|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neoadjuvant radiotherapy for rectal cancer management显示文摘Thirty per cent of all colorectal tumours develop in the rectum.The location of the rectum within the bony pelvis and its proximity to vital structures presents significant therapeutic challenges when considering neoadjuvant options and surgical interventions.Most patients with early rectal cancer can be adequately managed by surgery alone.However,a significant proportion of patients with rectal cancer present with locally advanced disease and will potentially benefit from down staging prior to surgery.Neoadjuvant therapy involves a variety of options including radiotherapy,chemotherapy used alone or in combination.Neoadjuvant radiotherapy in rectal cancer has been shown to be effective in reducing tumour burden in advance of curative surgery.The gold standard surgical rectal cancer management aims to achieve surgical removal of the tumour and all draining lymph nodes,within an intact mesorectal package,in order to minimise local recurrence.It is critically important that all rectal cancer cases are discussed at a multidisciplinary meeting represented by all relevant specialties.Pre-operative staging including CT thorax,abdomen,pelvis to assess for distal disease and magnetic resonance imaging to assess local involvement is essential.Staging radiology and MDT discussion are integral in identifying patients who require neoadjuvant radiotherapy.While Neoadjuvant radiotherapy is potentially beneficial it may also result in morbidity and thus should be reserved for those patients who are at a high risk of local failure,which includes patients with nodal involvement,extramural venous invasion and threatened circumferential margin.The aim of this review is to discuss the role of neoadjuvant radiotherapy in the management of rectal cancer. | Gerard Feeney Rishabh Sehgal Margaret Sheehan Aisling Hogan Mark Regan Myles Joyce Michael Kerin | 2019 | World Journal of Gastroenterology2019，25，33： | 28 |
| 2 | PCR-based methodologies for detection and characterization of Listeria monocytogenes and Listeria ivanovii in foods and environmental sources显示文摘Listeria monocytogenes is an important foodborne pathogen responsible for listeriosis,a fatal disease.It is widely distributed in various foods and environmental sources.In this review,we focused on addressing PCR-based technologies,including conventional PCR,qPCR and droplet digital PCR(ddPCR).Specifically,we described(a)conventional PCR and mono-,duplex-and multiplex-qPCR methodologies;(b)development and applications of gene HlyA-,Iap-,PrfA–and SsrA-based conventional and qPCR assays as well as PCR assays targeting newly identified gene targets for specific detection of L.monocytogenes;differentiation of viable from dead L.monocytogenes by qPCR in conjugation with propidium monoazide pretreatment;PCR-based serotype identification of L.monocytogenes isolates;PCR-based detection of L.ivanovii,infecting ruminants,differentiation of L.monocytogenes from other Listeria species;and sigB-gene based PCR identification of Listeria spp;(c)applications of ddPCR in detection of L.monocytogenes;and(d)application of qPCR assays in detection and subtyping of L.monocytogenes in milk and dairy products;meats,meat products and meat-processing environment;and seafood,seafood products and processing environment.Our goal was to provide a relatively comprehensive overview of PCR-based methodologies available in detection,characterization and subtyping of various strains of L.monocytogenes in foods and environmental sources. | Jin-Qiang Chen Stephanie Healey Patrick Regan Pongpan Laksanalamai Zonglin Hu | 2017 | Food Science and Human Wellness2017，6，2： | 9 |
