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| 1 | Prevalence and determinants of delayed gastric emptying in hospitalised Type 2 diabetic patients显示文摘AIM: To determine the prevalence of delayed gastric emptying (GE) in older patients with Type 2 diabetes mellitus. METHODS: One hundred and forty seven patients with Type 2 diabetes, of whom 140 had been hospitalised, mean age 62.3 ± 8.0 years, HbA1c 9.1% ± 1.9%, treated with either oral hypoglycemic drugs or insulin were studied. GE of a solid meal (scintigraphy), autonomic nerve function, upper gastrointestinal symptoms, acute and chronic glycemic control were evaluated. Gastric emptying results were compared to a control range of hospitalised patients who did not have diabetes. RESULTS: Gastric emptying was delayed (T50 > 85 min) in 17.7% patients. Mean gastric emptying was slower in females (T50 72.1 ± 72.1 min vs 56.9 ± 68.1 min, P = 0.02) and in those reporting nausea (112.3 ± 67.3 vs 62.7 ± 70.0 min, P < 0.01) and early satiety (114.0 ± 135.2 vs 61.1 ± 62.6 min, P = 0.02). There was no correlation between GE with age, body weight, duration of diabetes, neuropathy, current glycemia or the total score for upper gastrointestinal symptoms. CONCLUSION: Prolonged GE occurs in about 20% of hospitalised elderly patients with Type 2 diabetes when compared to hospitalised patients who do not have diabetes. Female gender, nausea and early satiety areassociated with higher probability of delayed GE. | Vladimir Kojecky Jaromir Bernatek Michael Horowitz Stanislav Zemek Jiri Bakala Ales Hep | 2008 | World Journal of Gastroenterology2008，14，10： | 8 |
| 2 | 乙酰半胱氨酸在急性心肌梗塞溶栓治疗中的抗氧化作用显示文摘27例急性心肌梗塞患者用链激酶溶栓治疗,其中20例联合静脉滴注乙酰半胱氨酸(NAC)。结果显示:联合应用NAC治疗后血浆还原型谷胱甘肽(GSH)及GSH与氧化型谷胱甘肽(GSSG)之比(GSH/GSSG)显著性增高(P<0.05),伴随GSSG显著性降低(P<0.05)。NAC治疗组心指数亦明显高于对照组(P<0.01)。 | 杨杰孚 IreneStafford Margaret A Arstall John D Horowitz | 1996 | 中华心血管病杂志1996，24，4： | 5 |
| 3 | Gastric emptying, postprandial blood pressure, glycaemia and splanchnic flow in Parkinson's disease显示文摘AIM: To determine gastric emptying, blood pressure, mesenteric artery blood flow, and blood glucose responses to oral glucose in Parkinson's disease. METHODS: Twenty-one subjects(13 M, 8 F; age 64.2 ± 1.6 years) with mild to moderate Parkinson's disease(Hoehn and Yahr score 1.4 ± 0.1, duration of known disease 6.3 ± 0.9 years) consumed a 75 g glucose drink, labelled with 20 MBq 99mTc-calcium phytate. Gastric emptying was quantified with scintigraphy, blood pressure and heart rate with an automated device, superior mesenteric artery blood flow by Doppler ultrasonography and blood glucose byglucometer for 180 min. Autonomic nerve function was evaluated with cardiovascular reflex tests and upper gastrointestinal symptoms by questionnaire. RESULTS: The mean gastric half-emptying time was 106 ± 9.1 min, gastric emptying was abnormally delayed in 3 subjects(14%). Systolic and diastolic blood pressure fell(P < 0.001) and mesenteric blood flow and blood glucose(P < 0.001 for both) increased, following the drink. Three subjects(14%) had definite autonomic neuropathy and 8(38%) had postprandial hypotension. There were no significant relationships between changes in blood pressure, heart rate or mesenteric artery blood flow with gastric emptying. Gastric emptying was related to the score for autonomic nerve function(R = 0.55, P < 0.01). There was an inverse relationship between the blood glucose at t = 30 min(R =-0.52, P < 0.05), while the blood glucose at t = 180 min was related directly(R = 0.49, P < 0.05), with gastric emptying. CONCLUSION: In mild to moderate Parkinson's disease, gastric emptying is related to autonomic dysfunction and a determinant of the glycaemic response to oral glucose. | Laurence G Trahair Thomas E Kimber Katerina Flabouris Michael Horowitz Karen L Jones | 2016 | World Journal of Gastroenterology2016，22，20： | 5 |
