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| 1 | Analysis of DC Grid Prospects in China显示文摘随着化石能源的日益枯竭,中国已将发展可再生能源提升至重要地位,并逐步实现能源结构的战略性调整。分析可再生能源发电的间歇性与不稳定性特点,以及可再生能源发电集中并网带来的稳定性问题,提出通过建设广域覆盖的直流电网以有效解决可再生能源集中并网的有功波动问题。建设全国性的直流骨干输电网,不仅可更有效地利用可再生能源,也将积极推动坚强智能电网的建设。与交流系统相比,直流电网在未来城市配电、微网等领域也有较大的优势。根据中国国情,对直流电网在中国建设的可行性进行了具体分析,并提出中国直流电网主干结构设想图,指出了直流电网建设的一些关键技术问题,为中国直流电网建设提供参考。 | WEN Jialiang WU Rui Peng Chang Wang Yu | 2012 | 中国电机工程学报2012，32，13： | 172 |
| 2 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 3 | IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation显示文摘 | Juan Peng Xuexian O Yang Seon Hee Chang Jiong Yang Chen Dong | 2010 | Cell Research2010，20，1： | 31 |
| 4 | Shortened Basal Internodes Encodes a Gibberellin 2-Oxidase and Contributes to Lodging Resistance in Rice显示文摘改进住宿抵抗的繁殖半矮子变化被证明了在自从绿 revolution.?However 的来临,增加谷物产量极其成功,在亚洲繁殖半矮子米饭变化的多数主要依赖于 SD1 的变异的等位基因的基因介绍,它编码赤霉素( GA ) 20-oxidase , OsGA20ox2 ,为催化 GA 生合成。这里,我们报导新米饭住宿抵抗基因,弄短的基础 Internodes (SBI ) ,它编码赤霉素 ? 2-oxidase 并且明确地控制灰煤杆的延伸通过撤销的基础 internodes GA 活动。SBI 主要在灰煤杆被表示基础 internodes。基因分析显示 SBI 是影响米饭高度和住宿抵抗的半主导的基因。SBI 突变而产生之遗传的变体显示不同活动并且与米饭变化的高度被联系。与 SBI 等位基因的更高的活动繁殖与改进住宿抵抗和增加的产量产生新米饭变化。SBI 的发现为生产半矮子米饭显型提供一个理想的基因资源并且为与提高的住宿抵抗和高产量引起米饭变化提供有效策略。 | Chang Liu Jinshan Gui Chenjian Fu Hasi Yu Dongliang Song Junhui Shen Peng Qin Xuanming Liu Bin Han Yuanzhu Yang Laigeng Li | 2018 | Molecular Plant2018，11，2： | 33 |
| 5 | Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality显示文摘Enhancing the terrestrial ecosystem carbon sink(referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide(CO_(2)) concentration and to achieve carbon neutrality target.To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality,this review summarizes major progress in terrestrial C budget researches during the past decades,clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world,and examines the role of terrestrial C sinks in achieving carbon neutrality target.According to recent studies,the global terrestrial C sink has been increasing from a source of (-0.2±0.9) Pg C yr^(-1)(1 Pg=1015g)in the 1960s to a sink of (1.9±1.1) Pg C yr^(-1) in the 2010s.By synthesizing the published data,we estimate terrestrial C sink of 0.20–0.25 Pg C yr^(-1) in China during the past decades,and predict it to be 0.15–0.52 Pg C yr^(-1) by 2060.The terrestrial C sinks are mainly located in the mid-and high latitudes of the Northern Hemisphere,while tropical regions act as a weak C sink or source.The C balance differs much among ecosystem types:forest is the major C sink;shrubland,wetland and farmland soil act as C sinks;and whether the grassland functions as C sink or source remains unclear.Desert might be a C sink,but the magnitude and the associated mechanisms are still controversial.Elevated atmospheric CO_(2) concentration,nitrogen deposition,climate change,and land cover change are the main drivers of terrestrial C sinks,while other factors such as fires and aerosols would also affect ecosystem C balance.The driving factors of terrestrial C sink differ among regions.Elevated CO_(2) concentration and climate change are major drivers of the C sinks in North America and Europe,while afforestation and ecological restoration are additionally important forcing factors of terrestrial C sinks in China.For future studies,we recommend the necessity for intensive and long-term ecosystem C monitoring over broad geographic scale to improve terrestrial biosphere models for accurately evaluating terrestrial C budget and its dynamics under various climate change and policy scenarios. | Yuanhe Yang Yue Shi Wenjuan Sun Jinfeng Chang Jianxiao Zhu Leiyi Chen Xin Wang Yanpei Guo Hongtu Zhang Lingfei Yu Shuqing Zhao Kang Xu Jiangling Zhu Haihua Shen Yuanyuan Wang Yunfeng Peng Xia Zhao Xiangping Wang Huifeng Hu Shiping Chen Mei Huang Xuefa Wen Shaopeng Wang Biao Zhu Shuli Niu Zhiyao Tang Lingli Liu Jingyun Fang | 2022 | Science China(Life Sciences)2022，65，5： | 32 |
