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| 1 | The Lymph Node Ratio is the Strongest Prognostic Factor after Resection of Pancreatic Cancer显示文摘 | Hartwig Riediger Tobias Keck Ulrich Wellner Axel Hausen Ulrich Adam Ulrich T. Hopt Frank Makowiec | 2009 | Journal of Gastrointestinal Surgery2009，，7： | 5 |
| 2 | Arguments for an individualized closure of the pancreatic remnant after distal pancreatic resection显示文摘AIM:To analyze risk factors for postoperative pancreatic fistula(POPF) rate after distal pancreatic resection(DPR).METHODS:We performed a retrospective analysis of 126 DPRs during 16 years.The primary endpoint was clinically relevant pancreatic fistula.RESULTS:Over the years,there was an increasing rate of operations in patients with a high-risk pancreas and a significant change in operative techniques.POPF was the most prominent factor for perioperative morbidity.Significant risk factors for pancreatic fistula were high body mass index(BMI) [odds ratio(OR) = 1.2(CI:1.1-1.3),P = 0.001],high-risk pancreatic pathology [OR = 3.0(CI:1.3-7.0),P = 0.011] and direct closure of the pancreas by hand suture [OR = 2.9(CI:1.2-6.7),P = 0.014].Of these,BMI and hand suture closure were independent risk factors in multivariate analysis.While hand suture closure was a risk factor in the low-risk pancreas subgroup,high BMI further increased the fistula rate for a high-risk pancreas.CONCLUSION:We propose a risk-adapted and indication-adapted choice of the closure method for the pancreatic remnant to reduce pancreatic fistula rate. | Ulrich Friedrich Wellner Frank Makowiec Olivia Sick Ulrich Theodor Hopt Tobias Keck | 2012 | World Journal of Gastrointestinal Surgery2012，4，5： | 3 |
| 3 | The Lymph Node Ratio is the Strongest Prognostic Factor after Resection of Pancreatic Cancer显示文摘 | Hartwig Riediger Tobias Keck Ulrich Wellner Axel Hausen Ulrich Adam Ulrich T. Hopt Frank Makowiec | 2009 | Journal of Gastrointestinal Surgery2009，，7： | 2 |
| 4 | Extracellular matrices for gastrointestinal surgery:Ex vivo testing and current applications显示文摘AIM:To assess the effects of bile and pancreatic juice on structural and mechanical resistance of extracellular matrices(ECMs) in vitro.METHODS:Small-intestinal submucosa(SIS),porcine dermal matrix(PDM),porcine pericardial matrix(PPM) and bovine pericardial matrix(BPM) were incubated in human bile and pancreatic juice in vitro.ECMs were examined by macroscopic observation,scanning electron microscopy(SEM) and testing of mechanical resistance.RESULTS:PDM dissolved within 4 d after exposure to bile or pancreatic juice.SIS,PPM and PDM retained their integrity for > 60 d when incubated in either digestive juice.The effect of bile was found to be far more detrimental to mechanical stability than pancreatic juice in all tested materials.In SIS,the loss of mechanical stability after incubation in either of the digestive secretions was less distinct than in PPM and BPM [mFmax 4.01/14.27 N(SIS) vs 2.08/5.23 N(PPM) vs 1.48/7.89 N(BPM)].In SIS,the extent of structural damage revealed by SEM was more evident in bile than in pancreatic juice.In PPM and BPM,structural damage was comparable in both media.CONCLUSION:PDM is less suitable for support of gastrointestinal healing.Besides SIS,PPM and BPM should also be evaluated experimentally for gastrointestinal indications. | Jens Hoeppner Goran Marjanovic Peter Helwig Ulrich Theodor Hopt Tobias Keck | 2010 | World Journal of Gastroenterology2010，16，32： | 2 |
| 5 | Impact of postoperative TNM stages after neoadjuvant therapy on prognosis of adenocarcinoma of the gastro-oesophageal junction tumours显示文摘AIM To compare prognostic relevance of postoperative tumour/node/metastasis(TMN) stages between patients with and without neoadjuvant treatment. METHODS Data from patients with adenocarcinoma of the gastrooesophageal junction(AEG) who had undergone surgical resection at a single German university centre were retrospectively analysed. Patients with or without neoadjuvant preoperative treatment were selected by exact matching based on preoperative staging. Standard assessment of preoperative(c)TNM stage was based on endoscopic ultrasound and computed tomography of the thorax and abdomen, according to the American Joint Committee on Cancer/Union for International Cancer Control classification system. Patients with cT1cN0cM0 and cT2cN0cM0 stages were excluded from the study, as these patients are generally not recommended for pretreatment. Longterm survival among the