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| 1 | Importance of early diagnosis of pancreaticobiliary maljunction without biliary dilatation显示文摘AIM:To clarify the strategy for early diagnosis of pancreaticobiliary maljunction(PBM) without biliary dilatation and to pathologically examine gallbladder before cancer develops.METHODS:The anatomy of the union of the pancreatic and bile ducts was assessed by using endoscopic retrograde cholangiopancreatography(ERCP).Patients with a long common channel in which communication between the pancreatic and bile ducts was maintained even during sphincter contraction were diagnosed as having PBM.Of these,patients in which the maximal diameter of the bile duct was less than 10 mm were diagnosed with PBM without biliary dilatation.The process of diagnosing 54 patients with PBM without biliary dilatation was retrospectively investigated.Histopathological analysis of resected gallbladder specimens from 8 patients with PBM without biliary dilatation or cancer was conducted.RESULTS:Thirty-six PBM patients without biliary dilatation were diagnosed with gallbladder cancer after showing clinical symptoms such as abdominal or back pain(n = 16) or jaundice(n = 12).Radical surgery for gallbladder cancer was only possible in 11 patients(31%) and only 4 patients(11%) survived for 5 years.Eight patients were suspected as having PBM without biliary dilatation from the finding of gallbladder wall thickening on ultrasound and the diagnosis was confirmed by ERCP and/or magnetic resonance cholangiopancreatography(MRCP).The median age of these 8 patients was younger by a decade than PBM patients with gallbladder cancer.All 8 patients underwent prophylactic cholecystectomy and bile duct cancer has not occurred.Wall thickness and mucosal height of the 8 resected gallbladders were significantly greater than controls,and hyperplastic changes,hypertrophic muscular layer,subserosal fibrosis,and adenomyomatosis were detected in 7(88%),5(63%),7(88%) and 5(63%) patients,respectively.Ki-67 labeling index was high and K-ras mutation was detected in 3 of 6 patients.CONCLUSION:To detect PBM without biliary dilatation before onset of gallbladder cancer,we should perform MRCP for individuals showing increased gallbladder wall thickness on ultrasound. | Kensuke Takuma Terumi Kamisawa Taku Tabata Seiichi Hara Sawako Kuruma Yoshihiko Inaba Masanao Kurata Goro Honda Koji Tsuruta Shin-ichiro Horiguchi Yoshinori Igarashi | 2012 | World Journal of Gastroenterology2012，18，26： | 13 |
| 2 | Global Wheat Head Detection(GWHD)Dataset:A Large and Diverse Dataset of High-Resolution RGB-Labelled Images to Develop and Benchmark Wheat Head Detection Methods显示文摘The detection of wheat heads in plant images is an important task for estimating pertinent wheat traits including head population density and head characteristics such as health,size,maturity stage,and the presence of awns.Several studies have developed methods for wheat head detection from high-resolution RGB imagery based on machine learning algorithms.However,these methods have generally been calibrated and validated on limited datasets.High variability in observational conditions,genotypic differences,development stages,and head orientation makes wheat head detection a challenge for computer vision.Further,possible blurring due to motion or wind and overlap between heads for dense populations make this task even more complex.Through a joint international collaborative effort,we have built a large,diverse,and well-labelled dataset of wheat images,called the Global Wheat Head Detection(GWHD)dataset.It contains 4700 high-resolution RGB images and 190000 labelled wheat heads collected from several countries around the world at different growth stages with a wide range of genotypes.Guidelines for image acquisition,associating minimum metadata to respect FAIR principles,and consistent head labelling methods are proposed when developing new head detection datasets.The GWHD dataset is publicly available at http://gffzzef49fa24bca249bbhcvkwbub6nqnw6bbc.ffgz.tsg.suse.edu.cn/and aimed at developing and benchmarking methods for wheat head detection. | Etienne David Simon Madec Pouria Sadeghi-Tehran Helge Aasen Bangyou Zheng Shouyang Liu Norbert Kirchgessner Goro Ishikawa Koichi Nagasawa Minhajul A.Badhon Curtis Pozniak Benoit de Solan Andreas Hund Scott C.Chapman Frédéric Baret Ian Stavness Wei Guo | 2020 | Plant Phenomics2020，2，1： | 13 |
