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| 1 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 2 | 基于AFM的纳米尺度线宽计量模型及其算法的研究显示文摘纳米尺度线宽的测量广泛应用于半导体制造、数据存储、微机电系统等领域。随着制造技术的进步,线宽的极限尺寸也变得越来越小,目前已经缩小至100 nm左右。在这一尺度范围内,由于样本制造技术的限制和测量仪器的影响,目前很难得到准确的测量结果。为了获得样本的真实几何尺寸信息,剔除测量方法和仪器本身对测量结果的影响,建立了一个基于AFM测量技术的线宽计量模型和相应算法。该模型将被测样本的截面轮廓用20个关键点分成5个部分共19段,用基于最小二乘的直线来拟合实际轮廓。应用该模型和算法可以分别得到单刻线轮廓拟合前后的顶部线宽b_T、b_(TF),中部线宽b_M、b_(MF),底部线宽b_B、b_(BF),左右边墙角A_L、A_R,以及高度h_。使用NanoScope Ⅲa型AFM对一个单晶硅(Si)线宽样本进行了测量,测量结果表明该模型和算法可以满足纳米尺度线宽计量的基本要求。 | 赵学增 褚巍 Theodore V Vorburger Joseph Fu John Song Cattien V Nguyen | 2004 | 机械工程学报2004，40，4： | 7 |
| 3 | Blockade of Endogenous Angiotensin-(1–7) in Hypothalamic Paraventricular Nucleus Attenuates High Salt-Induced Sympathoexcitation and Hypertension显示文摘Angiotensin(Ang)-(1–7) is an important biologically-active peptide of the renin-angiotensin system. This study was designed to determine whether inhibition of Ang-(1–7) in the hypothalamic paraventricular nucleus(PVN) attenuates sympathetic activity and elevates blood pressure by modulating pro-inflammatory cytokines(PICs)and oxidative stress in the PVN in salt-induced hypertension. Rats were fed either a high-salt(8% NaCl) or a normal salt diet(0.3% NaCl) for 10 weeks, followed by bilateral microinjections of the Ang-(1–7) antagonist A-779 or vehicle into the PVN. We found that the mean arterial pressure(MAP), renal sympathetic nerve activity(RSNA), and plasma norepinephrine(NE) were significantly increased in salt-induced hypertensive rats. The high-salt diet also resulted in higher levels of the PICs interleukin-6, interleukin-1 beta, tumor necrosis factor alpha, and monocyte chemotactic protein-1, as well as higher gp91 phoxexpression and superoxide production in the PVN. Microinjection of A-779(3 nmol/50 nL) into the bilateral PVN of hypertensive rats not only attenuated MAP, RSNA, and NE, but also decreased the PICs and oxidative stress in the PVN. These results suggest that the increased MAP and sympathetic activity in salt-induced hypertension can be suppressed by blockade of endogenous Ang-(1–7) in the PVN, through modulation of PICs and oxidative stress. | Xiao-Jing Yu Yu-Wang Miao Hong-Bao Li Qing Su Kai-Li Liu Li-Yan Fu Yi-Kang Hou Xiao-Lian Shi Ying Li Jian-Jun Mu Wen-Sheng Chen Wei Cui Guo-Qing Zhu Philip J.Ebenezer Joseph Francis Yu-Ming Kang | 2019 | Neuroscience Bulletin2019，35，1： | 4 |
| 4 | Mitotic phosphorylation of PRC1 at Thr470 is required for PRC1 oligomerization and proper central spindle organization显示文摘在细胞分裂期间,染色体分离被和着丝点的锭子微导管的相互作用安排。进在分开的染色单体之间的一支组织中央锭子的 interpolarmicrotubules 的戏剧的改变为胞质分裂的开始和实行被要求。中央锭子组织要求有丝分裂的 kinesins, chromosomal 旅客蛋白质建筑群,和微导管捆绑蛋白质 PRC1。由在 Thr470 和 Thr481 的 Cdc2 的 PRC1 isphosphorylated 在有丝分裂期间。然而,在 Thr470 的功能的关联 ofPRC1 磷酸化留下了逃犯。这里,我们证明 thenon-phosphorylatable 异种 PRC1 (T470A ) 然而并非 phospho-mimicking 异种 PRC1 (T470E ) 的那表情引起中央锭子的异常组织。Immunoprecipitation 实验与野类型的 PRC1 显示那 bothPRC1 (T470A ) 和 PRC1 (T470E ) 突变蛋白质伙伴,建议 Thr470 的 thatphosphorylation 不改变 PRC1 自我协会。另外,在 vitroco 沉积,实验证明 PRC1 绑在独立于 Thr470 的 phosphorylationstate 的微导管。胶化过滤实验建议了 PRC1 的 Thr470 promotesoligomerization 的那磷酸化。给 Thr470 磷酸化的那预防禁止 PRC1oligomerization 试管内并且引起中央锭子体内的一个异常组织的事实,我们建议这 phosphorylation 依赖的 PRC1 oligomerization 保证中央锭子汇编在房间周期发生在适当时间。 | Chuanhai Fu Feng Yan Fang Wu Quan Wu Joseph Whittaker Haiying Hu Renming Hu Xuebiao Yao | 2007 | Cell Research2007，17，5： | 3 |
