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| 1 | B?cell translocation gene 1 serves as a novel prognostic indicator ofhepatocellular carcinoma显示文摘 | Mitsuro Kanda Hiroyuki Sugimoto Shuji Nomoto Hisaharu Oya Soki Hibino Dai Shimizu Hideki Takami Ryoji Hashimoto Yukiyasu Okamura Suguru Yamada Tsutomu Fujii Goro Nakayama Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2015 | International Journal of Oncology2015，，2： | 3 |
| 2 | Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development显示文摘AIM: To investigate factors that accurately predict hepatocellular carcinoma(HCC) development after antiviral therapy in chronic hepatitis C(CHC) patients. METHODS: CHC patients who received pegylated interferon and ribavirin were enrolled in this cohort study that investigated the ability of alpha-fetoprotein(AFP) to predict HCC development after interferon(IFN) therapy. RESULTS: Of 1255 patients enrolled, 665 developed sustained virological response(SVR) during mean follow-up period of 5.4 years. HCC was occurred in 89 patients, and 20 SVR patients were included. Proportional hazard models showed that HCC occurred in SVR patients showing AFP ≥ 5 ng/m L before therapy and in non-SVR patients showing AFP ≥ 5 ng/m L before and 1 year after therapy besides older age, and low platelet counts. SVR patients showing AFP ≥ 5 ng/m L before therapy and no decrease in AFP to < 5 ng/m L 1 year after therapy had significantly higher HCC incidence than non-SVR patients showing AFP ≥ 5 ng/m L before therapy and decreased AFP(P = 0.043). AFP ≥ 5 ng/m L before therapy was significantly associated with low platelet counts and high values of alanine aminotransferase(ALT) in stepwise logistic regression analysis. After age, gender, platelet count, and ALT was matched by propensity score, significantly lower HCC incidence was shown in SVR patients showing AFP < 5 ng/m L before therapy than in those showing AFP ≥ 5 ng/m L.CONCLUSION: The criteria of AFP < 5 ng/m L before and 1 year after IFN therapy is a benefical predictor for HCC development in CHC patients. | Yasuto Takeuchi Fusao Ikeda Toshiya Osawa Yasuyuki Araki Kouichi Takaguchi Youichi Morimoto Noriaki Hashimoto Kousaku Sakaguchi Tatsuro Sakata Masaharu Ando Yasuhiro Makino Shuji Matsumura Hiroki Takayama Hiroyuki Seki Shintarou Nanba Yuki Moritou Tetsuya Yasunaka Hideki Ohnishi Akinobu Takaki Kazuhiro Nouso Yoshiaki Iwasaki Kazuhide Yamamoto | 2015 | World Journal of Hepatology2015，7，19： | 3 |
| 3 | Screening for hilar biliary invasion in ampullary cancer patients显示文摘BACKGROUND The treatment for ampullary cancer is pancreatoduodenectomy or local ampullectomy.However,effective methods for the preoperative investigation of hilar biliary invasion in ampullary cancer patients have not yet been identified.AIM To determine the necessity of and an appropriate method for investigating hilar biliary invasion of ampullary cancer.METHODS Among 43 ampullary cancer patients,34 underwent endoscopic treatment(n=9)or surgery(n=25).The use of imaging findings(thickening and enhancement of the bile duct wall on contrast-enhanced computed tomography,irregularity on endoscopic retrograde cholangiography,thickening of the entire bile duct wall on intraductal ultrasonography(IDUS),and partial thickening of the bile duct wall on IDUS)and biliary biopsy results for diagnosing hilar biliary invasion of ampullary cancer was compared.RESULTS Hilar invasion was not observed in every patient.Among the patients who did not undergo biliary stent insertion,the combination of partial thickening of the bile duct wall on IDUS and biliary biopsy results showed the highest accuracy(100%)for diagnosing hilar biliary invasion.However,each imaging method and biliary biopsy yielded some false-positive results.CONCLUSION Although some false-positive results were obtained with each method,the combination of partial thickening of the bile duct wall on IDUS and biliary biopsy results was useful for diagnosing hilar biliary invasion of ampullary cancer.However,hilar invasion of ampullary cancer is rare;therefore,the investigation of hilar biliary invasion of ampullary cancer might be unnecessary. | Tadayuki Takagi Mitsuru Sugimoto Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Jun Nakamura Mika Takasumi Minami Hashimoto Tsunetaka Kato Ryoichiro Kobashi Takumi Yanagita Yuko Hashimoto Shigeru Marubashi Takuto Hikichi Hiromasa Ohira | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，9： | 2 |
