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| 1 | 曲酸与阿魏酸对酪氨酸酶的抑制作用研究显示文摘本实验采用Lineweaver-Burk双倒数法探讨了曲酸与阿魏酸对蘑菇酪氨酸酶催化L-DOPA氧化的抑制作用并推测其抑制机理。通过对曲酸与阿魏酸的IC50与抑制常数KI的测定可知,曲酸对酪氨酸酶的抑制作用明显高于阿魏酸。分别采用分光光度法和ImageJ图像分析与处理软件定量地测定曲酸与阿魏酸对虾血淋巴和苹果褐变的抑制作用。曲酸对虾血淋巴褐变的抑制作用优于阿魏酸;对于苹果褐变,阿魏酸的抑制作用则高于曲酸。 | 金一琼 陈周谭 赖富饶 Anupam Giri 吴晖 | 2012 | 现代食品科技2012，28，4： | 19 |
| 2 | Appendiceal mucocoeles and pseudomyxoma peritonei显示文摘Mucocoele of the appendix occurs when obstruction of the appendiceal lumen results in mucus accumulation and consequent abnormal dilatation. The most impor- tant aetiology, from a surgical perspective, is either mucinous cystadenoma or cystadenocarcinoma. In the latter, a spontaneous or iatrogenic rupture of the mucocoele can lead to mucinous intraperitoneal ascites, a syndrome known as pseudomyxoma peritonei. Optimal management of mucoceles is achieved through accurate preoperative identification and subsequent careful resection. We report two cases and subsequently discuss the clinical presentation of mucocoeles, their association with pseudomyxoma peritonei and an optimal management of both conditions. | Anupam Dixit John HP Robertson Satvinder S Mudan Charles Akle | 2007 | World Journal of Gastroenterology2007，13，16： | 14 |
| 3 | Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis显示文摘AIM: Disabled-2 (DAB2) is a candidate tumor-suppressor gene identified in ovarian cancer that negatively influences mitogenic signal transduction of growth factors and blocks ras activity. In a recent study, we observed down-regulation of DAB2 transcripts in ESCCs using cDNA microarrays. In the present study, we aimed to determine the clinical significance of loss of DAB2 protein in esophageal tumorigenesis, hypothesizing that DAB2 promoter hypermethylation-mediated gene silencing may account for loss of the protein. METHODS: DAB2 expression was analyzed by immunohistochemistry in 50 primary esophageal squamous cell carcinomas (ESCCs), 30 distinct hyperplasia, 15 dysplasia and 10 non-malignant esophageal tissues. To determine whether promoter hypermethylation contributes to loss of DAB2 expression in ESCCs, methylation status of DAB2 promoter was analyzed in DAB2 immuno-negative tumors using methylation-specifi c PCR. RESULTS: Loss of DAB2 protein was observed in 5/30 (17%) hyperplasia, 10/15 (67%) dysplasia and 34/50 (68%) ESCCs. Significant loss of DAB2 protein was observed from esophageal normal mucosa to hyperplasia, dysplasia and invasive cancer (Ptrend < 0.001). Promoter hypermethylation of DAB2 was observed in 2 of 10 (20%) DAB2 immuno-negative ESCCs. CONCLUSION: Loss of DAB2 protein expression occurs in early pre-neoplastic stages of development of esophageal cancer and is sustained down the tumorigenic pathway. Infrequent DAB2 promoter methylation in ESCCs suggests that epigenetic genesilencing is only one of the mechanisms causing loss of DAB2 expression in ESCCs. | Kumar Anupam Chatopadhyay Tusharkant Siddhartha Datta Gupta Ralhan Ranju | 2006 | World Journal of Gastroenterology2006，12，37： | 11 |
| 4 | Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review显示文摘The inflammatory process plays a central role in the development and progression of numerous pathological situations,such as inflammatory bowel disease(IBD),autoimmune and neurodegenerative diseases,metabolic syndrome,and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease(CD) and ulcerative colitis(UC). Both pathological situations usually involve recurring or bloody diarrhea,pain,fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However,surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants,including vegetables and fruits which are the major dietary sources of these compounds for humans,together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids,evidencing a remarkable free-radical scavenging capacity. However,accumulating evidence suggests that flavonoids have many other biological properties,including anti-inflammatory,antiviral,anticancer,and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs. | Ali Salaritabar Behrad Darvishi Farzaneh Hadjiakhoondi Azadeh Manayi Antoni Sureda Seyed Fazel Nabavi Leo R Fitzpatrick Seyed Mohammad Nabavi Anupam Bishayee | 2017 | World Journal of Gastroenterology2017，23，28： | 10 |
