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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 3 | 血管周围脂肪组织中的Bmal1通过血管紧张素原转录调控管理静息期血压显示文摘血管周围脂肪组织(perivascular adipose tissue,PVAT)围绕血管,构成了在生理条件下保持血管张力所需的脉管系统的独特的功能整体层。然而,关于PVAT与血压调节之间的关系的资料很少,包括其对昼夜血压变化的潜在作用。 | Chang L Xiong W Zhao X Fan Y Guo Y Garcia-Barrio M Zhang J Jiang Z Lin JD Chen YE 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 23 |
| 4 | Knockdown of FoxM1 by siRNA interference decreases cell proliferation, induces cell cycle arrest and inhibits cell invasion in MHCC-97H cells in vitro显示文摘 | Qi-fei WU Chang LIU Ming-hui TAI Dong LIU Lei LEI Rui-tao WANG Min TIAN Yi Lü | 2010 | Acta Pharmacologica Sinica2010，31，3： | 13 |
| 5 | Hydrochemical characteristics and recharge sources of Lake Nuoertu in the Badain Jaran Desert显示文摘We present a case study of physical and chemical indicators and isotope characteristics of Lake Nuoertu,one of the largest and deepest lakes of the Badain Jaran Desert.We analyze the concentrations of eight ions,total dissolved solids,and stable isotope composition of the lake and groundwater,as well as radioactive isotope tritium concentration in groundwater.The results show that annual and seasonal variations of the physical and chemical characteristics of Lake Nuoertu water are significantly greater than those of groundwater.The lake is uniformly mixed in the horizontal and vertical directions,and the hydrochemical types of the lake at different depths are consistent for Na–Cl–CO3–(SO4).Stable isotope composition of the lake and groundwater at Nuoertu is distributed along the local evaporation line(EL)slope,which is less than the slope of the global meteoric water line.The comparatively small slope shows the characteristic strong evaporation in the study area.Lake water isotopes are mostly in the upper right corner of the EL,whereas groundwater is mostly in the lower left corner.The main recharge source of Nuoertu lake water is groundwater,in combination with lake water and groundwater level change.The age of tufa springs around Nuoertu is about75–80 a,which shows that the initial recharge source of the lake is a mix between modern and 1952 or older;however,further research is required. | Yue Wu Naiang Wang Liqiang Zhao Zhenyu Zhang Li Chen Ying Lu Xiaonan L Jinlong Chang | 2014 | Chinese Science Bulletin2014，59，9： | 12 |
| 6 | Primary scientific results of Chang'E-1 lunar mission显示文摘The strategic plan for the development of the unmanned Chinese Lunar Exploration Program is characterized by three distinct stages: 'orbiting around', 'landing on' and 'returning from' the Moon. The first Chinese lunar probe, Chang'E-1, which was successfully launched on October 24th, 2007 at Xichang Satellite Launch Center, and guided to crash on the Moon on March 1st, 2009, at 52.36°E, 1.50°S, in the north of Mare Fecunditatis, is the first step towards the 'orbiting around' stage. The Chang'E-1 mission lasted 495 days, exceeding the expected life-span by about four months. A total of 1.37 TB raw data was received from Chang'E-1. It was then processed into 4 TB scientific data products at various levels. Many scientific results have been obtained by analyzing these data, including especially the 'global lunar image from the first Chinese lunar explora- tion mission'. All scientific goals of Chang'E-1 have been achieved. It provides much useful materials for further advances of lunar sciences and planetary chemistry. Meanwhile, these results will serve as a firm basis for future Chinese lunar missions. | OUYANG ZiYuan1,2, LI ChunLai1, ZOU YongLiao1, ZHANG HongBo1, Lü Chang1, LIU JianZhong1, LIU JianJun1, ZUO Wei1, SU Yan1, WEN WeiBin1, BIAN Wei1, ZHAO BaoChang3, WANG JianYu4, YANG JianFeng3, CHANG Jin5, WANG HuanYu6, ZHANG XiaoHui7, WANG ShiJin7, WANG Min1, REN Xin1, MU LingLi1, KONG DeQing1, WANG XiaoQian1, WANG Fang1, GENG Liang1, ZHANG ZhouBin1, ZHENG Lei1, ZHU XinYing1, ZHENG YongChun1, LI JunDuo1, ZOU XiaoDuan1, XU Chun1, SHI ShuoBiao1, GAO YiFei1 & GAO GuanNan1 1 National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China 2 Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China 3 Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi’an 710119, China 4 Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China 5 Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008, China 6 Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China 7 Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing 100190, China | 2010 | Science China Earth Sciences2010，53，11： | 11 |