| 3 | 试纸法快速检测工业废水中重金属铜离子显示文摘介绍了一种可以快速、便捷、灵敏地进行现场半定量和定量测定水体中重金属Cu2+浓度的络天青-氨基化纤维素试纸。该试纸的检出限为0.1 mg/L,在pH值为6.0~7.0时,检测的线性范围为0.1~10.0 mg/L,反应时间为120 s。该方法可与微型光谱仪或Cu2+标准比色板联用,可以同时进行定量或者半定量检测。该试纸弥补了显色剂易从试纸上脱落的不足,增强了试纸的稳定性与准确性。该方法可应用于工业废水中Cu2+的测定,与原子吸收分光光度法的测定结果相比较,两者基本一致。 | 李黎 Fiona Regan | 2013 | 工业用水与废水2013，44，5： | 7 |
| 4 | 老年糖尿病病人心脏病的治疗问题显示文摘许多实验室和临床研究指出老化和糖尿病过程可能引起心脏功能及其结构的改变。这些改变与心肌缺血无关。上述两种情况伴有间质胶原的积聚使左室舒张期顺应性降低,并有心室弛缓率降低。在亚临床状态时,衰老的心肌细胞增大,但在糖尿病时并无此种情况描述。在亚临床状态病人中一部分可进展为收缩期功能异常、心力衰竭和心律失常。但尚无确切证据说明两种状态下弥散性心肌病变是由于心壁内小血管病造成的。治疗上需要特别注意强心剂的应用。 | Regan T J 王桂珍 杨德发 | 1990 | 国外医学(老年医学分册)1990，11，3： | 7 |
| 5 | Role of human papillomavirus in oropharyngeal squamous cell carcinoma: A review显示文摘Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell carcinoma have been changing. Research into HPVrelated oropharyngeal squamous cell carcinoma is rapidly expanding, however many molecular pathological and clinical aspects of the role of HPV remain uncertain and are the subject of ongoing investigation. A detailed search of the literature pertaining to HPV-related oropharyngeal squamous cell carcinoma was performed and information on the topic was gathered. In this article, we present an extensive review of the current literature on the role of HPV in oropharyngeal squamous cell carcinoma, particularly in relation to epidemiology, risk factors, carcinogenesis, biomarkers and clinicalimplications. HPV has been established as a causative agent in oropharyngeal squamous cell carcinoma and biologically active HPV can act as a prognosticator with better overall survival than HPV-negative tumours. A distinct group of younger patients with limited tobacco and alcohol exposure have emerged as characteristic of this HPV-related subset of squamous cell carcinoma of the head and neck. However, the exact molecular mechanisms of carcinogenesis are not completely understood and further studies are needed to assist development of optimal prevention and treatment modalities. | Robbie SR Woods Esther M O'Regan Susan Kennedy Cara Martin John J O'Leary Conrad Timon | 2014 | World Journal of Clinical Cases2014，2，6： | 5 |
| 6 | Prevalence and methodologies for detection,characterization and subtyping of Listeria monocytogenes and L.ivanovii in foods and environmental sources显示文摘Listeria monocytogenes,one of the most important foodborne pathogens,can cause listeriosis,a lethal disease for humans.L.ivanovii,which is closely related to L.monocytogenes,is also widely distributed in nature and infects mainly warm-blooded ruminants,causing economic loss.Thus,there are high priority needs for methodologies for rapid,specific,cost-effective and accurate detection,characterization and subtyping of L.monocytogenes and L.ivanovii in foods and environmental sources.In this review,we(A)described L.monocytogenes and L.ivanovii,world-wide incidence of listeriosis,and prevalence of various L.monocytogenes strains in food and environmental sources;(B)comprehensively reviewed different types of traditional and newly developed methodologies,including culture-based,antigen/antibody-based,LOOP-mediated isothermal amplification,matrix-assisted laser desorption ionization-time of flight-mass spectrometry,DNA microarray,and genomic sequencing for detection and characterization of L.monocytogenes in foods and environmental sources;(C)comprehensively summarized different subtyping methodologies,including pulsed-field gel electrophoresis,multi-locus sequence typing,ribotyping,and phage-typing,and whole genomic sequencing etc.for subtyping of L.monocytogenes strains from food and environmental sources;and(D)described the applications of these methodologies in detection and subtyping of L.monocytogenes in foods and food processing facilities. | Jin-Qiang Chena Patrick Regan Pongpan Laksanalamai Stephanie Healey Zonglin Hua | 2017 | Food Science and Human Wellness2017，6，3： | 5 |
