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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Innovation speed: a conceptual model of context, antecedents and outcomes 显示文摘 | KESSLER E H CHAKRABARTI A K | 1996 | Academy of Management Review1996，，21： | 1 |
| 3 | Innovation speed: a conceptual model of context, antccedents~ and outcomes显示文摘 | KESSLER E H CHAKRABARTI A K | 1996 | Academy of Management Review1996，21，4： | 1 |
| 4 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 5 | Passive ventricular remodeling in cardiac disease: focus on heterogeneity显示文摘 | KESSLER E L BOULAKSIL M VAN RIJEN H V | 2014 | Front Physiol2014，5，5： | 1 |
| 6 | Innovation speed:a conceptual model of context,antecedents,and outcomes显示文摘 | KESSLER E H CHAKRABARTI A K | 2008 | Academy of Management Review2008，21，4： | 1 |
| 7 | Fracture mechanisms of the Strombus gigas conch shell : implica-tions for the design of brittle laminates 显示文摘 | KUHN- SPEARING L T KESSLER H CHATEAU E | 1996 | Journal of MaterialsScience1996，31，24： | 1 |
| 8 | Synthesis of TS-1 in fluoride medium,A new way to a cheap and efficient catalyst for phenol hydroxylation显示文摘 | Grieneisen J L Kessler H Fache E | 2000 | Microporous and Mesoporous Materials2000，37，3： | 1 |
| 9 | Innovation speed:A conceptual model of context, antecedents, and outcomes显示文摘 | Kessler E H Chakrabarti A K | 1996 | Academy of Management Review1996，，21： | 1 |
| 10 | Therapeutic po- tential of RGD peptides in acute renal injury 显示文摘 | Goligorsky MS Noiri E Kessler H Romanov V | 1997 | Kidney Int1997，51，5： | 1 |
| 11 | Is faster really better?An empirical test of the implication of innovation speed显示文摘 | Kessler E H Bierly P E | 2002 | IEEE Transactions on Engineering Management2002，49，： | 1 |
| 12 | Is faster really better?an empirical test of the implications of innovation speed显示文摘 | Kessler Eric H Bierly Ⅲ Paul E | 2002 | IEEE Transactions on Engineering Management2002，，2： | 1 |
| 13 | Therapeutic Potential of RGD Peptides in Acute Renal Injury显示文摘 | Goligorsky M S Noiri E Kessler H | 1997 | Kidney Int1997，51，14： | 1 |
| 14 | Innovation speed:a conceptual model of context,antecedents,and outcomes显示文摘 | KESSLER E H CHAKRABARTI A K | 1996 | Academy of Management Review1996，21，4： | 1 |
| 15 | Synthesis of TS-1 in fluoride medium, A new way to a cheap and efficient catalyst for phenol hydroxylation显示文摘 | Grieneisen J L Kessler H Fache E | 2000 | Microporous and Mesoporous Materials2000，37，3： | 1 |
| 16 | Innovation speed : a con-ceptual model of context,antecedents,and outcomes显示文摘 | Kessler E H Chakrabarti A K | 1996 | The Academy of Management Review1996，21，4： | 1 |
| 17 | Identification of different states of hepatitis B virus infection with a quantitative PCR assay显示文摘 | PREININGER S STELZL E | 2000 | Chin Diagn Lab Immuno2000，7，2： | 1 |
| 18 | Post traumatic stress disorder in the National Comorbidity Survey 显示文摘 | Kessler R C Sonnega H Bromet E | 1995 | Archives General Psychiatry1995，52，12： | 1 |
| 19 | Identification of different states of hepatitis B virus infection with a quantitative PCR assay显示文摘 | Kessler H H Preininger S Stelzl E | 2000 | Clin Diagn Lab Immunol2000，7，2： | 1 |
| 20 | Coming to terms with the terms of risks显示文摘 | Kraemer H C Kazdin A E Offord D R Kessler R C Jensen P S Kupfer D J | 1997 | Archives of General Psychiatry1997，54，： | 1 |
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