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| 1 | 3D printing of bone tissue engineering scaffolds显示文摘Tissue engineering is promising in realizing successful treatments of human body tissue loss that current methods cannot treat well or achieve satisfactory clinical outcomes.In scaffold-based bone tissue engineering,a high performance scaffold underpins the success of a bone tissue engineering strategy and a major direction in the field is to produce bone tissue engineering scaffolds with desirable shape,structural,physical,chemical and biological features for enhanced biological performance and for regenerating complex bone tissues.Three-dimensional(3D)printing can produce customized scaffolds that are highly desirable for bone tissue engineering.The enormous interest in 3D printing and 3D printed objects by the science,engineering and medical communities has led to various developments of the 3D printing technology and wide investigations of 3D printed products in many industries,including biomedical engineering,over the past decade.It is now possible to create novel bone tissue engineering scaffolds with customized shape,architecture,favorable macro-micro structure,wettability,mechanical strength and cellular responses.This article provides a concise review of recent advances in the R&D of 3D printing of bone tissue engineering scaffolds.It also presents our philosophy and research in the designing and fabrication of bone tissue engineering scaffolds through 3D printing. | Chong Wang Wei Huang Yu Zhou Libing He Zhi He Ziling Chen Xiao He Shuo Tian Jiaming Liao Bingheng Lu Yen Wei Min Wang | 2020 | Bioactive Materials2020，5，1： | 20 |
| 2 | Antioxidant effects of the orientin and vitexin in Trollius chinensis Bunge in D-galactose-aged mice显示文摘Total flavonoids are the main pharmaceutical components of Trollius chinensis Bunge, and orientin and vitexin are the monomer components of total flavonoids in Trollius chinensis Bunge. In this study, an aged mouse model was established through intraperitoneal injection of D-galactose for 8 weeks, followed by treatment with 40, 20, or 10 mg/kg orientin, vitexin, or a positive control (vitamin E) via intragastric administration for an additional 8 weeks. Orientin, vitexin, and vitamin E improved the general medical status of the aging mice and significantly increased their brain weights. They also produced an obvious rise in total antioxidant capacity, superoxide dismutase, catalase, and glutathione peroxidase levels in the serum, and the levels of superoxide dismutase, catalase and glutathione peroxidase, Na+-K+-ATP enzyme, and Ca2+-Mg2+-ATP enzyme in the liver, brain and kidneys. In addition, they significantly reduced malondialdehyde levels in the liver, brain and kidney and lipofuscin levels in the brain. They also significantly improved the neuronal ultrastructure. The 40 mg/kg dose of orientin and vitexin had the same antioxidant capacity as vitamin E. These experimental findings indicate that orientin and vitexin engender anti-aging effects through their antioxidant capacities. | Fang An Guodong Yang Jiaming Tian Shuhua Wang | 2012 | Neural Regeneration Research2012，7，33： | 20 |
| 3 | A high resolution lithospheric magnetic field model over China显示文摘CHAMP satellite data and ground-based magnetic observations are used and combined to map the lithospheric magnetic field over China by means of the revised spherical cap harmonic analysis(R-SHCA)modeling technique.The magnetic field is described to a spatial resolution of 150 km at the mean Earth’s radius,which represents a good compromise between the resolutions afforded by surface and satellite data.We compare the magnetic anomalies modeled at the regional scale with composite regions containing large-scale of tectonic structures.These regions,including the Tarim Basin and the Tibetan Plateau,are correlated with regional magnetic anomalies at satellite altitude but contain a significant number of small-scale and complex magnetic structures at the mean Earth’s radius.These magnetic anomalies are globally consistent with the known geological features in China but also offer a way to delineate the contours of the geological blocks and to discuss the connection between magnetic anomalies and the heat flow distribution in this region. | OU JiaMing DU AiMin E.THBAULT XU WenYao TIAN XiaoBo ZHANG TieLong | 2013 | Science China Earth Sciences2013，56，10： | 7 |