| 7 | Positive Solutions to Singular Boundary Value Problems with Sign Changing Nonlinearities on the Half-Line via Upper and Lower Solutions显示文摘This paper presents a lower and upper solution technique for singular second order boundaryvalue problems on the half line. | Bao Qiang YAN Donal O'REGAN Ravi P. AGARWAL | 2007 | Acta Mathematica Sinica,English Series2007，23，8： | 5 |
| 8 | Cardiovascular drugs in the treatment of infantile hemangioma显示文摘Since the introduction of propranolol in the treatment of complicated infantile hemangiomas(IH) in 2008, other different beta-blockers, including timolol, acetabutolol, nadolol and atenolol, have been successfully used for the same purpose. Various hypotheses including vasoconstriction, inhibition of angiogenesis and the induction of apoptosis in proliferating endothelial cells have been advanced as the potential beta-blockerinduced effect on the accelerated IH involution, although the exact mechanism of action of beta-blockers remains unknown. This has generated an extraordinary interest in IH research and has led to the discovery of the role of the renin-angiotensin system(RAS) in the biology of IH, providing a plausible explanation for the beta-blocker induced effect on IH involution and the development of new potential indications for RAS drugs such as angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers in the treatment of IH. This review is focused on the current use of cardiovascular drugs in the treatment of IH. | Israel Fernandez-Pineda Regan Williams Lucia Ortega-Laureano Ryan Jones | 2016 | World Journal of Cardiology2016，8，1： | 4 |
| 9 | 澳大利亚人乳头状瘤病毒疫苗计划实施5年对年轻人群生殖器疣患病情况的影响:国家调查数据分析显示文摘目的评估2007年中开始的澳大利亚人乳头状瘤病毒(HPV)疫苗计划对生殖器疣患病情况的影响。设计国家调查数据趋势分析。数据来源数据收集于2004--2011年度澳大利亚8所性健康服务机构;其中2所最大的临床中心收集了自我报告的本中心2009年度HPV疫苗现状。研究对象2004--2011年度首次就诊的85770名澳大利亚出生的国民;其中7686(9.0%)名患生殖器疣。主要结局测量比较前疫苗时期(2004—2007年中)和疫苗时期(2007年中-2001年末)不同人群生殖器疣新发病率变化趋势。结果疫苗时期21岁以下和21~30岁女性诊断患有生殖器疣的比例明显下降,发病率分别从2007年度的11.5%和11.3%下降至2011年度的0.85%和3.1%,P均〈0.001。在30岁以上的女性中未发现发病率的明显下降。在21岁以下和21~30岁异性恋男性人群中疫苗时期生殖器疣的发病率较前疫苗时期明显下降,分别由2007年度12.1%和18.2%下降至2011年度2.2%和8.9%,P均〈0.001。30岁以上的异性恋男性人群中发病率无明显下降。2011年235名21岁以下女性在使用HPV疫苗后无新发生殖器疣病例。结论年轻女性生殖器疣发病率的显著下降和2011年度部分年轻女性使用疫苗后的零发病率,说明HPV疫苗获得实验室外的良好功效。异性恋男性生殖器疣发病率的显著下降可能是由于群体免疫所致。 | Hammad Ali,lecturer Basil Donovan, professor HandanWand,senior lecturer Tim R H Read, sexual health physician David G Regan,senior lecturer Andrew E Grulich, professor Christopher K FaMey, professor Rebecca J Guy, associate professor 尹婕(译) 潘凌亚(校) | 2013 | 英国医学杂志中文版2013，16，4： | 4 |
| 10 | 象山港大黄鱼Pseudosciaena crocea网箱养殖区沉积物-水界面营养盐通量研究显示文摘2013年5月、8月和11月调查了象山港大黄鱼网箱养殖区及附近沉积物中总有机氮(TON)、总有机碳(TOC)和总磷(TP)含量,并采用实验室模拟法研究了底泥耗氧率(SOCs)和沉积物-水界面营养盐(NH+4、NO-2+NO-3和PO3-4)通量。结果表明:养殖区(YZ)沉积物中的TON和TP含量显著高于距离养殖区50m(F1)和100m(F2)的区域(P<0.05)。底泥释放NH+4到上覆水中,但是从上覆水中吸收NO-2+NO-3和PO3-4。沉积物-水界面营养盐通量表现出明显的季节性变化,在8月,NH+4及PO3-4的释放量达到最大值。上覆水中NH+4、NO-2+NO-3和PO3-4的质量浓度随着沉积物-水界面营养盐通量的变化而变化。研究表明,象山港大黄鱼养殖活动对养殖区底泥造成了一定污染,且通过影响沉积物-水界面营养盐通量影响上覆水中营养盐分布,最终给整个养殖系统造成生态负担。 | 廖红芳 郑忠明 REGAN Nicholaus 朱津永 | 2016 | 海洋学研究2016，34，1： | 4 |
| 11 | Osteopontin as a means to cope with environmental insults:regulation of inflammation, tissue remodeling, and cell survival 显示文摘 | Denhardt DT Noda M O'Regan AW | 2001 | J Clin Invest2001，107，9： | 3 |
| 12 | Emerging material platforms for integrated microcavity photonics显示文摘Many breakthroughs in technologies are closely associated with the deep understanding and development of new material platforms.As the main material used in microelectronics,Si also plays a leading role in the development of integrated photonics.The indirect bandgap,absence ofχ(2)nonlinearity and the parasitic nonlinear absorptions at the telecom band of Si imposed technological bottlenecks for further improving the performances and expanding the functionalities of Si microcavities in which the circulating light intensity is dramatically amplified.The past