| 3 | Diagnosis and clinical implications of pancreatobiliary reflux显示文摘Oddi 的括约肌在远侧的结束被定位胰腺并且胆汁管并且调整胆汁和胰液的流出。一条普通隧道能那么长连接胰腺并且胆汁管在十二指肠的墙外面被定位,,发生在 pancreaticobiliary maljunction (PBM ) ;在如此的情况中,括约肌行动机能上地不影响连接。因为在胰腺的管以内的水疗院压力通常比在胆汁管大,胰液经常倒流进在 PBM 的胆汁的管(pancreatobiliary 倒流) ,导致致癌物在胆道的非位的条件。Pancreatobiliary 倒流能经由次要的十二指肠的乳头状的小突起在胆汁,刺激分泌素的动态磁性的回声 cholangiopancreatography,和 pancreatography 从提高的淀粉酶水平被诊断。最近,没有 PBM, pancreatobiliary 倒流能发生在个人,变得明显。没有 PBM, Pancreatobiliary 倒流可能甚至在一些个人与胆汁的致癌作用有关。因为很少全身的研究与正常 pancreaticobiliary 连接在个人关于 pancreatobiliary 倒流的临床的关联和含意存在,包括适当管理的进一步未来的临床的研究应该被执行。 | Terumi Kamisawa Hajime Anjiki Naoto Egawa Masanao Kurata Goro Honda Kouji Tsuruta | 2008 | World Journal of Gastroenterology2008，14，43： | 12 |
| 4 | Sclerosing cholangitis associated with autoimmune pancreatitis differs from primary sclerosing cholangitis显示文摘AIM:To clarify the characteristic features of biliary le-sions in patients with autoimmune pancreatitis(AIP) and compare them with those of primary sclerosing cholangitis(PSC) .METHODS:The clinicopathological characteristics of 34 patients with sclerosing cholangitis(SC) associated with AIP were compared with those of 4 patients with PSC.RESULTS:SC with AIP occurred predominantly in el-derly men.Obstructive jaundice was the most frequent initial symptom in SC with AIP.Only SC patients with AIP had elevated serum IgG4 levels,and sclerosing diseases were more frequent in these patients.SC pa-tients with AIP responded well to steroid therapy.Seg-mental stenosis of the lower bile duct was observed only in SC patients with AIP,but a beaded and pruned-tree appearance was detected only in PSC patients.Dense infi ltration of IgG4-positive plasma cells was de-tected in the bile duct wall and the periportal area,as well as in the pancreas,of SC patients with AIP.CONCLUSION:SC with AIP is distinctly different from PSC.The two diseases can be discriminated based on cholangiopancreatographic findings and serum IgG4 levels. | Terumi Kamisawa Kensuke Takuma Hajime Anjiki Naoto Egawa Masanao Kurata Goro Honda Kouji Tsuruta | 2009 | World Journal of Gastroenterology2009，15，19： | 9 |
| 5 | Influences of Cross Pollination on Pollen Tube Growth and Fruit Set in Zuili Plums (Prunus salicina)显示文摘Zuili plum (Prunus salicina L.) trees usually set fruit poorly, although they produce high quality fruit. To elucidate the causes of the poor fruit set, pollen tube growth into pistils and fruit set percentage were investigated after cross-, self-and open-pollination. Ovule development in Zuili pistils was also investigated. Pollen tube penetration into the ovules via the obturator and micropyle was best when Zuili pistils were pollinated by cv. Black Amber (P. domestica) pollen grains, although cross-pollinations with Hongxinli and Miili (P. salicina) pollen were more effective than self-and open-pollination. The fruit set percentage was also highest in pistils pollinated with Black Amber pollen grains. Morphological observation of Zuili pistils revealed that the trees produce 'double pistils' , developing two ovaries from a basal pistil, at a rate as high as 28%. In such abnormal pistils, most ovules were lacking an embryo sac or were entirely degenerated. The percentage of normally developed ovules was 24.3% and 8.9% in normal and double pistils, respectively. From these results, we conclude that the main causes of poor fruit set of Zuili plums are a lack of effective cross-pollination and the production of high percentages of double pistils in which normally developed ovules are scarcely formed. | Hui-Juan Jia Feng-Jie He Cai-Zhen Xiong Fu-Rong Zhu Goro Okamoto | 2008 | Journal of Integrative Plant Biology2008，50，2： | 8 |
