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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | 0varian cancer cell proliferation and motility is induced by engagement of integrin alpha(v)beta3/ Vitronectin teraction显示文摘 | Hapke S Kessler H Luber B et a1 | 2003 | Biol Chem2003，384，7： | 1 |
| 4 | Evaluation of a new assay for HBV DNA quantitation inpatients with chronic hepatitis B显示文摘 | H H Kessler | | 0，，： | 1 |
| 5 | Changes in prefron-tal- limbic function in major depression after 15 months oflong - term psychotherapy 显示文摘 | Buchheim A VivianiR Kessler H | 2012 | PLoS One2012，7，33： | 1 |
| 6 | The emerging science of quantitative imaging biomarkers terminology and definitions for scientific studies and regulatory submissions 显示文摘 | KESSLER L G BARNHART H X BUCKLER A J | 2014 | Stat Methods Med Res2014，24，1： | 1 |
| 7 | Innovation speed: a conceptual model of context, antecedents and outcomes 显示文摘 | KESSLER E H CHAKRABARTI A K | 1996 | Academy of Management Review1996，，21： | 1 |
| 8 | Homocysteine and dementia显示文摘 | Kessler H Bleich S Falkai P | 2003 | Fortschr Neurol Psychiatr2003，71，3： | 1 |
| 9 | Innovation speed: a conceptual model of context, antccedents~ and outcomes显示文摘 | KESSLER E H CHAKRABARTI A K | 1996 | Academy of Management Review1996，21，4： | 1 |
| 10 | Cilengitide: the first anti-anglogenie small molecule drug candidate design, syn- thesis and clinical evaluation 显示文摘 | Mas-Moruno C Rechenmacher F Kessler H | 2010 | Antieancer Agents Med Chem2010，10，10： | 1 |
| 11 | 查看详情显示文摘 | Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D | | 0，，： | 1 |
| 12 | Percutaneous drainage as the treatment of choice for neonatal ovarian cysts显示文摘 | Kessler A Nagar H Graif M | 2006 | Pediatr Ra- diol2006，36，9： | 1 |
| 13 | Immunogenicity of biopharmaceuticals显示文摘 | Kessler M Goldsmith D Schellekens H | 2006 | Nephrol Dial Transplant2006，21，5： | 1 |
| 14 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 15 | Passive ventricular remodeling in cardiac disease: focus on heterogeneity显示文摘 | KESSLER E L BOULAKSIL M VAN RIJEN H V | 2014 | Front Physiol2014，5，5： | 1 |
| 16 | Manufacture of fresh cheese from uhrafiltered milk with reduced amount of acid whey 显示文摘 | SCHKODA P KESSLER H G | 1996 | IDF Bull1996，311，： | 1 |
| 17 | Removing pectin and lignin during chemical processing of hemp for textile applications显示文摘 | WANG H M POSTLE R KESSLER R W | 2003 | Textile Research Journal2003，73，8： | 1 |
| 18 | Obstructive vs nonobstructive dilatation of the renal collecting system in children: Distinction with duplex sonography显示文摘 | Kessler RM Quevedo H Lankau CA | 1993 | A JR1993，160，： | 1 |
| 19 | Minimal--invasive Biopsie und praoperative Markierung suspekter Mammalasionen 显示文摘 | Sittek H Kessler M Untch M | 2004 | Gynakol Geburtshilfliche Rundsch2004，44，2： | 1 |
| 20 | Secondary progress manganism associated with markedly decraed striatal D2 receptor density 显示文摘 | Kessler K R Wundedich G Hefter H | 2003 | Mov Disord2003，18，2： | 1 |
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