| 6 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 7 | Three-dimensional path planning for unmanned aerial vehicle based on interfered fluid dynamical system显示文摘This paper proposes a method for planning the three-dimensional path for low-flying unmanned aerial vehicle(UAV) in complex terrain based on interfered fluid dynamical system(IFDS) and the theory of obstacle avoidance by the flowing stream. With no requirement of solutions to fluid equations under complex boundary conditions, the proposed method is suitable for situations with complex terrain and different shapes of obstacles. Firstly, by transforming the mountains, radar and anti-aircraft fire in complex terrain into cylindrical, conical, spherical, parallelepiped obstacles and their combinations, the 3D low-flying path planning problem is turned into solving streamlines for obstacle avoidance by fluid flow. Secondly, on the basis of a unified mathematical expression of typical obstacle shapes including sphere, cylinder, cone and parallelepiped, the modulation matrix for interfered fluid dynamical system is constructed and 3D streamlines around a single obstacle are obtained. Solutions to streamlines with multiple obstacles are then derived using weighted average of the velocity field. Thirdly, extra control force method and virtual obstacle method are proposed to deal with the stagnation point and the case of obstacles' overlapping respectively. Finally, taking path length and flight height as sub-goals, genetic algorithm(GA) is used to obtain optimal 3D path under the maneuverability constraints of the UAV. Simulation results show that the environmental modeling is simple and the path is smooth and suitable for UAV. Theoretical proof is also presented to show that the proposed method has no effect on the characteristics of fluid avoiding obstacles. | Wang Honglun Lyu Wentao Yao Peng Liang Xiao Liu Chang | 2015 | Chinese Journal of Aeronautics2015，28，1： | 27 |
| 8 | Effect of pre-moxibustion on apoptosis and proliferation of gastric mucosa cells显示文摘瞄准:与导致压力的溃疡在老鼠在胃的粘膜房间的 apoptosis 和增长上观察艾灸前的效果,并且分析在那些效果和热吃惊蛋白质 70 的表示(HSP70 ) 之间的关系。方法:六十只健康 Sprague Dawley 老鼠随机被分配进四个组,也就是组织 A, B, C 和 D。压力溃疡的动物模型走水路被建立沉浸和抑制应力。分别地,当那些在 Zusanli 和 Liangmen 点在组 C 收到了艾灸时,在组 A, B,和 D 的老鼠用作抑制,模型,和 non-acupoint 控制。Immunohistochemical 方法论被用来检测 HSP70 的表示, apoptosis 索引(AI,乘 10-6/mum2 ) 并且增长索引(PCNA-LI,乘 10-6/mum2 ) 。转变生长因素高山的粘膜表示哈(TGF-alpha ) 被放射性免疫测定检测。结果:在 Zusanli 和 Liangmen 点的艾灸显著地减少了胃的损害和胃的粘膜房间的 apoptosis,当显著地增加了时象胃的粘膜房间的增长一样的 TGF-alpha 和 HSP70 的粘膜表示。与组 A 相比,溃疡索引( UI )( 26.8 +/- 9.8 对 12.0 +/- 5.9 , P <
0.01 ), AI ( 9.6 +/- 4.2 对 4.4 +/- 2.6 , P <
0.05 )并且 HSP70 的表示( 9.6 +/- 4.2 对 4.4 +/- 2.6 , P <
0.05 )显著地被增加,但是 TGF-alpha 的内容( 104.7 +/- 51.2 pg/mL 对 254.0 +/- 86.9 pg/mL , P <
0.01 )并且 PCNA-LI ( 6.9 +/- 4.7 对 14.9 +/- 4.6 , P <
0.05 )显著地在组 B 被减少。然而,溃疡索引价值(UI ) 和 AI 在与组 B 和 D 相比的组 C 显然是更低的(14.1 +/- 5.4 对 26.8 +/- 9.8 和 26.2 +/- 7.7, P <
0.01; 3.0 +/- 1.6 对 9.6 +/- 4.2 和 8.2 +/- 5.2 , P <