various postoperative TNM stages was compared between the groups of patients with or without neoadjuvant treatment. For statistical assessments, a P-value of ≤ 0.05 was considered significant.RESULTS The study included a total of 174 patients. The group of patients who had received preoperative neoadjuvant treatment included more cases of AEG(Siewert) type 1 carcinoma(P < 0.001), and consequently oesophagectomy was performed more frequently among these patients(P < 0.001). The two groups(with or without preoperative neoadjuvant treatment) had comparable preoperative T stages, but the group of patients with preoperative neoadjuvant treatment presented a higher rate of preoperative N-positive disease(P = 0.020). Overall long-term survival was not different between the two groups of patients according to tumours of different AEG classifications, receipt of oesophagectomy or gastrectomy, nor between patients with similar postoperative TNM stage, resection margin and grading. However, an improvement of long-term survival was found for patients with nodal down-staging after neoadjuvant therapy(P = 0.053).CONCLUSION The prognostic relevance of postoperative TNM stages is similar for AEG in patients with or without neoadjuvant preoperative treatment, but treatment-related nodal down-staging prognosticates longer-term survival. | Michael Thomaschewski Richard Hummel Ekaterina Petrova Juliana Knief Ulrich Friedrich Wellner Tobias Keck Dirk Bausch | 2018 | World Journal of Gastroenterology2018，24，13： | 2 |
| 6 | Long-Term Outcome after 92 Duodenum-Preserving Pancreatic Head Resections for Chronic Pancreatitis: Comparison of Beger and Frey Procedures显示文摘 | Tobias Keck Ulrich Friedrich Wellner Hartwig Riediger Ulrich Adam Olivia Sick Ulrich Theodor Hopt Frank Makowiec | 2010 | Journal of Gastrointestinal Surgery2010，，3： | 2 |
| 7 | Laparoscopic pancreatic resections显示文摘 | Dirk Bausch Tobias Keck | 2013 | Langenbeck’s Archives of Surgery2013，，7： | 2 |
| 8 | Procalcitonin (PCT)-guided algorithm reduces length of antibiotic treatment in surgical intensive care patients with severe sepsis: results of a prospective randomized study显示文摘 | S. Schroeder M. Hochreiter T. Koehler A.-M. Schweiger B. Bein F. S. Keck T. Spiegel | 2009 | Langenbeck’s Archives of Surgery2009，，2： | 2 |
| 9 | Initial performance results of the OMEGA laser system显示文摘 | T.R Boehly D.L Brown R.S Craxton R.L Keck J.P Knauer J.H Kelly T.J Kessler S.A Kumpan S.J Loucks S.A Letzring F.J Marshall R.L McCrory S.F.B Morse W Seka J.M Soures C.P Verdon | 1997 | Optics Communications1997，，1： | 2 |
| 10 | Challenges and Solution for the Delivery of Biotech Drugs A Review of Drug Nanocrystal Technology and Lipid Nanoparticle显示文摘 | Muller R H Keck C M | 2004 | J Biotech2004，113，： | 1 |
| 11 | A catalytic asymmetric vinylogous Mukaiyama aldol reaction 显示文摘 | HEUMANN L V KECK G E | 2007 | Org Lett2007，9，21： | 1 |
| 12 | Top management team structure: differential effect by environmental eontext显示文摘 | | 1992 | Organization Science1992，8，： | 1 |
| 13 | The feature and service interaction problem in telecommunications systems:a survey显示文摘 | Kuehn P J | 1998 | IEEE Transactions on Software Engineering1998，24，10： | 1 |
| 14 | Kinetic solubility and dissolution velocity of rutin Nanocrystals显示文摘 | MAULUDIN R MULLER R H KECK C M | 2009 | European Joumal of Pharmaceutical Sciences2009，36，： | 1 |
| 15 | ABCB1(MDR1)-type P-glycoproteins at the blood-brainbarrier modulate the activity of the Hypothalamic-Pituitary-Adrenocortical system:implications for af-fective disorder显示文摘 | Muller MB Keck ME Binder EB | 2003 | Neuropsychopharmacology2003，28，11： | 1 |
| 16 | New ground in hybrid packaging显示文摘 | White D Keck S Smith I | 1990 | Hybrid Circuit Technology1990，12，1： | 1 |
| 17 | Inhibition of bladder tumors growth by the green tea derivative epigallocateehin-3-Gallate显示文摘 | Kemberling JK Hampton JA Keck RW | 2003 | J Urol2003，170，3： | 1 |
| 18 | Caspase-mediate cell death predominates following engraftment of neural progenitor cells into traumatically injured rat brain显示文摘 | Bakshi A Keck CA Koshkin VS | 2005 | Brain Res2005，1065，12： | 1 |
| 19 | The use of paraphrase in summary writing: A comparison of L1 and L2 writers 显示文摘 | Keck C | 2006 | Journal of Second Language Writing2006，15，4： | 1 |
| 20 | Adipose tissue engineering:three different approaches to seed preadipocytes on a collagen-elastin matrix显示文摘 | Keck M Haluza D Selig HF | | 0，，05： | 1 |
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