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| 1 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 2 | 3D printing of bone tissue engineering scaffolds显示文摘Tissue engineering is promising in realizing successful treatments of human body tissue loss that current methods cannot treat well or achieve satisfactory clinical outcomes.In scaffold-based bone tissue engineering,a high performance scaffold underpins the success of a bone tissue engineering strategy and a major direction in the field is to produce bone tissue engineering scaffolds with desirable shape,structural,physical,chemical and biological features for enhanced biological performance and for regenerating complex bone tissues.Three-dimensional(3D)printing can produce customized scaffolds that are highly desirable for bone tissue engineering.The enormous interest in 3D printing and 3D printed objects by the science,engineering and medical communities has led to various developments of the 3D printing technology and wide investigations of 3D printed products in many industries,including biomedical engineering,over the past decade.It is now possible to create novel bone tissue engineering scaffolds with customized shape,architecture,favorable macro-micro structure,wettability,mechanical strength and cellular responses.This article provides a concise review of recent advances in the R&D of 3D printing of bone tissue engineering scaffolds.It also presents our philosophy and research in the designing and fabrication of bone tissue engineering scaffolds through 3D printing. | Chong Wang Wei Huang Yu Zhou Libing He Zhi He Ziling Chen Xiao He Shuo Tian Jiaming Liao Bingheng Lu Yen Wei Min Wang | 2020 | Bioactive Materials2020，5，1： | 20 |
| 3 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 4 | Correlation between BRAF^(V600E) mutation and clinicopathological features in pediatric papillary thyroid carcinoma显示文摘In adults, the presence of the BRAF^(V600E) mutation in papillary thyroid cancer(PTC) has been demonstrated to be strongly associated with aggressive cancer-cell characteristics and poor patient prognosis. In contrast, the frequency of this mutation in pediatric PTC has undergone limited study, and the few available estimates range from 0 to 63%. Furthermore, the role of the BRAF^(V600E) mutation in pediatric PTC is controversial; thus, the present study aimed to investigate the prevalence and role of the BRAF^(V600E) mutation in48 pediatric patients with PTC, aged 3–13 years. Of these patients, 41 were diagnosed with classic PTC, five were found to have a follicular variant of PTC, and two to exhibit a diffuse sclerosing PTC variant. The BRAF^(V600E) mutation was identified to be present in 35.4% of the 48 analyzed patients, and in 41.5% of the patients diagnosed with classical PTC. Furthermore, the presence of the BRAF^(V600E) mutation was found to be associated with a patient age at diagnosis of less than ten years(P=0.011), the performance of a thyroidectomy(P=0.03), exhibited tumor multifocality(P=0.02) and/or extra-thyroidal invasion(P=0.003), and both a low MACIS(Metastases, Age, Completeness of resection, Invasion, Size)(P=0.036) and AMES(Age, Metastasis, Extent of tumor,Size)(P=0.001)score. Together, these data suggest that the presence of the BRAF^(V600E) mutation may be negatively correlated with partial aggressive clinicopathological features of pediatric PTC. | Jiangqiao Geng Huanmin Wang Yuanhu Liu Jun Tai Yaqiong Jin Jie Zhang Lejian He Libing Fu Hong Qin Yingluan Song Jinzhu Su Aiying Zhang Xin Wen Yongli Guo Xin Ni | 2017 | Science China(Life Sciences)2017，60，7： | 9 |