| 5 | Green tea and the risk of gastric cancer: Epidemiological evidence显示文摘Gastric cancer (GC) is one of the leading causes of cancer death in the world. Numerous efforts are being made to find chemoprotective agents able to reduce its risk. Amongst these, green tea has been reported to have a protective effect against stomach cancer. This article aims to critically evaluate all epidemiological studies reporting an association between green tea consumption and GC risk. MEDLINE, EBSCOHOST and Google Scholar were used to search for clinical trials of green tea and its correlation to stomach cancer. Studies include cohort and case-control studies. Outcome of interests are inverse association, no association, and positive association. Seventeen epidemiologic studies were reviewed. Eleven studies were conducted in Japan, five in China, and one with Japanese descendent in Hawaii. Ten case-control studies and seven cohortstudies were included. The relative risks or odds ratio of GC for the highest level of green tea consumption was compared. Seven studies suggested no association, eight an inverse association, and one a positive association. One study had shown a significantly lowered GC risk when tea was served warm to cold. Another study also showed a significantly risk with lukewarm tea. All studies that analyzed men and women separately have suggested a reduced risk in women than in men, albeit no significant difference. This review demonstrates that there is insufficient information to support green tea consumption reduces the risk of GC. More studies on the subject matter are warranted. | I-Chun Hou Saral Amarnani Mok T Chong Anupam Bishayee | 2013 | World Journal of Gastroenterology2013，19，24： | 8 |
| 6 | A Novel Multi-agent Formation Control Law With Collision Avoidance显示文摘In this paper a stable formation control law that simultaneously ensures collision avoidance has been proposed.It is assumed that the communication graph is undirected and connected.The proposed formation control law is a combination of the consensus term and the collision avoidance term(CAT).The first order consensus term is derived for the proposed model,while ensuring the Lyapunov stability.The consensus term creates and maintains the desired formation shape,while the CAT avoids the collision.During the collision avoidance,the potential function based CAT makes the agents repel from each other.This unrestricted repelling magnitude cannot ensure the graph connectivity at the time of collision avoidance.Hence we have proposed a formation control law,which ensures this connectivity even during the collision avoidance.This is achieved by the proposed novel adaptive potential function.The potential function adapts itself,with the online tuning of the critical variable associated with it.The tuning has been done based on the lower bound of the critical variable,which is derived from the proposed connectivity property.The efficacy of the proposed scheme has been validated using simulations done based on formations of six and thirty-two agents respectively. | Arindam Mondal Laxmidhar Behera Soumya Ranjan Sahoo Anupam Shukla | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，3： | 7 |