0.05 ,分别地),但是 TGF-alpha 的内容( 237.0 +/- 72.6 pg/mL 对 104.7 +/- 51.2 pg/mL 和 154.1 +/- 61.3 pg/mL , P <
0.01 )并且 HSP70 的表示( 0.13 +/- 0.03 对 0.08 +/- 0.06 和 0.06 +/- 0.04 , P <
0.05 )在组 C 是更高的。而且, PCNA-LI 比在组 B 在组 C 是显著地更高的(21.6 +/- 4.1 对 6.9 +/- 4.7, P <
0.01 ) 。结论:在 Zusanli 和 Liangmen 点的艾灸在支持 TGF-alpha 的合成和胃的粘膜房间的增长与它的行动有关仔细在导致压力的胃溃疡在老鼠胃粘膜上有保护的效果,它是,压制胃的粘膜房间 apoptosis,和起来调整的 HSP70 表示。 | Shou-Xiang Yi Yan Peng Xiao-Rong Chang Na Peng Jie Yan Yap-Ping Lin | 2007 | World Journal of Gastroenterology2007，13，15： | 25 |
| 9 | Transcatheter arterial chemoembolization followed by immediate radiofrequency ablation for large solitary hepatocellular carcinomas显示文摘AIM: To assess the technical safety and efficacy of transcatheter arterial chemoembolization (TACE) combined with immediate radiofrequency ablation (RFA) for large hepatocellular carcinomas (HCC) (maximum diameter ≥ 5 cm). METHODS: Individual lesions in 18 patients with HCCs (mean maximum diameter: 7.5 cm; range: 5.1-15.5 cm) were treated by TACE combined with percutaneous RFA between January 2010 and June 2012. All of the patients had previously undergone one to four cycles of TACE treatment. Regular imaging and laboratory tests were performed to evaluate the rate of technical success, technique-related complications, local-regional tumor responses, recurrence-free survival time and survival rate after treatment.RESULTS: Technical success was achieved for all 18 visible HCCs. Complete response (CR) was observed in 17 cases, and partial response was observed in 1 case 1 mo after intervention. The CR rate was 94.4%. Local tumors were mainly characterized by coagulative necrosis. During follow-up (2-29 mo), the mean recurrencefree survival time was 16.8 ± 4.0 mo in 17 cases of CR. The estimated overall survival rate at 6, 12, and 18 mo was 100%. No major complications were observed. Levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the blood of 17 patients transiently increased on the third day after treatment (ALT 200.4 ± 63.4 U/L vs 24.7 ± 9.3 U/L, P < 0.05; AST 228.1 ± 25.4 U/L vs 32.7 ± 6.8 U/L, P < 0.05). Severe pain occurred in three patients, which was controlled with morphine and fentanyl. CONCLUSION: TACE combined with immediate RFA is a safe and effective treatment for large solitary HCCs. Severe pain is a major side effect, but can be controlled by morphine. | Zhi-Jun Wang Mao-Qiang Wang Feng Duan Peng Song Feng-Yong Liu Zhong-Fei Chang Yan Wang Jie-Yu Yan Kai Li | 2013 | World Journal of Gastroenterology2013，19，26： | 24 |
| 10 | Association of high expression in rat gastric mucosal heat shock protein 70 induced by moxibustion pretreatment with protection against stress injury显示文摘AIM:To study the effect of moxibustion on Zusanli or Liangmeng point on gastric mucosa injury in stress-induced ulcer rats and its correlation with the expression of heat shock protein 70 (HSP70). METHODS:Sixty healthy SD rats (30 males,30 females) were divided into control group,injury model group,Zushanli point group,Liangmeng point group. Stress gastric ulcer model was induced by binding cold stress method. Gastric mucosa ulcer injury (UI) index was calculated by Guth method. Gastric mucosa blood flow (GMBF) was recorded with a biological signal analyzer. Protein content and gene expression in gastric mucosal HSP70 were detected by immunohistochemistry (IHC) and reverse transcription polymerase chain reaction (RT-PCR). Thiobarbital method was used to determine