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| 1 | Reduced esophageal cancer incidence in statin users,particularly with cyclo-oxygenase inhibition显示文摘AIM:To examine the association between statin use and the development of esophageal cancer METHODS:We performed a systematic review and meta-analysis.Multiple databases(Pubmed,EMBASE,Cochrane Library,Web of Science,Wiley Interscience and Google Scholar) were systematically searched for studies reporting the association of statin use and the development of esophageal cancer.Literature searching and data abstraction were performed independently by two separate researchers.The quality of studies reviewed was evaluated using the Newcastle-Ottawa Quality assessment scale.Meta-analysis on the relationship between statin use and cancer incidence was performed.The effect of the combination of statin plus a cyclo-oxygenase inhibitor was also examined.RESULTS:Eleven studies met eligibility criteria,9 high and 2 medium quality.All were observational studies.Studies examining adenocarcinoma development in Barrett's esophagus included 317 cancers and 1999 controls,population-based studies examining all esophageal cancers included 371203 cancers and 6083150 controls.In the Barrett's population the use of statins(OR = 0.57;95%CI:0.43-0.75) and cyclo-oxygenase inhibitors(OR = 0.59;95%CI:0.45-0.77) were independently associated with a reduced incidence of adenocarcinoma.Combined use of a statin plus cyclooxygenase inhibitor was associated with an even lower adenocarcinoma incidence(OR = 0.26;95%CI:0.1-0.68).There was more heterogeneity in the population-based studies but pooled adjusted data showed that statin use was associated with a lower incidence of all combined esophageal cancers(OR = 0.81;95%CI:0.75-0.88).CONCLUSION:Statin use in patients with Barrett's oesophagus is associated with a significantly lower incidence of adenocarcinoma.The chemopreventive actions of statins,especially combined with cyclooxygenase inhibitors deserve further exploration. | Ian Leonard Phillip Beales Abigail Hensley Yoon Loke | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，3： | 5 |
| 2 | Development of a 100 J,10 Hz laser for compression experiments at the High Energy Density instrument at the European XFEL显示文摘In this paper we review the design and development of a 100 J, 10 Hz nanosecond pulsed laser, codenamed DiPOLE100 X,being built at the Central Laser Facility(CLF). This 1 kW average power diode-pumped solid-state laser(DPSSL) is based on a master oscillator power amplifier(MOPA) design, which includes two cryogenic gas cooled amplifier stages based on DiPOLE multi-slab ceramic Yb:YAG amplifier technology developed at the CLF. The laser will produce pulses between 2 and 15 ns in duration with precise, arbitrarily selectable shapes, at pulse repetition rates up to 10 Hz, allowing real-time shape optimization for compression experiments. Once completed, the laser will be delivered to the European X-ray Free Electron Laser(XFEL) facility in Germany as a UK-funded contribution in kind, where it will be used to study extreme states of matter at the High Energy Density(HED) instrument. | Paul Mason Saumyabrata Banerjee Jodie Smith Thomas Butcher Jonathan Phillips Hauke Hoppner Dominik Moller Klaus Ertel Mariastefania De Vido Ian Hollingham ANDrew Norton Stephanie Tomlinson Tinesimba Zata Jorge Suarez Merchan Chris Hooker Mike Tyldesley Toma Toncian Cristina HernANDez-Gomez Chris Edwards John Collier | 2018 | High Power Laser Science and Engineering2018，6，4： | 4 |
| 3 | Improved Graft Mesenchymal Stem Cell Survival in Ischemic Heart With a Hypoxia-Regulated Heme Oxygenase-1 Vector显示文摘 | Yao Liang Tang Yi Tang Y. Clare Zhang Keping Qian Leping Shen M. Ian Phillips | 2005 | Journal of the American College of Cardiology2005，，7： | 2 |
| 4 | The potential role of antisense oligodeoxynucleotide therapy for cardiovascular disease显示文摘 | Ian M Phillips SM Galli | 2000 | Drugs2000，60，2： | 1 |
