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| 1 | Impaired T-cell differentiation in diabetic foot ulceration显示文摘Foot ulceration is one of the most debilitating complications associated with diabetes,but its cause remains poorly understood.Several studies have been undertaken to understand healing kinetics or find possible therapies to enhance healing.However,few studies have been directed at understanding the immunological alterations that could influence wound healing in diabetes.In this study,we analysed the T-cell receptor(TCR)repertoire diversity in TCR-αβ^(+)T cells.We also analysed the distribution and phenotype of T cells obtained from the peripheral blood of healthy controls and diabetic individuals with or without foot ulcers.Our results showed that diabetic individuals,especially those with foot ulcers,have a significantly lower naive T-cell number and a poorer TCR-Vβrepertoire diversity.We also showed that the reduced TCR-Vβrepertoire diversity in diabetic individuals was mainly owing to the accumulation of effector T cells,the major source of tumour necrosis factor-αproduction,which was even more pronounced in patients with acute foot ulceration.Moreover,the expression of several inflammatory chemokine receptors was significantly reduced in diabetic patients.In conclusion,effector T-cell accumulation and TCR repertoire diversity reduction appear to precede the development of foot ulcers.This finding may open new immunological therapeutic possibilities and provide a new prognostic tool in diabetic wound care. | João Moura João Rodrigues Marta Gonçalves Cláudia Amaral Margarida Lima Eugénia Carvalho | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 3 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 4 | Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic显示文摘AIM:To determine the prevalence of a family history suggestive of Lynch syndrome (LS) among patients with colorectal cancer (CRC) followed in a coloproctology outpatient clinic in Southern Brazil.METHODS:A consecutive sample of patients with CRC were interviewed regarding personal and family histories of cancer.Clinical data and pathology features of the tumor were obtained from chart review.RESULTS:Of the 212 CRC patients recruited,61 (29%) reported a family history of CRC,45 (21.2%) were diagnosed under age 50 years and 11 (5.2%) had more than one primary CRC.Family histories consistent with Amsterdam and revised Bethesda criteria for LS were identified in 22 (10.4%) and 100 (47.2%) patients,respectively.Twenty percent of the colorectal tumors had features of the high microsatellite instability phenotype,which was associated with younger age at CRC diagnosis and with Bethesda criteria (P < 0.001).Only 5.3% of the patients above age 50 years had been previously submitted for CRC screening and only 4% of patients with suspected LS were referred for genetic risk assessment.CONCLUSION:A significant proportion of patients with CRC were at high risk for LS.Education and training of health care professionals are essential to ensure proper management. | Patrícia Koehler-Santos Patricia Izetti Jamile Abud Carlos Eduardo Pitroski Silvia Liliana Cossio Suzi Alves Camey Cláudio Tarta Daniel C Damin Paulo Carvalho Contu Mario Antonello Rosito Patricia Ashton-Prolla Joāo Carlos Prolla | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 5 | Propolis effects on pro-inflammatory cytokine production and Toll-like receptor 2 and 4 expression in stressed mice显示文摘 | Ana Carolina Pagliarone Cláudio Lera Orsatti Michelle Cristiane Búfalo Fabiane Missima Tatiana Fernanda Bachiega Jo?o Pessoa Araújo Júnior José Maurício Sforcin | 2009 | International Immunopharmacology2009，，11： | 1 |
