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| 1 | 减少急性冠状动脉综合征和卒中患者求医的延误——美国心脏协会心血管护理委员会和卒中委员会的科学声明显示文摘在寻求急性冠状动脉综合征和卒中症状的治疗方面,患者延误是限制提供这些疾病的确定性治疗的主要因素。尽管数十年来的研究和公众教育活动一直旨在缩短患者延误时间,但大多数患者仍然不能及时求医。在本科学声明中,我们总结了以下证据:(1)证明早期治疗的益处;(2)描述患者延误问题的程度;(3)确定与患者延误及时求医有关的因素;(4)揭示当前减少患者延误措施的不足。最后,提出临床实践和今后研究的建议。 | Debra K. Moser Laura P. Kimble Mark J. Alberts Angelo Alonzo Janet B. Croft Kathleen Dracup Kelly R. Evenson Alan S. Go Mary M. Hand Rashmi U. Kothari George A. Mensah Dexter L. Morris Arthur M. Pancioli Barbara Riegel Julie Johnson Zerwic 李宏建 曲东锋 | 2006 | 国际脑血管病杂志2006，14，10： | 39 |
| 2 | Nature:研究鉴定出蛋白Nlrp9b抵抗轮状病毒感染机制显示文摘轮状病毒(rotavirus)是婴儿和儿童罹患肠胃炎和腹泻的一种最为常见的原因,每年导致全世界大约21.5万人死亡。它是高度传染性的和潜在致命性的。这种病毒特异性地感染宿主小肠中的肠上皮细胞,并且已进化出抵抗干扰素和NF-KB信号的策略来躲避免疫系统,这就提出一个问题:其他的宿主因子是否参与肠道粘膜中的抗病毒反应。不过,针对体内(特别是通过NLR炎性体)检测和限制肠道病毒的机制,人们知之甚少。 | Shu Zhu, Zheng Wei, Noah W. Palm, Yi Yang, Hua Yu, Hua-Bing Li, Geng Wang, Xuqiu Lei, Marcel R. de Zoete, Jun Zhao, Yunjiang Zheng, Haiwei Chen, Liang Shan, Richard A. Flavell Siyuan Ding, Ningguo Feng, Harry B. Greenberg Siyuan Ding, Harry B. Greenberg Penghua Wang, Yujiao Zhao Wen Pan, Jun Lu Jun Zhao, Yuval Kluger Kellie A. Jurado, Clara Abraham, Erol Fikrig Erol Fikrig, Richard A. Flavell | 2017 | 现代生物医学进展2017，17，27： | 10 |
| 3 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 5 |
| 4 | Treating Clostridium difficile Infection With Fecal Microbiota Transplantation显示文摘 | Johan S. Bakken Thomas Borody Lawrence J. Brandt Joel V. Brill Daniel C. Demarco Marc Alaric Franzos Colleen Kelly Alexander Khoruts Thomas Louie Lawrence P. Martinelli Thomas A. Moore George Russell Christina Surawicz | 2011 | Clinical Gastroenterology and Hepatology2011，，12： | 5 |
| 5 | 脑海绵状血管畸形临床诊疗指南概要:血管瘤联盟科学咨询委员会临床专家组基于系统文献评价的共识推荐显示文摘背景尽管脑海绵状血管畸形(cerebral cavernous malformation, CCM)的相关研究文献已相当丰富,但在诊断和治疗策略方面仍存在着争议。目的制订CCM诊疗指南。方法作为代表CCM患者和研究的患者支持团体,血管瘤联盟(www.angioma.org)召集了一个包括CCM临床专家在内的多学科写作组来帮助总结现有的CCM临床诊疗相关文献,重点关注5个主题:(1)流行病学和自然病程;(2)遗传检测和咨询;(3)诊断标准和影像学标准;(4)神经外科注意事项;(5)神经内科注意事项。写作组根据预定方案进行了文献回顾和证据评价,最终制定推荐意见,并且确立了共识、争议和知识空白。结果根据方法学标准从1983年1月1日至2014年9月31日期间公开发表的1 270篇文献中筛选出98篇,并确定了另外38篇近期或相关的文献。各主题作者利用这些文献总结了现有知识并形成了23项共识诊疗推荐,同时根据美国心脏协会/美国卒中协会标准进行了推荐强度(效应量)和证据水平(确定性估计)评级。其中,尚无A级证据(因为缺乏随机对照试验),B级证据11项(48%),C级证据12项(52%);Ⅰ级推荐8项(35%),Ⅱ级推荐10项(43%),Ⅲ级推荐5项(22%)。结论现有证据支持对CCM诊疗的推荐,但这些证据的级别和推荐强度普遍较低,因此需要进一步研究来帮助进行更好的临床实践并更新这些推荐。完整的推荐文档包括引用文献的纳入标准、关于各项推荐更详尽的评判标准以及各种争议和知识空白的总结,同样通过了同行评议并可在线获取(www.angioma.org/CCMGuidelines)。 | Amy Akers Rustam Al-Shahi Salman Issam A. Awad Kristen Dahlem Kelly Flemming Blaine Hart Helen Kim Ignacio Jusue-Torres Douglas Kondziolka Cornelia Lee Leslie Morrison Daniele Rigamonti Tania Rebeiz Elisabeth Toumier-Lasserve Darrel Waggoner Kevin Whitehead 鄂同舟 雷宇 倪伟 顾宇翔 | 2017 | 国际脑血管病杂志2017，25，7： | 4 |
| 6 | Comparing the Hurricane Disaster Risk of U.S. Coastal Counties显示文摘 | Rachel A. Davidson Kelly B. Lambert | 2001 | Natural Hazards Review2001，，3： | 3 |
| 7 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 3 |
| 8 | Preoperative Nutritional Status Is an Important Predictor of Survival in Patients Undergoing Surgery for Renal Cell Carcinoma显示文摘 | Todd M. Morgan Dominic Tang Kelly L. Stratton Daniel A. Barocas Christopher B. Anderson Justin R. Gregg Sam S. Chang Michael S. Cookson S. Duke Herrell Joseph A. Smith Peter E. Clark | 2011 | European Urology2011，，6： | 2 |