| 5 | PolyaCrylamide+-Al2 (SO4)3 and polyaCrylamide+CaO remove coliform bacteria and nutrients from swine wastewater 显示文摘 | James A Entry Ian Phillips Helen Stratton | 2003 | Enviro mental Pollution2003，，121： | 1 |
| 6 | Seuderi Split Cycle Research Engine:Overview, Architecture and Operation 显示文摘 | Ford Phillips Ian Gilbert Jean-Pierre Pirault and Marc Megel | 2011 | SAE Paper2011，，： | 1 |
| 7 | Prevalence and Morphology of Pouch and Ileal Adenomas in Familial Adenomatous Polyposis显示文摘 | Christopher J. Groves Iain G. Beveridge David J. Swain Brian?P. Saunders Ian C. Talbot R. John Nicholls Robin K. Phillips | 2005 | Diseases of the Colon & Rectum2005，，4： | 1 |
| 8 | Delivery, deposition and redistribution of fine sediments within macrotidal Fitzroy Estuary/Keppel Bay: Southern Great Barrier Reef, Australia显示文摘 | Ian T W Phillip W F | 2010 | Continental Shelf Research2010，30，： | 1 |
| 9 | Large Villous Adenomas Arising in Ileal Pouches in Familial Adenomatous Polyposis: Report of Two Cases显示文摘 | Iain G. Beveridge M.R.C.P. David J. W. Swain R.N. Chris J. Groves M.R.C.P. Brian P. Saunders M.R.C.P. Alastair C. Windsor F.R.C.S. Ian C. Talbot F.R.C.Path. R. John Nicholls F.R.C.S. Robin K. S. Phillips F.R.C.S | 2004 | Diseases of the Colon & Rectum2004，，1： | 1 |
| 10 | Toxicity Reduction Evaluation, Toxicity Identification Evaluation and Toxicity Tracking in Direct Toxicity Assessment显示文摘 | Matt Hutchings Ian Johnson Elaine Hayes Andrew E. Girling John Thain Kevin Thomas Rachel Benstead Graham Whale Joy Wordon Ruth Maddox Phillip Chown | 2004 | Ecotoxicology2004，，5： | 1 |
| 11 | Rosiglitazone Reduces the Accelerated Neointima Formation After Arterial Injury in a Mouse Injury Model of Type 2 Diabetes显示文摘 | J. William Phillips Kurt G. Barringhaus John M. Sanders Zandong Yang Meng Chen Sean Hesselbacher Ann C. Czarnik Klaus Ley Jerry Nadler Ian J. Sarembock | 2003 | Circulation: Journal of the American Heart Association2003，，16： | 1 |
| 12 | Effect of emulsion drop-size distribution upon coalescence in simple shear flow: A population balance study显示文摘 | Ian M. Klink Ronald J. Phillips Stephanie R. Dungan | 2010 | Journal of Colloid And Interface Science2010，，2： | 1 |
| 13 | Joubert syndrome ( and related disorders) 显示文摘 | Melissa A Dan Doherty Phillip F Ian A | 2007 | European Journal of Human Genetics2007，15，： | 1 |
| 14 | The Comparative In Vitro Activity of FK-037 (Cefoselis), a New Broad-Spectrum Cephalosporin显示文摘 | Anna King Linda Bethune Ian Phillips | 1995 | Clin Mierobiol Infection1995，1，1： | 1 |
| 15 | Mobilizing of haematopoietic stem cells to ischemic myocardium by plasmid-mediated stromal-cell-derived factor-1α treatment显示文摘 | Yao Liang Tang Keping Qian Y. Clare Zhang Leping Shen M. Ian Phillips | 2004 | Regulatory Peptides2004，，1： | 1 |
| 16 | Cloning and functional characterisation of a cis -muuroladiene synthase from black peppermint ( Mentha <ce:hsp sp='0.25'/>×<ce:hsp sp='0.25'/> piperita ) and direct evidence for a chemotype unable to synthesise farnesene显示文摘 | Ian M. Prosser Racheal J. Adams Michael H. Beale Nathan D. Hawkins Andrew L. Phillips John A. Pickett Linda M. Field | 2005 | Phytochemistry2005，，15： | 1 |
| 17 | Cardiac mortality is higher around Christmas and New Year's than at any other time:the holidays as a risk factor for death显示文摘 | David P Phillip Jason R Jarvinen Ian S Abramson | 2004 | Circulation2004，110，： | 1 |
| 18 | Perforating unconsolidated sand:an experimental and theoretical investigation显示文摘 | Walton Ian C Atwood David C Halleck Phillip M | 2002 | SPE Drilling and Completion2002，17，3： | 1 |
| 19 | Perforating unconsolidated sand:An experimental and theoretical investigation显示文摘 | Walton Ian C Atwood David C Halleck Phillip M | 2002 | SPE Drilling and Completion2002，17，3： | 1 |
| 20 | Hypoxic Preconditioning Enhances the Benefit of Cardiac Progenitor Cell Therapy for Treatment of Myocardial Infarction by Inducing CXCR4 Expression显示文摘 | Yao Liang Tang Wuqiang Zhu Min Cheng Lijuan Chen John Zhang Tao Sun Raj Kishore M Ian Phillips Douglas W. Losordo Gangjian Qin | 2009 | Circulation Research2009，，10： | 1 |
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