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| 1 | ICD-11慢性疼痛分类显示文摘1.引言 慢性疼痛是持续时间超过正常恢复时间的疼痛,它失去了一般生理伤害性感受的警示作用。通常将持续或复发的时间超过3到6个月的疼痛定义为慢性疼痛。 | Treede RD Rief W Barke A 胡理 罗层 陈军 | 2015 | 中国疼痛医学杂志2015，21，7： | 16 |
| 2 | Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage Ⅱ and Ⅲ rectal adenocarcinoma:The Freiburg experience(1989-2002)显示文摘AIM:To evaluate the long-term outcome of standard5-FU based adjuvant or neoadjuvant radiochemotherapyand to identify the predictive factors,especially anemiabefore and after radiotherapy as well as hemoglobinincrease or decrease during radiotherapy.METHODS:Two hundred and eighty-six patientswith Union International Contre Cancer(UICC)stageⅡ and Ⅲ rectal adenocarcinomas,who underwentresection by conventional surgical techniques(lowanterior or abdominoperineal resection),receivedeither postoperative(n=233)or preoperative(n=53)radiochemotherapy from January 1989 until July 2002.Overall survival(OAS),cancer-specific survival(CSS),disease-free survival(DFS),local-relapse-free(LRS)and distant-relapse-free survival(DRS)were evaluatedusing Kaplan-Meier,Log-rank test and Cox's proportionalhazards as statistical methods.Multivariate analysis wasused to identify prognostic factors.Median follow-uptime was 8 years.RESULTS:Anemia before radiochemotherapy was anindependent prognostic factor for improved DFS(riskratio 0.76,P=0.04)as well as stage,grading,R status(free radial margins),type of surgery,carcinoembryonicantigen(CEA)levels,and gender.The univariate analysisrevealed that anemia was associated with impaired LRS (better local control)but with improved DFS.In contrast,hemoglobin decrease during radiotherapy was anindependent risk factor for DFS(risk ratio 1.97,P=0.04).During radiotherapy,only 30.8% of RO-resected patientssuffered from hemoglobin decrease compared to 55.6%if R1/2 resection was performed(P=0.04).The 5-yearOAS,CSS,DFS,LRS and DRS were 47.0%,60.0%,41.4%,67.2%,and 84.3%,respectively.Significantdifferences between preoperative and postoperativeradiochemotherapy were not found.CONCLUSION:Anemia before radiochemotherapyand hemoglobin decrease during radiotherapy have nopredictive value for the outcome of rectal cancer.Stage,grading,R status(free radial margins),type of surgery,CEA levels,and gender have predictive value for theoutcome of rectal cancer. | Christian Weissenberger Geissler Michael Otto Florian Barke Annette Henne Karl von Plehn Georg Rein Alex Müller Christine Bartelt Susanne Henke Michael | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 3 | Enhanced microfracture techniques in cartilage knee surgery: Fact or fiction?显示文摘The limited intrinsic healing potential of human articular cartilage is a well-known problem in orthopedic surgery. Thus a variety of surgical techniques have been developed to reduce joint pain, improve joint function and delay the onset of osteoarthritis. Microfractures as a bone marrow stimulation technique present the most common applied articular cartilage repair procedure today. Unfortunately the deficiencies of fibrocartilaginous repair tissue inevitably lead to breakdown under normal joint loading and clinical results deteriorate with time. To overcome the shortcomings of microfracture, an enhanced microfracture technique was developed with an additional collagen Ⅰ/Ⅲ membrane(Autologous, Matrix-Induced Chondrogenesis, AMIC). This article reviews the pre-clinical rationale of microfractures and AMIC, presents clinical studies and shows the advantages and disadvantages of these widely usedtechniques. PubM ed and the Cochrane database were searched to identify relevant studies. We used a comprehensive search strategy with no date or language restrictions to locate studies that examined the AMIC technique and microfracture. Search keywords included cartilage, microfracture, AMIC, knee, ChondroGide. Besides this, we included our own experiences and study authors were contacted if more and non published data were needed. Both cartilage repair techniques represent an effective and safe method of treating full-thickness chondral defects of the knee in selected cases. While results after microfracture deteriorate with time, mid-term results after AMIC seem to be enduring. Randomized studies with long-term followup are needed whether the grafted area will maintain functional improvement and structural integrity over time. | Stefan Bark Tomasz Piontek Peter Behrens Sabiah Mkalaluh Deike Varoga Justus Gille | 2014 | World Journal of Orthopedics2014，5，4： | 3 |
