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| 1 | Coronary artery disease in congenital single coronary artery in adults:A Dutch case series显示文摘AIM:To assess the current diagnostic and therapeutic management and the clinical implications of congenital single coronary artery(SCA) in adults.METHODS:We identified 15 patients with a SCA detected from four Dutch angiography centers in the period between 2010 and 2013.Symptomatic patients who underwent routine diagnostic coronary angiography(CAG) for suspected coronary artery disease and who incidentally were found to have isolated SCA were analyzed.RESULTS:Fifteen(7 females) with a mean age of 58.5 ± 13.78 years(range 43-86) had a SCA.ConventionalCAG demonstrated congenital isolated SCA originating as a single ostium from the right sinus of Valsalva in 6 patients and originating from the left in 9 patients.Minimal to moderate coronary atherosclerotic changes were found in 4,and severe stenotic lesions in another 4 patients.Seven patients were free of coronary atherosclerosis.Runs of non-sustained ventricular tachycardia were documented in 2 patients,one of whom demonstrated transmural ischemic changes on presentation.Myocardial perfusion scintigraphic evidence of transmural myocardial ischemia was found in 1 patient due to kinking and squeezing of the SCA with an interarterial course between the aorta and pulmonary artery.Multi-slice computed tomography(MSCT) was helpful to delineate the course of the anomalous artery relative to the aorta and pulmonary artery.Percutaneous coronary intervention was successfully performed in 3 patients.Eight patients were managed medically.Arterial bypass graft was performed in 4 patients with the squeezed SCA.CONCLUSION:SCA may be associated with transient transmural myocardial ischemia and aborted sudden death in the absence of coronary atherosclerosis.The availability and sophistication of MSCT facilitates the delineation of the course of a SCA.We present a Dutch case series and review of the literature. | Salah AM Said Willem G de Voogt Suat Bulut Jacques Han Peter Polak Rogier LG Nijhuis Jeroen W op den Akker Andries Slootweg | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 2 | Understanding the Removal and Fate of Selected Drugs of Abuse in Sludge and Biosolids from Australian Wastewater Treatment Operations显示文摘Illicit and pharmaceutical drugs are considered to be emerging contaminants of concern,and much research effort has gone into assessing their occurrence in wastewater.However,little information exists on their presence in treated sludge or biosolids.In this study,we examined sludge and biosolids from a large metropolitan wastewater treatment plant(WWTP)in Australia to determine the occurrence of five drugs of abuse,including benzoylecgonine as indicator of cocaine consumption,methamphetamine and 3,4-methylenedioxy methamphetamine(MDMA)as representative illicit stimulants,and codeine and morphine as pharmaceuticals with potential environmental risk.The samples were solid-phase extracted and analyzed by liquid chromatography–tandem mass spectrometry(LC–MS/MS).Benzoylecgonine and MDMA were present in raw sludge but were notably degraded during solids treatment processes,and were not detected in the dewatered sludge(after treatment)or in biosolids.Methamphetamine,codeine,and morphine were detected in all biosolids samples at mean concentrations of 20–50 lg kg^-1.The presence of these three drugs in biosolids shows that these compounds are relatively stable in the solids and in soil,and can persist in biosolids for at least several years.A simple environmental risk assessment based on estimated risk quotients(RQs)for these compounds indicated that the potential environmental risks associated with the land application of biosolids are very low at typical Australian biosolids application rates. | Meena K.Yadav Cobus Gerber Christopher P.Saint Ben Van den Akker Michael D.Short | 2019 | Engineering2019，5，5： | 3 |
