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| 1 | Cryptosporidiosis-an overview显示文摘Apicomplexan protozoan parasites of the genus Cryptosporidium infect the gastrointestinal tract and lungs of a wide variety of animals, including humans. The majority of human infections are due to either Cryptosporidium hominis (C. hominis) and/or Cryptosporidium parvum (C. parvum). The parasite has a complex life cycle that includes both asexual and sexual stages. While there are invasive free living stages, proliferation and differentiation take place within a unique parasitrophorous vacuole under the host cell brush border but outside the host cell cytoplasm. Infection is spread by environmentally resistant spores that primarily contaminate drinking water and occasionally food sources, which may cause significant outbreaks of diarrhea that generally lasts less than 2 w in immunocompetent individuals. In immunodeficient or immunosuppressed individuals, diarrhea may be copious and can result in significant morbidity and mortality, particularly in AIDS patients. Although diagnosis is relatively simple, effective drug treatment, particulary for infections in immunodeficient patients, has not been uniformly successful. This overview summarizes the species known to infect humans, aspects of the parasite life cycle, sources of infection, the pathophysiology of cryptosporidiosis, the immune response to infection, diagnosis, treatment and some aspects of cryptosporidiosis in China. | Gordon J Leitch | 2011 | The Journal of Biomedical Research2011，25，1： | 2 |
| 2 | Locoregional Recurrence After Sentinel Lymph Node Dissection With or Without Axillary Dissection in Patients With Sentinel Lymph Node Metastases: The American College of Surgeons Oncology Group Z0011 Randomized Trial显示文摘 | Armando E. Giuliano Linda McCall Peter Beitsch Pat W. Whitworth Peter Blumencranz A. Marilyn Leitch Sukamal Saha Kelly K. Hunt Monica Morrow Karla Ballman | 2010 | Annals of Surgery2010，，3： | 2 |
| 3 | Polyploidy in angiosperms显示文摘 | Leitch I J Bennett M D | 1997 | Trends Plant Sci1997，2，12： | 2 |
| 4 | Reactive nitrogen and oxygen species ameliorate experimental cyptosporidiosis in the neonatal BALB/c mouse mode显示文摘 | Leitch GJ and Qing H | 1999 | Infetion and Immunity1999，67，1： | 2 |
| 5 | Conversion of a RAPD-generated PCR product, containing a novel dispersed repetitive element,into a last and robust assay for the pres- ence of rye chromatin in wheat 显示文摘 | Francis H A Leitch A R Koebner R M D | 1995 | Theoretical and Applied Genetics1995，90，： | 1 |
| 6 | Validating the performance of the mammary sentinel lymph node team显示文摘 | Euhus DM Peters GN Leitch AM | | 0，，： | 1 |
| 7 | Genome size evolu- tion in relation to leaf strategy and metabolic rates revisited 显示文摘 | Beaulieu J M Leitch I J Knight C A | 2007 | Annals of Botany2007，99，： | 1 |
| 8 | Redefining the R1 resec- tion in pancreatic cancer显示文摘 | Verbeke C Leitch D Menon K | 2006 | Br J Surg2006，93，10： | 1 |
| 9 | The revised ACPGBI model is a simple and accurate predictor of operative mortality after potentially curative resection of colorectal cancer显示文摘 | Richards CH Leitch EF Anderson JH | | 0，，： | 1 |
| 10 | Synthesis of phenol formaldehyde resol resins using organosolv pine lig- nins显示文摘 | Wang Mingcun Mathew Leitch Xu Chunbao | 2009 | Eur PoIyrn J2009，45，： | 1 |
| 11 | The importance of the left atrioventricular interval during atrioventricular sequential pacing显示文摘 | CHEVALIER S BASTA M LEITCH J W | 1997 | PACE1997，20，： | 1 |
| 12 | In situ localization of parental genomes in a wide hybrid显示文摘 | Schwarzacher T Leitch A R Bennett M D | 1989 | Annals of Botany1989，64，： | 1 |
| 13 | Arginine-derived nitric oxide reduces facal oocyst shedding in nude mice infected with Cryptosporidium parvum显示文摘 | Leitch G J Qing H E | 1994 | Infection and Immunity1994，62，11： | 1 |
| 14 | Genome size is a strong predictor of cell size and stomatal density in angio- sperms 显示文摘 | Beaulieu J M Leitch I J Patel S | 2008 | New Phytologist2008，179，： | 1 |
| 15 | Redefining the R1 resection in pancreatic cancer显示文摘 | Verbeke CS Leitch D Menon KV | 2006 | Br J Surg2006，93，10： | 1 |
| 16 | Prevention and treatment of postburn scars and contraeture 显示文摘 | Robson MC Barnett RA Leitch IO | 1993 | World J Surg1993，16，1： | 1 |
| 17 | Journal of NuclearMaterials显示文摘 | McRae G A Coleman C E Leitch B W | 2010 | 396: 1302010，396，： | 1 |
| 18 | Effects of esculin and esculetin on the survival of Escherichia coli O157 in human faecal slurries, continuous-flow simula- tions of the rumen and colon and in calves显示文摘 | Duncan S H Leitch E C Stanley K N | 2004 | Br J Nu tr2004，91，5： | 1 |
| 19 | Entrepreneurship education and training: can entrepreneurship be taught?显示文摘 | Colette Henry Frances Hill Claire Leitch | 2005 | Part I Education Training2005，47，2： | 1 |
| 20 | Interactive Textiles: New Materials in the New Millennium Part1显示文摘 | Leitch P Tassinari TH | 2000 | J Ind Text2000，29，3： | 1 |
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