| 4 | Mesenteric lymph reperfusion may exacerbate brain injury in a rat model of superior mesenteric artery occlusion shock显示文摘BACKGROUND:The intestinal lymphatic pathway and intestinal ischemia/reperfusion are mainly involved in mesenteric lymph duct ligation or drainage;moreover,intervention by reducing the lymph liquid reflux might relieve lung and other organ dysfunction induced by intestinal ischemia/reperfusion;however,research addressing mesenteric lymph reperfusion (MLR) and brain injury has not yet to be reported.OBJECTIVE:To observe the effect of MLR on brain tissue in a rat model of superior mesenteric artery occlusion (SMAO) shock,and to explore the molecular mechanism of MLR.DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment at a neuro-pathophysiology level was performed at the Institute of Microcirculation,Hebei North University;Department of Pathophysiology,Basic Medical College;Department of Pathology,the First Hospital of Hebei North University between December 2007 and March 2009.MATERIALS:Adenosine triphosphate (ATP) standard was provided by the National Institute for the Control of Pharmaceutical and Biological Products;lactic acid (LA),superoxide dismutase (SOD),malonaldehyde (MDA),nitrogen monoxidum (NO),nitric oxide synthase (NOS),myeloperoxidase (MPO) and ATPase assay kits were provided by Nanjing Jiancheng Bioengineering Institute,China.METHODS:A total of 24 male Wistar rats were randomly divided into four groups.In the sham-surgery group (n=6),both the mesenteric lymph duct and the superior mesenteric artery were not blocked;in the MLR group (n=6),the mesenteric lymph duct was occluded for 1 hour followed by 2-hour reperfusion;in the SMAO group (n=6),the superior mesenteric artery was occluded for 1 hour followed by 2-hour reperfusion;in the MLR + SMAO group (n=6),both the mesenteric lymph duct and superior mesenteric artery were occluded for 1 hour followed by 2-hour reperfusion.MAIN OUTCOME MEASURES:Mean arterial blood pressure prior to and following ischemia/reperfusion;brain tissue morphology levels of LA,MDA,SOD,NO,NOS,MPO,ATPase and ATP following reperfusion.RESULTS:MLR did not cause changes in mean arterial blood pressure,brain tissue morphology,LA,MDA,NO,ATP,SOD,NOS,MPO and ATPase.However,SMAO caused a rapid decrease and gradual increase of mean arterial blood pressure.Neuronal necrosis,degeneration and swelling were observed in brain tissue.Contents of MDA,NO,LA and ATP as well as activities of NOS and MPO were significantly increased (P < 0.05),but activities of SOD and Na+-K+-ATPase were significantly decreased (P < 0.05).MLR aggravated neuronal damage in a rat model of SMAO shock.Following MLR,mean arterial blood pressure was significantly decreased (P < 0.05),contents of MDA and NO as well as activities of NOS and MPO were significantly increased (P < 0.05),but activities of Ca2+-ATPase,Mg2+-ATPase and Ca2+-Mg2+-ATPase as well as ATP content were significantly decreased (P < 0.05).CONCLUSION:MLR aggravates brain injury in a rat model of SMAO shock,which correlates with oxygen-derived free radical injury,NO synthesis and release,sequestration of neutrophilic granulocytes,decreasing activity of cell membrane pumps and energy metabolism dysfunction.Pathogenesis of the intestinal lymphatic pathway should be thoroughly investigated to prevent ischemia/reperfusion injury. | Zigang Zhao Chunyu Niu Aimin Shang Jiaming Tian Rui Han Chunhui Zhang Yuping Zhang Jing Zhang | 2010 | Neural Regeneration Research2010，5，9： | 7 |