malondialdehyde (MDA) content. Gastric mucosal endothelin (ET) and prostaglandin E2 (PGE2) were analyzed by radioimmunoassay. RESULTS:High gastric mucosal UI index,high HSP70 expression,low GMBF and PGF2,elevated MDA and ET were observed in gastric mucosa of rats subjected to cold stress. Moxibustion on Zusanli or Liangmeng point decreased rat gastric mucosal UI index,MDA and ET. Conversely,the expression of HSP70,GMBF,and PGE2 was elevated in gastric mucosa after pretreatment with moxibustion on Zusanli or Liangmeng point. The observed parameters were significantly different between Zusanli and Liangmeng points. CONCLUSION:Pretreatment with moxibustion on Zusanli or Liangmeng point protects gastric mucosa against stress injury. This protection is associated with the higher expression of HSP70 mRNA and protein,leading to release of PGE2 and inhibition of MDA and ET,impairment of gastric mucosal index. | Xiao-Rong Chang La Peng Shou-Xiang Yi Yan Peng Jie Yan | 2007 | World Journal of Gastroenterology2007，13，32： | 22 |
| 11 | Study on early warning index of spatial deformation for high concrete dam显示文摘Owing to the deficiency in early warning for high concrete dam,a formula was established to characterize the deformation behavior of high concrete dam as a whole.The early warning index of spatial deformation was calculated by low probability principle on the basis of the deformation entropy formula proposed.The steps were as follows.Firstly,the probability method was utilized to define the degree of order and degree of chaos for each survey point.Secondly,the weight distribution among the survey points was calculated by projection pursuit analysis.Thirdly,the formula of holistic deformation entropy,which can represent the degree of order of high concrete dam,was established on the basis of synergetics and information entropy.Lastly,the early warning index of deformation entropy was computed by low probability method based on series of calculated deformation entropy values.An example showed that the dynamic property of deformation entropy is in accordance with both environmental variables and deflection deformation.Moreover,deformation entropy can be used to improve warning ability and safety management for high concrete dam. | LEI Peng CHANG XiaoLin XIAO Feng ZHANG GuiJin SU HuaiZhi | 2011 | Science China(Technological Sciences)2011，54，6： | 23 |
| 12 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 13 | Genome-Wide Association Studies of Image Traits Reveal Genetic Architecture of Drought Resistance in Rice显示文摘理解植物怎么对干旱作出回应能有益于繁殖的干旱抵抗(医生) 。用一台非破坏性的 phenotyping 设备,为 507 米饭就职的 51 个基于图象的特点(i 特点) 被提取。这些 i 特点能被用来监视干旱回答 ? 并且高评估医生可遗传性和这些特点的大变化在自然人口在干旱应力下面被观察。染色体宽的协会研究(GWAS )?i 特点和传统的医生特点识别了 470 协会 loci,某包含知道医生相关的基因。这 470 loci, 443 loci (94%) 用 i 特点被识别, 437 loci (93%) 与以前报导的医生相关的量的特点 loci,和 313 loci (66.6%)co 局部性被 GWAS reproducibly 在不同的年里识别。协会网络,基于 GWAS 建立了结果,揭示中心 i 特点和中心 loci。这表明把的可行性和必要性复杂医生特点进可继承、简单的 i 特点。作为原则的证明,我们说明了这条综合途径的力量以前识别 unreported 医生相关的基因。OsPP15 与中心 i 特点被联系,并且它在医生的角色被基因转变实验证实。而且, i 特点能被用于医生连接分析,并且 69 个 i 特点地点协会被 recombinant 的 GWAS 和连接分析识别生来的线人口。最后,我们证实了 i 特点的关联在这个领域里搀。我们的学习为医生为原因的基因的基因解剖和发现提供一条有希望的新奇途径。 | Zilong Guo Wanneng Yang Yu Chang Xiaosong Ma Haifu Tu Fang Xiong Ni Jiang Hui Feng Chenglong Huang Peng Yang Hu Zhao Guoxing Chen Hongyan Liu Lijun Luo Honghong Hu Qian Liu Lizhong Xiong | 2018 | Molecular Plant2018，11，6： | 21 |
