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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | Effect of the antioxidant probucol on soluble thrombomodulin (sTM) in hypercholesterolemic rabbits显示文摘 | Hong SC Zhao SP Liu Q | 2008 | Int J Cardiol2008，123，2： | 1 |
| 3 | A steady flow analysis on the stented and nonstented sidewall aneurysm models 显示文摘 | Yu SC Zhao JB | 1999 | IVied Eng Phys1999，21，： | 1 |
| 4 | Probucol up-regulates paraoxonase 1 expression in hepatocytes of hypercholesterolemic rabbits显示文摘 | Hong SC Zhao SP Wu ZH | 2006 | J Cardiovasc Pharmacol2006，47，1： | 1 |
| 5 | Role of seneory nervous system vasoactive peptide in hypertention显示文摘 | Supowit SC Zhao H | 2002 | Brax J med Biol Res2002，35，： | 1 |
| 6 | Effect of the anti-oxidant probucol on soluble thrombomodulin (sTM) in hypercholesterolemic rabbits显示文摘 | Hong SC Zhao SP Liu Q | 2008 | Int J Cardiol2008，123，2： | 1 |
| 7 | Treatment of unruptured cerebral aneurysms in California显示文摘 | Johnston SC Zhao S Dudley RA | 2001 | Stroke2001，32，3： | 1 |
| 8 | Effect of the anti-oxidant probucol on soluble thrombomodulin(sTM)in hypercholesterolemic rabbits显示文摘 | Hong SC Zhao SP Liu Q | 2008 | Int J Cardiol2008，123，2： | 1 |
| 9 | Expression of COX-2 mRNA in peripheral blood monocytes from patients with acute myocardial infarction and its significance显示文摘 | Zhao SP Deng P Huang HG Xu ZM Dai HY Hong SC | 2005 | Clin Chem2005，51，11： | 1 |
| 10 | Gatism treated with neuroanastomosis显示文摘 | Zhao J | 1993 | J Neurol Orthop Med Surg1993，14，： | 1 |
| 11 | Effect of probucol on HDL metabolism and class B type Ⅰ scavenger receptor(SR-BI)expression in the liver of hypercholesterolemic rabbits显示文摘 | Hong SC Zhao SP Wu ZH | 2007 | Int J Cardiol2007，115，1： | 1 |
| 12 | First prospective, population- based inflammatory bowel disease incidence study in ma- inland of China: the emergence Of 'western' disease显示文摘 | Zhao J Ng SC Lei Y | 2013 | Inflamm Bowel Dis2013，19，9： | 1 |
| 13 | Effect of the anti-oxidant probucol on soluble thrombomodulin in hypercholesterolemic rabbits显示文摘 | HONG SC ZHAO SP LIU Q | 2008 | Int J Cardiol2008，123，2： | 1 |
| 14 | Comparison of methotrexate resistance conferred by a mutant dihydrofolate reduction(DHFR)cDNA in two different retroviral vectors显示文摘 | Takebe N Nakahara S Zhao SC et al | 2002 | Cancer Gene Therapy2002，7，： | 1 |
| 15 | Relationship between the Apolipoprotein AI,B gene polymorphism and the risk of non-traumatic osteonecrosis显示文摘 | Yin JM Zhao L Zhao SC | 2014 | Lipids Health Dis2014，13，1： | 1 |
| 16 | Retroviral transduction of human dihydropyrimidine dehydrogenase cDNA confers resistance to 5-fluorouracil in murine hematopoietic progenitor cells and human CD34^+ -enriched peripheral blood progenitor cells显示文摘 | Takebe N Zhao SC Ural AU | 2001 | Cancer Gene Therapy2001，8，： | 1 |
| 17 | Effect of probucol on HDL metabolism and class B type I scavenger receptor(SR-B I) expression in the liver of hypercholesterolemic rabbits显示文摘 | Hong SC Zhao SP Wu ZH | 2007 | Int J Cardio2007，115，1： | 1 |
| 18 | Glutamic acid decar- boxylase 65 and 67 expression in the lateral septum is up-regulated in association with the postpartum period in mice显示文摘 | Zhao C Driessen T Gammie SC | 2012 | Brain Res2012，1470，1： | 1 |
| 19 | Effect of probucol on HDL metabolism and class B type Ⅰ scavenger receptor (SR-BI) expression in the liver of hypercholesterolemie rabbits显示文摘 | Hong SC Zhao SP Wu ZH | 2007 | Int J Cardiol2007，115，1： | 1 |
| 20 | Two sRNA RyhB homologs from Yersinia pestis biovar microtus expressed in vivo have differential Hfq-dependent stability显示文摘 | Deng ZL Meng XR Su SC Liu ZZ Ji XL Zhang YQ Zhao XN Wang XY Yang RF Han YP | | 0，，6： | 1 |
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