| 5 | Factors of spatial distribution of recreation areas in peri-urban Beijing显示文摘在北京基于外部城市的区域的案例研究,这份报纸试图识别将影响仙子城市的娱乐区域的空间分发的因素,由分析从问询表,联机调查,文档和领域调查(2007 ) 收集了数据。为了完成健全信息,从不同管理部门的相关数据,主人和陆地使用类型,在案例研究区域包含了被收集。为在北京的仙子城市的娱乐区域的一个采样数据库被建立,并且象统计分析一样的 GIS 空间分析被使用。结果显示娱乐区域的空间分发被四个因素主要地影响,例如旅游吸引力和环境条件,政策和空间统治,消费需求和偏爱,陆地价格和可获得性。旅游吸引力和环境条件是为公共娱乐区域的主导的因素。商业娱乐区域高度与可接近性被联系。农业娱乐区域通常在 large-scaled 附近被纳入特殊农田舞台的区域。同时,娱乐企业簇在集体娱乐市场生长影响的郊区出现了。由陆地价格控制了,商业娱乐区域在他们的规模和发展中的紧张上被区分。政策和空间统治使娱乐区域的安排成为了平衡的更多和更多面向人。一个仙子城市的娱乐区域模型因此根据这分析被建立,它能指导城市的计划并且设计,陆地使用计划和娱乐资源开发。 | LIU Jiaming WANG Run CHEN Tian | 2010 | Journal of Geographical Sciences2010，20，5： | 6 |
| 6 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 7 | Air-Stable Ultrabright Inverted Organic Light-Emitting Devices with Metal Ion-Chelated Polymer Injection Layer显示文摘Here,this work presents an air-stable ultrabright inverted organic lightemitting device(OLED)by using zinc ionchelated polyethylenimine(PEI)as electron injection layer.The zinc chelation is demonstrated to increase the conductivity of the PEI by three orders of magnitude and passivate the polar amine groups.With these physicochemical properties,the inverted OLED shows a record-high external quantum efficiency of 10.0% at a high brightness of 45,610 cd m^(-2) and can deliver a maximum brightness of 121,865 cd m^(-2).Besides,the inverted OLED is also demonstrated to possess an excellent air stability(humidity,35%)with a half-brightness operating time of 541 h@1000 cd m^(-2) without any protection nor encapsulation. | Shihao Liu Chunxiu Zang Jiaming Zhang Shuang Tian Yan Wu Dong Shen Letian Zhang Wenfa Xie Chun-Sing Lee | 2022 | Nano-Micro Letters2022，14，1： | 3 |
| 8 | A novel scheme for ultrashort terahertz pulse generation over a gapless wide spectral range:Raman-resonance-enhanced four-wave mixing显示文摘Ultrashort energetic terahertz(THz)pulses have created an exciting new area of research on light interactions with matter.For material studies in small laboratories,widely tunable femtosecond THz pulses with peak field strength close to MV cm-1 are desired.Currently,they can be largely acquired by optical rectification and difference frequency generation in crystals without inversion symmetry.We describe in this paper a novel scheme of THz pulse generation with no frequency tuning gap based on Raman-resonance-enhanced four-wave mixing in centrosymmetric media,particularly diamond.We show that we could generate highly stable,few-cycle pulses with near-Gaussian spatial and temporal profiles and carrier frequency tunable from 5 to>2o THz.They had a stable and controllable carrier-envelop phase and carried~15 nJ energy per pulse at 10 THz(with a peak field strength of~1 MV cm^(-1)at focus)from a O.5-mm-thick diamond.The measured THz pulse characteristics agreed well with theoretical predictions.Other merits of the scheme are discussed,including the possibility of improving the THz output energy to a much higher level. | Jiaming Le Yudan Su Chuanshan Tian A.H.Kung Y.Ron Shen | 2023 | Light(Science & Applications)2023，12，2： | 2 |
| 9 | Potential therapeutic effects and applications of Eucommiae Folium in secondary hypertension显示文摘Eucommiae Folium(EF),a traditional Chinese medicine,has been used to treat secondary hypertension,including renal hypertension and salt-sensitive hypertension,as well as hypertension caused by thoracic aortic endothelial dysfunction,a high-fat diet,and oxidized low-density lipoprotein.The antihypertensive components of EF are divided into four categories:flavonoids,iridoids,lignans,and phenylpropanoids,such as chlorogenic acid,geniposide acid and pinoresinol diglucoside.EF regulates the occurrence and development of hypertension by regulating biological processes,such as inhibiting inflammation,regulating the nitric oxide synthase pathway,reducing oxidative stress levels,regulating endothelial vasoactive factors,and lowering blood pressure.However,its molecular antihypertensive mechanisms are still unclear and require further investigation.In this review,by consulting the relevant literature on the antihypertensive effects of EF and using network pharmacology,we summarized the active