| 6 | Original single-incision laparoscopic cholecystectomy for acute inflammation of the gallbladder显示文摘AIM:To investigate the safety and feasibility of our original single-incision laparoscopic cholecystectomy (SILC) for acute inflamed gallbladder (AIG).METHODS:One hundred and ten consecutive patients underwent original SILC for gallbladder disease without any selection criteria and 15 and 11 of these were diagnosed with acute cholecystitis and acute gallstone cholangitis,respectively.A retrospective review was performed not only between SILC for AIG and non-AIG,but also between SILC for AIG and traditional laparoscopic cholecystectomy (TLC) for AIG in the same period.RESULTS:Comparison between SILC for AIG and nonAIG revealed that the operative time was longer in SILC for AIG (97.5min vs 85.0min,P=0.03).The open conversion rate (2/26 vs 2/84,P=0.24) and complication rate (1/26 vs 3/84,P=1.00) showed no differences,but a need for additional trocars was more frequent in SILC for AIG (5/24 vs 3/82,P=0.01).Comparison between SILC for AIG and TLC for AIG revealed no differences based on statistical analysis.CONCLUSION:Our original SILC technique was ade-quately safe and feasible for the treatment of acute cholecystitis and acute gallstone cholangitis. | Kazunari Sasaki Goro Watanabe Masamichi Matsuda Masaji Hashimoto | 2012 | World Journal of Gastroenterology2012，18，9： | 7 |
| 7 | Liver resection for hepatocellular carcinoma using a microwave tissue coagulator: Experience of 1118 cases显示文摘A I M : To present our extensive experience of hepatectomy for hepatocellular carcinoma using a microwave tissue coagulator to demonstrate the effectiveness of this device. METHODS: A total of 1118 cases(1990-2013) were reviewed,with an emphasis on intraoperative blood loss,postoperative bile leakage and fluid/abscess formation,and adaptability to anatomical resection and hepatectomy with hilar dissection.RESULTS: The median intraoperative blood loss was 250 m L; postoperative bile leakage and fluid/abscess formation were seen in 3.0% and 3.3% of cases,respectively. Anatomical resection was performed in 275 cases,including 103 cases of hilar dissection that required application of microwave coagulation near the hepatic hilum. There was no clinically relevant biliary tract stricture or any vascular problems due to heat injury. Regarding the influence of cirrhosis on intraoperative blood loss,no significant difference was seen between cirrhotic and non-cirrhotic patients(P = 0.38),although cirrhotic patients tended to have smaller tumors and underwent less invasive operations. CONCLUSION: This study demonstrated outcomes of an extensive experience of hepatectomy using heat coagulative necrosis by microwave tissue coagulator. | Kazunari Sasaki Masamichi Matsuda Masaji Hashimoto Goro Watanabe | 2015 | World Journal of Gastroenterology2015，21，36： | 7 |
| 8 | An automated spring-loaded needle for endoscopic ultrasound-guided abdominal paracentesis in cancer patients显示文摘AIM: To evaluate the feasibility of using an automatedspring-loaded needle device for endoscopic ultrasound(EUS)-guided abdominal paracentesis(EUS-P) to see if this would make it easier to puncture the mobile and lax gastric wall for EUS-P.METHODS: The EUS database and electronic medical records at Fukushima Medical University Hospital were searched from January 2001 to April 2011. Patients with a history of cancer and who underwent EUS-P using an automated spring-loaded needle device with a 22-gauge puncture needle were included. The needle was passed through the instrument channel and advanced through the gastrointestinal wall under EUS