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| 1 | Nonalcoholic fatty liver disease and HFE gene mutations:A Polish study显示文摘AIM:To describe a Polish population with nonalcoholic fatty liver disease(NAFLD)with regard to HFE gene mutations,as well as analyzing demographic and clinical data.METHODS:Sixty-two consecutive patients with biopsy-proven NAFLD were included in the study.Demographic,clinical,and laboratory data were summarized in a database.C282Y and H63D mutations of the HFE gene were analyzed using polymerase chain reactionrestriction fragment lenght polymorphism.RESULTS:The analyzed cohort consisted of 62 homo-geneic Caucasian participants,66.1%men and 33.9% women,with a median age of 48 years.The median body mass index was 29.05 kg/m 2 .Hypercholesterolemia was observed in 74.2%of patients and hypertriglyceridemia in 32.2%;16.1%had type 2 diabetes mellitus(DMt2).On liver biopsy,22.6%of NAFLD patients were found to have severe fibrosis.There were no differences between frequencies of HFE gene mutations in subgroups of NAFLD patients with less and more severe liver fibrosis.Obesity,older age,female gender and DMt2 were associated with more advanced fibrosis in this Polish cohort,as well as higher glucose level,serum iron and transaminase aspartate aminotransferase/alanine aminotransferase ratio.CONCLUSION:HFE mutations conferred no additional hepatic fibrosis risk in NAFLD,but higher serum iron was a risk factor for severe liver damage in NAFLD,regardless of HFE mutations. | Joanna Raszeja-Wyszomirska Grzegorz Kurzawski Malgorzata Lawniczak Joanna Miezynska-Kurtycz Jan Lubinski | 2010 | World Journal of Gastroenterology2010，16，20： | 4 |
| 2 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘 | John Burn Anne-Marie Gerdes Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diane Eccles D Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm G Dunlop Judy WC Ho Shirley V Hodgson Annika Lindblom Jan Lubinski Pa | 2011 | The Lancet2011，，9809： | 3 |
| 3 | A study of the buckling of rotary drillingstrings显示文摘 | LUBINSKI A | 1950 | Drilling and Production Practice1950，，： | 1 |
| 4 | Spontaneous and therapeutic abortions and the risk of breastcancer among BRCA1mutation carriers显示文摘 | Eitan Friedman Joanne Kotsopulos Jan Lubinski | 2006 | Breast Cancer Res2006，15，8： | 1 |
| 5 | The terminal portion of the T wave : a new electrocardiographic marker of risk of ventricular arrhythmias 显示文摘 | Lubinski A Komacewicz-Jach Z Wnuk-Wojnar AM | 2000 | Pacing Clin Electrophysiol2000，23，11： | 1 |
| 6 | Helical Buckling of Tubing Sealed in Packers显示文摘 | Lubinski A Althouse W S Logan J L | 1962 | JPT1962，14，3： | 1 |
| 7 | Helical Buckling of Tubing Sealed in Packers显示文摘 | Lubinski A Althouse W S Logan J L | 1962 | Journal of Petroleum Technology1962，14，3： | 1 |
| 8 | New insight into repolarization abnormalities in patients with congenital Long QT syndrome:The increased transmural dispersion of repolarization显示文摘 | LUBINSKI A LEWICKA-NOWAK E KEMPA M | 1998 | Pacing Chin Electrophsiol1998，21，12： | 1 |
| 9 | Tiotropium as a controller of hronehoconstriction 显示文摘 | Lubinski W | 2004 | Pol Merkur Lekarki2004，，： | 1 |
| 10 | Helica Packers显示文摘 | Lubinski A | 1962 | JPT1962，14，3： | 1 |
| 11 | Prospective e- valuation of alcohol consumption and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers 显示文摘 | Cybulski C Lubinski J Huzarski T et a/ | 2015 | Breast Cancer Res Treat2015，151，2： | 1 |
| 12 | Factors influencing ovulation and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers显示文摘 | Kotsopoulos J Lubinski J Gronwald J | 2015 | Int J Cancer2015，137，5： | 1 |
| 13 | Familial amniotic bands显示文摘 | Lubinsky M Sujansky E Sanger W | 1983 | Am J Med Genet1983，14，： | 1 |
| 14 | Developing Mathematics Teachers: The Transition from Pre-service to Experienced Teacher 显示文摘 | Cady J Meier S Lubinski C | 2006 | The Journal of Educational Research2006，99，5： | 1 |
| 15 | Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA 2 routation:a case-control study显示文摘 | Risch HA Lubinski J | 2007 | Lancet Oncol2007，8，1： | 1 |
| 16 | Prevalence of very short QT intervals in patients with idiopathic ventricular fibrillation and implanted ICD显示文摘 | Filipecki A Trusz M Lubinski A | 2004 | Circulation2004，110，： | 1 |
| 17 | Salpingo-oophorectomy and the risk of ovarian,fallopiantube,and peritoneal cancers in women with a BRCAl or BRCA2mutation显示文摘 | Finch A Beiner M Lubinski J | 2006 | JAMA2006，296，： | 1 |
| 18 | Genetic epidemiology studies in hereditary non -- polyposis colorectal cancer 显示文摘 | Scott R J Lubinski J | 2009 | Methods Mol Biol2009，472，： | 1 |
| 19 | Familial amniotic bands显示文摘 | Lubinsky M Sujansky E Sanger W | 1983 | Am J Med Genet1983，14，： | 1 |
| 20 | Breast cancer risk following bilatersl oophorectomy in BRCA1 and BRCA2 mutation carriere:an international case-control study显示文摘 | Eisen A Lubinski J Klijn J | 2005 | J Clin Oncol2005，23，30： | 1 |
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