|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Gold nanoparticles for biology andmedicine显示文摘 | Giljohann D Seferos DS Daniel WL | | 0，，19： | 1 |
| 3 | Scanometric microRNA array profiling of prostate cancer markers using spherical nucleic acid-gold nanoparticle conjugates显示文摘 | Alhasan AH Kim DY Daniel WL | 2012 | Anal Chem2012，84，9： | 1 |
| 4 | Scanometric microRNA array profiling of prostate cancer markers using spherical nucleic acid-gold nanoparticle conjugates显示文摘 | Alhasan AH Kim DY Daniel WL | 2012 | Anal Chem2012，84，： | 1 |
| 5 | Analysis of DNA strand breaks induced in rodent liver in vivo,hepatocytes in primary culture,and a human cell line by chlorinated acetic acids and chlorinated acetaldehydes显示文摘 | Chang WL Daniel FB DeAngelo AB | 1992 | Envion Mol Mutagen1992，20，4： | 1 |
| 6 | Gold nanoparticles for biology and medicine显示文摘 | Giljohann DA Seferos DS Daniel WL | 2010 | Angew Chern Int Ed Engl2010，49，19： | 1 |
| 7 | Gold nanoparticles for biology and medicine显示文摘 | Giljohann DA Seferos DS Daniel WL | | 0，，19： | 1 |
| 8 | Gold nan- oparticles for biology and medicine显示文摘 | Giljohann DA Seferos DS Daniel WL | 2010 | Angew Chem Int EdEngl2010，49，19： | 1 |
| 9 | Distinct proliferative and differentiated stages ofmurine MC3T3-EI cells in culture: an in vitro model of osteoblast development显示文摘 | Quarles LD Daniel AY Laura WL | 1992 | Bone Miner Res1992，7，6： | 1 |
| 10 | Immunohistochemiscal distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma显示文摘 | Hanlin LW Danielle WL Lisa MY | 2001 | Am J Surg Pathol2001，25，： | 1 |
| 11 | Gold nanoparticles for biology and medicine显示文摘 | Giljohann DA Seferos DS Daniel WL | 2010 | Angew Chem Int Ed Engl2010，49，19： | 1 |
| 12 | Templated spherical high density lipoprotein nanoparticles 显示文摘 | Thaxton CS Daniel WL Giljohann DA | 2009 | J Am Chem Soc2009，131，4： | 1 |
| 13 | Polyvalent oligonucleoti-de gold nanoparticle conjugates as delivery vehicles for platinum(IV) warheads 显示文摘 | Dhar S Daniel WL Giljohann DA | 2009 | / Am Chem Soc2009，131，14： | 1 |
| 14 | The minimally invasive approach to appendectomy : ls less better显示文摘 | Corey WL Daniel JO | 2012 | Eur J Pediatr Surg2012，，22： | 1 |
| 15 | New drugs: sipuleucel-T, cabazitaxel, and collagenase clostridium histolyticum 显示文摘 | HUSSAR D DANIEL WL | 2010 | J Am Pharm Assoc2010，50，6： | 1 |
| 16 | Colorimetric Cu2+ detection using DNA-modified gold-nanoparticle aggregates as probes and click chemistry显示文摘 | Xu XY Daniel WL Wei W | | 0，，05： | 1 |
| 17 | Gold nanopartieles for biology and medicine显示文摘 | Giljohann DA Seferos DS Daniel WL | 2010 | Angew Chem Int Ed Engl2010，49，19： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员