| 7 | A Review of Heat Transfer Enhancement through Flow Disruption in a Microchannel显示文摘In this paper a comprehensive review of heat transfer enhancement through microchannels has been presented. Over the past few years due to multifunction, shrinking package size and high power dissipation, the heat flux per unit area has increased significantly. Microchannels, with their large heat transfer surface to volume ratio and their small volumes, have shown a good thermal performance. Microchannels have been proven to be a high performance cooling technique which is able to dissipate heat flux effectively from localized hot spots over small surface area. A good amount of heat transfer augmentation techniques have been reported on flow disruption through microchannel. These techniques promote free stream separation at the leading edge which results in boundary layer development and enhanced mixing leading to increased heat transfer. Flow disruption can be achieved through passive surface modifications, such as, shape of channel, dimple surfaces, ribs, cavities, groove structures, porous medium, etc. Combined effects of these geometrical configurations in heat transfer augmentation are also reported in the literature. In this paper recent developments in experimental and numerical simulations of single-phase liquid cooled microchannel have been discussed to analyze the pressure drop, friction and heat transfer characteristics due to different flow conditions, roughness structure and passive surface modifications. It has been observed that the flow disruption techniques are effective for heat transfer enhancement with lower penalties of increased pressure drop. The review concludes with suggestions for future research in this area. | Anupam Dewan Pankaj Srivastava | 2015 | Journal of Thermal Science2015，24，3： | 7 |
| 8 | Terpenoids as potential chemopreventive and therapeutic agents in liver cancer显示文摘Despite significant advances in medicine, liver cancer, predominantly hepatocellular carcinoma remains a major cause of death in the United States as well as the rest of the world. As limited treatment options are currently available to patients with liver cancer, novel preventive control and effective therapeutic approaches are considered to be reasonable and decisive measures to combat this disease. Several naturally occurring dietary and non-dietary phytochemicals have shown enormous potential in the prevention and treatment of several cancers, especially those of the gastrointestinal tract. Terpenoids, the largest group of phytochemicals, traditionally used for medicinal purposes in India and China, are currently being explored as anticancer agents in clinical trials. Terpenoids (also called 'isoprenoids') are secondary metabolites occurring in most organisms, particularly plants. More than 40 000 individual terpenoids are known to exist in nature with new compounds being discovered every year. A large number of terpenoids exhibit cytotoxicity against a variety of tumor cells and cancer preventive as well as anticancer efficacy in preclinical animal models. This review critically examines the potential role of naturally occurring terpenoids, from diverse origins, in the chemoprevention and treatment of liver tumors. Both in vitro and in vivo effects of these agents and related cellular and molecular mechanisms are highlighted. Potential challenges and future directions involved in the advancement of these promising natural compounds in the chemoprevention and therapy of human liver cancer are also discussed. | Roslin J Thoppil Anupam Bishayee | 2011 | World Journal of Hepatology2011，3，9： | 7 |
| 9 | Gastric remnant twist in the immediate post-operative period following laparoscopic sleeve gastrectomy显示文摘Twist of stomach remnant post sleeve gastrectomy is a rare entity and difficult to diagnose pre-operatively. We are reporting a case of gastric volvulus post laparoscopic sleeve gastrectomy, which was managed conservatively. A 38-year-old lady with a body mass index of 54 underwent laparoscopic sleeve gastrectomy. Sleeve gastrectomy was performed over a 32 French bougie using Endo-GIA tri-stapler. On post-operative day 1, patient had nausea and non-bilious vomiting. An upper gastrointestinal gastrografin study on postoperative days 1 and 2 revealed collection of contrast in the fundic area of stomach with poor flow distally, and she vomited gastrograffin immediately post procedure. With the suspicion of a stricture in the mid stomach as the cause, the patient was taken back for a exploratory laparoscopy and intra-operative endoscopy. We found a twist in the gastric