guidance into the echo-free space in the abdominal cavity and ascitic fluid was collected. The confirmed diagnosis of malignant ascites included positive cytology and results from careful clinical observation for at least 6 mo in patients with negative cytology. The technical success rate, cytology results and complications were evaluated.RESULTS: We found 11 patients who underwent EUS-P with an automated spring-loaded needle device. In 4 cases, ascites was revealed only with EUS but not in other imaging modalities. EUS-P was done in 7 other cases because there was minimal ascitic fluid and no safe window for percutaneous abdominal aspiration. Ascitic fluid was obtained in all cases by EUS-P. The average amount aspirated was 14.1 mL(range 0.5-38 mL) and that was sent for cytological exam. The etiology of ascitic fluid was benign in 5 patients and malignant in 6. In all cases, ascitic fluid was obtained with the first needle pass. No procedure-related adverse effects occurred.CONCLUSION: EUS-P with an automated springloaded needle device is a feasible and safe method for ascites evaluation. | Rei Suzuki Atsushi Irisawa Manoop S Bhutani Takuto Hikichi Tadayuki Takagi Goro Shibukawa Ai Sato Masaki Sato Tsunehiko Ikeda Ko Watanabe Jun Nakamura Srinadh Annangi Kazuhiro Tasaki Katsutoshi Obara Hiromasa Ohira | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，2： | 3 |
| 9 | B?cell translocation gene 1 serves as a novel prognostic indicator ofhepatocellular carcinoma显示文摘 | Mitsuro Kanda Hiroyuki Sugimoto Shuji Nomoto Hisaharu Oya Soki Hibino Dai Shimizu Hideki Takami Ryoji Hashimoto Yukiyasu Okamura Suguru Yamada Tsutomu Fujii Goro Nakayama Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2015 | International Journal of Oncology2015，，2： | 3 |
| 10 | Global Wheat Head Detection 2021:An Improved Dataset for Benchmarking Wheat Head Detection Methods显示文摘The Global Wheat Head Detection(GWHD)dataset was created in 2020 and has assembled 193,634 labelled wheat heads from 4700 RGB images acquired from various acquisition platforms and 7 countries/institutions.With an associated competition hosted in Kaggle,GWHD_2020 has successfully attracted attention from both the computer vision and agricultural science communities.From this first experience,a few avenues for improvements have been identified regarding data size,head diversity,and label reliability.To address these issues,the 2020 dataset has been reexamined,relabeled,and complemented by adding 1722 images from 5 additional countries,allowing for 81,553 additional wheat heads.We now release in 2021 a new version of the Global Wheat Head Detection dataset,which is bigger,more diverse,and less noisy than the GWHD_2020 version. | Etienne David Mario Serouart Daniel Smith Simon Madec Kaaviya Velumani Shouyang Liu Xu Wang Francisco Pinto Shahameh Shafiee Izzat SATahir Hisashi Tsujimoto Shuhei Nasuda Bangyou Zheng Norbert Kirchgessner Helge Aasen Andreas Hund Pouria Sadhegi-Tehran Koichi Nagasawa Goro Ishikawa Sébastien Dandrifosse Alexis Carlier Benjamin Dumont Benoit Mercatoris Byron Evers Ken Kuroki Haozhou Wang Masanori Ishii Minhajul ABadhon Curtis Pozniak David Shaner LeBauer Morten Lillemo Jesse Poland Scott Chapman Benoit de Solan Frédéric Baret Ian Stavness Wei Guo | 2021 | Plant Phenomics2021，3，1： | 2 |
| 11 | Comparison of Surgical Results of D2 Versus D3 Gastrectomy (Para-Aortic Lymph Node Dissection) for Advanced Gastric Carcinoma: A Multi-Institutional Study显示文摘 | Chikara Kunisaki Hirotoshi Akiyama Masato Nomura Goro Matsuda Yuichi Otsuka Hidetaka Ono Yutaka Nagahori Hideo Hosoi Masazumi Takahashi Fumihiko Kito Hiroshi Shimada | 2006 | Annals of Surgical Oncology2006，，5： | 2 |