| 14 | Aerosolized Amikacin as Adjunctive Therapy of Ventilator-associated Pneumonia Caused by Multidrug-resistant Gram-negative Bacteria: A Single-center Randomized Controlled Trial显示文摘 | Chang Liu Yu-Ting Zhang Zhi-Yong Peng Qing Zhou Bo Hu Hui Zhou Jian-Guo Li | 2017 | Chinese Medical Journal2017，，10： | 20 |
| 15 | Toxicity of cadmium and its competition with mineral nutrients for uptake by plants:A review显示文摘Cadmium(Cd)is a toxic heavy metal occurring in the environment naturally and is also generated through various anthropogenic sources and acts as a pollutant.Human health is affected by Cd pollution in farmland soils because food is the main source of Cd intake in the non-smoking population.For crops,Cd toxicity may result from a disturbance in uptake and translocation of mineral nutrients and disturbance in plant metabolism,inhibiting plant growth and development.However,plants have Cd tolerance mechanisms,including restricted Cd uptake,decreased Cd root-to-shoot translocation,enhanced antioxidant enzyme activities,and increased production of phytochelatins.Furthermore,optimal supply of mineral nutrients is one of the strategies to alleviate the damaging effects of Cd on plants and to avoid its entry into the food chain.The emerging molecular knowledge contributes to understanding Cd uptake,translocation,and remobilization in plants.In this review,Cd toxicity and tolerance mechanisms,agricultural practices to minimize Cd accumulation,Cd competition with essential elements(calcium,copper,iron,zinc,and manganese),and genes associated with Cd uptake are discussed in detail,especially regarding how these mineral nutrients and genes play a role in decreasing Cd uptake and accumulation in crop plants. | Shiyu QIN Hongen LIU Zhaojun NIE Zed RENGEL Wei GAO Chang LI Peng ZHAO | 2020 | Pedosphere2020，30，2： | 20 |
| 16 | Chemical poison and regeneration of SCR catalysts for NOx removal from stationary sources显示文摘有 NH 3 的没有 x 的选择催化减小(SCR ) 是一种有效技术不把 x 从静止来源移开,例如开火煤的发电厂和工业锅炉。一些在苍蝇灰的元素撤销催化剂由于活跃地点上的强壮的化学吸着。毒物可以由简单地堵住活跃地点行动或由一个电子相互作用改变反应物和产品的吸附行为。这评论主要集中于在 V 2 O 5-based 催化剂,环境良性的催化剂和低温度催化剂。几普通毒物包括 alkali/alkaline 地球金属, 2 和重金属等等因此被提交,他们催化剂上的毒害的机制被讨论。毒害的催化剂的新生方法和毒物抵抗催化剂的发展也被比较并且分析。最后,在发展毒害抵抗催化剂的未来研究方向和为 SCR 催化剂的灵巧的有效新生方法被建议。 | Junhua LI Yue PENG Huazhen CHANG Xiang LI John C. CRITTENDEN Jiming HAO | 2016 | Frontiers of Environmental Science & Engineering2016，10，3： | 12 |
| 17 | Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest显示文摘蛋白质说出 NVP (1 ) 从巢 vespae 被孤立。T 他现在的学习的目的是阐明 NVP (1 ) 是否并且怎么调制 HepG2 房间的增长。在 6.6 μg/ml 的集中的 NVP (1 ) 能在阶段 G 1 逮捕房间周期并且禁止 cyclinB, cyclinD1 和 cyclinE 的 mRNA 表示。NVP (1 ) 压制了 cdk2 蛋白质表示,但是增加了 p27 和 p21 蛋白质表示。然而, NVP (1 ) 没改变 p16 蛋白质表示层次。NVP (1 ) 在由原子染色质冷凝作用显示了的 HepG2 房间支持了 apoptosis,并且另外,表明小径的细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵) 被激活。而且,当 HepG2 房间是有英皇家空军之阶级最低之兵禁止者 PD98059 的 pretreated 时,津贴蛋白质表示水平被稀释。这些结果证明 NVP (1 ) 通过表明小径的英皇家空军之阶级最低之兵禁止 HepG2 的增长。NVP (1 ) 能是为肝癌症的潜在的药。 | Changdong Wang Peng Chen Hongjuan Jin Xu Yan Lu Gan Yi Li Shiyi Zhou Junli Chang Yuesheng Wang Guangxiao Yang Guangyuan He | 2008 | Acta Biochimica et Biophysica Sinica2008，40，11： | 11 |
| 18 | Four new constituents from Taraxacum mongolicum显示文摘二新黄酮 glycosides ,isoetin-7-O-β- d-glucopyranosyl-2 ′- O -- l-arabinopyranoside ( 1 )和isoetin-7-O-β- d-glucopyranosyl-2 ′- O -- d-glucopyranoside ( 2 ),新 lignan , mongolicumin A ( 3 ),和新 guaianolide , mongolicumin B ( 4 )从薄公英属 mongolicum 的天线部分被孤立。他们的结构被主要阐明光谱分析。 | Shu Yun Shi Qi Zhou Hua Peng Chang Xin Zhou Ming Hui Hu Qiao Feng Tao Xiao Jiang Hao Joachim Stoeckigt Yu Zhao | 2007 | Chinese Chemical Letters2007，18，11： | 11 |