tube which was too tight for the endoscope to pass through. This was managed conservatively with a long stent to keep the gastric tube straight and patent. The stent was discontinued in 7 d and the patient did well. In laparoscopic sleeve gastrectomy the stomach is converted into a tube and is devoid of its supports. If the staples fired are not aligned appropriately, it can predispose this stomach tube to undergo torsion along its long axis. Such a twist can be avoided by properly aligning the staples and by placing tacking sutures to the omentum and new stomach tube. This twist is a functional obstruction rather than a stricture; thus, it can be managed by endoscopy and stent placement. | Gokulakkrishna Subhas Anupam Gupta Mubashir Sabir Vijay K Mittal | 2015 | World Journal of Gastrointestinal Surgery2015，7，11： | 6 |
| 10 | Hepatitis C virus infection,microRNA and liver disease progression显示文摘Hepatitis C virus(HCV) is a global health problem with an estimated 170-200 million peoples(approximately3% of world population) are chronically infected worldwide and new infections are predicted to be on rise in coming years. HCV infection remains categorized as a major risk factor for chronic hepatitis,liver cirrhosis and hepatocellular carcinoma worldwide. There has been considerable improvement in our understanding of virus life cycle since,the discovery of HCV two-decades ago.MicroRNAs(miRNAs) are important players in establishment of HCV infection and their propagation in infected hepatocytes. They target crucial host cellular factors needed for productive HCV replication and augmented cell growth.Very first anti-miRNA oligonucleotides,miravirsen has been tested in clinical trial and shown promising results as therapeutic agent in treatment against chronic HCV infection.Deregulated expression of miRNAs has been linked to the pathogenesis associated with HCV infection by controlling signaling pathways such as,proliferation,apoptosis and migration. Circulating miRNAs emerging as growing field in identification of biomarkers in disease progression and their potential as a means of communication between cells inside the liver is an exciting area of research in future.This review focuses on recent studies enforcing the contribution of miRNAs in HCV life cycle and coordinated regulation in HCV mediated liver disease progression. | Shubham Shrivastava Anupam Mukherjee Ratna B Ray | 2013 | World Journal of Hepatology2013，5，9： | 6 |
| 11 | Global, 30-m resolution continuous fields of tree cover: Landsat-based rescaling of MODIS vegetation continuous fields with lidar-based estimates of error显示文摘We developed a global,30-m resolution dataset of percent tree cover by rescaling the 250-m MOderate-resolution Imaging Spectroradiometer(MODIS)Vegetation Continuous Fields(VCF)Tree Cover layer using circa-2000 and 2005 Landsat images,incorporating the MODIS Cropland Layer to improve accuracy in agricultural areas.Resulting Landsat-based estimates maintained consistency with the MODIS VCF in both epochs(RMSE=8.6%in 2000 and 11.9%in 2005),but showed improved accuracy in agricultural areas and increased discrimination of small forest patches.Against lidar measurements,the Landsat-based estimates exhibited accuracy slightly less than that of the MODIS VCF(RMSE=16.8%for MODIS-based vs.17.4%for Landsat-based estimates),but RMSE of Landsat estimates was 3.3 percentage points lower than that of the MODIS data in an agricultural region.The Landsat data retained the saturation artifact of the MODIS VCF at greater than or equal to 80%tree cover but showed greater potential for removal of errors through calibration to lidar,with post-calibration RMSE of 9.4%compared to 13.5%in MODIS estimates.Provided for free download at the Global Land Cover Facility(GLCF)website(www.landcover.org),the 30-m resolution GLCF tree cover dataset is the highest-resolution multi=temporal depiction of Earth’s tree cover available to the Earth science community. | Joseph O.Sexton Xiao-Peng Song Min Feng Praveen Noojipady Anupam Anand Chengquan Huang Do-Hyung Kim Kathrine M.Collins Saurabh Channan Charlene DiMiceli John R.Townshend | 2013 | International Journal of Digital Earth2013，6，5： | 5 |
