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| 1 | Screening for hilar biliary invasion in ampullary cancer patients显示文摘BACKGROUND The treatment for ampullary cancer is pancreatoduodenectomy or local ampullectomy.However,effective methods for the preoperative investigation of hilar biliary invasion in ampullary cancer patients have not yet been identified.AIM To determine the necessity of and an appropriate method for investigating hilar biliary invasion of ampullary cancer.METHODS Among 43 ampullary cancer patients,34 underwent endoscopic treatment(n=9)or surgery(n=25).The use of imaging findings(thickening and enhancement of the bile duct wall on contrast-enhanced computed tomography,irregularity on endoscopic retrograde cholangiography,thickening of the entire bile duct wall on intraductal ultrasonography(IDUS),and partial thickening of the bile duct wall on IDUS)and biliary biopsy results for diagnosing hilar biliary invasion of ampullary cancer was compared.RESULTS Hilar invasion was not observed in every patient.Among the patients who did not undergo biliary stent insertion,the combination of partial thickening of the bile duct wall on IDUS and biliary biopsy results showed the highest accuracy(100%)for diagnosing hilar biliary invasion.However,each imaging method and biliary biopsy yielded some false-positive results.CONCLUSION Although some false-positive results were obtained with each method,the combination of partial thickening of the bile duct wall on IDUS and biliary biopsy results was useful for diagnosing hilar biliary invasion of ampullary cancer.However,hilar invasion of ampullary cancer is rare;therefore,the investigation of hilar biliary invasion of ampullary cancer might be unnecessary. | Tadayuki Takagi Mitsuru Sugimoto Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Jun Nakamura Mika Takasumi Minami Hashimoto Tsunetaka Kato Ryoichiro Kobashi Takumi Yanagita Yuko Hashimoto Shigeru Marubashi Takuto Hikichi Hiromasa Ohira | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，9： | 2 |
| 2 | Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C: a Japanese multi-center study显示文摘 | Takeshi Okanoue Yoshito Itoh Hiroaki Hashimoto Kohichiroh Yasui Masahito Minami Tetsuo Takehara Eiji Tanaka Morikazu Onji Joji Toyota Kazuaki Chayama Kentaro Yoshioka Namiki Izumi Norio Akuta Hiromitsu Kumada | 2009 | Journal of Gastroenterology2009，，9： | 2 |
| 3 | The potential clinical value of GML and the p53 gene as a predictor of chemosensitivity for colorectal cancer显示文摘 | Hashimoto Y Ueda K Minami K | 2001 | Int J Clin Oncol2001，6，2： | 1 |
| 4 | The potential clinical value of GML and the p53 gene as a predictor of chemosensitivity for colorectal cancer显示文摘 | Ueda K Minami K | 2001 | Iht J Clin Oncol2001，6，2： | 1 |
| 5 | The comparative arthropathy of fluoroquinolones in dogs显示文摘 | Takizawa T Hashimoto K Minami T | 1999 | Hum Exp Toxicol1999，18，6： | 1 |
| 6 | Spatio-temporally regulated expressior of receptor tyrosine kinases, mRorl, mRor2, during mous development: implications in development and function of th nervous system 显示文摘 | Oishi I Takeuchi S Hashimoto R Nagabukuro A Ued T Liu Z J Hatta T Akira S Matsuda Y Yamamura H Otani H Minami Y | 1999 | Genes Cells1999，4，1： | 1 |
| 7 | Low oxygen tension during in vitro maturation is beneficial for supporting the subsequent development of bovine cumulus-oocyte complexes 显示文摘 | Hashimoto S Minami N Takakura R | 2000 | Mol Reprod Dev2000，57，4： | 1 |
| 8 | Bovine immature oocytes acquire developmental competence during meiotic arrest in vitro显示文摘 | Hashimoto S Minami N Takakura R | 2002 | Biol Reprod2002，66，6： | 1 |
| 9 | The role of nitric oxide in the baroreceptor-cardiac reflex in conscious Wistar rats显示文摘 | Minami N Imai Y Hashimoto J | 1995 | Am J Physiol1995，269，： | 1 |
| 10 | Low oxygen tension during in vitro maturation is beneficial for supporting the subsequent development of bovine cumulus-oocyte complexes 显示文摘 | Hashimoto S Minami N Takakura R | 2000 | Mol Reprod Deve2000，57，4： | 1 |
| 11 | Low oxy- gen tension during in vitro maturation is beneficial for supporting the subsequent development of bovine cu- mulus-oocyte complexes 显示文摘 | Hashimoto S Minami N Takakura R | 2000 | Molecular Reproduction and Development2000，57，： | 1 |
| 12 | Functional and binding studies of insurmountable antagonism of 606A,a novel AT1-receptor antagonist in rabbit tissues显示文摘 | KUROSAWA Y MINAMI K HASHIMOTO Y | 1999 | J Cardiovasc Pharmacol1999，34，1： | 1 |
| 13 | The potential clinical value of GMC and the p53 gene as a predictor 显示文摘 | Hashimoto Y Deda K Minami K | 2001 | Int J Clin Oncol2001，6，2： | 1 |