two decades have witnessed the burgeoning of the novel material platforms that are compatible with the complementary metal-oxide-semiconductor(COMS)process.In particular,the unprecedented optical properties of the emerging materials in the thin film form have resulted in revolutionary progress in microcavity photonics.In this review article,we summarize the recently developed material platforms for integrated photonics with the focus on chip-scale microcavity devices.The material characteristics,fabrication processes and device applications have been thoroughly discussed for the most widely used new material platforms.We also discuss open challenges and opportunities in microcavity photonics,such as heterogeneous integrated devices,and provide an outlook for the future development of integrated microcavities. | Jin Liu Fang Bo Lin Chang Chun-Hua Dong Xin Ou Blake Regan Xiaoqin Shen Qinghai Song Baicheng Yao Wenfu Zhang Chang-Ling Zou Yun-Feng Xiao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，10： | 3 |
| 13 | MicroRNA-21 and PDCD4 expression in colorectal cancer显示文摘 | K.H. Chang N. Miller E.A.H. Kheirelseid H. Ingoldsby E. Hennessy C.E. Curran S. Curran M.J. Smith M. Regan O.J. McAnena M.J. Kerin | 2011 | European Journal of Surgical Oncology2011，，7： | 3 |
| 14 | 综合老化腐蚀试验显示文摘介绍了综合老化腐蚀试验,包括其循环试验条件、腐蚀试验结果验证及试验方法的改进,指出该方法是检验工业防护涂层实用性的最有效试验方法之一。 | J Quill J Gauntner S Fowler J Regan 张恒 孙杏蕾 | 2015 | 上海涂料2015，53，5： | 3 |
| 15 | Advances in Digital Control for High-frequency Switched-mode Power Converters显示文摘Over the last decade,practical digital control of high-frequency switched-mode power converters has moved from proof-of-concept demonstrations to controller chips commercially available from multiple vendors,with applica-tions to point-of-load and isolated DC/DC converters,microprocessor power supplies,power-factor-correction rectifiers,and others.This paper summarizes some of the advances in the area,including approaches to realizations of high-per-formance,high-frequency digital pulse-width modulated(DPWM) controllers,related analysis,modeling and design techniques,as well as performance gains enabled by digital control such as dynamic response and efficiency improve-ments.Examples of experimentally demonstrated results are presented,together with pointers to areas of current and future research and development. | Dragan Maksimovi Regan Zane Luca Corradini | 2010 | 电力电子技术2010，44，12： | 3 |
| 16 | Enhanced Efficiency of Human Pluripotent Stem Cell Genome Editing through Replacing TALENs with CRISPRs显示文摘 | Qiurong Ding Stephanie N. Regan Yulei Xia Leoníe A. Oostrom Chad A. Cowan Kiran Musunuru | 2013 | Cell Stem Cell2013，，4： | 2 |
| 17 | Generalized I-Contractions and Pointwise R-Subweakly Commuting Maps显示文摘为点的普通的固定的点和不变的近似的存在明智 R-subweakly 变换并且兼容地图被建立。我们的结果统一并且概括各种各样的已知的结果到军士 muting 地图砰的一个更一般的班。 | D.O'REGAN N.HUSSAIN | 2007 | Acta Mathematica Sinica,English Series2007，23，8： | 2 |
| 18 | An Upper and Lower Solution Theory for the Problem(G′(y))′+f(t,y)=0 on Finite and Infinite Intervals显示文摘A new upper and lower solution theory is presented for the second order problem(G'(y))'+f(t,y)=0 on finite and infinite intervals.The theory on finite intervals is based on a Leray-Schauderalternative,whereas the theory on infinite intervals is based on results on the finite interval and adiagonalization process. | Ravi P.AGARWAL Donal O'REGAN Svatoslav STANEK | 2006 | Acta Mathematica Sinica,English Series2006，22，3： | 2 |
| 19 | 显示文摘 | Regan B O Graetzel M | 1991 | Nature1991，353，： | 2 |
| 20 | Reproductive outcomes in women with congenital uterine anomalies detected by three-dimensional ultrasound screening显示文摘 | Brigitte Woelfer Rehan Salim Saikat Banerjee Janine Elson Lesley Regan Davor Jurkovic | 2001 | Obstetrics & Gynecology2001，，： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员