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| 1 | Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial显示文摘 | Gunnar Folprecht Thomas Gruenberger Wolf O Bechstein Hans-Rudolf Raab Florian Lordick J?rg T Hartmann Hauke Lang Andrea Frilling Jan Stoehlmacher Jürgen Weitz Ralf Konopke Christian Stroszczynski Torsten Liersch Detlev Ockert Thomas Herrmann Eray Goekkurt | 2010 | Lancet Oncology2010，，1： | 3 |
| 2 | 用于433MHz ISM频带的低功耗超再生接收器显示文摘设计师经常选择超再生接收器(super-regenerative recelvr)——尽管它的频率不稳定,选择性较差——用于那些以功耗为主要问题的电池供电短距离无线应用,例如远程无钥匙进入系统,汽车警报、生物医学监视器、传感器网络、计算机外设(参考文献1)。超再生检测器还能通过斜率检测来解调频率调制信号。 | Cedric Mélange Johan Bauwelinck Jan Vandewege | 2006 | 电子设计技术 EDN CHINA2006，13，5： | 2 |
| 3 | C-Methyl-flavonoids from the leaf waxes of some Myrtaceae显示文摘 | Eckhard Wollenweber Rüdiger Wehde Marion D?rr Günter Lang Jan F Stevens | 2000 | Phytochemistry2000，，8： | 1 |
| 4 | Human impact on the environment in the Ethiopian and Eritrean highlands—a state of the art显示文摘 | Jan Nyssen Jean Poesen Jan Moeyersons Jozef Deckers Mitiku Haile Andreas Lang | 2003 | Earth Science Reviews2003，，3： | 1 |
| 5 | Critical analysis of cyanoacrylate in intestinal and colorectal anastomosis显示文摘 | Zhouqiao Wu Geesien S. A. Boersema Konstantinos A. Vakalopoulos Freek Daams Cloe L. Sparreboom Gert‐Jan Kleinrensink Johannes Jeekel Johan F. Lange | 2014 | J. Biomed. Mater. Res2014，，3： | 1 |
| 6 | Simultaneous splenectomy increases risk for opportunistic pneumonia in patients after liver transplantation显示文摘 | Ulf P. Neumann Jan M. Langrehr Udo Kaisers Martina Lang Volker Schmitz Peter Neuhaus | 2002 | Transplant International2002，，5： | 1 |
| 7 | Transjugular intrahepatic portosystemic shunt improves oxygenation in hepatopulmonary syndrome显示文摘 | Jonathan L. Riegler Kevin A. Lang Stephen P. Johnson Jan H. Westerman | 1995 | Gastroenterology1995，，3： | 1 |
| 8 | SIGNIFICANCE OF A T-LYMPHOCYTOTOXIC CROSSMATCH IN LIVER AND COMBINED LIVER-KIDNEY TRANSPLANTATION显示文摘 | Ulf P. Neumann Martina Lang Anja Moldenhauer Jan M. Langrehr Matthias Glanemann Andreas Kahl Ullrich Frei Wolf O. Bechstein Peter Neuhaus | 2001 | Transplantation2001，，8： | 1 |
| 9 | Serum bile acids in liver transplantation – early indicator for acute rejection and monitor for antirejection therapy显示文摘 | H. Jan?en Reinhard Lange Jochen Erhard Giuliano Testa Massimo Malagó Petra Jan?en Friedrich W. Eigler Christoph E. Broelsch | 2001 | Transplant International2001，，6： | 1 |
| 10 | Serum bile acids in liver transplantation – early indicator for acute rejection and monitor for antirejection therapy显示文摘 | H. Jan?en Reinhard Lange Jochen Erhard Giuliano Testa Massimo Malagó Petra Jan?en Friedrich W. Eigler Christoph E. Broelsch | 2001 | Transplant International2001，，6： | 1 |
| 11 | The Basel Ⅱ reform and retail credit markets显示文摘 | Jan Krahnen William W Lang | 2005 | Journal of Financial Services Research2005，，28： | 1 |
| 12 | Extraction and DFT study on the complexation of H3O^+ with hexaethylp-tert-butylcalix atone hexaaoctate 显示文摘 | Jan Lang | 2007 | J Mole Struct2007，846，： | 1 |
| 13 | Thoracoscopy versus thoracotomy: a prospective comparison of trauma and quality of life显示文摘 | Rolf F?rster Martin Storck Jan Sch?fer Eva H?nig Gunter Lang Florian Liewald | 2002 | Langenbeck’s Archives of Surgery2002，，1： | 1 |
| 14 | Loss of PSP94 expression is associated with early PSA recurrence and deteriorates outcome of PTEN deleted prostate cancers显示文摘Objective: Prostate secretory protein of 94 amino acids(PSP94) is a target gene of the EZH2 transcriptional repressor and is often downregulated in prostate cancer;however, its prognostic value is disputed.Methods: Immunohistochemical analysis of a tissue microarray of 12, 432 prostate cancer specimens was performed to evaluate PSP94 expression. Correlation of PSP94 expression with tumor phenotype, patient prognosis, TMPRSS2:ERG fusion status, EZH2 expression and PTEN deletion was studied.Results: PSP94 expression was increased in benign prostatic hyperplasia;however, it was downregulated in 48% and negative in42% of the 9, 881 interpretable prostate cancer specimens. The loss of PSP94 expression was inversely correlated to EZH2 expression(P < 0.0001) and largely unrelated to the ERG status, but strongly correlated with high Gleason grade, advanced tumor stage, and nodal metastasis(P <0.0001 each). The fraction of PSP94-negative cancer specimens increased from 40% in pT2 to 52%in pT3 b-pT4(P < 0.0001) and from 40% in Gleason 3+3 = 6 to 46% in Gleason 4+3 = 7 and 60% in Gleason ≥4+4 = 8(P <0.0001). Loss of PSP94 was linked to early prostate-specific antigen