| 14 | Which scope is appropriate for endoscopic retrograde cholangiopancreatography after Billroth II reconstruction:An esophagogastroduodenoscope or a colonoscope?显示文摘BACKGROUND Recently,with the advent of more advanced devices and endoscopic techniques,endoscopic retrograde cholangiopancreatography(ERCP)in Billroth II(B-II)patients has been increasingly performed.However,the procedures are difficult,and the techniques and strategies have not been defined.AIM To reveal the appropriate scope for ERCP in B-II patients.METHODS Sixty ERCP procedures were performed on B-II patients between June 2005 and May 2018 at Fukushima Medical University Hospital,and in 44 cases,this was the first ERCP procedure performed by esophagogastroduodenoscopy(EGDS)or colonoscopy(CS)after B-II gastrectomy.These cases were divided into two groups:17 cases of ERCP performed by EGDS(EGDS group)and 27 cases of ERCP performed by CS(CS group).The patient characteristics and ERCP procedures were compared between the EGDS and CS groups.RESULTS The procedural time was significantly shorter in the EGDS group than in the CS group[median(range):60(20-100)vs 90(40-128)min,P value<0.01].CS was an independent factor of a longer ERCP procedural time according to the univariate and multivariate analyses(odds ratio:3.97,95%CI:1.05-15.0,P value=0.04).CONCLUSION Compared to CS,EGDS shortened the procedural time of ERCP in B-II patients. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Mika Takasumi Minami Hashimoto Tsunetaka Kato TakutoHikichi Hiromasa Ohira | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，8： | 1 |
| 15 | Blocking on the CXCR4/mTOR signalling pathwayinduces the anti-metastatic properties and autophagic celldeath in peritoneal disseminated gastric cancer cells显示文摘 | Hashimoto I Koizumi K Tatematsu M Minami T Cho S Tak-eno N | 2008 | Eur JCancer2008，44，： | 1 |
| 16 | Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells显示文摘 | Isaya Hashimoto Keiichi Koizumi Mikiko Tatematsu Takayuki Minami Seiji Cho Nobuhiro Takeno Akitoshi Nakashima Hiroaki Sakurai Shigeru Saito Kazuhiro Tsukada Ikuo Saiki | 2008 | European Journal of Cancer2008，，7： | 1 |
| 17 | Can the wet suction technique change the efficacy of endoscopic ultrasound-guided fine-needle aspiration for diagnosing autoimmune pancreatitis type 1? A prospective single-arm study显示文摘BACKGROUND Other than surgery,endoscopic ultrasound-guided fine-needle aspiration(EUSFNA)is the only procedure for histologically diagnosing autoimmune pancreatitis(AIP).However,adequate specimens are difficult to obtain.Recently,more adequate specimens were reported to be obtained with EUS-FNA with a wet suction technique(WEST)than with conventional EUS-FNA.AIM To histologically diagnose AIP by EUS-FNA with a WEST.METHODS Eleven patients with possible type 1 AIP between February 2016 and August 2018 underwent EUS-FNA with a WEST(WEST group),with four punctures by 19 or 22 G needles.As a historical control,23 type 1 AIP patients who underwent no fewer than four punctures with 19 or 22 G needles were enrolled(DRY group).Patient characteristics and histological findings were compared between the two groups.RESULTS Three histopathological factors according to the International Consensus Diagnostic Criteria were significantly greater in the WEST group than the DRY group[lymphoplasmacytic infiltrate without granulocytic infiltration:9(81.8%)vs 6(26.1%),P=0.003,storiform fibrosis:5(45.5%)vs 1(4.3%),P=0.008,abundant(>10 cells/HPF)IgG4-positive cells:7(63.6%)vs 5(21.7%),P=0.026].Level 1 or level 2 histopathological findings were observed more often in the WEST group than in the DRY group[8(72.7%)vs 3(13.0%),P=0.001].CONCLUSION EUS-FNA with a WEST was more successful than standard EUS-FNA in histologically diagnosing AIP. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Mika Takasumi Minami Hashimoto Tsunetaka Kato Takuto Hikichi Kenji Notohara Hiromasa Ohira | 2020 | World Journal of Clinical Cases2020，8，1： | 1 |
| 18 | Low oxygen tension duringin vitro maturation is beneficial for supporting the subsequent development of bovine cumulus oocyte complexes显示文摘 | Hashimoto S Minami N Takakura R | 2000 | Molecular Reproduction and Development2000，53，： | 1 |
| 19 | Bovine immature oocytes acquire developmental competence during meiotic arrest in vitro显示文摘 | Hashimoto S Minami N Takakura R | 2002 | Biol Reprod2002，66，6： | 1 |
| 20 | Excessive concentration of glucose during in vitro maturation impairs the developmental competence of bovine oocytes after in vitro fertilization显示文摘 | HASHIMOTO S MINAMI N YAMADA M | 2000 | Mol Reprod2000，56，： | 1 |
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