| 4 | Gender-associated differences in urea breath test for Helicobacter pylori infection referrals and results among dyspeptic patients显示文摘AIM: To verify whether there is a gender difference in the 13C-urea breath test results in a large cohort. METHODS: The test results of dyspeptic patients referred for 13C-urea breath testing between January and December, 2007 were evaluated. Testing was carried out at the health insurance organization branches and evaluated at a central laboratory in Israel. RESULTS: Of a total of 28 746 test results, 18 122 (63.04%) were from females and 10 624 (36.95%) from males. Overall, 10 188 (35.4%) results [expressed as delta over baseline (DOB)] were positive (DOB 13C > 5), 18,326 (63.7%) were negative (DOB 13C < 3.5) and 232 (0.8%) were borderline (DOB 13C 3.5-5). There was a significant difference between the total positive rate among females and males (34.8% vs 37.2%, respectively, P = 0.0003). The mean test value was increased by approximately 10 units for females compared to males (P < 0.01) and this difference was consistent for all age groups (i.e., between 10-80 years of age, P < 0.01). CONCLUSION: More females were referred to 13C-urea breath testing. More males had positive results. The mean test values were significantly higher among females of all age groups, possibly representing an increased bacterial load among females and suggesting gender-associated differences in Helicobacter pylori host interactions. | Menachem Moshkowitz Noya Horowitz Anat Beit-Or Zamir Halpern Erwin Santo | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，3： | 4 |
| 5 | Atorvastatin Reduces the Ability of Clopidogrel to Inhibit Platelet Aggregation: A New Drug–Drug Interaction显示文摘 | Wei C. Lau Lucy A. Waskell Paul B. Watkins Charlene J. Neer Kevin Horowitz Amy S. Hopp Alan R. Tait David G.M. Carville Kirk E. Guyer Eric R. Bates | 2003 | Circulation: Journal of the American Heart Association2003，，1： | 3 |
| 6 | Opportunities and Challenges for the Development of China's Community Gardens显示文摘Since the 1970s,community gardens have played an important role in promoting the development of sustainable communities and improving urban environments in the United States. Despite the popularity of spontaneous urban farming activities in China,community gardens have not caught on as an ecologically and socially sustainable urban development strategy. Based on a comparison of community garden development in China and the U.S.,the authors of this article fi nd that the development of community gardens in China will require close collaboration between city planning officials,real estate agencies,urban citizens,and landscape architects. | LIU Juanjuan Sarah Horowitz ZHANG Weining | 2013 | Journal of Landscape Research2013，5，Z3： | 3 |
| 7 | Nephropathy in dietary hyperoxaluria:A potentially preventable acute or chronic kidney disease显示文摘Hyperoxaluria can cause not only nephrolithiasis and nephrocalcinosis,but also renal parenchymal disease histologically characterized by deposition of calcium oxalate crystals throughout the renal parenchyma,profound tubular damage and interstitial inflammation and fibrosis.Hyperoxaluric nephropathy presents clinically as acute or chronic renal failure that may progress to endstage renal disease(ESRD).This sequence of events,well recognized in the past in primary and enteric hyperoxalurias,has also been documented in a few cases of dietary hyperoxaluria.Estimates of oxalate intake in patients with chronic dietary hyperoxaluria who developed chronic kidney disease or ESRD were comparable to the reported average oxalate content of the diets of certain populations worldwide,thus raising the question whether dietary hyperoxaluria is a primary cause of ESRD in these regions.Studies addressing this question have the potential of improving population health and should be undertaken,alongside ongoing studies which are yielding fresh insights into the mechanisms of intestinal absorption and renal excretion of oxalate,and into the mechanisms of development of oxalate-induced renal parenchymal disease.Novel preventive and therapeutic strategies for treating all types of hyperoxaluria are expected to develop from these studies. | Robert H Glew Yijuan Sun Bruce L Horowitz Konstantin N Konstantinov Marc Barry Joanna R Fair Larry Massie Antonios H Tzamaloukas | 2014 | World Journal of Nephrology2014，3，4： | 3 |
