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| 1 | Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED. | ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu | 2003 | Asian Journal of Andrology2003，5，1： | 38 |
| 2 | Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats显示文摘 | Fu WJ Haynes TE Kohli R | 2005 | J Nutr2005，135，4： | 1 |
| 3 | Embryos of the polyembryonic wasp Macrocentrus cingulum evade encapsulation of its host Ostrinia furnacalis by a Helix pomatia lectin binding protein on the extraembryonic membrane显示文摘 | Hu J Yu XQ Fu WJ Zhang WQ | | 0，，04： | 1 |
| 4 | Arterial stiffness,cardiovagal baroreflex sensitivity and postural blood pressure changes in older adults:the Rotterdam Study显示文摘 | Mattace Raso FU van den Meiracker AH Bos WJ | 2007 | J Hypertens2007，25，： | 1 |
| 5 | Urinary tubular biomarkers in short-term type 2 diabetes mellitus patients:a cross-sectional study显示文摘 | Fu WJ Xiong SL Fang YG | 2012 | Endocrine2012，41，1： | 1 |
| 6 | Vaporesection for managing benign prostatic hyperplasia using a 2-mierom continuous-wave laser: a prospective trial with 1-year follow-up显示文摘 | FU WJ HONG BF YANG Y | 2009 | BJU Int2009，103，3： | 1 |
| 7 | Small interference RNA targeting Krüppel-like factor 8 inhibits the renal carcinoma 786-0 cells growth in vitro and in vivo显示文摘 | Fu WJ Li JC Wu XY | 2010 | J Cancer Res Clin Oncol2010，136，8： | 1 |
| 8 | Vaporesection for man- aging benign prostatic hyperplasia using a 2-microm con- tinuous-wave laser:a prospective trial with 1-year follow up显示文摘 | Fu WJ Hong BF Yang Y | 2009 | BJU 1nt2009，103，3： | 1 |
| 9 | Vaporesection for managing benign prostatic hyperplasia using a 2-micron continuous-wave laser:prospective trial with I-year follow-up显示文摘 | Fu WJ Hong BF Yang Y | 2009 | BJU Int2009，103，3： | 1 |
| 10 | Nutcracker phenomenon: a new diag- nostic method of muhislice computed tomography angiogxaphy显示文摘 | Fu WJ Hong BF Gao JP | 2006 | Int J Urol2006，13，7： | 1 |
| 11 | Comparison of 2-micron continuous wave laser vaporesection of the prostate and transurethral resection of the prostate: a prospective nonrandomized trial with 1-year follow-up显示文摘 | Fu WJ Zhang X Yang Y | 2010 | J Urol2010，75，1： | 1 |
| 12 | Mosquitoes and mosquito- borne arboviruses in the Qinghai-Tibet Plateau--focused on the Qinghai area, China 显示文摘 | Li WJ Wang JL Li MH Fu SH Wang HY Wang ZY Jiang SY Wang XW Guo P Zhao SC Shi Y Lu NN Nasci RS Tang Q Liang GD | 2010 | Am J Trop Med Hyg2010，82，4： | 1 |
| 13 | THE NUMERICAL SOLUTION OF FIRST KIND INTEGRAL EQUATION FOR THE HELMHOLTZ EQUATION ON SMOOTH OPEN ARCS显示文摘Consider solving the Dirichlet problem of Helmholtz equation on unbounded region R2\Г with Г a smooth open curve in the plane. We use simple-layer potential to construct a solution. This leads to the solution of a logarithmic integral equation of the first kind for the Helmholtz equation. This equation is reformulated using a special change of variable, leading to a new first kind equation with a smooth solution function. This new equation is split into three parts. Then a quadrature method that takes special advantage of the splitting of the integral equation is used to solve the equation numerically. An error analysis in a Sobolev space setting is given. And numerical results show that fast convergence is clearly exhibited. | Tang, WJ Fu, HY Shen, LJ | 2001 | Journal of Computational Mathematics2001，19，5： | 1 |
| 14 | Tahyna virus infection, a neglected arboviral disease in the Qinghai-Tibet Plateau of China 显示文摘 | Li WJ Cao YX Fu SH Wang JL Li MH Jiang S Wang XE Xing SY Feng LH Wang ZQ Shi Y Zhao SC Wang HY Wang ZY Liang GD | 2014 | Vector Borne Zoonotic Dis2014，14，5： | 1 |
| 15 | Tumor epithelial cell matrix metalloproteinase 9 is a target for antimetastatic therapy in colorectal cancer显示文摘 | Lubbe WJ Zhou ZY Fu W | 2006 | Clin Cancer Res2006，12，6： | 1 |
| 16 | Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats显示文摘 | Fu WJ Haynes TE Kohli R | 2005 | J Nutr2005，135，4： | 1 |
| 17 | Changes of the tubular markers in type 2 diabetes mellitus with glomerular hyperfiltration显示文摘 | Fu WJ Li BL Wang SB | 2012 | Diabetes Res Clin Pract2012，95，1： | 1 |
| 18 | A modified visual loop-mediated isothermal amplieation method for diagnosis and differentiation of main pathogens from My- eobacterium tuberculosis complex 显示文摘 | Hong M Zha L Fu WL Zou MJ Li WJ Xu DG | 2012 | Mierobiol Biotechn- ol2012，28，： | 1 |
| 19 | Urinary tubular biomarkers in short-term type 2 diabetes mellitus patients: a cross-sectional study显示文摘 | Fu WJ Xiong SL Fang YG | 2012 | Endocrine2012，41，1： | 1 |
| 20 | Experinent researches on anti-in-flamatory activity of mizolastine显示文摘 | Fu M Fan PS Liao WJ | 2003 | J Clin Dematol2003，32，11： | 1 |
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