| 12 | AN INVESTIGATION OF TURBULENT RECTANGULAR JET DISCHARGED INTO A NARROW CHANNEL WEAK CROSSFLOW显示文摘A computational investigation of the mean flow field of turbulent rectangular jets issuing into a narrow channel crossflow is presented. The length of the jet slot spans more than 55% of the crossflow channel bed, leaving a small clearance between the jet edge and sidewalls. A finite volume code employing the standard k-ε model is used to predict the mean, three-dimensional flow field. The mean flow field is investigated for two velocity ratios (6 and 9). Important flow features, such as the formation of different vortical structures and their characteristics owing to different values of the velocity ratio, are discussed. Some predicted results are compared with the experimental data reported in the literature. The predicted mean and turbulent flow properties are shown to be in good agreement with the experimental data. | PATHAK Manabendra DASS Anoop K. DEWAN Anupam | 2008 | Journal of Hydrodynamics2008，20，2： | 5 |
| 13 | Joining Performance and Microstructure of the 2024/7075 Aluminium Alloys Welded Joints by Vaporizing Foil Actuator Welding显示文摘Vaporizing foil actuator welding(VFAW) was used for joining 2024-T3 and 7075-T6 aluminum alloy sheets, and the resulting joint microstructure was analyzed. 2024/7075 aluminum alloy pairs with suitable processing parameters can be prepared by using VFAW. Dynamic preform addresses the poor formability problem of target material and advantage of VFAW on dissimilar materials in some conditions. But with standoff sheet inserting in the flyer and target, 2024/7075 welded pairs gets the better weld strength, compared with flyer preformed method. The microstructure of the circular weld area of the welded joint showed a wave interface, in which a thin melt layer formed at the center and edge parts. The crystal grains near the bonding interface were remarkably elongated and refined. Therefore, the joining of the 2024/7075 pairs was facilitated through plastic forming and melting. | 孟正华 WANG Xu GUO Wei HU Zhili Anupam Vivek HUA Lin Glenn S DAEHN | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，2： | 4 |
| 14 | Function of longitudinal vs circular muscle fibers in esophageal peristalsis, deduced with mathematical modeling显示文摘We summarize from previous works the functions of circular vs. longitudinal muscle in esophageal peristaltic bolus transport using a mix of experimental data, the conservation laws of mechanics and mathematical modeling. Whereas circular muscle tone generates radial closure pressure to create a local peristaltic closure wave, longitudinal muscle tone has two functions, one physiological with mechanical implications, and one purely mechanical. Each of these functions independently reduces the tension of individual circular muscle fibers to maintain closure as a consequence of shortening of longitudinal muscle locally coordinated with increasing circular muscle tone. The physiological function is deduced by combining basic laws of mechanics with concurrent measurements of intraluminal pressure from manometry, and changes in cross sectional muscle area from endoluminal ultrasound from which local longitudinal shortening (LLS) can be accurately obtained. The purely mechanical function of LLS was discovered from mathematical modeling of peristaltic esophageal transport with the axial wall motion generated by LLS. Physiologically, LLS concentrates circular muscle fibers where closure pressure is highest. However, the mechanical function of LLS is to reduce the level of pressure required to maintain closure. The combined physiological and mechanical consequences of LLS are to reduce circular muscle fiber tension and power by as much as 1/10 what would be requiredfor peristalsis without the longitudinal muscle layer, a tremendous benefit that may explain the existence of longitudinal muscle fiber in the gut. We also review what is understood of the role of longitudinal muscle in esophageal emptying, reflux and pathology. | James G Brasseur Mark A Nicosia Anupam Pal Larry S Miller | 2007 | World Journal of Gastroenterology2007，13，9： | 4 |
