|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis显示文摘AIM: Disabled-2 (DAB2) is a candidate tumor-suppressor gene identified in ovarian cancer that negatively influences mitogenic signal transduction of growth factors and blocks ras activity. In a recent study, we observed down-regulation of DAB2 transcripts in ESCCs using cDNA microarrays. In the present study, we aimed to determine the clinical significance of loss of DAB2 protein in esophageal tumorigenesis, hypothesizing that DAB2 promoter hypermethylation-mediated gene silencing may account for loss of the protein. METHODS: DAB2 expression was analyzed by immunohistochemistry in 50 primary esophageal squamous cell carcinomas (ESCCs), 30 distinct hyperplasia, 15 dysplasia and 10 non-malignant esophageal tissues. To determine whether promoter hypermethylation contributes to loss of DAB2 expression in ESCCs, methylation status of DAB2 promoter was analyzed in DAB2 immuno-negative tumors using methylation-specifi c PCR. RESULTS: Loss of DAB2 protein was observed in 5/30 (17%) hyperplasia, 10/15 (67%) dysplasia and 34/50 (68%) ESCCs. Significant loss of DAB2 protein was observed from esophageal normal mucosa to hyperplasia, dysplasia and invasive cancer (Ptrend < 0.001). Promoter hypermethylation of DAB2 was observed in 2 of 10 (20%) DAB2 immuno-negative ESCCs. CONCLUSION: Loss of DAB2 protein expression occurs in early pre-neoplastic stages of development of esophageal cancer and is sustained down the tumorigenic pathway. Infrequent DAB2 promoter methylation in ESCCs suggests that epigenetic genesilencing is only one of the mechanisms causing loss of DAB2 expression in ESCCs. | Kumar Anupam Chatopadhyay Tusharkant Siddhartha Datta Gupta Ralhan Ranju | 2006 | World Journal of Gastroenterology2006，12，37： | 11 |
| 2 | Analysis of asphalt mix surface-tread rubber interaction by using finite element method显示文摘The surface texture of the pavement plays a very important role in driving the frictional properties at the tire rubber-pavement interface. Particularly, the hysteretic friction due to viscoelastic deformations of rubber depends mainly on the pavement surface texture. In the present paper, the effect of micromechanical pavement surface morphology on rubber block friction was brought in by comparing the friction results for three different asphalt mix morphological surfaces, named stone mastic asphalt(SMA), ultra-thin surfacing(UTS) and porous asphalt(PA). The asphalt surface morphologies of these mixes were captured by using an X-ray tomographer, from which the resulting images micromechanical finite element(FE) meshes for SMA, UTS and PA pavements were developed by means of the SimpleWare software. In the FE model, the rubber and asphalt binder were modeled as viscoelastic(VE) materials and the formulation was given in the large deformation framework. FE simulations were then carried out by using contact algorithm between rubber and the road surface. It was observed that the rubber friction inversely varies with the sliding speed and positively varies with the pressure for all the pavement morphological and stiffness conditions. Furthermore, it was observed that the highly porous pavement surface results in large dissipation of energy, hence, large rubber friction which shows that the mix characteristics of pavements have a significant effect on rubber friction. | Santosh Kumar Srirangam Kumar Anupam Cor Kasbergen Athanasios (Tom) Scarpas | 2017 | Journal of Traffic and Transportation Engineering(English Edition)2017，4，4： | 2 |
| 3 | In vivo antianxiety and antidepressant activity of Murraya paniculata leaf extracts显示文摘OBJECTIVE: Different parts of Murraya paniculata have been used traditionally for treating several ailments including mental disorders. The present study was designed to evaluate the antianxiety and antidepressant potential of M. paniculata leaves using elevated plus maze model and forced swim test, respectively.METHODS: Extracts of M. paniculata made with petroleum ether(60–80 °C), chloroform, ethanol and water were evaluated for antianxiety and antidepressant activity. The anxiolytic chloroform extract was subjected to column chromatography, yielding five fractions(F_1–F_5). Fraction F_5(100 mg/kg), which showed notable anxiolytic activity, was further chromatographed to get four subfractions(F_(5.1)–F_(5.4)). Simultaneously, the ethanol extract was partitioned with ethyl acetate to obtain ethyl acetate soluble fraction(EASF) and ethyl acetate insoluble fraction. Phytochemical screening of bioactive extracts/fractions and detection of mahanimbine in M. paniculata leaf extract by thin-layer chromatography was also carried out.RESULTS: Fraction F_(5.3)(25 mg/kg) and EASF(20 mg/kg) showed significant anxiolytic and antidepressant activity, respectively. Thin-layer chromatography and phytochemical screening demonstrated the absence of mahanimbine in M. paniculata leaves. Coumarins were observed to be responsible for the anxiolytic activity.CONCLUSION: The results validate the traditional use of M. paniculata leaves in the treatment of mental disorders. | Pragya Sharma Sonali Batra Ashwani Kumar Anupam Sharma | 2017 | Journal of Integrative Medicine2017，15，4： | 2 |
