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| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | Petawatt class lasers worldwide显示文摘The use of ultra-high intensity laser beams to achieve extreme material states in the laboratory has become almost routine with the development of the petawatt laser. Petawatt class lasers have been constructed for specific research activities,including particle acceleration, inertial confinement fusion and radiation therapy, and for secondary source generation(x-rays, electrons, protons, neutrons and ions). They are also now routinely coupled, and synchronized, to other large scale facilities including megajoule scale lasers, ion and electron accelerators, x-ray sources and z-pinches. The authors of this paper have tried to compile a comprehensive overview of the current status of petawatt class lasers worldwide.The definition of ‘petawatt class' in this context is a laser that delivers >200 TW. | Colin Danson David Hillier Nicholas Hopps David Neely | 2015 | High Power Laser Science and Engineering2015，3，1： | 16 |
| 3 | 金属标准物质中杂质的辉光放电质谱法溯源分析显示文摘标准物质定值分析的溯源性要求比常规分析高很多。在常规分析中,有证标准物质(CRM)可用于校准以及建立可溯源性。尽管与标准物质生产和认定相关的ISO导则并没有十分明确地提到校准,但众多标准物质生产者在定值分析时却不接受基准标准物质用于校准。这些要求制约了标准物质定值方法的使用,因为这些方法可以采用已知高纯度的标准物质、化学计量法及已知高纯度标准物质的混合物进行校准。有效的固体取样技术,例如通常使用的块状标准物质进行校准的辉光放电质谱法(GD-MS)或火花源发射光谱法(spark-OES),似乎不太适合定值分析。尤其是固体样品中痕量元素分析测定的有力工具辉光放电质谱法,除金属杂质外,使用特定气体混合物,这种方法也可以分析相关的非金属杂质如硫和磷。我们开发了一种可以使用已知高纯度的标准物质混合物和化学计量法的校准方法,这种校准方法同样可用于辉光放电质谱法。与溶液中基体匹配技术类似,此校准方法基于掺杂的粉末压片。本文还结合铜和钢标准物质的定值分析结果进行了陈述。 | RECKNAGEL Sebastian KIPPHARDT Heinrich LANGE Britta HOPPE Marion | 2012 | 冶金分析2012，32，2： | 6 |
| 4 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 5 | Atorvastatin Reduces the Ability of Clopidogrel to Inhibit Platelet Aggregation: A New Drug–Drug Interaction显示文摘 | Wei C. Lau Lucy A. Waskell Paul B. Watkins Charlene J. Neer Kevin Horowitz Amy S. Hopp Alan R. Tait David G.M. Carville Kirk E. Guyer Eric R. Bates | 2003 | Circulation: Journal of the American Heart Association2003，，1： | 3 |
| 6 | The kallikrein-kinin system: a promising therapeutic target for traumatic brain injury显示文摘Traumatic brain injury(TBI),which results from an outside force causing mechanical disruption of brain tissue,is potentially life-threatening and therefore a critical public health problem throughout the world.In the USA,approximately 1.7 million individuals per year sustain a TBI,and about 43%of patients hospitalized because of TBI develop long-term physical disability as well as psychological disorders,such as neurocognitive deficits,epilepsy,and depression(Roozenbeek et al.,2013).The primary brain | Sarah Hopp Christiane Albert-Weissenberger | 2015 | Neural Regeneration Research2015，10，6： | 3 |
| 7 | USING THE ANALYTICAL HIERARCHY PROCESS TO SUPPORT SUSTAINABLE USE OF GEO-RESOURCES IN METROPOLITAN AREAS显示文摘Sand and gravel are important raw materials which are needed for many civil engineering projects. Due to economic reasons, sand and gravel pits are frequently located in the periphery of metropolitan areas which are often subject to competing land-use interests. As a contribution to land-use conflict solving, the Analytic Hierarchy Process (AHP) is applied within a Geographic Information System (GIS) environment. Two AHP preference matrix scenario constellations are evaluated and their results are used to create a land-use conflict map. | Oswald MARINONI Andreas HOPPE | 2006 | Journal of Systems Science and Systems Engineering2006，15，2： | 3 |
| 8 | 针刺治疗紧张型头痛患者的随机、对照试验 | Melchart D. Streng A. Hoppe A. 郭俊 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，12： | 2 |