| 4 | Adjuvant Gemcitabine Plus S-1 Chemotherapy Improves Survival After Aggressive Surgical Resection for Advanced Biliary Carcinoma显示文摘 | Yoshiaki Murakami Kenichiro Uemura Takeshi Sudo Yasuo Hayashidani Yasushi Hashimoto Hiroyuki Nakamura Akira Nakashima Taijiro Sueda | 2009 | Annals of Surgery2009，，6： | 2 |
| 5 | Correlation of CCL20 expression in rectal mucosa with the developmentof ulcerative colitis?associated neoplasia显示文摘 | Kiyoshi Hashimoto Susumu Saigusa Toshimitsu Araki Koji Tanaka Yoshiki Okita Hiroyuki Fujikawa Mikio Kawamura Yoshinaga Okugawa Yuji Toiyama Yasuhiro Inoue Keiichi Uchida Yasuhiko Mohri Masato Kusunoki | 2013 | Oncology Letters2013，，5： | 1 |
| 6 | Function and diagnostic value of Anosmin‐1 in gastric cancer progression显示文摘 | Mitsuro Kanda Dai Shimizu Tsutomu Fujii Satoshi Sueoka Yuri Tanaka Kazuhiro Ezaka Hideki Takami Haruyoshi Tanaka Ryoji Hashimoto Naoki Iwata Daisuke Kobayashi Chie Tanaka Suguru Yamada Goro Nakayama Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasu | 2016 | Int. J. Cancer2016，，3： | 1 |
| 7 | Second harmonic generation from thermally poled CdS microcrystal-containing glasses 显示文摘 | Yoshitsugu Yamanoto Hiroyuki Nasu Tadanori Hashimoto | 2001 | J NonCryst Solids2001，281，： | 1 |
| 8 | Transposon tagging in rice显示文摘 | Takeshi Izawa Tohru Ohnishi Toshitsugu Nakano Nobuhiro Ishida Hiroyuki Enoki Hisako Hashimoto Kimiko Itoh Rie Terada Chuanyn Wu Chikara Miyazaki Tomoko Endo Shigeru Iida Ko Shimamoto | 1997 | Plant Molecular Biology (-)1997，，1： | 1 |
| 9 | Increased midkine levels in sera from patients with Alzheimer’s disease显示文摘 | Ragaa H.M. Salama Hisako Muramatsu Eiji Shimizu Kenji Hashimoto Shintaro Ohgake Hiroyuki Watanabe Naoya Komatsu Naoe Okamura Kaori Koike Naoyuki Shinoda Shin-ichi Okada Masaomi Iyo Takashi Muramatsu | 2005 | Progress in Neuropsychopharmacology & Biological Psychiatry2005，，4： | 1 |
| 10 | Translational implication of Kallmann syndrome-1 gene expression inhepatocellular carcinoma显示文摘 | Yuri Tanaka Mitsuro Kanda Hiroyuki Sugimoto Dai Shimizu Satoshi Sueoka Hideki Takami Kazuhiro Ezaka Ryoji Hashimoto Yukiyasu Okamura Naoki Iwata Chie Tanaka Suguru Yamada Tsutomu Fujii Goro Nakayama Masahiko Koike Shuji Nomoto Michitaka Fujiwara Yasuhiro | 2015 | International Journal of Oncology2015，，6： | 1 |
| 11 | Microtexture in the friction-stir weld of an aluminum alloy显示文摘 | Yutaka S. Sato Hiroyuki Kokawa Keiske Ikeda Masatoshi Enomoto Takenori Hashimoto Shigetoshi Jogan | 2001 | Metallurgical and Materials Transactions A2001，，4： | 1 |
| 12 | N-acylated and D-enantiomer derivatives of a nonamer core peptide of lactoferricin B showing improved antimicrobial activity显示文摘 | Hiroyuki Wakabayashi Hiroshi Matsumoto Koichi Hashimoto | 1999 | Antimicrobial Agents Chemotherapy1999，43，5： | 1 |
| 13 | Precipitation sequence in friction stir weld of 6063 aluminum during aging显示文摘 | Yutaka S. Sato Hiroyuki Kokawa Masatoshi Enomoto Shigetoshi Jogan Takenori Hashimoto | 1999 | Metallurgical and Materials Transactions A1999，，12： | 1 |
| 14 | Relationship Between C-Reactive Protein and Progression of Early Carotid Atherosclerosis in Hypertensive Subjects显示文摘 | Hiroyuki Hashimoto Kazuo Kitagawa Hidetaka Hougaku Hideki Etani Masatsugu Hori | 2004 | Stroke: Journal of the American Heart Association2004，，7： | 1 |
| 15 | C-reactive protein is an Independent Predictor of the Rate of Increase in Early Carotid Atherosclerosis显示文摘 | Hiroyuki Hashimoto Kazuo Kitagawa | 2001 | Circulation2001，104，： | 1 |
| 16 | Corrosion of ultra-fine grained copper fabricated by equal-channel angular pressing显示文摘 | Hiroyuki Miyamoto Kohei Harada Takuro Mimaki Alexei Vinogradov Satoshi Hashimoto | 2008 | Corrosion Science2008，，5： | 1 |
| 17 | C-reactive protein is an Independent Predictor of the Rate of Increase in Early Carotid Atherosclerosis显示文摘 | Hiroyuki Hashimoto Kazuo Kitagawa | 2001 | Circulation2001，104，1： | 1 |
| 18 | Nonalcoholic steatohepatitis: risk factors for liver fibrosis显示文摘 | Masahiko Shimada Etsuko Hashimoto Hiroyuki Kaneda Sanshirou Noguchi Naoaki Hayashi | 2002 | Hepatology Research2002，，4： | 1 |
| 19 | Spray Characterization of an Air-assist Pressure-swirl Atomizer Injecting High-viscosity Jatropha Oils 显示文摘 | YONG FAN NOZOMU HASHIMOTO HIROYUKI NISHIDA | 2014 | Fuel2014，121，： | 1 |
| 20 | The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis显示文摘 | Keiichi Uchida Yuhki Koike Kiyoshi Hashimoto Susumu Saigusa Mikihiro Inoue Kohei Otake Koji Tanaka Kohei Matsushita Yoshiki Okita Hiroyuki Fujikawa Toshimitsu Araki Yasuhiko Mohri Masato Kusunoki Paolo Gionchetti | 2015 | Gastroenterology Research and Practice2015，，： | 1 |
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