3篇
您的检索式：作者名="Qiangwei Fu"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A small molecule UPR modulator for diabetes identified by high throughput screening显示文摘Unfolded protein response(UPR) is a stress response that is specific to the endoplasmic reticulum(ER).UPR is activated upon accumulation of unfolded(or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the synthesis of chaperones.In addition,UPR also enhances degradation of unfolded proteins and reduces global protein synthesis to alleviate additional accumulation of unfolded proteins in the ER.Herein,we describe a cell-based ultra-high throughput screening(uHTS) campaign that identifies a small molecule that can modulate UPR and ER stress in cellular and in vivo disease models.Using asialoglycoprotein receptor 1(ASGR) fused with Cypridina luciferase(CLuc) as reporter assay for folding capacity,we have screened a million small molecule library and identified APC655 as a potent activator of protein folding,that appears to act by promoting chaperone expression.Furthermore,APC655 improved pancreatic β cell viability and insulin secretion under ER stress conditions induced by thapsigargin or cytokines.APC655 was also effective in preserving β cell function and decreasing lipid accumulation in the liver of the leptin-deficient(ob/ob) mouse model.These results demonstrate a successful uHTS campaign that identified a modulator of UPR,which can provide a novel candidate for potential therapeutic development for a host of metabolic diseases. | Valeria Marrocco Tuan Tran Siying Zhu Seung Hyuk Choi Ana M.Gamo Sijia Li Qiangwei Fu Marta Diez Cunado Jason Roland Mitch Hull Van Nguyen-Tran Sean Joseph Arnab K.Chatterjee Nikki Rogers Matthew S.Tremblay Weijun Shen | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 1 |
| 2 | The Prototype Theory and Polysemy显示文摘 | Fu Qiangwei | 2017 | 校园英语2017，，47： | 0 |
| 3 | AraENCODE:A comprehensive epigenomic database of Arabidopsis thaliana显示文摘Dear Editor,Arabidopsis thaliana is an important model organism in plant biology and genetics.The genome of Arabidopsis ecotype Columbia-0 has been sequenced and completely annotated(Cheng et al.,2017),which facilitates the genomics research of plants.Over the past two decades,advances in the gene regulation studies have elucidated a spectrum of epigenetic molecular phenomena,including DNA methylation,histone modification,chromatin accessibility,and chromatin interaction,which collectively form an additional layer of information based on DNA sequence(Law and Jacobsen,2010).The epigenome landscape has been characterized in Arabidopsis as more high-throughput analyses were developed(Zhao et al.,2022).Without a doubt,in-depth studies of gene expression regulation heavily rely on such epigenomic information.However,the utilization of this knowledge poses a challenge for certain groups lacking bioinformatics analysts or adequate computing resources. | Fuming Lai Qiangqiang Fu Liang Xie Yaping Fangi Qiangwei Zhou Guoliang Li | 2023 | Molecular Plant2023，16，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员