| 8 | Whey protein: The “whey” forward for treatment of type 2 diabetes?显示文摘A cost-effective nutritional approach to improve postprandial glycaemia is attractive considering the rising burden of diabetes throughout the world. Whey protein, a by-product of the cheese-making process, can be used to manipulate gut function in order to slow gastric emptying and stimulate incretin hormone secretion, thereby attenuating postprandial glycaemic excursions. The function of the gastrointestinal tract plays a pivotal role in glucose homeostasis, particularly during the postprandial period, and this review will discuss the mechanisms by which whey protein slows gastric emptying and stimulates release of gut peptides, including the incretins. Whey protein is also a rich source of amino acids, and these can directly stimulate beta cells to secrete insulin, which contributes to the reduction in postprandial glycaemia. Appetite is suppressed with consumption of whey, due to its effects on the gut-brain axis and the hypothalamus. These properties of whey protein suggest its potential in the management of type 2 diabetes. However, the optimal dose and timing of whey protein ingestion are yet to be defined, and studies are required to examine the long-term benefits of whey consumption for overall glycaemic control. | Linda E Mignone Tongzhi Wu Michael Horowitz Christopher K Rayner | 2015 | World Journal of Diabetes2015，6，14： | 2 |
| 9 | Comparative Effects of Low and High Doses of the Angiotensin-Converting Enzyme Inhibitor, Lisinopril, on Morbidity and Mortality in Chronic Heart Failure显示文摘 | Milton Packer Philip A. Poole-Wilson Paul W. Armstrong John G.F. Cleland John D. Horowitz Barry M. Massie Lars Rydén Kristian Thygesen Barry F. Uretsky | 1999 | Circulation1999，，23： | 2 |
| 10 | Bemisia tabaci Biotype Dynamics and Resistance to Insecticides in Israel During the Years 2008-2010显示文摘The sweetpotato whitefly Bemisia tabaci(Hemiptera:Aleyrodidae)is an extremely polyphagous insect pest that causes significant crop losses in Israel and worldwide.B.tabaci is a species complex of which the B and Q biotypes are the most widespread and damaging worldwide.The change in biotype composition and resistance to insecticide in Israel was monitored during the years 2008-2010 to identify patterns in population dynamics that can be correlated with resistance outbreaks.The results show that B biotype populations dominate crops grown in open fields,while Q biotype populations gradually dominate crops grown in protected conditions such as greenhouses and nethouses,where resistance outbreaks usually develop after several insecticide applications.While in previous years,Q biotype populations were widely detected in many regions in Israel,significant domination of the B biotype across populations collected was observed during the year 2010,indicating the instability of the B.tabaci population from one year to another.Reasons for the changing dynamics and the shift in the relative abundance of B.tabaci biotype,and their resistance status,are discussed. | Svetlana Kontsedalov Fauzi Abu-Moch Galina Lebedev Henryk Czosnek A Rami Horowitz Murad Ghanim | 2012 | Journal of Integrative Agriculture2012，11，2： | 2 |
| 11 | A phase I trial of the bombesin/gastrin-releasing peptide (BN/GRP) antagonist RC3095 in patients with advanced solid malignancies显示文摘 | G. Schwartsmann L. P. DiLeone M. Horowitz D. Schunemann A. Cancella A. S. Pereira M. Richter F. Souza A. Brondani Rocha F. H. Souza P. Pohlmann G. Nucci | 2006 | Investigational New Drugs2006，，5： | 2 |
| 12 | Divide-and-conquer for parallel processing显示文摘 | Horowitz E Zorat A | 1983 | IEEE Trans Computer1983，32，： | 2 |