| 4 | 慢性继发性内脏痛显示文摘慢性内脏痛(chronic visceral pain, CVP)是一种常见且致残性疾病,发病率高。第10版国际疾病分类(International classification of diseases, ICD-10)并没有对慢性内脏痛作出系统描述。慢性继发性内脏痛(chronic secondary visceral pain, CSVP)是指继发于头颈部、胸部、腹部、盆腔等内脏器官的疾病或潜在疾病所产生的慢性疼痛,可因持续性的炎症、血管机制或机械因素所致,疼痛强度的变化不一定与疾病的发生发展过程完全一致。并且潜在疾病治愈后,慢性内脏痛可持续存在。本文介绍了ICD-11中关于慢性继发性内脏痛的新分类方法,该方法能够简化诊断过程,并有助于更准确地收集流行病学相关的数据。此外,新的分类能够促进慢性继发性内脏痛的个体化治疗,并激励相关科学研究。必须区分慢性继发性内脏痛与慢性原发性内脏痛,因为他们各自为独立的疾病。 | 胡永生 曹伯旭 赵倬翎 杜涛 袁文茜 宋学军 刘小立 万有 樊碧发 韩济生 Aziz Q Giamberardino MA Barke A | 2021 | 中国疼痛医学杂志2021，27，6： | 3 |
| 5 | Field-effect transistor with a chemically synthesized MoS2 sensing channel for label-free and highly sensitive electrical detection of DNA hybridization显示文摘A field-effect transistor (FET) with two-dimensional (2D) few-layer MoS2 as a sensing-channel material was investigated for label-free electrical detection of the hybridization of deoxyribonucleic acid (DNA) molecules. The high-quality MoS2-channel pattern was selectively formedthrough the chemical reaction of the Mo layer with H2S gas. The MoS2 FET was very stable in an electrolyte and inert to pH changes due to the lack of oxygen-containing functionalities on the MoS2 surface. Hybridization of single-stranded target DNA molecules with single-stranded probe DNA molecules physically adsorbed on the MoS2 channel resulted in a shift of the threshold voltage (Vt,) in the negative direction and an increase in the drain current. The negative shift in Vth is attributed to electrostatic gating effects induced by the detachment of negatively charged probe DNA molecules from the channel surface after hybridization. A detection limit of 10 fM, high sensitivity of 17 mWdec, and high dynamic range of 106 were achieved. The results showed that a bio-FET with an ultrathin 2D MoS2 channel can be used to detect very small concentrations of target DNA molecules specifically hybridized with the probe DNA molecules. | Doo-Won Lee Jinhwan Lee II Yung Sohn Bo-Yeong Kim Young Min Son Hunyoung Bark JaehyuckJung Minseok Choi Tae Hyeong Kim Changgu Lee Nae-Eung Lee | 2015 | Nano Research2015，8，7： | 3 |
| 6 | Morphine Modulates NFκB Activation in Macrophages显示文摘 | Sabita Roy Kelly J. Cain Rebecca B. Chapin Richard G. Charboneau Roderick A. Barke | 1998 | Biochemical and Biophysical Research Communications1998，，2： | 2 |
| 7 | Lens capsule and epithelium in age-related cataract 显示文摘 | Straatsma BR Lighffoot DO Barke RM | 1991 | Am J Ophthalmol1991，112，： | 2 |
| 8 | Performance comparison of spread-spectrum methods on an interference-limited HF channel 显示文摘 | BARK G | 1999 | IEE Proceedings on Communications1999，146，1： | 1 |
| 9 | Influence of genetic capacity for lean tissue accreltion in pig feed Rectopamine显示文摘 | Bark L J | | 0，，70： | 1 |
| 10 | Effect of menstrual cycle on resting brain metabolism in female rhesus monkeys 显示文摘 | Rilling JK Lacreuse A Barks SK | 2008 | Neuroreport2008，19，5： | 1 |
| 11 | Oxidation of organic substances by compounds of trivalent manganese 显示文摘 | Bark J | 1983 | Micro Chem J1983，28，3： | 1 |
| 12 | Effect of high pressure thermal sterilization on the formation of food process- ing contaminants显示文摘 | Sevenich R Bark F Crews C | 2013 | Innovative Food Science & Emerging Technologies2013，20，： | 1 |
| 13 | A review of the effects of out-of-round wheels on track and vehicle components显示文摘 | BARKED W CHIU W K | 2005 | IMechE Journal of Rail and Rapid Transit2005，，： | 1 |
| 14 | Aerobic glyeolysis in the primate brain: reconsidering the implications for growth and mainte- nance显示文摘 | Bauernfeind AL Barks SK Duka T | 2014 | Brain Struct Funct2014，219，4： | 1 |
| 15 | The significance of morphological changes in cerebral arteries after subarachnoid hemorrhage显示文摘 | Mayberg MR Okada T Bark DH | 1990 | Neurosurg1990，72，4： | 1 |
| 16 | The EU Leader Initiative and Endogenous Rural Development:the Application of the Program in Two Rural Areas of Andalusia,Southern Spain显示文摘 | Barke M Newton M | | 0，，03： | 1 |
| 17 | A compact model for NBTI degradation and recovery under use-pro- file variations and its application to aging analysis of digital integrated circuits 显示文摘 | Kleeberger V B Barke M Werner C | 2014 | Microelectronics Reliabil- ity2014，54，67： | 1 |
| 18 | Feed additive study with newly weanling pigs: efficacy of supplement copper, antibiotics and organic acids显示文摘 | EDMONDS C A IZQUIERDO O A BARK D H | 1985 | J Anim Sci1985，60，： | 1 |
| 19 | A comparison of cluster- ing methods for river benthic community analysis 显示文摘 | Cao Y Bark A W Williams W P | 1977 | Hy- drobiologia1977，347，13： | 1 |
| 20 | Plasticity of neurons and glia following neonatal hypoxic-ischemic brain injury in rats显示文摘 | Skoff RP Bessert D Barks JD | 2007 | Neurochem Res2007，32，2： | 1 |
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