| 5 | An Efficient Multi-hop Broadcast Protocol for Emergency Messages Dissemination in VANETs显示文摘Black-burst based multi-hop broadcast protocols are effective means to disseminate Emergency messages(EMs)in Vehicular ad hoc networks(VANETs).However,Clear to broadcast(CTB)collision will happen and reduce propagation speed.Aiming at this problem,we propose a Black-burst and multi-channel based multihop broadcast(BMMB)protocol.Vehicles with multiple antennas can transmit and sense black-burst at different channels simultaneously based on multi-channel technology.Compared with existing black-burst based methods,BMMB shortens the iterative procedure to find out the optimal segment.Only one relay vehicle can be rapidly selected within the optimal segment without CTB collision.BMMB enables alternative broadcast methods,i.e.,unidirectional broadcast and multi-directional broadcast for straight roads and intersections respectively.Theoretical analysis is done for performance evaluation of BMMB,and simulation results demonstrate that BMMB performs better in terms of average one-hop delay and propagation speed. | WU Libing NIE Lei FAN Jing HE Yanxiang LIU Qin WU Dan | 2017 | Chinese Journal of Electronics2017，26，3： | 4 |
| 6 | Research approaches to mass casualty incidents response:development from routine perspectives to complexity science显示文摘 | Shen Weifeng Jiang Libing Zhang Mao Ma Yuefeng Jiang Guanyu He Xiaojun | 2014 | Chinese Medical Journal2014，，13： | 4 |
| 7 | Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum显示文摘The cerebellum is critical for controlling motor and non-motor functions via cerebellar circuit that is composed of defined cell types, which approximately account for more than half of neurons in mammalsThe molecular mechanisms controlling developmental progression and maturation processes of various cerebellar cell types need systematic investigationHere, we analyzed transcriptome profiles of 21119 single cells of the postnatal mouse cerebellum and identified eight main cell clusters. Functional annotation of differentially expressed genes revealed trajectory hierarchies of granule cells (GCs) at various states and implied roles of mitochondrion and ATPases in the maturation of Purkinje cells (PCs), the sole output cells of the cerebellar cortexFurthermore, we analyzed gene expression patterns and co-expression networks of 28 ataxia risk genes, and found that most of them are related with biological process of mitochondrion and around half of them are enriched in PCs. Our results also suggested core transcription factors that are correlated with interneuron differentiation and characteristics for the expression of secretory proteins in glia cells, which may participate in neuronal modulationThus, this study presents a systematic landscape of cerebellar gene expression in defined cell types and a general gene expression framework for cerebellar development and dysfunction. | Jian Peng Ai-li Sheng Qi Xiao Libing Shen Xiang-Chun Ju Min Zhang Si-Ting He Chao Wu Zhen-Ge Luo | 2019 | Journal of Molecular Cell Biology2019，11，8： | 2 |
| 8 | Factors involved in the success of Castanea henryi stem cuttings in different cutting mediums and cutting selection periods显示文摘Chinquapin(Castanea henryi) is a dual-purpose tree species in China valued for as a source of timber and starch.We investigated the effect of four cutting mediums(pure vermiculite;peat:river sand at 3:1 v/v;peat:krasnozem at 1:1 v/v;and pure krasnozem) and three stem cutting periods(March,May,and July) on rooting performance of C.henryi cuttings.Different cutting periods and cutting mediums greatly influenced the rooting rate of C.henryi,ranging from 3.35 to 77.31%.Principal component analysis indicated that the best combination of cutting period and cutting medium was semi-hardwood cuttings(May cuttings)+krasnozem.Histological evidence indicated that adventitious root initials were present by week 5-6,and that the site of root primordia initiation was observed in the vascular cambium.Stem anatomical structures observed at different periods indicated that a xylem/radius ratio of29.90-37.42% and a fractured phloem fiber ring are indicative of rooting success.The relational model between rooting index and medium properties indicated that nutrient content and porosity significantly influenced callus production.However,pH strongly affected C.henryi root formation,with the Pearson correlation coefficients for May and July cuttings of-0.856 and-0.947,respectively.Our protocol is helpful to achieve mass clone propagation of improved C.henryi genotypes,thus overcoming a common hurdle in chinquapin breeding programs. | Wangzun Chen Libing He Shiyi Tian Joseph Masabni Huan Xiong Feng Zou Deyi Yuan | 2021 | Journal of Forestry Research2021，32，4： | 2 |
