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| 1 | Is early limited surgery associated with a more benign disease course in Crohn's disease?显示文摘AIM:To analyze the difference in disease course and need for surgery in patients with Crohn’s disease(CD).METHODS:Data of 506 patients with incident CD were analyzed(age at diagnosis:31.5±13.8 years).Both hospital and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which includes incident CD patients diagnosed between January 1,1977 and December 31,2008.Follow-up data were collected until December 31,2009.All patients included had at least 1year of follow-up available.Patients with indeterminate colitis at diagnosis were excluded from the analysis.RESULTS:Overall,73 patients(14.4%)required resective surgery within 1 year of diagnosis.Steroid exposure and need for biological therapy were lower in patients with early limited surgery(P<0.001 and P=0.09).In addition,surgery rates during follow-up in patients with and without early surgery differed significantly after matching on propensity scores(P<0.001,HR=0.23).The need for reoperation was also lower in patients with early limited resective surgery(P=0.038,HR=0.42)in a Kaplan-Meier and multivariate Cox regression(P=0.04)analysis.However,this advantage was not observed after matching on propensity scores(PLogrank=0.656,PBreslow=0.498).CONCLUSION:Long-term surgery rates and overall exposure to steroids and biological agents were lower in patients with early limited resective surgery,but reoperation rates did not differ. | Petra Anna Golovics Laszlo Lakatos Attila Nagy Tunde Pandur Istvan Szita Mihaly Balogh Csaba Molnar Erzsebet Komaromi Barbara Dorottya Lovasz Michael Mandel Gabor Veres Lajos S Kiss Zsuzsanna Vegh Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，43： | 3 |
| 2 | Evolution of disease phenotype in adult and pediatric onset Crohn's disease in a population-based cohort显示文摘AIM:To investigate the evolution of disease phenotypein adult and pediatric onset Crohn's disease(CD) populations,diagnosed between 1977 and 2008.METHODS:Data of 506 incident CD patients were analyzed(age at diagnosis:28.5 years,interquartile range:22-38 years).Both in-and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which included incident patients diagnosed between January 1,1977 and December 31,2008 in adult and pediatric onset CD populations.Disease phenotype according to the Montreal classification and long-term disease course was analysed according to the age at onset in time-dependent univariate and multivariate analysis.RESULTS:Among this population-based cohort,seventy-four(12.8%) pediatric-onset CD patients were identified(diagnosed ≤ 17 years of age).There was no significant difference in the distribution of disease behavior between pediatric(B1:62%,B2:15%,B3:23%) and adult-onset CD patients(B1:56%,B2:21%,B3:23%) at diagnosis,or during follow-up.Overall,the probability of developing complicated disease behaviour was 49.7% and 61.3% in the pediatric and 55.1% and 62.4% in the adult onset patients after 5-and 10-years of follow-up.Similarly,time to change in disease behaviour from non stricturing,non penetrating(B1) to complicated,stricturing or penetrating(B2/B3) disease was not significantly different between pediatric and adult onset CD in a Kaplan-Meier analysis.Calendar year of diagnosis(P = 0.04),ileal location(P < 0.001),perianal disease(P < 0.001),smoking(P = 0.038) and need for steroids(P < 0.001) were associated with presence of,or progression to,complicated disease behavior at diagnosis and during follow-up.A change in disease location was observed in 8.9% of patients and it was associated with smoking status(P = 0.01),but not with age at diagnosis.CONCLUSION:Long-term evolution of disease behavior was not different in pediatric-and adult-onset CD patients in this population-based cohort but was associated to location,perianal disease and smoking status. | Barbara Dorottya Lovasz Laszlo Lakatos Agnes Horvath Istvan Szita Tunde Pandur Michael Mandel Zsuzsanna Vegh Petra Anna Golovics Gabor Mester Mihaly Balogh Csaba Molnar Erzsebet Komaromi Lajos Sandor Kiss Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，14： | 2 |