| 12 | Retroperitoneal cavernous hemangioma resected by a pylorus preserving pancreaticoduodenectomy显示文摘A retroperitoneal hemangioma is a rare disease. We report on the diagnosis and treatment of a retroperitoneal hemangioma which had uncommonly invaded into both the pancreas and duodenum, thus requiring a pylorus preserving pancreaticoduodenectomy (PpPD). A 36-year-old man presented to our hospital with abdominal pain. An enhanced computed tomography scan without contrast enhancement revealed a 12 cm × 9 cm mass between the pancreas head and right kidney. Given the high rate of malignancy associated with retroperitoneal tumors, surgical resection was performed. Intraoperatively, the tumor was inseparable from both the duodenum and pancreas and PpPD was performed due to the invasive behavior. Although malignancy was suspected, pathological diagnosis identified the tumor as a retroperitoneal cavernous hemangioma for which surgical resection was the proper diagnostic and therapeutic procedure. Reteoperitoneal cavernous hemangioma is unique in that it is typically separated from the surrounding organs. However, clinicians need to be aware of the possibility of a case, such as this, which has invaded into the surrounding organs despite its benign etiology. From this case, we recommend that combined resection of inseparable organs should be performed if the mass has invaded into other tissues due to the hazardous nature of local recurrence. In summary, this report is the first to describe a case of retroperitoneal hemangioma that had uniquely invaded into surrounding organs and was treated with PpPD. | Marie Hanaoka Masaji Hashimoto Kazunari Sasaki Masamichi Matsuda Takeshi Fujii Kenichi Ohashi Goro Watanabe | 2013 | World Journal of Gastroenterology2013，19，28： | 2 |
| 13 | Expression of Masu Salmon Δ5-Desaturase-Like Gene Elevated EPA and DHA Biosynthesis in Zebrafish显示文摘 | Alimuddin Goro Yoshizaki Viswanath Kiron Shuichi Satoh Toshio Takeuchi | 2007 | Marine Biotechnology2007，，1： | 2 |
| 14 | Telomere Reduction in Human Liver Tissues with Age and Chronic Inflammation显示文摘 | Hiroshi Aikata Hideki Takaishi Yoshiiku Kawakami Shoichi Takahashi Mikiya Kitamoto Toshio Nakanishi Yasuhiro Nakamura Fumio Shimamoto Goro Kajiyama Toshinori Ide | 2000 | Experimental Cell Research2000，，2： | 2 |
| 15 | Longterm Outcomes of Early-Stage Gastric Carcinoma Patients Treated with Laparoscopy-Assisted Surgery显示文摘 | Michitaka Fujiwara Yasuhiro Kodera Kazunari Misawa Mizunobu Kinoshita Takashi Kinoshita Shinichi Miura Norifumi Ohashi Goro Nakayama Masahiko Koike Akimasa Nakao | 2008 | Journal of the American College of Surgeons2008，，1： | 2 |
| 16 | Phase II Trial of Radiotherapy After Hyperbaric Oxygenation With Multiagent Chemotherapy (Procarbazine, Nimustine, and Vincristine) for High-Grade Gliomas: Long-Term Results显示文摘 | Kazuhiko Ogawa Shogo Ishiuchi Osamu Inoue Yoshihiko Yoshii Atsushi Saito Takashi Watanabe Shiro Iraha Takafumi Toita Yasumasa Kakinohana Takuro Ariga Goro Kasuya Sadayuki Murayama | 2012 | International Journal of Radiation Oncology Biology Physics2012，，2： | 2 |
| 17 | SJES14121200034975显示文摘 | Kenneth Cusi Zhi Chang Steve Harrison Romina Lomonaco Fernando Bril Beverly Orsak Carolina Ortiz-Lopez Joan Hecht Ariel E. Feldstein Amy Webb Christopher Louden Martin Goros Fermin Tio | 2014 | Journal of Hepatology2014，，1： | 1 |
| 18 | A new co-dominant PCR-based marker to identify the high-molecular-weight glutenin subunit combination '5 +10' of common wheat 显示文摘 | GORO I TOSHIKI N | 2007 | Wheat Information Service2007，103，： | 1 |
| 19 | The Barriers and Solutions to Integration of the EAFTA and TPP显示文摘 | Goro Takahashi | 2013 | Journal of Global Policy and Governance2013，，2： | 1 |
| 20 | Function and diagnostic value of Anosmin‐1 in gastric cancer progression显示文摘 | Mitsuro Kanda Dai Shimizu Tsutomu Fujii Satoshi Sueoka Yuri Tanaka Kazuhiro Ezaka Hideki Takami Haruyoshi Tanaka Ryoji Hashimoto Naoki Iwata Daisuke Kobayashi Chie Tanaka Suguru Yamada Goro Nakayama Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasu | 2016 | Int. J. Cancer2016，，3： | 1 |
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