| 9 | An improved multi-attribute decision-making based network selection algorithm for heterogeneous vehicular network显示文摘1 Introduction With sharply rising quantity of urban vehicles over the past few decades,traffic jams and safety have gradually become outstanding problems.In recent years,Vehicular Ad hoc Network(VANET)is appeared and utilized to solve traffic related issues.It is a type of self-organized and open-structured network,and provides Vehicle-to-Everything(V2X)communications.Almost all kinds of applications in VANET rely on efficient data transmission and interaction[1-3]. | Lei NIE Bo LIU Peng LI Heng HE Libing WU | 2022 | Frontiers of Computer Science2022，16，3： | 2 |
| 10 | Cationic conjugated polymers for detection and inactivation of pathogens显示文摘Conjugated polymers(CPs) are referred to a kind of fluorescent polymer materials with delocalized π-conjugated backbones.For the last decades, cationic CPs(CCPs) have been widely used in biosensor, imaging and biomedical fields due to their good photophysical properties and solubility in water medium resulting from side chain modification with ionized moieties. In this mini-review, we mainly introduced the applications of CCPs in detection and inactivation of pathogen with typical examples, and also briefly discussed the relevant mechanisms. We hold the expectation that this mini-review can offer researchers a general reference and inspire them to construct new systems with high performances of pathogen detection and antimicrobial activity. | Ping He Fengting Lv Libing Liu Shu Wang | 2017 | Science China Chemistry2017，60，12： | 1 |
| 11 | Potential Submarine Geologic Hazards at the Entrance of the Pearl River Estuary in the Northern South China Sea显示文摘The potential submarine geologic hazards were distinguished and categorized at the entrance of the Pearl River Estuary in the northern South China Sea, based upon the analysis of side scan sonar and sub-bottom profiler surveying data of about 2500 km long, in an area about 2000 km^2 around the Wanshan Archipelago. The data obtained in the survey has the highest spatial resolution by far, which could reveal more detailed distributions and characteristics of the geologic hazards than before. In the study region, three paleo-channels that were buried about 10–30 m below the seabed were found; more than 10 shallow gas areas were discovered. The sand waves found in the region were generally small and located near the islands, and twenty pockmarks found on the seabed were mostly concentrated to north of Zhuzhou island. There are also many man-made obstacles in the region, such as wreckages, pipeline, etc. In this paper we provide a detailed distribution map of the submarine geologic hazards in this region for the first time, and discuss their formation and harmfulness, which will provide a scientific basis for marine engineering construction, marine geologic disaster prevention and mitigation. | ZHANG Zhiqiang WEI Zhiqiang HE Huizhong WEI Wei QIAN Libing LI Tuanjie | 2016 | Journal of Ocean University of China2016，15，4： | 1 |
| 12 | HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression显示文摘 | De Huang Tingting Li Xinghua Li Long Zhang Linchong Sun Xiaoping He Xiuying Zhong Dongya Jia Libing Song Gregg L. Semenza Ping Gao Huafeng Zhang | 2014 | Cell Reports2014，，6： | 1 |
| 13 | The Transition Algorithm Based on Parametric Spline Curve for High-speed Machining of Continuous Short Line Segments显示文摘 | Zhang Libing You Youpeng He Jun | 2011 | International Journal Ad- vanced Manufacturing Technology2011，52，： | 1 |
| 14 | Comparative QSAR modeling of antitumor activity of ARC-111 analogues using stepwise MLR, PLS, and ANN techniques显示文摘 | Yanjun Yu Rongxin Su Libing Wang Wei Qi Zhimin He | 2010 | Medicinal Chemistry Research2010，，9： | 1 |