ingredients and pharmacological mechanisms of EF in the treatment of hypertension to clarify how EF is associated with secondary hypertension,the related components,and underlying mechanisms.The results of the network pharmacology analysis indicated that EF treats hypertension through a multicomponent,multi-target and multi-pathway mechanism.In particular,we discussed the role of EF targets in the treatment of hypertension,including epithelial sodium channel,heat shock protein70,rhoassociated protein kinase 1,catalase,and superoxide dismutase.The relevant signal transduction pathways,the ras homolog family member A(RhoA)/Rho-associated protein kinase(ROCK)and nicotinamide adenine dinucleotide phosphate(NADPH)oxidase/eNOS/NO/Ca^(2+)pathways,are also discussed. | Mengyuan Li Yanchao Zheng Sha Deng Tian Yu Yucong Ma Jiaming Ge Jiarong Li Xiankuan Li Lin Ma | 2022 | Journal of Pharmaceutical Analysis2022，12，5： | 2 |
| 10 | Influence of mesenteric lymph reperfusion on neurotransmitter expression in brain tissue of a superior mesenteric artery occlusion shock rat model显示文摘BACKGROUND: Previous studies have shown that mesenteric lymph reperfusion (MLR) exacerbates brain injury in a rat model of superior mesenteric artery occlusion (SMAO) shock. However, little is known about the influence of MLR on neurotransmitter expression in brain tissue. OBJECTIVE: To observe the effect of MLR on brain tissue injury by measuring monoamine and cholinergic neurotransmitter levels. DESIGN, TIME AND SETTING: A randomized, controlled, animal experiment was performed at the Institute of Microcirculation, Hebei North University, China; Research Room of Microcirculation and Laboratory of Biochemistry, Department of Pathophysiology, Basic Medical College, Hebei North University between December 2007 and March 2009. MATERIALS: Choline acetyltransferase (ChAT) and acetylcholine esterase (AChE) kits were provided by Nanjing Jiancheng Bioengineering Institute, China; dopamine (DA) and noradrenalin (NE) standards were provided by the National Institute for the Control of Pharmaceutical and Biological Products; HP1100 chromatograph of liquid was provided by Agilent, USA. METHODS: A total of 24 male, Wistar rats were randomly assigned to 4 groups: sham-surgery, MLR, SMAO, and MLR + SMAO groups, with 6 rats in each group. In the MLR or SMAO groups, the mesenteric lymph duct or superior mesenteric artery was blocked for 1 hour. In the MLR + SMAO group, the mesenteric lymph duct and superior mesenteric artery were occluded for 1 hour, followed by 2-hour reperfusion. ChAT and AChE levels were measured using the synthesized and hydrolyzed acetylcholine method, respectively. Liquid chromatography was employed to quantitatively analyze DA and NE levels, using relative retention time and the external standard method. MAIN OUTCOME MEASURES: ChAT, AChE, DA, and NE levels. RESULTS: AChE levels were significantly increased, but ChAT levels were significantly decreased in the MLR and MLR + SMAO groups following 2-hour reperfusion (P < 0.01). However, AChE activity in the MLR + SMAO group was greater than in the MLR group (P < 0.05). DA and NE levels were significantly decreased in the SMAO and MLR + SMAO groups (P < 0.01), while DA levels in the MLR + SMAO group were less than in the SMAO group (P < 0.05). CONCLUSION: MLR exacerbated brain injury in a rat model of SMAO shock, which correlated with the intestinal lymphatic pathway. MLR decreased DA levels, but increased AChE activity, in a rat model of SMAO shock. | Chunyu Niu Zigang Zhao Aimin Shang Jiaming Tian Chunhui Zhang Rui Han Yuping Zhang Jing Zhang | 2010 | Neural Regeneration Research2010，5，11： | 2 |