| 7 | Cytokine production during the inhibition of acute vascular rejection in a concordant hamster-to-rat cardiac xenotransplantation model显示文摘当前的学习的目的是调查 interleukin (IL ) 的角色的背景 -2, 干扰素(IFN ) ,在一致 hamster-to-rat 的 IL-4 和 IL-10 心脏的 xenotransplantation 模型。方法 A hamster-to-rat 心脏的移植作为金色的叙利亚的仓鼠心的接受者用 SD 老鼠被执行。60 只 SD 老鼠的一个总数被划分成四个组并且如下对待:控制组(n=15 ) ;脾切除术组(n=15 ) ;CsA 组(n=15 ) ;CsA + 脾切除术组(n=15 ) 。IL-2, IFN- , IL-4 和 IL-10 的层次被酶测量连接 immunosorbent 试金(ELISA ) 。Sera 在每个组在不同时间点被收获:白天 1,和 3 象日子一样,异种皮移植停止在控制组和 CsA 组跳动;白天 1, 3, 7, 14 和 30 在脾切除术组和 CsA+splenectomy 组。P-selectin 和细胞间的粘附 molecule-1 (ICAM-1 ) 的表示被异种皮移植的 immunohistochemical 分析在心脏的 xenotransplantation 以后检验。IL-2 和 IFN- 的结果浆液层次是 upregulated 在未经治疗(白天 3 ) 并且与 CsA + 脾切除术相比的对待脾切除术的动物(白天 7 ) 对待动物(白天 7 ) 。IL-10 是在跟随脾切除术 + CsA 的长期的幸存接受者的 upregulated。既不 P-selectin 也不 ICAM-1 表示在长期的幸存异种皮移植被检测。结论浆液 IL-2 和 IFN- 被提高跟随尖锐脉管的拒绝。浆液 IL-10 在跟随一致心脏的 xenotransplantation 的长期的幸存老鼠被相关到免疫力的抑制和保护的效果。 | ZHANG Xiao-gang Lü Yi WANG Bo LI Hui YU Liang LIU Chang WU Zheng LIU Xue-min | 2007 | Chinese Medical Journal2007，，2： | 10 |
| 8 | Effects of bile acids on proliferation and ultrastructural alteration of pancreatic cancer cell lines显示文摘AIM: Pancreatic cancer in the head is frequently accompanied by jaundice and high bile acid level in serum. This study focused on the direct effects of bile acids on proliferation and ultrastructural alteration of pancreatic cancer.METHODS: Pancreatic cancer cell lines PANC-1, MIA PaCa2 and PGHAM-1 were explored in this study. The cell lines were cultured in media supplemented with certain bile acids,CA, DCA, LCA, TCDC, TDCA and GCA. Their influence on cell growth was measured with MTT assay after 72 h of incubation. Cell cycles of PANC-1 cells in 40 μM of bile acids media were analyzed by flow cytometry. Ultrastructural alteration of PANC-1 cells induced by DCA was observed using scanning and transmission electron microscope (SEM and TEM).RESULTS: At various concentrations of bile acids and incubation time, no enhanced effects of bile acids on cell proliferation were observed. Significant inhibitory effects were obtained in almost all media with bile acids. DCA and CA increased the percentage of G0+G1 phase cells, while GCA and TDCA elevated the S phase cell number. After 48 h of incubation in DCA medium, PANC-1 cells showed some structural damages such as loss of their microvilli and vacuolization of organelles in cytoplasm.CONCLUSION: Bile acids can reduce proliferation of pancreatic cancer cells due to their direct cytotoxicity. This result implies that elevation of bile acids in jaundiced serum may inhibit pancreatic cancer progression. | Zheng Wu Yi Lü Bo Wang Chang Liu Zuo-Ren Wang Department of Hepatobiliary Surgery,The First Hospital of Xi’an Jiaotong University,Xi’an 710061,Shaanxi Province,China | 2003 | World Journal of Gastroenterology2003，9，12： | 8 |
| 9 | Rapid exhumation of the Tianshan Mountains since the early Miocene:Evidence from combined apatite fission track and(U-Th)/He thermochronology显示文摘Combined apatite fission track(AFT)and(U-Th)/He(AHe)thermochronometries can be of great value for investigating the history of exhumation of orogenic belts.We evaluate the results of such a combined approach through the study on rock samples collected from the Baluntai section in the Tianshan Mountains,northwestern China.Our results show that AFT ages range from^60 to 40 Ma and AHe ages span^40–10 Ma.Based on the strict thermochronological constraints imposed by AHe ages,forward modeling of data derived from AFT analyses provides a well-constrained Cenozoic thermal history.The modeled results reveal a history of relatively slow exhumation during the early Cenozoic times followed