| 3 | Hyponatremia, Hypernatremia, and Mortality in Patients With Chronic Kidney Disease With and Without Congestive Heart Failure显示文摘 | Csaba P. Kovesdy Evan H. Lott Jun Ling Lu Sandra M. Malakauskas Jennie Z. Ma Miklos Z. Molnar Kamyar Kalantar-Zadeh | 2012 | Circulation2012，，5： | 2 |
| 4 | The risk of lymphoma and immunomodulators in patients with inflammatory bowel diseases: Results from a population-based cohort in Eastern Europe显示文摘 | Peter L. Lakatos Barbara D. Lovasz Gyula David Tunde Pandur Zsuzsanna Erdelyi Gabor Mester Mihaly Balogh Istvan Szipocs Csaba Molnar Erzsebet Komaromi Petra A. Golovics Zsuzsanna Vegh Michael Mandel Agnes Horvath Miklos Szathmari Lajos S. Kiss Laszlo Laka | 2012 | Journal of Crohn’s and Colitis2012，，： | 1 |
| 5 | Risk of colorectal cancer and small bowel adenocarcinoma in Crohn’s disease: A population-based study from western Hungary 1977–2008显示文摘 | Peter Laszlo Lakatos Gyula David Tunde Pandur Zsuzsanna Erdelyi Gabor Mester Mihaly Balogh Istvan Szipocs Csaba Molnar Erzsebet Komaromi Lajos S. Kiss Laszlo Lakatos | 2010 | Journal of Crohn’s and Colitis2010，，2： | 1 |
| 6 | Associations of pre‐transplant anemia management with post‐transplant delayed graft function in kidney transplant recipients显示文摘 | Miklos Z. Molnar Csaba P. Kovesdy Laszlo Rosivall Suphamai Bunnapradist Junichi Hoshino Elani Streja Mahesh Krishnan Kamyar Kalantar‐Zadeh | 2012 | Clin Transplant2012，，5： | 1 |
| 7 | IBD in the elderly population: Results from a population-based study in Western Hungary, 1977–2008显示文摘 | Peter Laszlo Lakatos Gyula David Tunde Pandur Zsuzsanna Erdelyi Gabor Mester Mihaly Balogh Istvan Szipocs Csaba Molnar Erzsebet Komaromi Lajos S. Kiss Laszlo Lakatos | 2010 | Journal of Crohn’s and Colitis2010，，： | 1 |
| 8 | Symptoms of Depression in Kidney Transplant Recipients: A Cross-sectional Study显示文摘 | Lilla Szeifert Miklos Zsolt Molnar Csaba Ambrus Agnes Borbala Koczy Agnes Zsofia Kovacs Eszter Panna Vamos Andras Keszei Istvan Mucsi Marta Novak | 2009 | American Journal of Kidney Diseases2009，，1： | 1 |
| 9 | Silicone Lymphadenopathy After Breast Augmentation: Case Reports, Review of the Literature, and Current Thoughts 显示文摘 | George J Zambacos Csaba Molnar | 2013 | Aesthetic Plast Surg2013，37，： | 1 |
| 10 | Common and conflicting objectives and practices of herders and conservation managers:the need for a conservation herder显示文摘The mutual dependence of extensive land-use and conservation management has become appar-ent in Europe in the last 20-30 yr.Extensive land-use often survives in protected areas only,in the form of conservation management.Knowledge of extensive herding and that of conservation management are parts of two knowledge systems(traditional and scientific)which often leads to conflicts between locals and con-servationists.We studied two herding/conservation systems(salt steppes and wood-pastures),and devel-oped an inventory on the common/similar and conflicting/different objectives and pasture management practices of herders and conservationists.Data were collected by participatory knowledge co-production in teamwork of the co-authors(herders,conservation managers,and scientists).Data were analyzed and discussed in teamwork too.Herders and conservationists identified 23 objectives and 29 management prac-tices.We found a number of common interests with respect to herding,the ideal state of pastures,legal provisions,and communication.Conflict resolution recommendations(e.g.,on time and place of grazing,pasture improvements)were also developed.We argue that by co-production of knowledge,and establish-ment of a herder“school”the mitigation of the existing conflicts would be more effective.Our conclusion is that a new profession is needed:that of the conservation herder.The conservation herder shall be an indi-vidual knowledgeable about herding and pasture management,trained in conservation and ecology,able to design management experiments,and develop novel but tradition-based management practices.As such,he/she could facilitate adaptation of extensive herding in the changing socio-economic environment. | Zsolt Molnar Jozsef Kis Csaba Vadasz Laszlo Papp Istvan Sandor Sandor Beres Gabor Sinka Anna Varga | 2016 | Ecosystem Health and Sustainability2016，2，4： | 0 |
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