| 11 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 12 | Flexible temperature sensor with high sensitivity ranging from liquid nitrogen temperature to 1200℃显示文摘Flexible temperature sensors have been extensively investigated due to their prospect of wide application in various flexible electronic products.However,most of the current flexible temperature sensors only work well in a narrow temperature range,with their application at high or low temperatures still being a big challenge.This work proposes a flexible thermocouple temperature sensor based on aerogel blanket substrate,the temperature-sensitive layer of which uses the screen-printing technology to prepare indium oxide and indium tin oxide.It has good temperature sensitivity,with the test sensitivity reaching 226.7μV℃^(−1).Most importantly,it can work in a wide temperature range,from extremely low temperatures down to liquid nitrogen temperature to high temperatures up to 1200℃,which is difficult to be achieved by other existing flexible temperature sensors.This temperature sensor has huge application potential in biomedicine,aerospace and other fields. | Zhaojun Liu Bian Tian Zhuangde Jiang Shuimin Li Jiaming Lei Zhongkai Zhang Jiangjiang Liu Peng Shi Qijing Lin | 2023 | International Journal of Extreme Manufacturing2023，5，1： | 1 |
| 13 | Intermedin/adrenomedullin 2 protects against tubular cell hypoxia‐reoxygenation injury in vitro by promoting cell proliferation and upregulating cyclin D 1 expression显示文摘 | Yanhong Wang Rongshan Li Xi Qiao Jihua Tian Xiaole Su Ruiping Wu Ruijing Zhang Xiaoshuang Zhou Jiaming Li Shan Shao | 2013 | Nephrology2013，，9： | 1 |
| 14 | CoSe_(2)/MoS_(2) Heterostructures to Couple Polysulfide Adsorption and Catalysis in Lithium-Sulfur Batteries显示文摘Lithium-sulfur batteries have been regarded as one of most promising next-generation energy storage devices because of their high energy density and low cost.However,polysulfide shuttling and slow kinetics hinder the practical application.We fabricated hierarchically heterostructured CoSe_(2)/MoS_(2) nanoarrays on carbon clothes as the sulfur cathode host.The resulting heterostructures facilitate electron conduction and improve electrolyte wetting.More importantly,the composite heterostructures couple the strong poly-sulfide adsorption of CoSe_(2) and high catalytic activity of MoS_(2) to synergistically accelerate polysulfide conversion,demonstrating higher catalytic activity than their individual components. | Zihan Shen Qingwen Zhou Huiling Yu Jiaming Tian Man Shi Chaoquan Hu Huigang Zhang | 2021 | Chinese Journal of Chemistry2021，39，5： | 1 |
| 15 | A NOVEL METHOD FOR MEASURING COMPLEX REFLECTION COEFFICIENT USING A FOUR-PORT REFLECTOMETER显示文摘A novel method for precise measurement of complex reflection coeffcient using a four-port reflectometer is presented. First, three new complex system constants are introduced,which depend only on the scattering parameters of the four-port reflectometer. Therefore, the stability of the reflectometer is greatly improved. Then, these complex system constants are used to determine the complex reflection coeffcient F of the device under test by calibrating the reflectometer. Finally, a four-port reflectometer comprising a magic tee and a power detector is constructed and excellent experimental results are obtained. | Tian Buning Tang Jiaming Liu Qizhong (institute of Antennas and EMS, Xidian University, Xi’an 71007l) | 2001 | Journal of Electronics(China)2001，18，4： | 1 |
| 16 | Short text hashing improved by integrating multi-granularity topics and tags显示文摘 | XU Jiaming XU Bo TIAN Guanhua | 2015 | Lecture Notes in Computer Science2015，9041，： | 1 |
| 17 | Experimental Study on a Controllable Underwater Towed System 显示文摘 | Wu Jiaming Ye Jiawei Yang Cheng Chen Yuanming Tian Huiping Xiong Xiaohui | 2005 | Ocean Engineering2005，32，1415： | 1 |
