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| 1 | Origin of raptorial feeding in juvenile euarthropods revealed by a Cambrian radiodontan显示文摘The rapid rise of arthropods during the Cambrian quickly established some clades, such as the euarthropod stem-group called Radiodonta, as the dominant and most diverse predators in marine ecosystems. Recent discoveries have shown that the size and dietary ecology of radiodontans are far more diverse than previously thought, but little is known about the feeding habits of juveniles. Here, we document a very small(~18-mm-long), near-complete specimen of the radiodontan Lyrarapax unguispinus from the early Cambrian Chengjiang Biota of China. This specimen is the smallest radiodontan individual known,representing a juvenile instar. Its adult-like morphology—especially the fully developed spinose frontal appendages and tetraradial oral cone—indicates that L. unguispinus was a well-equipped predator at an early developmental stage, similar to modern raptorial euarthropods, such as mantises, mantis shrimps and arachnids. This evidence, coupled with the basal phylogenetic position of radiodontans, confirms that raptorial feeding habits in juvenile euarthropods appeared early in the evolutionary history of the group. | Jianni Liu Rudy Lerosey-Aubril Michael Steiner Jason A. Dunlop Degan Shu John R. Paterson | 2018 | National Science Review2018，5，6： | 8 |
| 2 | Protein misfolding in neurodegenerative diseases:implications and strategies显示文摘A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse.Therapeutic options are currently being explored that target different steps in the production and processing of proteins implicated in neurodegenerative disease,including synthesis,chaperone-assisted folding and trafficking,and degradation via the proteasome and autophagy pathways.Other therapies,like mTOR inhibitors and activators of the heat shock response,can rebalance the entire proteostatic network.However,there are major challenges that impact the development of novel therapies,including incomplete knowledge of druggable disease targets and their mechanism of action as well as a lack of biomarkers to monitor disease progression and therapeutic response.A notable development is the creation of collaborative ecosystems that include patients,clinicians,basic and translational researchers,foundations and regulatory agencies to promote scientific rigor and clinical data to accelerate the development of therapies that prevent,reverse or delay the progression of neurodegenerative proteinopathies. | Patrick Sweeney Hyunsun Park Marc Baumann John Dunlop Judith Frydman Ron Kopito Alexander McCampbell Gabrielle Leblanc Anjli Venkateswaran Antti Nurmi Robert Hodgson | 2017 | Translational Neurodegeneration2017，6，1： | 4 |
| 3 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘 | John Burn Anne-Marie Gerdes Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diane Eccles D Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm G Dunlop Judy WC Ho Shirley V Hodgson Annika Lindblom Jan Lubinski Pa | 2011 | The Lancet2011，，9809： | 3 |
| 4 | Pectin May Hinder the Unfolding of Xyloglucan Chains during Cell Deformation: Implications of the Mechanical Performance of Arabidopsis Hypocotyls with Pectin Alterations显示文摘种房间墙,象大量的其它一样生物材料,是自然增强纤维的合成材料。他们的机械性质自己高度依赖于生硬含纤维的阶段和软矩阵阶段的相互影响并且在矩阵变丑上。用特定的 Arabidopsis thaliana 异种,我们与改变的 xyloglucan 和果胶作文在胚轴的主要房间墙中学习了矩阵集会的机械角色。标准 microtensile 测试和周期的装载协议象少些展出 50% 的 qua2 一样与影响 RGII 硼酸盐 diester 交叉结合和妨碍的 xyloglucan fucosylation 在 mur1 胚轴上被执行 homogalacturonan 与相比野类型。作为控制,野类型的植物(Col-0 ) 和在果胶网络展出特定的 xyloglucan fucosylation 和没有差别的 mur2 被利用。在标准张力的测试,有果胶改变的异种的胚轴的最终的压力层次(张力的力量)(mur1, qua2 ) 是相当未受影响的,而他们的张力的僵硬显著地与 Col-0 相比被减少。周期的装载测试显示了一在首先拉紧然而,其度为 mur1 和 qua2 胚轴是高得多的期间在第一个周期和塑料变丑以后所有胚轴使硬。基于机械数据和当前的房间墙模型,在纤维素纤丝之间的合拢的 xyloglucan 链可以趋于在胚轴拉紧期间展开,这被假定。这回答被几何限制可能由于果胶刚硬妨碍。 | Willie Abasolo Michaela Eder Kazuchika Yamauchi Nicolai Obel Antje Reinecke Lutz Neumetzler John W.C. Dunlop Gregory Mouille Markus Pauly Herman Hofte Ingo Burgert | 2009 | Molecular Plant2009，2，5： | 2 |
| 5 | Developments and Chal- lenges in the Utilization of Magnesium Alloys 显示文摘 | Dahle A K John D H Dunlop G L | 2000 | Mater Forum2000，，24： | 1 |
| 6 | Development and challenges in the utilization of magnesium alloys 显示文摘 | Dahle A K John D H Dunlop G L | 2000 | Materials Forum2000，，24： | 1 |
| 7 | Glutamate-based therapeutic approaches: targeting the glutamate transport system 显示文摘 | John Dunlop | 2006 | Current Opinion in Pharmacology2006，6，： | 1 |
| 8 | Control Your Inventory in a World of Lean Retailing 显示文摘 | Abemathy Frederick H Dunlop John T Hammond Janice H etc | 2000 | Harvard Business Review2000，78，6： | 1 |
| 9 | Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘 | John C Mathers Mohammad Movahedi Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diana Eccles Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm Dunlop Judy WC Ho Shirley Hodgson Annika Lindblom Jan Lubinski Pat | 2012 | Lancet Oncology2012，，12： | 1 |
| 10 | Control Your Inventory in a World of Lean Retailing 显示文摘 | Abemathy Frederick H Dunlop John T Hammond Janice H etc | 2000 | Harvard Business Review2000，78，6： | 1 |
| 11 | Control Your Inventory in a World of Lean Retailing显示文摘 | Abemathy Frederick H Dunlop John T Hammond Janice H etc | 2000 | Harvard Business Review2000，78，6： | 1 |
| 12 | The preparation of4-fluoro-and 4,4′-difluorobenzophenone显示文摘 | Dunlop R D Gardner John H | 1933 | J Am Chem Soc1933，55，16： | 1 |
| 13 | Developments and challenges in the utilization of magnesium alloys 显示文摘 | Dahle S t John DH Dunlop G L | 2000 | Mater Forum2000，24，2： | 1 |
| 14 | Amiloride is neuroprotective in an MPTP model of Parkinson’s disease显示文摘 | Robert L. Arias Mei-Li A. Sung Dmytro Vasylyev Mei-Yi Zhang Kristin Albinson Katie Kubek Natasha Kagan Chad Beyer Qian Lin Jason M. Dwyer Margaret M. Zaleska Mark R. Bowlby John Dunlop Michael Monaghan | 2008 | Neurobiology of Disease2008，，3： | 1 |
| 15 | Developments and challenges in the utilization of magnesium alloys显示文摘 | Dahle A K St John D H Dunlop G L | | 0，，24： | 1 |
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