| 5 | Control of T H 17/T reg Balance by Hypoxia-Inducible Factor 1显示文摘 | Eric V. Dang Joseph Barbi Huang-Yu Yang Dilini Jinasena Hong Yu Ying Zheng Zachary Bordman Juan Fu Young Kim Hung-Rong Yen Weibo Luo Karen Zeller Larissa Shimoda Suzanne L. Topalian Gregg L. Semenza Chi V. Dang Drew M. Pardoll Fan Pan | 2011 | Cell2011，，5： | 3 |
| 6 | Do medical students studying in the United Kingdom have an adequate factual knowledge of basic life support?显示文摘BACKGROUND: Healthcare professionals have a duty to maintain basic life support(BLS) skills. This study aims to evaluate medical students' factual knowledge of BLS and the training they receive.METHODS: A cross-sectional, closed-response questionnaire was distributed to the fi rst-and fourth-year students studying at institutions in the United Kingdom. The paper questionnaire sought to quantify respondent's previous BLS training, factual knowledge of the BLS algorithm using five multiple choice questions(MCQs), and valuate their desire for further BLS training. Students received 1 point for each correctly identifi ed answer to the 5 MCQ's.RESULTS: A total of 3,732 complete responses were received from 21 medical schools. Eighty percent(n=2,999) of students completed a BLS course as part of their undergraduate medical studies. There was a signifi cant difference(P<0.001) in the percentage of the fourth-year students selecting the correct answer in all the MCQ's compared to the fi rst-year students except in identifyingthe correct depth of compressions required during CPR(P=0.095). Overall 10.3%(95% CI 9.9% to 10.7%) of respondents correctly identified the answer to 5 MCQ's on BLS: 9% of the first-year students(n=194) and 12% of the fourth-year students(n=190). On an institutional level the proportion of students answering all MCQ's correctly ranged from 2% to 54% at different universities. Eighty-one percent of students(n=3,031) wished for more BLS training in their curriculum.CONCLUSION: Factual knowledge of BLS is poor among medical students in the UK. There is a disparity in standards of knowledge across institutions and respondents indicating that they would like more training. | Robert D.Willmore Damjan Veljanoski Feray Ozdes Bethan Stephens James Mooney Seamus G.Crumley Arpan Doshi Philippa Davies Shreya Badhrinarayanan Emily Day Kristian Tattam April Wilson Nathan Crang Lorna Green Craig A.Mounsey Howell Fu Joseph Williams Michelle S.D'souza Dhanya Sebastian Liam A.Mcgiveron Matthew G.Percy James Cohen Imogen J.John Alice Lethbridge Imogen Watkins Omar Amin Mubasher A.Qamar John Gerrard Hanrahan Emily Cramond-Wong | 2019 | World Journal of Emergency Medicine2019，10，2： | 2 |
| 7 | 纳米尺度表面形貌测量的双图像拼接法显示文摘与传统探针相比,使用碳纳米管探针能探测到更精细的样本表面形貌,为减小针尖形貌和尺寸造成的测量误差提供了一个良好途径。然而,在普通探针上黏贴碳纳米管时总是难以避免地出现一个倾斜角度,它使得对刻线样本进行测量时只能获得单侧较精确的边墙数据,而另外一侧失真较大。提出一种双图像拼接方法,样本在经过一次测量以后被旋转180°,然后重新测量,分别保留两次测量中较好的一侧边墙测量数据,并把它们拼接成一幅更接近真实样本的图像。采用基于ICP算法的图像配准技术匹配两次测量图像,消除两次测量的位置偏差, 并应用双线性插值和最小二乘拟合方法对配准后的图像进行处理,计算得到更准确的线宽和边墙角等单刻线样本的特征尺寸值。 | 褚巍 赵学增 Joseph Fu Theodore V.Vorburger | 2005 | 机械工程学报2005，41，9： | 2 |