| 15 | 米曲霉发酵大米中抗氧化物质对酪氨酸酶的抑制作用显示文摘本实验采用两种不同米曲霉菌种(Aspergillus soji,A.orgzae)在35℃和湿度>90%的条件下对大米进行固态发酵6 d,比较发酵大米在发酵过程中活性物质的金属螯合、多酚氧化酶抑制、氧自由基吸收能力及总酚含量的变化。A.orgzae发酵的大米在金属螯合、多酚氧化酶抑制和氧自由基吸收能力上优于A.soji,两者在总酚含量上没有较大差别,且在发酵第4 d时大米的上述四项活性都趋于稳定,故选取A.orgzae发酵4 d的大米探讨其所含活性物质对酪氨酸酶的抑制作用。采用Lineweaver-Burk双倒数法探讨A.orgzae发酵大米中活性物质对蘑菇酪氨酸酶催化L-多巴氧化的抑制作用并推测其抑制机理。同时,虾血淋巴和虾黑变的抑制实验也证明了米曲霉发酵大米对酪氨酸酶的有效抑制作用。 | 金一琼 赖富饶 陈周潭 Anupam GIRI 吴晖 | 2012 | 现代食品科技2012，28，7： | 4 |
| 16 | 基于中间过渡层的5A06/0Cr18Ni10Ti气化冲击焊接工艺研究显示文摘利用气化冲击焊接技术,制备了力学性能良好基于中间层的5A06铝合金与0Cr18Ni10Ti不锈钢气化冲击焊接接头,中间层3003铝合金与飞板5A06铝合金和靶板0Cr18Ni10Ti界面焊接良好,接头结合区域呈圆环状。通过信号采集系统分析了铝箔气化时间和电流随能量输入的变化,采用OM和SEM分析了接头界面的微观形貌和元素分布。研究了能量输入对铝箔气化的时刻和接头力学性能的影响。结果表明,随着能量输入的增加,铝箔气化所需时间减小,最终碰撞速率增大,从而使焊接区域直径增大;接头的抗拉力和抗剪力随能量输入的增大而增大。当能量输入为9 kJ时,接头的最大抗拉力为44.0 k N,抗剪力为2.1 kN;5A06/3003界面呈中间对称波状结合,3003/0Cr18Ni10Ti界面以金属间化合物连接,结合区域错位分布。 | 苏珊 陈树君 肖珺 Yu MAO Anupam VIVEK Glenn DAEHN | 2019 | 金属学报2019，55，8： | 3 |
| 17 | Is non-biological treatment of rheumatoid arthritis as good as biologics?显示文摘The management of rheumatoid arthritis(RA) in the past three decades has undergone a paradigm shift from symptomatic relief to a 'treat-to-target' approach. This has been possible through use of various conventional and biologic disease modifying anti-rheumatic drugs(DMARDs) which target disease pathogenesis at a molecular level. Cost and infection risk preclude regular use of biologics in resource-constrained settings. In therecent years, evidence has emerged that combination therapy with conventional DMARDs is not inferior to biologics in the management of RA and is a feasible cost-effective option. | Jyoti Ranjan Parida Durga Prasanna Misra Anupam Wakhlu Vikas Agarwal | 2015 | World Journal of Orthopedics2015，6，2： | 3 |
| 18 | Curcumin and Liver Cancer: A Review显示文摘 | Altaf S. Darvesh Bharat B. Aggarwal Anupam Bishayee | 2012 | Current Pharmaceutical Biotechnology2012，，1： | 3 |
| 19 | Clinical variants of pityriasis rosea显示文摘Pityriasis rosea(PR) is a common erythemato-squamous dermatosis which almost always, is easily diagnosed. Mostly the disease presents in its classical form. However, clinical dermatology is all about variations and PR is not an exception. Variants of the disease in some cases may be troublesome to diagnose and confuse clinicians. Prompt diagnosis and treatment of the condition becomes necessary to avoid unnecessary investigations. We hereby review and illustrate atypical presentations of the disease, including diverse forms of location and morphology of the lesions, the course of the eruption, and its differential diagnoses. | Francisco Urbina Anupam Das Emilio Sudy | 2017 | World Journal of Clinical Cases2017，5，6： | 3 |
| 20 | Current and emerging therapeutic strategies in pancreatic cancer: Challenges and opportunities显示文摘Pancreatic carcinoma(PC)is one of the leading causes of cancer-related deaths worldwide.Despite early detection and advances in therapeutics,the prognosis remains dismal.The outcome and therapeutic approach are dependent on the stage of PC at the time of diagnosis.The standard of care is surgery,followed by adjuvant chemotherapy.The advent of newer drugs has changed the landscape of adjuvant therapy.Moreover,recent trials have highlighted the role of neoadjuvant therapy and chemoradiotherapy for resectable and borderline resectable PC.As we progress towards a better understanding of tumor biology,genetics,and microenvironment,novel therapeutic strategies and targeted agents are now on the horizon.We have described the current and emerging therapeutic strategies in PC. | Manish Manrai TVSVGK Tilak Saurabh Dawra Sharad Srivastava Anupam Singh | 2021 | World Journal of Gastroenterology2021，27，39： | 3 |
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