| 18 | Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration显示文摘Low back pain,mainly caused by intervertebral disc degeneration(IVDD),is a common health problem;however,current surgical treatments are less than satisfactory.Thus,it is essential to develop novel non-invasive surgical methods for IVDD treatment.Here,we describe a therapeutic strategy to inhibit IVDD by injecting hydrogels modified with the extracellular matrix of costal cartilage(ECM-Gels)that are loaded with cartilage endplate stem cells(CESCs).After loaded with CESCs overexpressing Sphk2(Lenti-Sphk2-CESCs)and injected near the cartilage endplate(CEP)of rats in vivo,ECM-Gels produced Sphk2-engineered exosomes(Lenti-Sphk2-Exos).These exosomes penetrated the annulus fibrosus(AF)and transported Sphk2 into the nucleus pulposus cells(NPCs).Sphk2 activated the phosphatidylinositol 3-kinase(PI3K)/p-AKT pathway as well as the intracellular autophagy of NPCs,ultimately ameliorating IVDD.This study provides a novel and efficient non-invasive combinational strategy for IVDD treatment using injectable ECM-Gels loaded with CESCs that express Sphk2 with sustained release of functional exosomes. | Liwen Luo Junfeng Gong Zhouguang Wang Yao Liu Jiaming Cao Jinghao Qin Rui Zuo Hongyu Zhang Shuai Wang Ping Zhao Di Yang Mengjie Zhang Yanqiu Wang Junfeng Zhang Yue Zhou Changqing Li Bing Ni Zhiqiang Tian MingHan Liu | 2022 | Bioactive Materials2022，7，9： | 1 |
| 19 | A large-area bionic skin for high-temperature energy harvesting applications显示文摘For the large amount of waste heat wasted in daily life and industrial production,we propose a new type of flexible thermoelectric generators(F-TEGs)which can be used as a large area bionic skin to achieve energy harvesting of thermal energy.With reference to biological structures such as pinecone,succulent,and feathers,we have designed and fabricated a biomimetic flexible TEG that can be applied in a wide temperature range which has the highest temperature energy harvesting capability currently.The laminated free structure of the bionic F-TEG dramatically increases the efficiency and density of energy harvesting.The F-TEGs(single TEG only 101.2 mg in weight),without an additional heat sink,demonstrates the highest output voltage density of 286.1 mV/cm^(2)and the maximum power density is 66.5 mW/m^(2) at a temperature difference of nearly 1000℃.The flexible characteristics of F-TEGs make it possible to collect the diffused thermal energy by flexible attachment to the outer walls of high-temperature pipes and vessels of different diameters and shapes.This work shows a new design and application concept for flexible thermal energy collectors,which fills the gap of flexible energy harvesting in high-temperature environment. | Zhaojun Liu Bian Tian Yao Li Jiaming Lei Zhongkai Zhang Jiangjiang Liu Qijing Lin Chengkuo Lee Zhuangde Jiang | 2023 | Nano Research2023，16，7： | 0 |
| 20 | Highly sensitive flexible heat flux sensor based on a microhole array for ultralow to high temperatures显示文摘With the growing demand for thermal management of electronic devices,cooling of high-precision instruments,and biological cryopreservation,heat flux measurement of complex surfaces and at ultralow temperatures has become highly imperative.However,current heat flux sensors(HFSs)are commonly used in high-temperature scenarios and have problems when applied in low-temperature conditions,such as low sensitivity and embrittlement.In this study,we developed a flexible and highly sensitive HFS that can operate at ultralow to high temperatures,ranging from−196°C to 273°C.The sensitivities of HFSs with thicknesses of 0.2 mm and 0.3 mm,which are efficiently manufactured by the screen-printing method,reach 11.21μV/(W/m2)and 13.43μV/(W/m2),respectively.The experimental results show that there is a less than 3%resistance change from bending to stretching.Additionally,the HFS can measure heat flux in both exothermic and absorptive cases and can measure heat flux up to 25 kW/m2.Additionally,we demonstrate the application of the HFS to the measurement of minuscule heat flux,such as heat dissipation of human skin and cold water.This technology is expected to be used in heat flux measurements at ultralow temperatures or on complex surfaces,which has great importance in the superconductor and cryobiology field. | Le Li Bian Tian Zhongkai Zhang Meng Shi Jiangjiang Liu Zhaojun Liu Jiaming Lei Shuimin Li Qijing Lin Libo Zhao Zhuangde Jiang | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
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