| 8 | Sustainable city development challenged by extreme weather in a warming world显示文摘The year of 2021 has witnessed many extreme weather events across the world that have shocked and challenged human society,in particular for the populous cities,challenging progress on sustainable city development.In the comment we highlighted the record-breaking rainstorm that is considered to happen only“once-in-a-thousand-years”on 20 July 2021 in Zhengzhou,China;and a series of short and long-term resilience enhancement and risk reducing measures to climate change and natural hazard risks.We found that increasing frequency and intensity of extreme weather events caused by human-induced climate change challenges progress on sustainable city development,but could also accelerate activities to enable cities to become more resilient.This comment is essential to advance towards the sustainable city development goal(SDG 11)in China’s mega cities,as well as informing progress for other global cities. | Changjia Li Tong Lu Bojie Fu Shuai Wang Joseph Holden | 2022 | Geography and Sustainability2022，3，2： | 2 |
| 9 | Towards a national circular economy indicator system in China: an evaluation and critical analysis 显示文摘 | Yong Geng Jia Fu Joseph Sarkis Bing Xue | 2012 | Journal of Cleaner Production2012，23，： | 1 |
| 10 | In the rough显示文摘 | Joseph Fu | 2002 | SPIE′s Oemagazine2002，2，3： | 1 |
| 11 | Towards a national circular economy indicator system in China: an evaluation and critical analysis显示文摘 | Yong Geng Jia Fu Joseph Sarkis Bing Xue | 2011 | Journal of Cleaner Production2011，，1： | 1 |
| 12 | 基于最小二乘拟合的不同探针测量线宽的比较显示文摘AFM探针的形貌和尺寸对纳米尺度线宽的测量有较大影响.首先建立了一个基于最小二乘的应用于AFM测量技术的线宽计量模型,并使用三种不同探针在NanoScopeⅢa型AFM上对设计线宽尺寸为1000nm的样本进行了测量.应用该模型和算法对线宽进行计算,揭示出探针尺寸对线宽测量结果的影响以及该模型对探针尺寸的依赖性. | 褚巍 赵学增 Joseph Fu 肖增文 | 2004 | 哈尔滨工业大学学报2004，36，11： | 1 |
| 13 | Complications in the Surgical Treatment of 19,360 Cases of Pediatric Scoliosis: A Review of the Scoliosis Research Society Morbidity and Mortality Database显示文摘 | Davis L. Reames Justin S. Smith Kai-Ming G. Fu David W. Polly Christopher P. Ames Sigurd H. Berven Joseph H. Perra Steven D. Glassman Richard E. McCarthy Raymond D. Knapp Robert Heary Christopher I. Shaffrey | 2011 | Spine2011，，18： | 1 |
| 14 | Retreatment in locally recurrent nasopharyngeal carcinoma:Current status and perspectives显示文摘1 Background Nasopharyngeal carcinoma(NPC)arises from the epithelial cells that cover and line the nasopharynx.While it is considered a rare cancer globally,it is commonly observed in South China and a few other ethnically distinct racial groups.Due to its propensity to spread early through the submucosal tissue and the highly infiltrative nature of this disease,NPC spreads easily through areas of lesser resistance within the pharyngobasilar fascia with a tendency for neural infiltration[1-3]. | Sharon Shuxian Poh Yoke Lim Soong Kiattisa Sommat Chwee Ming Lim Kam Weng Fong Terence WK Tan Melvin LK Chua Fu Qiang Wang Jing Hu Joseph TS Wee | 2021 | Cancer Communications2021，41，5： | 1 |