| 15 | Inference of Reference Conditions for Nutrient Concentrations of Chaohu Lake Based on Model Extrapolation显示文摘In the mid-eastern China,there are few or no lakes which are in the absence of anthropogenic disturbances,or their sediments remain undisturbed.As a result,the reference lakes distribution and paleolimnological reconstruction approaches usually are inappropriate to estimate lake reference conditions for nutrients.This yields the necessity of using the extrapolation methods to estimate the lake reference conditions for nutrients within those regions.The lake reference conditions for nutrients could be inferred inversely from the law of mass conservation,current lake nutrient concentration,and the loadings from watershed.Considering the scarcity of hydrological and water quality data associated with lakes and watersheds in China,as well as the low requirement of the watershed nutrient loadings models for these data,the soil conservation service(SCS) distributed hydrological model and the universal soil loss equation(USLE) were applied.The SCS model simulates the runoff process of the watershed,thereby calculating dissolved nutrients annually.The USLE estimates the soil erosion and particulate nutrients annually in a watershed.Then,with the loadings from atmospheric deposition and point source,the previous annual average nutrient concentrations could be acquired given the current nutrient concentrations in a lake.Therefore,the nutrient reference conditions minimally impacted by human activities could be estimated.Based on the proposed model,the reference conditions for total nitrogen and total phosphorus of Chaohu Lake,Anhui Province,China are 0.031 mg/L and 0.640 mg/L,respectively.The proposed reference conditions estimation model is of clear physical concept,and less data required.Thus,the proposed approach can be used in other lakes with similar circumstances. | ZHOU Yuliang JIN Juliang LIU Li ZHANG Libing He Jun WANG Zhesun | 2013 | Chinese Geographical Science2013，23，1： | 0 |
| 16 | Draft Genome of White-blotched River Stingray Provides Novel Clues for Niche Adaptation and Skeleton Formation显示文摘The white-blotched river stingray(Potamotrygon leopoldi)is a cartilaginous fish native to the Xingu River,a tributary of the Amazon River system.As a rare freshwater-dwelling cartilaginous fish in the Potamotrygonidae family in which no member has the genome sequencing information available,P.leopoldi provides the evolutionary details in fish phylogeny,niche adaptation,and skeleton formation.In this study,we present its draft genome of 4.11 Gb comprising 16,227 contigs and 13,238 scaffolds,with contig N50 of 3937 kb and scaffold N50 of 5675 kb in size.Our analysis shows that P.leopoldi is a slow-evolving fish that diverged from elephant sharks about 96 million years ago.Moreover,two gene families related to the immune system(immunoglobulin heavy constant delta genes and T-cell receptor alpha/delta variable genes)exhibit expansion in P.leopoldi only.We also identified the Hox gene clusters in P.leopoldi and discovered that seven Hox genes shared by five representative fish species are missing in P.leopoldi.The RNA sequencing data from P.leopoldi and other three fish species demonstrate that fishes have a more diversified tissue expression spectrum when compared to mammals.Our functional studies suggest that lack of the gc gene encoding vitamin D-binding protein in cartilaginous fishes(both P.leopoldi and Callorhinchus milii)could partly explain the absence of hard bone in their endoskeleton.Overall,this genome resource provides new insights into the niche adaptation,body plan,and skeleton formation of P.leopoldi,as well as the genome evolution in cartilaginous fishes. | Jingqi Zhou Ake Liu Funan He Yunbin Zhang Libing Shen Jun Yu Xiang Zhang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
| 17 | Hepatoblastoma with neonatal necrotizing enterocolitis:Two case reports显示文摘We report two children with hepatoblastoma(HB)with a history of neonatal necrotizing enterocolitis(NEC).Case 1 was diagnosed with HB at 5 months of age.Liver enlargement was found during the NEC operation at 3 months of age and then was clinically diagnosed by imaging.After six chemotherapy courses,a partial hepatectomy was performed.Three months after ceasing the chemotherapy,a chest computed tomography scan suggested that distant metastasis of the tumor should be considered,and the lesion was removed.However,9 months after the operation,alpha-fetoprotein