by a significantly accelerated exhumation process since the early Miocene with the rate increasing from<30 m/Myr to>100 m/Myr,which is consistent with the inference from the exhumation rates calculated based on both AFT and AHe age data by age-closure temperature and mineral pair methods.Further accelerated exhumation since the late Miocene is recorded by an AHe age(~11 Ma)from the bottom of the Baluntai section.Together with the previous low-temperature thermochronological data from the other parts of the Tianshan Mountains,the rapid exhumation since the early Miocene is regarded as an important exhumation process likely prevailing within the whole range. | Lü HongHua CHANG Yuan WANG Wei ZHOU ZuYi | 2013 | Science China Earth Sciences2013，56，12： | 7 |
| 10 | Lattice Boltzmann Flux Solver:An Efficient Approach for Numerical Simulation of Fluid Flows显示文摘A lattice Boltzmann flux solver(LBFS)is presented for simulation of fluid flows.Like the conventional computational fluid dynamics(CFD)solvers,the new solver also applies the finite volume method to discretize the governing differential equations,but the numerical flux at the cell interface is not evaluated by the smooth function approximation or Riemann solvers.Instead,it is evaluated from local solution of lattice Boltzmann equation(LBE)at cell interface.Two versions of LBFS are presented in this paper.One is to locally apply one-dimensional compressible lattice Boltzmann(LB)model along the normal direction to the cell interface for simulation of compressible inviscid flows with shock waves.The other is to locally apply multi-dimensional LB model at cell interface for simulation of incompressible viscous and inviscid flows.The present solver removes the drawbacks of conventional lattice Boltzmann method(LBM)such as limitation to uniform mesh,tie-up of mesh spacing and time interval,limitation to viscous flows.Numerical examples show that the present solver can be well applied to simulate fluid flows with non-uniform mesh and curved boundary. | Shu Chang Wang Y Yang L M Wu J | 2014 | Transactions of Nanjing University of Aeronautics and Astronautics2014，31，1： | 7 |
| 11 | Soil pH Dynamics and Nitrogen Transformations Under Long-Term Chemical Fertilization in Four Typical Chinese Croplands显示文摘Long-term fertilization experiment provides the platform for understanding the proton budgets in nitrogen transformations of agricultural ecosystems.We analyzed the historical(1990-2005) observations on four agricultural long-term experiments in China(Changping,Chongqing,Gongzhuling and Qiyang) under four different fertilizations,i.e.,no-fertilizer(control),sole chemical nitrogen fertilizer(F N),sole chemical phosphorous and potassium fertilizers(F PK) and chemical nitrogen,phosphorous and potassium fertilizers(F NPK).The significant decline in topsoil pH was caused not only by chemical N fertilization(0.29 and 0.89 pH at Gongzhuling and Qiyang,respectively) but also by chemical PK fertilization(0.59 pH at Gongzhuling).The enhancement of available nutrients in the topsoil due to long-term direct nutrients supply with chemical fertilizers was in the descending order of available P(168-599%)>available K(16-189%)>available N(9-33%).The relative rate of soil pH decline was lower under long-term judicious chemical fertilization(-0.036-0.034 pH yr-1) than that under long-term sole N or PK fertilization(0.016-0.086 pH yr-1).Long-term judicious chemical fertilization with N,P and K elements decreases the nutritional limitation to normal crop growth,under which more N output was distributed in biomass removal rather than the loss via nitrate leaching.We concluded that the N distribution percentage of nitrate leaching to biomass removal might be a suitable indicator to the sensitivity of agricultural ecosystems to acid inputs. | MENG Hong-qi XU Ming-gang L Jia-long HE Xin-hua LI Jian-wei SHI Xiao-jun PENG Chang WANG Bo-ren ZHANG Hui-min | 2013 | Journal of Integrative Agriculture2013，12，11： | 6 |