| 9 | Morphine Modulates NFκB Activation in Macrophages显示文摘 | Sabita Roy Kelly J. Cain Rebecca B. Chapin Richard G. Charboneau Roderick A. Barke | 1998 | Biochemical and Biophysical Research Communications1998，，2： | 2 |
| 10 | UV reflectance but no evidence for colour mimicry in a putative brood-deceptive orchid Corybas cheesemanii显示文摘 | M. M. KELLY A. C. GASKETT | 2014 | Current Zoology2014，60，1： | 2 |
| 11 | Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10显示文摘 | Mingzhong Zheng Dora Bocangel Blair Doneske Abner Mhashilkar Rajagopal Ramesh Kelly K. Hunt Suhendan Ekmekcioglu R. Bryan Sutton Nancy Poindexter Elizabeth A. Grimm Sunil Chada | 2007 | Cancer Immunology Immunotherapy2007，，2： | 2 |
| 12 | Eosinophilic Esophagitis: A 10-Year Experience in 381 Children显示文摘 | Chris A. Liacouras Jonathan M. Spergel Eduardo Ruchelli Ritu Verma Maria Mascarenhas Edisio Semeao Jonathan Flick Janice Kelly Terry Brown–Whitehorn Petar Mamula Jonathan E. Markowitz | 2005 | Clinical Gastroenterology and Hepatology2005，，： | 2 |
| 13 | Preoperative Chemotherapy Does Not Increase Morbidity or Mortality of Hepatic Resection for Colorectal Cancer Metastases显示文摘 | Charles R. Scoggins Michael L. Campbell Christine S. Landry Beatrix A. Slomiany Charles E. Woodall Kelly M. McMasters Robert C. G. Martin | 2009 | Annals of Surgical Oncology2009，，1： | 2 |
| 14 | Smoldering and polarized inflammation in the initiation and promotion of malignant disease显示文摘 | Frances Balkwill Kellie A. Charles Alberto Mantovani | 2005 | Cancer Cell2005，，3： | 2 |
| 15 | Homocysteine, MTHFR 677C→T polymorphism, and risk of ischemic stroke: Results of a meta-analysis显示文摘 | P. J. Kelly J. Rosand J. P. Kistler V. E. Shih S. Silveira A. Plomaritoglou K. L. Furie | 2002 | Neurology2002，，4： | 2 |
| 16 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
| 17 | Locoregional Recurrence After Sentinel Lymph Node Dissection With or Without Axillary Dissection in Patients With Sentinel Lymph Node Metastases: The American College of Surgeons Oncology Group Z0011 Randomized Trial显示文摘 | Armando E. Giuliano Linda McCall Peter Beitsch Pat W. Whitworth Peter Blumencranz A. Marilyn Leitch Sukamal Saha Kelly K. Hunt Monica Morrow Karla Ballman | 2010 | Annals of Surgery2010，，3： | 2 |
| 18 | Reduction in endotoxemia, oxidative and inflammatory stress, and insulin resistance after Roux-en-Y gastric bypass surgery in patients with morbid obesity and type 2 diabetes mellitus显示文摘 | Scott V. Monte Joseph A. Caruana Husam Ghanim Chang Ling Sia Kelly Korzeniewski Jerome J. Schentag Paresh Dandona | 2012 | Surgery2012，，4： | 2 |
| 19 | Importance of Low Preoperative Platelet Count in Selecting Patients for Resection of Hepatocellular Carcinoma: A Multi-Institutional Analysis显示文摘 | Shishir K. Maithel Peter J. Kneuertz David A. Kooby Charles R. Scoggins Sharon M. Weber Robert C.G. Martin Kelly M. McMasters Clifford S. Cho Emily R. Winslow William C. Wood Charles A. Staley | 2011 | Journal of the American College of Surgeons2011，，4： | 2 |
| 20 | Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA , IDH1 , EGFR , and NF1显示文摘 | Roel G.W. Verhaak Katherine A. Hoadley Elizabeth Purdom Victoria Wang Yuan Qi Matthew D. Wilkerson C. Ryan Miller Li Ding Todd Golub Jill P. Mesirov Gabriele Alexe Michael Lawrence Michael O'Kelly Pablo Tamayo Barbara A. Weir Stacey Gabriel Wendy Winckler | 2010 | Cancer Cell2010，，1： | 2 |
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