| 6 | Comparative and demographic analysis of orangutan genomes显示文摘 | Locke DP Hillier LW Warren WC Worley KC Nazareth LV Muzny DM Yang SP Wang Z Chinwalla AT Minx P Mitreva M Cook L Delehaunty KD Fronick C Schmidt H Fulton LA Fulton RS Nelson JO Magrini V Pohl C Graves TA Markovic C Cree A Dinh HH Hume J Kovar CL Fowler GR | | 0，，： | 1 |
| 7 | Inhibition of tissue inflammation and bacterial translocation as ones of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice显示文摘 | Flaviano S. Martins Angélica T. Vieira Samir D.A. Elian Rosa M.E. Arantes Fabiana C.P. Tiago Lirlandia P. Sousa Helena R.C. Araújo Paulo F. Pimenta Cláudio A. Bonjardim Jacques R. Nicoli Mauro M. Teixeira | 2013 | Microbes and Infection2013，，： | 1 |
| 8 | Spatial sex segregation in the dioecious grass Poa ligularis in northern Patagonia: the role of environmental patchiness 显示文摘 | Bertiller MB Sain CL Bisigato AJ Coronato FR Aries JO Graff P | 2002 | Biodivers Conserv2002，11，： | 1 |
| 9 | Caspase-3 activation after neonatal rat cerebral hypoxia-ischemia显示文摘 | Wang XY Karlsson JO Zhu CL | 2001 | Biol Neonate2001，79，34： | 1 |
| 10 | Caspase-3 activation after neonatal rat cerebral hypoxia-ischemia显示文摘 | Wang XY Karlsson JO Zhu CL | | 0，，： | 1 |
| 11 | Approaches to local connectivity in autism using resting state functional connectivity MRI显示文摘 | Maximo JO Keown CL Nair A | 2013 | Front Hum Neurosci2013，25，7： | 1 |
| 12 | Cloning and characterization of a thermostable intracellular α-amylase gene from the hyperthermophilic bacterium Thermotoga maritima MSB8 显示文摘 | Lim WJ Park S R An CL Lee JY Hong SY Shin EC Kim EJ Kim JO Kim H Yun HD | 2003 | Res Microbiol2003，154，： | 1 |
| 13 | The effects of KB-2796 and BAYK 8644 on fentanyl-induced analgesia in rats显示文摘 | Wong JO Chang CL Cheng JT | 1994 | Acta Anaesthesiol Sin1994，32，1： | 1 |
| 14 | Update of recommendations of hematopoietic colony stimulating factors: evidence-based clinical practice guidelines 显示文摘 | Ozer H Armitage JO Bennett CL | 2000 | J Clin Oncol2000，18，20： | 1 |
| 15 | Evaluation of the Structure–Activity Relationship of Rifabutin and Analogs: A Drug–Membrane Study显示文摘 | Marina Pinheiro Catarina Pereira‐Leite Mariana Arêde Cláudia Nunes Jo?o M. Caio Cristina Moiteiro Juan J. Giner‐Casares Marlene Lúcio Gerald Brezesinski Luis Camacho Salette Reis | 2013 | ChemPhysChem2013，，12： | 1 |
| 16 | A medical device/drug delivery system for treatment of glaucoma 显示文摘 | Sehultz CL Poling TR Mint JO | 2009 | Clin Exp Optom2009，4，： | 1 |
| 17 | 2000 update of recommendations for the use of hematopoietic colonystimulating factors: evidence-based, clinical practice guidelines显示文摘 | Ozer H Armitage JO Bennett CL | 2002 | J Clin Oncol2002，20，15： | 1 |
| 18 | Effect of Chronic Treatment with Conventional and Organic Purple Grape Juices ( Vitis labrusca ) on Rats Fed with High-Fat Diet显示文摘 | Marcia Gilceane Cardozo Niara Medeiros Denise Santos Lacerda Daniela Campos Almeida Jo?o Ant?nio Pegas Henriques Caroline Dani Cláudia Funchal | 2013 | Cellular and Molecular Neurobiology2013，，8： | 1 |
| 19 | Silicon Effects on Metal Tolerance and Structural Changes in Maize (Zea mays L.) Grown on a Cadmium and Zinc Enriched Soil显示文摘 | Karina Patrícia Vieira Cunha Clístenes Williams Araújo Nascimento | 2009 | Water Air and Soil Pollution (-)2009，，1： | 1 |
| 20 | Management of the non-toxic-appearing acutely febrile child: a 21st century approach 显示文摘 | Jhaveri R Byington CL Klein JO | 2011 | J Pediatr2011，159，2： | 1 |
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