| 12 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 13 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 14 | Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice显示文摘AIM To evaluate the effect of orally administered plecanatide on colorectal dysplasia in Apc^(+/Min-FCCC) mice with dextran sodium sulfate(DSS)-induced inflammation. METHODS Inflammation driven colorectal carcinogenesis was induced in Apc^(+/Min-FCCC) mice by administering DSS in their drinking water. Mice were fed a diet supplemented with plecanatide(0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid,flat and indeterminate dysplasia was evaluated. Plecanatide-mediated activation of guanylate cyclase-C(GC-C) signaling was assessed in colon tissues by measuring cyclic guanosine monophosphate(cG MP) by ELISA, protein kinase G-II and vasodilator stimulated phosphoprotein by immunoblotting. Ki-67, c-myc and cyclin D1 were used as markers of proliferation. Cellular levels and localization of b-catenin in colon tissues were assessed by immunoblotting and immunohistochemistry, respectively. Uroguanylin(UG) and GC-C transcript levels were measured by quantitative reverse transcription polymerase chain reaction(RT-PCR). A mouse cytokine array panel was used to detect cytokines in the supernatant of colon explant cultures. RESULTS Oral treatment of Apc^(+/Min-FCCC) mice with plecanatide produced a statistically significant reduction in the formation of inflammation-driven polypoid, flat and indeterminate dysplasias. This anti-carcinogenic activity of plecanatide was accompanied by activation of cG MP/GC-C signaling mediated inhibition of Wnt/b-catenin signaling and reduced proliferation. Plecanatide also decreased secretion of pro-inflammatory cytokines(IL-6, IL-1 TNF), chemokines(MIP-1, IP-10) and growth factors(GCSF and GMCSF) from colon explants derived from mice with acute DSS-induced inflammation. The effect of plecanatidemediated inhibition of inflammation/dysplasia on endogenous expression of UG and GC-C transcripts was measured in intestinal tissues. Although GC-C expression was not altered appreciably, a statistically significant increase in the level of UG transcripts was detected in the proximal small intestine and colon, potentially due to a reduction in intestinal inflammation and/or neoplasia. Taken together, these results suggest that reductions in endogenous UG, accompanied by dysregulation in GC-C signaling, may be an early event in inflammation-promoted colorectal neoplasia; an event that can potentially be ameliorated by prophylactic intervention with plecanatide.CONCLUSION This study provides the first evidence that orally administered plecanatide reduces the multiplicity of inflammation-driven colonic dysplasia in mice, demonstrating the utility for developing GC-C agonists as chemopreventive agents. | Wen-Chi L Chang Shet Masih Anusha Thadi Viren Patwa Apoorva Joshi Harry S Cooper Vaseem A Palejwala Margie L Clapper Kunwar Shailubhai | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 5 |
| 15 | 胃肠道恶性神经外胚层肿瘤:19例临床病理、免疫组化和分子分析显示文摘胃肠道恶性神经外胚层肿瘤临床非常罕见,目前对其具体发病机制尚不清楚。该文旨在分析胃肠道恶性神经外胚层肿瘤的临床病理特征、治疗及预后。该文收集19例胃肠道恶性神经外胚层肿瘤患者,平均肿瘤直径为4.2 cm。肿瘤最常见的原发部位为小肠(57.9%),其次为胃(15.8%)、结肠(10.5%)、回盲部(5.3%)、食管下端(5.3%)和肛管(5.3%)。 | Chang B Yu L Guo W W 魏建国(摘译) 方三高(审校) | 2020 | 临床与实验病理学杂志2020，36，1： | 5 |
| 16 | Spacelike Mobius Hypersurfaces in Four Dimensional Lorentzian Space Form显示文摘In this paper, we first set up an alternative fundamental theory of M?bius geometry for any umbilic-free spacelike hypersurfaces in four dimensional Lorentzian space form, and prove the hypersurfaces can be determined completely by a system consisting of a function W and a tangent frame {E_i}. Then we give a complete classification for spacelike M?bius homogeneous hypersurfaces in four dimensional Lorentzian space form. They are either M?bius equivalent to spacelike Dupin hypersurfaces or to some cylinders constructed from logarithmic curves and hyperbolic logarithmic spirals. Some of them have parallel para-Blaschke tensors with non-vanishing M?bius form. | Yan Bin LIN Ying Lü Chang Ping WANG | 2019 | Acta Mathematica Sinica,English Series2019，35，4： | 4 |
