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| 1 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Approaches to Flexible CIGS Thin-film Solar Cells显示文摘 | Kessler F Herrmann D Powalla M | 2005 | Thin Solid Films2005，，： | 1 |
| 4 | Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein显示文摘 | KESSLER PD PODSAKOFF G M CHEN X | 1996 | Proc Natl Acad Sci USA1996，93，14： | 1 |
| 5 | Long-term treatment of cervical dystonia with Botulinum toxin A:Efficacy,safety,and antibody frequency German Dystonia Study Group显示文摘 | Kessler KR Skutta M Benecke R | 1999 | J Neurol1999，246，： | 1 |
| 6 | The use of 3-Ddose volume analysis to predict radiation hepatitis显示文摘 | Lawrence T S Ten Haken R K Kessler M L | 1992 | Int J Radiat Oncol Biol Phys1992，23，9： | 1 |
| 7 | Dynamic mechanical analysis of carbon/epoxy composites for structural pipeline repair 显示文摘 | Goertzen W K Kessler M R | 2007 | Composite B2007，38，1： | 1 |
| 8 | Bibliographic Coupling Between Scientific Papers 显示文摘 | Kessler M M | 1963 | American Documentation1963，14，1： | 1 |
| 9 | Twelve- month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States显示文摘 | Kessler RC Petukhova M Sampson NA | 2012 | Int J Methods Psychiatr Res2012，21，3： | 1 |
| 10 | Self-healing structural composite materials显示文摘 | Kessler M R Sottos N R White S R | 2003 | Composites Part A2003，34，： | 1 |
| 11 | Cultured sympatheic neurons synthesize and release the cytokine interleukin-1显示文摘 | Fredin M Bennett MVL Kessler JA | 1992 | Proc Natl Acad Sci LISA1992，89，10： | 1 |
| 12 | CD4^+ T ceils con- tribute to postischemic liver injury in mice by interacting with sinu- soidal endothelium and platelets 显示文摘 | Khandoga A Hanschen M Kessler JS | 2006 | Hepatology2006，43，： | 1 |
| 13 | Evaluation of breast lesions by power Doppler sonography显示文摘 | Milz P Lienemann A Kessler M | 2001 | Eur Radiol2001，11，4： | 1 |
| 14 | Highly Efficient Cu ( In, Ga) Se2 Mini-Modules 显示文摘 | KESSLER J WENNERBERG J BODEGARD M | 2003 | Solar Energy Materials & Solar Ceils2003，75，12： | 1 |
| 15 | Lifetime cooecurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the national comorbidity survey 显示文摘 | Kessler R C Crum R M Warner L A | 1997 | Archives of General Psychiatry1997，54，： | 1 |
| 16 | Approaches to flexible CIGS thin-film solar cells 显示文摘 | Kessler F Herrmann D Powalla M | 2005 | Thin Solid Films2005，480，： | 1 |
| 17 | Percutaneous drainage as the treatment of choice for neonatal ovarian cysts显示文摘 | Kessler A Nagar H Graif M | 2006 | Pediatr Ra- diol2006，36，9： | 1 |
| 18 | Self-healing structural com- posite materials显示文摘 | Kessler M R Sottos N R White S R | 2003 | Composites Part A: applied science and manu- facturing2003，34，8： | 1 |
| 19 | Immunogenicity of biopharmaceuticals显示文摘 | Kessler M Goldsmith D Schellekens H | 2006 | Nephrol Dial Transplant2006，21，5： | 1 |
| 20 | Underreporting of blood and body fluid exposures among health care studentsand trainees in the acute care setting:A 2007 survey 显示文摘 | Kessler C S McGuinn M Spec A | 2011 | Am J Infect Control2011，39，2： | 1 |
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