recurrence, but with little absolute effect(P < 0.0001).However, it provided additional prognostic impact in cancer specimens with PTEN deletion. Loss of PSP94 deteriorated prognosis of cancer patients with PTEN deletion by more than 10%(P < 0.0001). The combination of PTEN deletion and PSP94 loss provided independent prognostic information that was observed in several subgroups defined by classical and quantitative Gleason grade.Conclusions: The results of our study suggest that combined PSP94/PTEN analysis can be potentially used in the clinical prognosis of prostate cancer. | Andreas M. Luebke Ali Attarchi-Tehrani Jan Meiners Claudia Hube-Magg Dagmar S. Lang Martina Kluth Maria Christina Tsourlakis Sarah Minner Ronald Simon Guido Sauter Franziska Buscheck Frank Jacobsen Andrea Hinsch Stefan Steurer Thorsten Schlomm Hartwig Huland Markus Graefen Alexander Haese Hans Heinzer Till S. Clauditz Eike Burandt Waldemar Wilczak Doris Hoflmayer | 2019 | Cancer Biology & Medicine2019，16，2： | 1 |
| 15 | Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication显示文摘 | Agnel Sfeir Settapong T. Kosiyatrakul Dirk Hockemeyer Sheila L. MacRae Jan Karlseder Carl L. Schildkraut Titia de Lange | 2009 | Cell2009，，1： | 1 |
| 16 | ERCC1/XPF Removes the 3′ Overhang from Uncapped Telomeres and Represses Formation of Telomeric DNA-Containing Double Minute Chromosomes显示文摘 | Xu-Dong Zhu Laura Niedernhofer Bernhard Kuster Matthias Mann Jan H.J Hoeijmakers Titia de Lange | 2003 | Molecular Cell2003，，6： | 1 |
| 17 | Avoiding or Reversing Hartmann’s Procedure Provides Improved Quality of Life After Perforated Diverticulitis显示文摘 | Jefrey Vermeulen Martijn P. Gosselink Jan J. V. Busschbach Johan F. Lange | 2010 | Journal of Gastrointestinal Surgery2010，，4： | 1 |
| 18 | Laparoscopic hepatectomy reduces postoperative complications and hospital stay in overweight and obese patients显示文摘BACKGROUND Laparoscopic liver surgery is currently considered the standard of care for various liver malignancies.However,studies focusing on perioperative outcome after laparoscopic hepatectomy(LH)in overweight patients are still sparse and its benefit compared to open hepatectomy(OH)is a matter of debate.AIM To analyze postoperative outcomes in overweight[body mass index(BMI)over 25 kg/m²]and obese(BMI over 30 kg/m²)patients undergoing LH and compare postoperative outcome with patients undergoing OH.METHODS Perioperative data of 68 overweight(BMI over 25 kg/m²)including a subcohort of obese(BMI over 30 kg/m²)patients(n=27)who underwent LH at our institution between 2015 and 2019 were retrospectively analyzed regarding surgical outcome and compared to an equal number of patients undergoing OH.RESULTS The mean BMI was 29.8±4.9 kg/m2 in the LH group and 29.7±3.6 kg/m2 in the OH group with major resections performed in 20.6%(LH)and 26.5%(OH)of cases,respectively.Operative time(194±88 min vs 275±131 min;P<0.001)as well as intensive care(0.8±0.7 d vs 1.1±0.8 d;P=0.031)and hospital stay(7.3±3.6 d vs 15.7±13.5 d;P<0.001)were significant shorter in the LH group.Also,overall complications(20.6%vs 45.6%;P=0.005)and major complications(1.5%vs 14.7%,P=0.002)were observed less frequently after LH.An additional investigation analyzing the subgroup of obese patients who underwent LH(n=27)and OH(n=29)showed a shorter operative time(194±81 min vs 260±137 min;P=0.009)and a reduced length of hospitalization(7.7±4.3 d vs 17.2±17 d;P<0.001)but no difference in postoperative complications or overall cost.CONCLUSION LH is safe and cost-effective in overweight and obese patients.Furthermore,LH is significantly associated with fewer postoperative complications and reduced hospital stay compared to OH in these patients. | Daniel Heise Jan Bednarsch Andreas Kroh Sandra Schipper Roman Eickhoff Marielle Coolsen Ronald Van Dam Sven Lang Ulf Neumann Florian Ulmer | 2021 | World Journal of Gastrointestinal Surgery2021，13，1： | 1 |
| 19 | A new mutation in the SH3BP2 gene showing reduced penetrance in a family affected with cherubism显示文摘 | Jan de Lange Merel C. van Maarle Hans P. van den Akker Egbert J.W. Redeker | 2007 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology2007，，3： | 1 |
| 20 | Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial显示文摘 | Gunnar Folprecht Thomas Gruenberger Wolf O Bechstein Hans-Rudolf Raab Florian Lordick J?rg T Hartmann Hauke Lang Andrea Frilling Jan Stoehlmacher Jürgen Weitz Ralf Konopke Christian Stroszczynski Torsten Liersch Detlev Ockert Thomas Herrmann Eray Goekkurt | 2010 | Lancet Oncology2010，，1： | 1 |
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