| 17 | ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS显示文摘AIM:To investigate the interstitial cells of Cajal(ICC) number using a new rat model.METHODS:Sprague-Dawley rats were assigned to two groups.The first group received gavage with Campylobacter jejuni(C.jejuni) 81-176.The second group was gavaged with placebo.Three months after clearance of Campylobacter from the stool,precise segments of duodenum,jejunum,and ileum were ligated in self-contained loops of bowel that were preserved in anaerobic bags.Deep muscular plexus ICC(DMP-ICC) were quantified by two blinded readers assessing the tissue in a random,coded order.The number of ICC per villus was compared among controls,Campylobacter recovered rats without small intestinal bacterial overgrowth(SIBO),and Campylobacter recovered rats with SIBO.RESULTS:Three months after recovery,27% of rats gavaged with C.jejuni had SIBO.The rats with SIBO had a lower number of DMP-ICC than controls in the jejunum and ileum.Additionally there appeared to be a density threshold of 0.12 DMP-ICC/villus that was associated with SIBO.If ileal density of DMP-ICC was < 0.12 ICC/villus,54% of rats had SIBO compared to 9% among ileal sections with > 0.12(P<0.05).If the density of ICC was < 0.12 DMP-ICC/villus in more than one location of the bowel,88% of these had SIBO compared to 6% in those who did not(P<0.001).CONCLUSION:In this post-infectious rat model,the development of SIBO appears to be associated with a reduction in DMP-ICC.Further study of this rat model might help understand the pathophysiology of postinfectious irritable bowel syndrome. | Sam-Ryong Jee Walter Morales Kimberly Low Christopher Chang Amy Zhu Venkata Pokkunuri Soumya Chatterjee Edy Soffer Jeffrey L Conklin Mark Pimentel | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 18 | 基于工作地点的分组干预对高血压控制的影响:一项随机临床研究显示文摘基于工作地点的干预可能为一种管理高血压的有效方法。但是目前缺少针对中国工作人群高血压控制情况的研究。本研究旨在评估基于工作地点的多组分别干预策略对改善血压控制的影响。研究设计及受试者:研究者在2013年1月至2014年12月于中国20个城区的60个工作地点进行了一系列高血压管理的随机临床试验。工作地点随机分为干预组(n=40)和对照组(n=20)。每个工作地点的受试者都需要完成一项横断面调查。 | 袁源(摘译) 叶鹏(审校) Wang Z Wang X Shen Y Li S Chen Z Zheng C Kang Y Jiang L Hao G Chang C Gao R | 2020 | 中华高血压杂志2020，28，6： | 3 |
| 19 | Carbon and nitrogen allocations in corn grown in Central and Northeast China: different responses to fertilization treatments显示文摘In order to reveal the impact of various fertilization strategies on carbon(C) and nitrogen(N) accumulation and allocation in corn(Zea mays L.), corn was grown in the fields where continuous fertilization management had been lasted about 18 years at two sites located in Central and Northeast China(Zhengzhou and Gongzhuling), and biomass C and N contents in different organs of corn at harvest were analyzed. The fertilization treatments included non-fertilizer(control), chemical fertilizers of either nitrogen(N), or nitrogen and phosphorus(NP), or phosphorus and potassium(PK), or nitrogen, phosphorus and potassium(NPK), NPK plus manure(NPKM), 150% of the NPKM(1.5NPKM), and NPK plus straw(NPKS). The results showed that accumulated C in aboveground ranged from 2 550–5 630 kg ha–1 in the control treatment to 9 300–9 610 kg ha–1 in the NPKM treatment, of which 57–67% and 43–50% were allocated in the non-grain organs, respectively. Accumulated N in aboveground ranged from 44.8–55.2 kg ha–1 in the control treatment to 211–222 kg ha–1 in the NPKM treatment, of which 35–48% and 33–44% were allocated in the non-grain parts, respectively. C allocated to stem and leaf for the PK treatment was 65 and 49% higher than that for the NPKM treatment at the both sites, respectively, while N allocated to the organs for the PK treatment was 18 and 6% higher than that for the NPKM treatment, respectively. This study demonstrated that responses of C and N allocation in corn to fertilization strategies were different, and C allocation was more sensitive to fertilization treatments than N allocation in the area. | MIAO Hui-tian Lü Jia-long XU Ming-gang ZHANG Wen-ju HUANG Shao-min PENG Chang CHEN Li-ming | 2015 | Journal of Integrative Agriculture2015，14，6： | 3 |
| 20 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
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