| 4 | Post‐transplant biliary complications: An analysis from a predominantly living donor liver transplant center显示文摘 | Manav Wadhawan Ajay Kumar Subash Gupta Neerav Goyal Rajeev Shandil Sunil Taneja Anupam Sibal | 2013 | J Gastroenterol Hepatol2013，，6： | 1 |
| 5 | Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors显示文摘 | Kodappully Sivaraman Siveen Sakshi Sikka Rohit Surana Xiaoyun Dai Jingwen Zhang Alan Prem Kumar Benny K.H. Tan Gautam Sethi Anupam Bishayee | 2014 | BBA - Reviews on Cancer2014，，2： | 1 |
| 6 | MORC2 Signaling Integrates Phosphorylation-Dependent, ATPase-Coupled Chromatin Remodeling during the DNA Damage Response显示文摘 | Da-Qiang Li Sujit S. Nair Kazufumi Ohshiro Anupam Kumar Vasudha S. Nair Suresh B. Pakala Sirigiri Divijendra Natha Reddy Rajendra P. Gajula Jeyanthy Eswaran L. Aravind Rakesh Kumar | 2012 | Cell Reports2012，，6： | 1 |
| 7 | Antitussive activity of the methanol extract of Passiflora incarnata leaves显示文摘 | Kamaldeep Dhawan Suresh Kumar Anupam Sharma | 2002 | Fitoterapia2002，73，： | 1 |
| 8 | Effect of gas phase modification of analcime zeolite composite membrane on separation of surfactant by ultrafiltration显示文摘 | Ashwin Potdar Anupam Shukla Anil Kumar | 2002 | J Membr Sci2002，210，： | 1 |
| 9 | Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies显示文摘 | Muthu K. Shanmugam Xiaoyun Dai Alan Prem Kumar Benny K.H. Tan Gautam Sethi Anupam Bishayee | 2013 | Biochemical Pharmacology2013，，11： | 1 |
| 10 | Automating Web navi- gation with the WebVCR显示文摘 | Anupam V Freire J Kumar B | 2003 | Computer Networks2003，33，1： | 1 |
| 11 | CNS activity of Calotropis gigantea roots显示文摘 | Ameeta Argal Anupam Kumar Pathak | 2006 | Journal of Ethnopharmacology2006，，1： | 1 |
| 12 | Phylogenetic reconstruction using secondary structures and sequence motifs of ITS2 rDNA of Paragonimus westermani (Kerbert, 1878) Braun, 1899 (Digenea: Paragonimidae) and related species显示文摘 | Prasad Pramod Kumar Tandon Veena Biswal Devendra Kumar Goswami Lalit Mohan Chatterjee Anupam | 2010 | BMC Genomics2010，10，3： | 1 |
| 13 | Artificial neural network modelling in biological removal of organic carbon and nitrogen for the treatment of slaughterhouse wastewater in a batch reactor显示文摘 | Pradyut Kundu Anupam Debsarkar Somnath Mukherjee Sunil Kumar | 2014 | Environmental Technology2014，，10： | 1 |
| 14 | Candida nivariensis as an etiologic agent of vulvovaginal candidiasis in a tertiary care hospital of New Delhi, India显示文摘 | Cheshta Sharma Sandeep Wankhede Sumathi Muralidhar Anupam Prakash Pradeep K. Singh Shallu Kathuria Deepa Anil Kumar Nilofar Khan Harbans S. Randhawa Jacques F. Meis Anuradha Chowdhary | 2013 | Diagnostic Microbiology & Infectious Disease2013，，1： | 1 |
| 15 | Suppression of alcohol-cessation-oriented hyper-anxiety by the benzoflavone moiety of Passiflora inearnata Linneaus in mice显示文摘 | Kamaldeep Dhawan Suresh Kumar Anupam Sharma | 2002 | JEthnopharmacol2002，81，2： | 1 |
| 16 | Thermal-diffusivity measurement of 3D-stitched C-SiC composites显示文摘 | Suresh Kumar Anil Kumar Anupam Shukl | 2009 | J Eur Ceram Soc2009，29，： | 1 |
| 17 | Anti-anxiety studies on extracts of Passiflora incarnata Linneaus显示文摘 | Kamaldeep Dhawan Suresh Kumar Anupam Sharma | 2001 | JEthnopharmacol2001，78，23： | 1 |
| 18 | Meningococcal meningoencephalitis after certolizumab pegol treatment in a patient with Crohn’s disease显示文摘 | Shounak Majumder Anupam Kumar | 2012 | Journal of Crohn’s and Colitis2012，，： | 1 |
| 19 | Comparative Anxiolytic Activity Profile of Various Preparations of Passiflora incamata Linneaus:A Comment on Medicinal Plants'Standardization显示文摘 | Kamaldeep Dhawan Suresh Kumar Anupam Sharma | 2002 | Journal of Alternative and Complementary Medicine2002，8，3： | 1 |
| 20 | Adsorptive removal of chromium (Ⅵ) from aqueous solution over powdered activated carbon: Optimisation through response surface methodology 显示文摘 | Kumar Anupam Suman Dutta Chiranjib Bhattacharjee | 2011 | Chemical Engineering Journal2011，173，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员