| 15 | MUC1 is expressed at high frequency in early-stage basal-like triple-negative breast cancer显示文摘 | Alan Siroy Fadi W. Abdul-Karim John Miedler Nancy Fong Pingfu Fu Hannah Gilmore Joseph Baar | 2013 | Human Pathology2013，，： | 1 |
| 16 | Generation of monoclonal antibodies to prostatic acid phosphatasc isoenzyme 2 and application in solid-phase enzyme immunoassay显示文摘 | Chii Yuh Kuo Kuang Wei Chen Joseph Fu | 1989 | Bioteehnology and Applied Biochemistry1989，11，： | 1 |
| 17 | Dynamic MicroRNA Expression Programs During Cardiac Differentiation of Human Embryonic Stem Cells: Role for miR-499显示文摘 | Kitchener D. Wilson Shijun Hu Shivkumar Venkatasubrahmanyam Ji-Dong Fu Ning Sun Oscar J. Abilez Joshua J.A. Baugh Fangjun Jia Zhumur Ghosh Ronald A. Li Atul J. Butte Joseph C. Wu | 2010 | Circulation: Cardiovascular Genetics2010，，： | 1 |
| 18 | Towards a national circular economy indicator system in China: an evaluation And critical analysis 显示文摘 | Yong Geng Jia Fu Joseph Sarkis Bing X ue | 2012 | Journal of Cleaner Production2012，，23： | 1 |
| 19 | Rapid “Open-Source” Engineering of Customized Zinc-Finger Nucleases for Highly Efficient Gene Modification显示文摘 | Morgan L. Maeder Stacey Thibodeau-Beganny Anna Osiak David A. Wright Reshma M. Anthony Magdalena Eichtinger Tao Jiang Jonathan E. Foley Ronnie J. Winfrey Jeffrey A. Townsend Erica Unger-Wallace Jeffry D. Sander Felix Müller-Lerch Fengli Fu Joseph Pearlber | 2008 | Molecular Cell2008，，2： | 1 |
| 20 | A small molecule UPR modulator for diabetes identified by high throughput screening显示文摘Unfolded protein response(UPR) is a stress response that is specific to the endoplasmic reticulum(ER).UPR is activated upon accumulation of unfolded(or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the synthesis of chaperones.In addition,UPR also enhances degradation of unfolded proteins and reduces global protein synthesis to alleviate additional accumulation of unfolded proteins in the ER.Herein,we describe a cell-based ultra-high throughput screening(uHTS) campaign that identifies a small molecule that can modulate UPR and ER stress in cellular and in vivo disease models.Using asialoglycoprotein receptor 1(ASGR) fused with Cypridina luciferase(CLuc) as reporter assay for folding capacity,we have screened a million small molecule library and identified APC655 as a potent activator of protein folding,that appears to act by promoting chaperone expression.Furthermore,APC655 improved pancreatic β cell viability and insulin secretion under ER stress conditions induced by thapsigargin or cytokines.APC655 was also effective in preserving β cell function and decreasing lipid accumulation in the liver of the leptin-deficient(ob/ob) mouse model.These results demonstrate a successful uHTS campaign that identified a modulator of UPR,which can provide a novel candidate for potential therapeutic development for a host of metabolic diseases. | Valeria Marrocco Tuan Tran Siying Zhu Seung Hyuk Choi Ana M.Gamo Sijia Li Qiangwei Fu Marta Diez Cunado Jason Roland Mitch Hull Van Nguyen-Tran Sean Joseph Arnab K.Chatterjee Nikki Rogers Matthew S.Tremblay Weijun Shen | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 1 |
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