocytosis of the apical junc- tional complex: mechanisms and possible roles in regulation of epithelial barriers 显示文摘 | Ivanov AI Nusrat A Parkos CA | 2005 | BioEssays2005，27，4： | 1 |
| 13 | Some new and known species of genera Tripylina Brzeski and Trischistoma Cobb, 1913 (Nematoda) with a discussion on their relationships 显示文摘 | Tahseen Q Nusrat T | 2010 | Journal of Nematology2010，42，： | 1 |
| 14 | Human junction adhesion molecule regulates tight junction resealing in epithelia显示文摘 | Liu Y Nusrat A Schnell F J | 2000 | J Cell Sci2000，113，13： | 1 |
| 15 | Application of factorial design in optimization of ultrasonic - assisted extraction of aluminum in juices and soft drinks 显示文摘 | Nusrat Jalbani Tasnecm G Kazi Bilal M Arain M K Jamali Hassan I Afridi R A Sarfraz | 2006 | Talanta2006，，70： | 1 |
| 16 | The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction显示文摘 | Nusrat A Chen JA Foley CS | 2000 | J Biol Chem2000，275，29： | 1 |
| 17 | Tight junction are membrane microdomains显示文摘 | Nusrat A Parkos C A Verkade P | 2001 | J Cell Sci2001，113，10： | 1 |
| 18 | Tight junctions and cell-cell interactions 显示文摘 | Utech M Bruwer M Nusrat A | 2006 | Methods Mol Biol2006，341，： | 1 |
| 19 | Endocytosis of the apical junctional complex : mechanisms and possible roles in regulation of epithelial barriers 显示文摘 | Ivanov AI Nusrat A Parkos CA | 2005 | Bioessays2005，27，4： | 1 |
| 20 | Clostridium difficile toxins disrupt epithelial barrier function by altering membrane mierodomain localization of tight junction proteins 显示文摘 | Nusrat von Eiehel-Streiber AC Turner JR | 2001 | Infect hnmun2001，69，3： | 1 |
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