| 19 | Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence显示文摘AIM: To demonstrate that administering heparanase inhibitor PI-88 at 160 mg/d is safe and promising in reducing hepatocellular carcinoma(HCC) recurrence for up to 3 year following curative resection. METHODS: A total of 143 patients(83.1% of the 172 participants in the phase Ⅱ study) participated in the follow-up study. Of these patients, 50 had received no treatment, 48 had received 160 mg/d PI-88, and 45 had received 250 mg/d PI-88 during the phase Ⅱ trial. Safety parameters and the following efficacy endpoints were investigated:(1) time to recurrence;(2) diseasefree survival; and(3) overall survival. RESULTS: PI-88 at 160 mg/d delayed the onset and frequency of HCC recurrence, and provided a clinically significant survival advantage for up to 3 years after treatment compared with those of the control group:(1) the recurrence-free rate increased from 50% to 63%, and(2) time to recurrence at the 36 th percentile was postponed by 78%. The efficacy of administering PI-88 at 250 mg/d was confounded by a high dropout rate(11 out of 54 patients). Additionally, subgroup analyses of patients with(1) multiple tumors or a single tumor ≥ 2 cm; and(2) hepatitis B or C revealed that administering PI-88 at 160 mg/d conferred the most significant survival advantage(56.8% improvement in disease-free survival, P = 0.045) for patients with both risk factors for recurrence. CONCLUSION: Administering PI-88 at 160 mg/d is a safe and well-tolerated dosage that may confer significant clinical benefits for patients with HCC. | Chun-Jen Liu Juliana Chang Po-Huang Lee Deng-Yn Lin Cheng-Chung Wu Long-Bin Jeng Yih-Jyh Lin King-Tong Mok Wei-Chen Lee Hong-Zen Yeh Ming-Chih Ho Sheng-Shun Yang Mei-Due Yang Ming-Chin Yu Rey-Heng Hu Cheng-Yuan Peng Kuan-Lang Lai Stanley Shi-Chung Chang Pei-Jer Chen | 2014 | World Journal of Gastroenterology2014，20，32： | 11 |
| 20 | Slope Stability Analysis Based on Group Decision Theory and Fuzzy Comprehensive Evaluation显示文摘A slope stability evaluation method is proposed combining group decision theory,the analytic hierarchy process and fuzzy comprehensive evaluation.The index weight assignment of each evaluation element is determined by group decision theory and the analytic hierarchy process,and the membership degree of each indicator is determined based on fuzzy set theory.According to the weights and memberships,the membership degrees of the criterion layer are obtained by fuzzy operations to evaluate the slope stability.The results show that(1)the evaluation method comprehensively combines the effects of multiple factors on the slope stability,and the evaluation results are accurate;(2)the evaluation method can fully leverage the experience of the expert group and effectively avoid evaluation errors caused by the subjective bias of a single expert;(3)based on a group decision theory entropy model,this evaluation method can quantitatively evaluate the reliability of expert decisions and effectively improve the efficiency of expert group discussion;and(4)the evaluation method can transform the originally fuzzy and subjective slope stability evaluation into a quantitative evaluation. | Peng Xia Xinli Hu Shuangshuang Wu Chunye Ying Chang Liu | 2020 | Journal of Earth Science2020，31，6： | 11 |
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