| 9 | Eosinophils in urine revisited显示文摘 | Rutling KA Hoppes P Blend D | 1994 | Clin Nephrol1994，41，1： | 2 |
| 10 | Linking molecular deadwood-inhabiting fungal diversity and community dynamics to ecosystem functions and processes in Central European forests显示文摘Fungi play vital roles in the decomposition of deadwood due to their secretion of various enzymes that break down plant cell-wall complexes.The compositions of woodinhabiting fungal(WIF)communities change over the course of the decomposition process as the remaining mass of wood decreases and both abiotic and biotic conditions of the wood significantly change.It is currently not resolved which substrate-related factors govern these changes in WIF communities and whether such changes influence the deadwood decomposition rate.Here we report a study on fungal richness and community structure in deadwood of Norway spruce and European beech in temperate forest ecosystems using 454 pyrosequencing.Our aims were to disentangle the factors that correspond to WIF community composition and to investigate the links between fungal richness,taxonomically-resolved fungal identity,and microbial-mediated ecosystem functions and processes by analyzing physico-chemical wood properties,lignin-modifying enzyme activities and wood decomposition rates.Unlike fungal richness,we found significant differences in community structure between deadwood of different tree species.The composition of WIF communities was related to the physico-chemical properties of the deadwood substrates.Decomposition rates and the activities of ligninmodifying enzymes were controlled by the succession of the fungal communities and competition scenarios rather than fungal OTU richness.Our results provide further insights into links between fungal community structure and microbialmediated ecosystem functions and processes. | Björn Hoppe Witoon Purahong Tesfaye Wubet Tiemo Kahl Jürgen Bauhus Tobias Arnstadt Martin Hofrichter François Buscot Dirk Krüger | 2016 | Fungal Diversity2016，，2： | 2 |
| 11 | A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics显示文摘 | Alexander Hoppe Nusret S. Güldal Aldo R. Boccaccini | 2011 | Biomaterials2011，，11： | 2 |
| 12 | Contribution of Hepatic Cytochrome P450 3A4 Metabolic Activity to the Phenomenon of Clopidogrel Resistance显示文摘 | Wei C. Lau Paul A. Gurbel Paul B. Watkins Charlene J. Neer Amy S. Hopp David G.M. Carville Kirk E. Guyer Alan R. Tait Eric R. Bates | 2004 | Circulation: Journal of the American Heart Association2004，，2： | 2 |
| 13 | Examples of FEM application in manufacturing technology显示文摘 | BECK T HOPPE S | 2002 | Journal of Materials Processing Technology2002，120，： | 1 |
| 14 | Surface Reconstruction from Unorganized Points显示文摘 | DEROSE T DUCHAMP T | 1992 | SIGGRAPH921992，，： | 1 |
| 15 | Optional vena cava filters:indications,management,and results显示文摘 | HOPPE H | 2009 | Dtsch Arztebl Int2009，106，24： | 1 |
| 16 | Acupuncture in patients with tension-type headache: randomised controlled trial显示文摘 | Melchart D Streng A Hoppe A | 2005 | BMJ2005，331，7513： | 1 |
| 17 | Large Glass Shell from GDP Shell显示文摘 | Hoppe M L | 2000 | Fusion Technology2000，38，1： | 1 |
| 18 | Hierarchical crosstraining in work-in-process-constrained systems 显示文摘 | Gel E S Hopp W J Van Oyen M P | 2007 | lie Transactions2007，39，2： | 1 |
| 19 | No evidence for cognitive side effects after 6 months of vagus nerve stimulation in epilepsy patients显示文摘 | Hoppe C Helmstaedter C Schermann J | 2001 | Epilepsy Behav2001，2，4： | 1 |
| 20 | Roentgenographic investigation of frequency and degree of canal curvatures in human permanent teeth显示文摘 | Schafer E Diez C Hoppe W | 2002 | J Endod2002，28，3： | 1 |
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