concentrations were increased,and abdominal imaging showed a recurrence of the tumor in situ,resulting in a hepatectomy.Case 2 was diagnosed with NEC shortly after birth and underwent an intestinal resection and anastomosis 1 month later.He was diagnosed with HB at 3 years of age.Hepatectomy was performed after five courses of chemotherapy.Chemotherapy was stopped after 10 courses,and alpha-fetoprotein concentrations were normal.At present,both children have survived and are in a healthy condition.Physicians should be aware of the possibility of HB and a history of NEC in children.Premature birth and low birth weight are common factors leading to the pathogenesis of HB and NEC.The association between these two diseases requires further study。 | Sidou He Xisi Wang Chao Duan Wen Zhao Chiyi Jiang Shihan Zhang Binglin Jian Wei Yang Tong Yu Libing Fu Huanmin Wang Xiaoli Ma | 2023 | Cancer Innovation2023，2，6： | 0 |
| 18 | Quantitative analysis of the difference of lesion degree between male and female COVID-19 based on digital modeling显示文摘The purpose of this study is to research the difference of lesion volume and its constituent ratio of lung volume of Novel Coronavirus Pneumonia(NCP)between male and female by digital technology.In this study,the CT imaging data and clinical data of 40 NCP patients in Huaihua were collected and divided into two groups:male(n=22)and female(n=18)according to gender. | Yu Huan Liu Guangxing Zhan Meizhi Zhang Zhenwu Sheng Ting Liu Yating Mi Sirong Xie Liang Zhang Feng Hu Luying He Wenyan Rao Libing | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 19 | Study on bone morphology and development of children based on digital three dimensional reconstruction显示文摘This study aims to construct the skeletal system of children at different ages through digital modeling techniques,explore the law of morphological development of childen's skeletal system,so as to provide a reference for the study of children's bone development and digital anatomy.In this study,12 normal boys were selected from 6 age stages(0-6 months,6-12 months,1-3 years old,3-5 years old,5-7 years old,7-10 years old).All patients underwent CT plain scan with a slice thickness of 0.625 mm.The collected CT data was imported into Mimics 19.0 software for three dimensional reconstruction of children's whole body bones.3D printing of children's bone model was used to construct children's bone system.T wo dissected bone specimens were randomly selected and compared with 3D printed models for specific bony landmarks to verify the accuracy of modeling. | Mi Sirong Xie Liang Hu Luying Zhang Feng He Wenyan Liu Guangxing Zhang Zhenwu Yu Huan Zhan Meizhi Liu Yating Sheng Ting Peng Wen Liu Qiangsheng Rao Libing | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 20 | Detection of FOXO1 break-apart status by fluorescence in situ hybridization in atypical alveolar rhabdomyosarcoma显示文摘The morphologies of alveolar rhabdomyosarcoma(ARMS) are various. Some cases entirely lack an alveolar pattern and instead display a histological pattern that overlaps with embryonal rhabdomyosarcoma(ERMS). The method of pathological diagnosis of ARMS and ERMS has been updated in the 4th edition of the World Health Organization's guidelines for classification of skeletal muscle tumors. Under the new guidelines, there is still no molecular test to distinguish between these two subtypes of rhabdomyosarcoma(RMS). In the present study, we applied fluorescent in situ hybridization(FISH) and found that the Forkhead box O1(FOXO1) gene broke apart, amplified, and displayed an aneuploid signal that was related to the RMS pathological subtype.Aside from the fact that FOXO1 break-apart and its amplification were correlated with atypical ARMS, aneuploidies were usually found in atypical ERMS. In conclusion, our results detail a potential biomarker to improve the accuracy of pathological diagnosis by discriminating between atypical ARMS and atypical ERMS. | Libing Fu Yaqiong Jin Chao Jia Jie Zhang Jun Tai Hongbin Li Feng Chen Jin Shi Yongli Guo Xin Ni Lejian He | 2017 | Science China(Life Sciences)2017，60，7： | 0 |
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