| 3 | 多病并存的多重挑战 这个时代已经到来——关注日益增长的脆弱人群的需求显示文摘多病并存(或称多重病)现象在初级卫生保健中已不是个别现象。最近在加拿大魁北克省沙格奈河地区进行的一项有21个社区医院参加的研究表明,在18~44岁组多重病的患病率为69%,45~64岁组为93%,65岁以上组达到98%,患慢性病的个数在年轻组为2.8而在老年组升至6.4。其他国家也报告了类似的疾病负担状况,如美国多病并存的患者人数将由2000年的6000万上升到2020年的8100万。 | Martin Fortin Hassan Soubhi Catherine Hudon Elizabeth A Bayliss Marian van den Akker 赛晓勇 | 2007 | 英国医学杂志中文版2007，10，5： | 2 |
| 4 | Crystal structure of heat-labile enterotoxin from Escherichia coli with increased thermostability introduced by an engineered disulfide bond in the A subunit 显示文摘 | Van Den Akker F Feil I K Roach C | 1997 | Protein Science1997，6，： | 1 |
| 5 | Large eddy simulations on the flow driven by a rushton turbine显示文摘 | Derksen J Van den Akker H E A | 1999 | AIChE J1999，45，： | 1 |
| 6 | Medical-grade honey kills antibiotic-resistant bacteria in vitro and eradicates skin colonization 显示文摘 | Kwakman PH Vanden Akker JP | 2008 | Clin Infect Dis2008，46，11： | 1 |
| 7 | Invasive mechanical ventilation as a risk factor for acute kidney injury in the critically ill: a systematic review and meta-analysis显示文摘 | van den Akker JP Egal M Groeneveld JA | 2013 | Crit Care2013，17，3： | 1 |
| 8 | Toddlers'tem- perament profiles: stability and relations to negative and positive parenting显示文摘 | van den Akker A L Dekovi6 M Prinzie P | 2010 | J Abnorm Child Psychol2010，38，4： | 1 |
| 9 | Pseudomonas aeruginosa dose response and bathing water infection显示文摘 | ROSER D J VAN DEN AKKER B BOASE S | 2014 | Epidemiol Infect Mar2014，142，： | 1 |
| 10 | Stem cell factor induces phosphatidylinositol 3-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells 显示文摘 | VAN dIJK T B VAN DEN AKKER E AMELSVOORT M P | 2000 | Blood2000，96，10： | 1 |
| 11 | Measurements on wave propagation and bubble and slug velocities in concurrent upward two-phase flow显示文摘 | LEGIUS H J W VAN DEN AKKER H E A NARUMO T | 1997 | Experimental Thermal and Fluid Science1997，1，5： | 1 |
| 12 | Herbivore impact on grassland plant diversity depends on habitat productivity and herbivore size显示文摘 | P akker E S Ritchie M E Olff H | 2006 | Ecology Letters2006，9，： | 1 |
| 13 | An experimental and numerical study ofturbulent swirling flow in gas cyclones 显示文摘 | HOEKSTRA A J DERKSEN J J VAN DEN AKKER H E A | 1999 | Chemical Engineering Science1999，54，： | 1 |
| 14 | Cellular decisions in cardiac outflow tract and coronary development: An act by VEGF and NOTCH 显示文摘 | vanden Akker NM Caolo V Molin DG | 2012 | Differentiation2012，84，1： | 1 |
| 15 | Measurements on Wave Propagation and Bubble and Slug Velocities in Cocurrent upward Two-Phase Flow Experimental 显示文摘 | Legius H J W M van den Akker H E A Narumo T | 1997 | Thermal arid Fluid Science1997，15，： | 1 |
| 16 | An experimental and numerical study of turbulent swirling flow in gas cyclones 显示文摘 | HOEKSTRA A J DERKSEN J J van Den Akker H E A | 1999 | Chem Eng Sci1999，54，13： | 1 |
| 17 | Degradation of 3-chlorobenzoate under low- oxygen conditions in pure and mixed cultures of the anoxygenic photoheterotroph Rhodopseudomonas palustris DCP3 and an aerobic aerobic Alcaligenes species 显示文摘 | KROONEMAN J VANDER AKKER S GOMES T M P | 1999 | Appl Environ Microbiol1999，65，1： | 1 |
| 18 | Initial nutritional management of the preterm infants显示文摘 | Vlaardingerbroek H van Goudoever JB van den Akker CH | 2009 | Early Hum Dev2009，85，11： | 1 |
| 19 | Toddlers' temperament profiles: stability and relations to negative and positive parenting显示文摘 | Van den Akker AL Dekovic' M Prinzie P | 2010 | J Abnorm Child Psychol2010，38，4： | 1 |
| 20 | Effect of elevating the skin temperature during topical ALA application on in vitro ALA penetration through mouse skin and in vivo PpLX production in human skin 显示文摘 | VAN DEN AKKEr JT BOOT K VERNON DI | 2004 | Photochem Photobiol Sci2004，3，3： | 1 |
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