| 13 | Gastroesophageal reflux disease symptoms:Prevalence,sociodemographics and treatment patterns in the adult Israeli population显示文摘AIM: To evaluate the prevalence and sociodemographics of gastroesophageal reflux disease (GERD) symptoms and to identify treatment patterns among GERD patients. METHODS: A telephone survey of a representative sample of the adult Israeli population was conducted. The questionnaire included detailed sociodemographics, history of GERD symptoms and the various treatments used. RESULTS: The survey included 2027 subjects. Twice weekly, once weekly and monthly GERD symptoms were reported by 8.4%, 12.5% and 21.5% of subjects, respectively. There was no difference in prevalence between men and woman; however, GERD symptoms were significantly more prevalent within the older age group and lower socioeconomic status. Among those reporting weekly symptoms, a quarter did not use any kind of therapy and another quarter used various traditional remedies (e.g. soda, milk, almonds, etc.). Antacids were used by 35.1%, H2 blockers by 13.2% and PPIs by 17.5%. CONCLUSION: We found that 12.5% of the adult Israeli population experience weekly GERD symptoms. GERD prevalence and sociodemographics are similar to those described in other Western countries, and treatment is still suboptimal. | Menachem Moshkowitz Noya Horowitz Zamir Halpern Erwin Santo | 2011 | World Journal of Gastroenterology2011，17，10： | 2 |
| 14 | GI symptoms in diabetes mellitus are associated with both poor glycemic control and diabetic complications显示文摘 | Peter Bytzer Nicholas J Talley Johann Hammer Lisa J Young Michael P Jones Michael Horowitz | 2002 | The American Journal of Gastroenterology2002，，3： | 2 |
| 15 | Awareness, self-management behaviors, health literacy and kidney function relationships in specialty practice显示文摘AIM To determine the relationship between chronic kidney disease(CKD) awareness(CKD-A), self-management behaviors(CKD-SMB) knowledge, performance of CKDSMBs, health literacy(HL) and kidney function. METHODS Participants were eligible patients attending an outpatient nephrology clinic. Participants were administered: Newest Vital Sign to measure HL, CKD self-managementknowledge tool(CKD-SMKT) to assess knowledge, past performance of CKD-SMB, CKD-A. Estimated GFR(e GFR) was determined using the MDRD-4 equation. Duration of clinic participation and CKD cause were extracted from medical charts. RESULTS One-hundred-fifty patients participated in the study. e GFRs ranged from 17-152 m L/min per 1.73 m2. Majority(83%) of respondents had stage 3 or 4 CKD, low HL(63%), and were CKD aware(88%). Approximately 40%(10/25) of patients in stages 1 and 2 and 6.4%(8/125) in stages 3 and 4 were unaware of their CKD. CKD-A differed with stage(P < 0.001) but not by HL level, duration of clinic participation, or CKD cause. Majority of respondents(≥ 90%) correctly answered one or more CKD-SMKT items. Knowledge of one behavior, 'controlling blood pressure' differed significantly by CKD-A. CKD-A was associated with past performance of two CKD-SMBs, 'controlling blood pressure'(P = 0.02), and 'keeping healthy body weight'(P = 0.01). Adjusted multivariate analyses between CKD-A and:(1) HL; and(2) CKD-SMB knowledge were nonsignificant. However, there was a significant relationship between CKD-A and kidney function after controlling for demographics, HL, and CKD-SMB(P < 0.05). CONCLUSION CKD-A is not associated with HL, or better CKD-SMBs. CKD-A is significantly associated with kidney function and substantially lower e GFR, suggesting the need for focused patient education in CKD stages 1. | Radhika Devraj Matthew E Borrego A Mary Vilay Junvie Pailden Bruce Horowitz | 2018 | World Journal of Nephrology2018，7，1： | 2 |
| 16 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 17 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 18 | Towards an explanatory and computational theory of scientific discovery显示文摘 | Chaomei Chen Yue Chen Mark Horowitz Haiyan Hou Zeyuan Liu Donald Pellegrino | 2009 | Journal of Informetrics2009，，3： | 2 |
| 19 | Semiparametric estimation of a proportional hazard model with unobserved heterogeneity显示文摘 | Loel L Horowitz | 1999 | Econmetrica1999，67，5： | 1 |
| 20 | Multimodal reperfusion therapy for acute isehemie stroke: factors predicting vessel recanalization 显示文摘 | Gupta R Vora NA Horowitz MB | 2006 | Stroke2006，37，4： | 1 |
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